Article
Chemistry, Analytical
Ruipeng Chen, Yunfeng Sun, Bingyang Huo, Zefeng Mao, Xiaojuan Wang, Shiyu Li, Ran Lu, Shuang Li, Jun Liang, Zhixian Gao
Summary: A universal surface-enhanced Raman scattering (SERS) aptasensor was developed for the detection of Zearalenone (ZEN) with a linear detection range from 0.005 to 500 ng mL(-1) and a detection limit of 0.001 ng mL(-1). The sensor showed excellent performance for analytical applications with real-world samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Food Science & Technology
Menghu Liu, Muhammad Zareef, Afang Zhu, Wenya Wei, Huanhuan Li, Quansheng Chen
Summary: This study demonstrated the use of core-shell silver-coated gold nanorods to monitor Pb2+ in food. The results showed the accuracy and potential of this method for monitoring food quality and safety.
Article
Biochemical Research Methods
Wendai Cheng, Ping Tang, Xuanmeng He, Xinyue Xing, Shengde Liu, Feng Zhang, Xiaoxu Lu, Liyun Zhong
Summary: The synthesized Au/Ag composite-based SERS nanoprobe showed significant advantages in sensitivity and response speed for quantitative characterization of Cr3+ content. This nanoprobe might offer a new strategy for dynamic monitoring of Cr3+ content in human metabolism.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Cheng Wang, Pin-Jie Chen, Chun-Hway Hsueh
Summary: In this study, an Au-Cu-Si activation layer was successfully used as a substitute for the commonly used gold layer in propagating surface plasmon resonance sensors. The results showed that Au-based TFMG is feasible and has advantages of lower cost and better performance.
Article
Chemistry, Multidisciplinary
Brinton King Eldridge, Saghar Gomrok, James W. Barr, Elise Anne Chaffin, Lauren Fielding, Christian Sachs, Katie Stickels, Paiton Williams, Yongmei Wang
Summary: Gap-enhanced Raman tags are a new type of optical probe that utilize the strong electric field inside the gap between two plasmonic metals to enhance the surface-enhanced Raman scattering response. Our study investigated Au@SiO22@Au nanoparticles with varying shell and gap thicknesses and found that the near-field enhancement spectra inside the gap were stronger than on the outer surface of the nanoparticle. We also discovered that a thin shell combined with a thin gap produced the greatest near-field enhancement.
Article
Chemistry, Physical
Zhuangzhuang Ling, Zhuo Li, Jiuchuan Wang, Huangrong Ge, Jinghuai Fang, Mingfei Cheng, Jing Wu
Summary: This study demonstrates the preparation of a high SERS activity and plasmonic photocatalytic properties nanoarray, SA-Ag/Au HCNAs, by combining Ag/Au hybrid coupled films with a sapphire array. The prepared SA-Ag/Au HCNAs show significantly enhanced plasmonic photocatalytic properties compared to pure Au and pure Ag. They also exhibit good stability and sensitivity as SERS substrates for probe molecules. This work provides a simple, low-cost, and scalable method for the preparation of hybrid coupled nanoarrays with potential applications in photocatalytic dye degradation, environmental monitoring, and biomedical analysis.
APPLIED SURFACE SCIENCE
(2024)
Article
Chemistry, Multidisciplinary
Ming Kong, Yingyi Wu, Dandan Men, Qianqian Ding, Honghua Zhang
Summary: In this study, porous Au-Ag alloy nanoparticle arrays with hydrophobic surfaces were prepared using the polystyrene colloidal crystal template combined with the chemical etching method. The arrays enable rapid and trace SERS detection for biochemical molecules and provide a material basis for the construction of high-quality SERS substrates.
Article
Chemistry, Analytical
Xiaoyu Qi, Yufei Ye, Hao Wang, Bianbian Zhao, Lixia Xu, Yuting Zhang, Xiaoli Wang, Nandi Zhou
Summary: An ultrasensitive and dual-recognition surface-enhanced Raman scattering (SERS) biosensor has been developed for the detection of Staphylococcus aureus (S. aureus). The biosensor utilizes teicoplanin (Tcp) functionalized gold-coated magnet nanoparticles (Fe3O4@Au-Tcp NPs) as the capture probe and S. aureus aptamer (Apt) functionalized silver coated gold nanoparticles (Au@Ag-DTNB-Apt NPs) as the signal probe. The biosensor demonstrates high sensitivity and specificity due to the SERS enhancement from the hot spot effect between Au NPs and Au@Ag NPs, as well as the dual-recognition ability based on Tcp and Apt. The biosensor is capable of detecting S. aureus in milk and orange juice samples.
