Article
Materials Science, Multidisciplinary
Anna Miklewska, Ryszard Tymkiewicz, Eleonora Kruglenko, Marcin Krajewski, Barbara Gambin
Summary: Magnetic nanoparticles (MNP)s of Fe3O4 were synthesized using the co-precipitation reaction and coated with polyethylene glycol (PEG). The concentration of nanoparticles in the ferrofluids strongly affects the heating efficiency, with PEG-coated nanoparticles showing higher heating effects.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
O. M. Lemine, Saja Algessair, Nawal Madkhali, Basma Al-Najar, Kheireddine El-Boubbou
Summary: This study reports the self-heating mechanisms of magnetite nanoparticles (MNPs) prepared by the Ko-precipitation Hydrolytic Basic (KHB) method. The MNPs exhibit favorable heating responses under magnetic excitation, making them promising candidates for magnetically triggered biomedical hyperthermia applications.
Article
Biophysics
Hemalatha Kothandaraman, Alamelumangai Kaliyamoorthy, Arulmozhi Rajaram, Chandunika R. Kalaiselvan, Niroj Kumar Sahu, Parthipan Govindasamy, Muralidharan Rajaram
Summary: Superparamagnetic iron oxide nanoparticles (SPIONPs) are widely used in clinical research, particularly in magnetic fluid hyperthermia (MFH) for cancer treatment. Coating the nanoparticles with biocompatible material enhances their stability and biocompatibility. The synthesized magnetite nanoparticles with oleic acid coating (OA-Fe3O4) show improved haemocompatibility and can be used in magnetic fluid hyperthermia applications.
JOURNAL OF BIOLOGICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Costica Caizer
Summary: Superparamagnetic hyperthermia (SPMHT) is a potential future method in cancer therapy that aims to efficiently destroy tumors with low toxicity, using magnetic nanoparticles to heat cancer cells to 42-43 degrees C. The effectiveness of SPMHT depends on finding optimal conditions such as nanoparticle size, amplitude and frequency of the magnetic field. A 3D computational study provided optimal conditions for Fe3O4 nanoparticles, including a diameter of 16 nm, a magnetic field amplitude of 10-25 kA/m, and a frequency of 200-500 kHz, for efficient tumor cell destruction.
Article
Multidisciplinary Sciences
Che-Hao Chang, Shih-Chieh Su, Tsun-Hsu Chang, Ching-Ray Chang
Summary: The epoxy/magnetite nanocomposites exhibit superparamagnetism under a static or low-frequency electromagnetic field, but show unexpected diamagnetism at microwave frequencies, which can be explained by revisiting the Debye relaxation law.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Ceramics
K. Hemalatha, K. Alamelumangai, R. Arulmozhi, R. K. Chandunika, Niroj Kumar Sahu, G. Parthipan, Muralidharan Rajaram
Summary: Magnetic Fluid Hyperthermia (MFH) is an emerging and safe technique for cancer treatment that utilizes superparamagnetic nanoparticles to temporarily raise the temperature of cancer cells. In this study, surface modified magnetic nanoparticles with enhanced stability, solubility, biocompatibility, and magnetic properties were synthesized and characterized. The cytotoxicity study and hyperthermia study confirmed the efficacy of these functionalized nanoparticles for cancer treatment.
CERAMICS INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Sukanda Vaewbundit, Punnama Siriphannon
Summary: Crosslinked chitosan/iron oxide nanocomposites were successfully synthesized at low temperatures using aqueous systems. The nanocomposites exhibited superparamagnetism and high cell viability, making them promising candidates for alternative medical applications.
Article
Agricultural Engineering
Bailiang Xue, Rui Tang, Danwei Xue, Ying Guan, Yongchang Sun, Wei Zhao, Jiaojun Tan, Xinping Li
Summary: In this study, high mechanical strength and lignin replacement rate of lignin-based epoxy vitrimers were successfully synthesized. These vitrimers exhibit excellent properties such as self-healing, reprocessing, and shape memory, suggesting their potential as renewable alternatives to bisphenol A epoxy vitrimers.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Roxana Dinu, Anastasiia Pidvoronia, Ugo Lafont, Olivier Damiano, Alice Mija
Summary: Renewable flavonoid and phlorotannin extracts were used to synthesize sustainable thermosetting resins with high performance. The designed thermosets showed high glass transition values, storage moduli, crosslinking densities, and gel content. These polyaromatic thermosets exhibited high mechanical strength, toughness, and heat resistance, and could be chemically recycled. They are recommended as environmentally friendly alternatives to petroleum-based epoxy resins in various industries.
Article
Polymer Science
Chaofan Wang, Yusheng Tang, Yuxiao Zhou, Yanyao Zhang, Jie Kong, Junwei Gu, Junliang Zhang
Summary: In this study, a novel epoxy-terminated and fluorine-containing polyaryletherketone (EFPAEK) was used to modify bisphenol A dicyanate ester (BADCy) resin, resulting in improved comprehensive properties such as increased bending strength, impact strength, heat resistance, bonding strength, decreased dielectric constant, and reduced water absorption rate.
