期刊
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
卷 23, 期 6, 页码 477-482出版社
WILEY
DOI: 10.1002/poc.1624
关键词
binding constant; binding site size; calf thymus DNA; chronocoulometry; fluorescence; sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate; square wave voltammetry; UV-Vis
资金
- Centre of Advanced Studies, Department of Chemistry, Jadavpur University
- CSIR, New Delhi, India
- Intramural MMDDA project at SINP
The anthracycline drugs, adriamycin and daunorubicin, efficient in the treatment of various human cancers, form strong intercalation complexes with DNA. The therapeutic efficiency and toxic properties of the drugs are associated with electron transfer processes, which correlate well with the redox behaviour of the compounds. Sodium 1,4-dihydroxy 9,10-anthraquinone-2-sulphonate (sodium quinizarin-2-sulphonate, NaLH2) (Na-Qz-2S) is a molecule that resembles anthracycline drugs and has a simpler structure in comparison to these drugs. Two electrons in the course of chemical action reduce this molecule like the anthracyclines. Electrochemical methods were used to identify this process. UV-Vis and fluorescence spectroscopy were used to analyse binding of the compound to calf thymus DNA. The binding constant and site size were evaluated for Na-Qz-2S and the same compared to that of the anthracyclines. Such comparisons are essential in order to understand whether the simpler hydroxy-anthraquinones can be a substitute for anthracycline drugs in cancer chemotherapy. Copyright (C) 2009 John Wiley & Sons, Ltd.
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