Article
Chemistry, Analytical
Xiaoxiao Hu, Cuilu Quan, Tiantian Ren, Linan Zhao, Yanting Shen, Yanyan Zhu, Jing Wang
Summary: A novel stimulus-responsive surface-enhanced Raman scattering (SERS) nanoprobe has been developed for sensitive glutathione (GSH) detection using manganese dioxide (MnO2) core and silver/gold nanoparticles (Ag/Au NPs). The MnO2 core acts as a scaffold to amplify the SERS signal and can be degraded in the presence of the target, significantly enhancing the nanoprobe sensitivity for GSH sensing. This sensing system offers a wide linear range and a low detection limit, and has potential applications in intracellular GSH detection and monitoring.
Article
Biochemical Research Methods
Chunchun Li, Yingrui Zhang, Ziwei Ye, Steven E. J. Bell, Yikai Xu
Summary: This article presents a sensitive and robust characterization technique, SERS, for studying the surface chemistry of nanomaterials in real-world applications. It allows real-time observation of molecule-metal interactions and provides information on surface orientation and chemical bond formation and breaking.
Article
Chemistry, Physical
Sungwoo Lee, Insub Jung, Soohyun Lee, Jaewon Lee, Myeong Jin Oh, Minsun Park, MohammadNavid Haddadnezhad, Woocheol Park, Sungho Park
Summary: We developed a highly sensitive and reliable immunoassay based on surface enhanced Raman scattering (SERS) using bimetallic alloy Ag@Au hollow dual-rim nanorings (DRNs). The Ag@Au hollow DRNs, consisting of concentrically overlapped hollow nanorings with different diameters connected by thin metal ligaments, exhibited strong single-particle SERS activity and biocompatibility. By using Ag@Au hollow DRNs as nanoprobes, a low limit of detection of 10 pM for human chorionic gonadotropin (HCG) hormone was achieved, highlighting their potential as ultrasensitive SERS nanoprobes.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Jie Huang, Tianxiang Zhou, Wenshi Zhao, Min Zhang, Zhibo Zhang, Wangsheng Lai, Naveen Reddy Kadasala, Huilian Liu, Yang Liu
Summary: In this study, magnetic core-shell-satellite nanocomposites were successfully prepared and applied for ultra-sensitive surface-enhanced resonance Raman scattering (SERRS) detection of bisphenol A (BPA). The nanocomposites exhibited outstanding SERRS sensitivity and saturation magnetization, providing a new idea for the tailored design of ultra-sensitive SERRS substrates. It shows great potential in pollutant detection, environmental monitoring, and food safety.
Article
Chemistry, Multidisciplinary
Hung Ji Huang, Ming-Hua Shiao, Yang-Wei Lin, Bei-Ju Lin, James Su, Yung-Sheng Lin, Han-Wei Chang
Summary: The study evaluated the effects of Au cores in Ag shells on enhancing surface-enhanced Raman scattering (SERS) with samples of different Au/Ag ratios. The synthesized Au@Ag-DNFs/Si samples showed that the Au core played a role in focusing the illumination light and enhancing the SERS response of the Ag coverage.
Article
Nanoscience & Nanotechnology
Yating Feng, Jiaxue Dai, Chuyun Wang, Hongyang Zhou, Jianhua Li, Gang Ni, Maofeng Zhang, Youju Huang
Summary: In this study, a sandwich structure based on surface-enhanced Raman scattering (SERS) was constructed, using AgNPs/Au@AgNRs, for the detection of perfluoro- and polyfluoroalkyl substances (PFAS). The results showed that the AgNPs/Au@AgNRs structure enabled highly sensitive detection of PFAS, with the ability to quantitatively detect model molecules and a wide range of PFAS. The sensitivity could reach 0.1 ppm. This research has significant implications for environmental sustainability and human health protection.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Takumi Sato, Keiko Esashika, Eiji Yamamoto, Toshiharu Saiki, Noriyoshi Arai
Summary: This study investigated the application of polymer-tethered nanoparticles (PTNPs) in biomolecule sensing using coarse-grained molecular dynamics simulations. The results indicated that the length and density of the grafted polymer influenced the distance between PTNP surfaces, and the coverage ratio of the hydrophobic surface affected the sandwiching probability of the sensing target. However, at high phi values, the PTNPs aggregated into multiple particles, hindering their sensing attributes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Pablo A. Mercada, Luis A. Perez, Eduardo A. Coronado
Summary: The study focused on determining the porosity degree of the m-SiO2 shell of GNRs@m-SiO2 at different concentrations of the porogenic surfactant CTAB by analyzing the extinction spectra features and using electrodynamics modeling. Changes in CTAB concentration affect both the porosity and thickness of the m-SiO2 shell.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Materials Science, Multidisciplinary
Pau Molet, Nicolas Passarelli, Luis A. Perez, Leonardo Scarabelli, Agustin Mihi
Summary: Ordered arrays of metal nanoparticles can generate surface lattice resonances with higher quality factors, showing great potential for engineering light-matter interactions. The internal architecture of gold-nanoparticle meta-molecules influences the optical response of plasmonic supercrystals.
ADVANCED OPTICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Gaelle Houthaeve, Gerardo Garcia-Diaz Barriga, Stephan Stremersch, Herlinde De Keersmaecker, Juan Fraire, Jo Vandesompele, Pieter Mestdagh, Stefaan De Smedt, Kevin Braeckmans, Winnok H. De Vos
Summary: The study investigates the effects of VNB photoporation on cell homeostasis, finding that A-type lamins are upregulated after photoporation and contribute to the recovery of the nucleus. Selective depletion of A-type lamins reduces cell viability, while stimulation of LMNA transcription increases the survival rate of successfully transfected cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Jose Mendoza Carreno, Nicolas Passarelli, Clara Otero, Lakshminarayana Polaravapu, Luis A. Perez, Juan Sebastian Reparaz, Maria Isabel Alonso, Agustin Mihi
Summary: The study introduced a quasi-3D photonic crystal to enhance the photoluminescence of cesium lead halide perovskite nanocrystals, demonstrating a significant improvement in light output by combining 2D gratings and DBRs.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Chemistry, Physical
Sergio D. Garcia Schejtman, Pablo A. Mercadal, Matias L. Picchio, Alicia V. Veglia, Eduardo A. Coronado
Summary: Supramolecular plasmonic polymer nanocomposites were synthesized by in situ formation of gold nanoparticles in a poly(vinyl alcohol) hydrogel using plant-derived gallic acid as reducing agent. The size and shape of the nanoparticles were tuned by changing the concentration of Au3+. The optical and chemical properties of the nanocomposites were analyzed experimentally and theoretically. The viscoelastic behavior of the hydrogel and its potential as a sensing platform were also investigated.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Nanoscience & Nanotechnology
Felix Sauvage, Van Phuc Nguyen, Yanxiu Li, Aranit Harizaj, J. Sebag, Dimitri Roels, Viktor Van Havere, Karen Peynshaert, Ranhua Xiong, Juan C. Fraire, Marie-Jose Tassignon, Katrien Remaut, Yannis M. Paulus, Kevin Braeckmans, Stefaan C. De Smedt
Summary: This paper introduces a new method for treating eye floaters, involving the generation of vapour nanobubbles by exposing gold nanoparticles or indocyanine green to low-energy laser pulses to disrupt collagen aggregates in the eyes. This approach may provide a safe and efficient treatment for millions of patients suffering from debilitating vitreous opacities and opens up the possibility of highly safe use of pulsed lasers in the posterior segment of the eye.
NATURE NANOTECHNOLOGY
(2022)
Correction
Multidisciplinary Sciences
Juan C. Fraire, Elnaz Shaabani, Maryam Sharifiaghdam, Matthias Rombaut, Charlotte Hinnekens, Dawei Hua, Jana Ramon, Laurens Raes, Eduardo Bolea-Fernandez, Toon Brans, Frank Vanhaecke, Peter Borghgraef, Chaobo Huang, Felix Sauvage, Tamara Vanhaecke, Joery De Kock, Ranhua Xiong, Stefaan De Smedt, Kevin Braeckmans
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Juan C. Fraire, Elnaz Shaabani, Maryam Sharifiaghdam, Matthias Rombaut, Charlotte Hinnekens, Dawei Hua, Jana Ramon, Laurens Raes, Eduardo Bolea-Fernandez, Toon Brans, Frank Vanhaecke, Peter Borghgraef, Chaobo Huang, Felix Sauvage, Tamara Vanhaecke, Joery De Kock, Ranhua Xiong, Stefaan De Smedt, Kevin Braeckmans
Summary: Biolistic delivery with light-triggered self-assembled nanobombs can efficiently transfect mammalian cells by propelling smaller nanoprojectiles through the cell membrane using vapor bubble formation. It outperforms electroporation in terms of transfection yield.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Pablo A. Mercadal, Juan C. Fraire, Eduardo A. Coronado
Summary: In recent work, a new quantity called the single hot spot active concentration enhancement factor (SHSACEF) is introduced to assess the contribution of surface-enhanced Raman spectroscopy (SERS) enhancement in colloidal samples. The capabilities of this method are tested by inducing nanoparticle (NP) aggregation and comparing experimental values with theoretical simulations.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Lucas Oorlynck, Yera Ye Ussembayev, Ingrid Amer Cid, Juan Fraire, Charlotte Hinnekens, Kevin Braeckmans, Filip Strubbe
Summary: To study the interactions between nanoparticles and their properties, single-particle measurements are needed. However, current methods for analyzing charge and size lack flexibility or require complex microfluidic devices. Accurate measurements of electrophoretic mobility based on optical detection are challenging due to low photon budget and required sampling frequency.
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
(2022)
Article
Polymer Science
Juan Cruz Bonafe Allende, Ruth N. Schmarsow, Eider Matxinandiarena, Sergio D. Garcia Schejtman, Eduardo A. Coronado, Cecilia I. AlvarezIgarzabal, Matias L. Picchio, Alejandro J. Muller
Summary: This research investigates the gelation of poly(vinyl alcohol) (PVA) triggered by the crystallization of a 3,4-dihydroxy-catechol in water. The strong hydrogen bond interactions between PVA and catechol groups result in the formation of supramolecular hydrogels with near-covalent elastic moduli and dynamic reversible gel-to-sol phase transitions. The concentration of the catechol derivative affects the gelation kinetics and physicochemical properties of these dynamic materials.
Review
Chemistry, Multidisciplinary
Ranhua Xiong, Felix Sauvage, Juan C. Fraire, Chaobo Huang, Stefaan C. De Smedt, Kevin Braeckmans
Summary: Delivering biological effector molecules in cultured cells is crucial for studying gene expression modulation. However, delivering these molecules across cell membranes while minimizing adverse effects remains challenging.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Juan C. Fraire, Maria Guix, Ana C. Hortelao, Noelia Ruiz-Gonzalez, Anna C. Bakenecker, Pouria Ramezani, Charlotte Hinnekens, Felix Sauvage, Stefaan C. De Smedt, Kevin Braeckmans, Samuel Sanchez
Summary: Nanomotors, powered by enzymes and triggered by laser irradiation, can improve drug delivery efficiency and overcome biological barriers. These nanomotors can collectively displace and disrupt protein fibers in a blocked microchannel. This active motion and mechanical disruption provide a clear advantage for improving therapy.
Article
Materials Science, Multidisciplinary
Jinhui Hu, Luis A. Perez, Juan Luis Garcia-Pomar, Agustin Mihi, Miquel Garriga, M. Isabel Alonso, Alejandro R. Goni
Summary: The strategy utilizing arrays of inverted silicon pyramids covered with thin gold film achieves substantial light absorption in the infrared spectral range. Resonant excitation at infrared wavelengths is achieved by tuning the size and separation of the inverted pyramids. Two fabrication routes for this kind of metal/silicon metamaterial are shown, either by photolithography or scalable nanoimprint techniques.
MATERIALS ADVANCES
(2022)