Article
Biochemistry & Molecular Biology
Costica Caizer, Isabela Simona Caizer
Summary: This paper introduces an innovative strategy for enhancing the biocompatibility of nanoparticles using gamma-cyclodextrins, and analyzes the impact of this organic layer on the efficiency of superparamagnetic hyperthermia. The study demonstrates that magnetic nanoparticles covered with gamma-cyclodextrin can be utilized under optimal conditions for an alternative cancer therapy with higher efficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Michal Zuk, Weronika Gaweda, Agnieszka Majkowska-Pilip, Magdalena Osial, Marcin Wolski, Aleksander Bilewicz, Pawel Krysinski
Summary: This study successfully synthesized multifunctional nanoparticle conjugates with magnetic and anticancer properties, showing high potential for effective in vivo applications.
Review
Nanoscience & Nanotechnology
Yuanyuan Lian, Lin Wang, Junyang Cao, Tingting Liu, Zhenju Xu, Bowen Yang, Tianqiao Huang, Xiaodan Jiang, Nannan Wu
Summary: This review discusses the potential and advantages of magnetic induction hyperthermia (MIH) in cancer therapy, the application and recent developments of magnetic nanoparticles in the field, as well as the progress and challenges in combining MIH with other treatment methods.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2021)
Article
Polymer Science
Kalyan Dutta, Niranjan Karak
Summary: BPA-based epoxy thermoset has toxic effects on human health, so there is a need for environmentally friendly bio-based alternatives. In this study, a gallic acid amide was synthesized from renewable gallic acid and diethanol amine, and the epoxy resin was obtained through a condensation reaction. The synthesized epoxy thermosets showed excellent properties.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Svetlana O. Ilyina, Anna V. Vlasova, Irina Y. Gorbunova, Nikolai I. Lukashov, Michael L. Kerber, Sergey O. Ilyin
Summary: The usual problem of meltable phase-change agents is their instability in form during heating, which can be solved by incorporating them into a continuous polymer matrix. This study demonstrates that molten paraffin wax forms a stable Pickering emulsion in an epoxy medium with the presence of asphaltenes extracted from heavy crude oil. The rheological studies reveal the viscoplastic behavior of the obtained dispersions at 25°C, which disappears upon heating and melting of the paraffin phase.
Article
Chemistry, Physical
Fatima Marino, Enriqueta R. Lopez, Angela Arnosa, Manuel A. Gonzalez Gomez, Yolanda Pineiro, Jose Rivas, Carmen Alvarez-Lorenzo, Josefa Fernandez
Summary: In this study, oleic acid coated zinc oxide nanoparticles were successfully synthesized and characterized for their thermal and tribological properties. The concentration of nanoparticles affected the density and viscosity, with the optimal concentration at 0.25 wt% showing the best tribological performance. The spherical shape of the nanoparticles and the mending effect were identified as the main factors contributing to the superior performance of the nanolubricant compared to the base oil.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Applied
Zulema Vargas-Osorio, Artem Klotschan, Marcela Arango-Ospina, Yolanda Pineiro, Liliana Liverani, Jose Rivas, Martin Michalek, Dusan Galusek, Aldo R. Boccaccini
Summary: The study demonstrates the bioactivity of SBA-15 mesoporous silica rods obtained through the use of acid mixture and glycerol-modified silane precursor. The materials showed homogeneous shape, high bioactivity, and lack of cytotoxicity when immersed in simulated body fluid and tested with osteoblast precursor cells. Increased H3PO4 concentration led to higher degradability of the materials.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Melania Maglio, Maria Sartori, Alessandro Gambardella, Tatiana Shelyakova, Valentin Alek Dediu, Matteo Santin, Yolanda Pineiro, Manuel Banobre Lopez, Jose Rivas, Anna Tampieri, Simone Sprio, Lucia Martini, Alessandro Gatti, Alessandro Russo, Gianluca Giavaresi, Milena Fini
Summary: The use of functionalized scaffolds incorporated with superparamagnetic nanoparticles and vascular endothelial growth factor (VEGF) injection into a magnetic scaffold resulted in increased bone regeneration in a large bone defect in sheep metatarsus. The magnetic field generated by implanted magnets allowed the capture of the injected nanoparticles, forming a VEGF gradient in the scaffold's porosity. Histomorphometric measurements showed improved bone growth and bone-to-implant contact, while atomic force microscopy (AFM) analysis revealed similar nanomechanical behavior of the regenerated tissue to the magnetic field distribution. This study demonstrates the potential of magnetic technologies combined with functionalized scaffolds to enhance bone formation and improve bone/scaffold interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Pelayo Garcia-Acevedo, Manuel A. Gonzalez-Gomez, Angela Arnosa-Prieto, Lisandra de Castro-Alves, Yolanda Pineiro, Jose Rivas
Summary: Challenging magnetic hyperthermia (MH) applications require precise determination of magnetic properties in order to maximize heat release. In this study, a mean-field energy barrier model is proposed and used to determine the effective anisotropy constant (K-eff) of a model system of magnetic nanoparticles. The results show that the K-eff values are independent of the specific spacing shell thicknesses and close to bulk magnetite/maghemite values.
Article
Nanoscience & Nanotechnology
Stefania Scialla, Nuria Genicio, Beatriz Brito, Malgorzata Florek-Wojciechowska, Graeme J. Stasiuk, Danuta Kruk, Manuel Banobre-Lopez, Juan Gallo
Summary: The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. Understanding the interactions between the embedded SPIONs and the surroundings in these (nano)systems is challenging, but crucial for predicting and explaining their final magnetic behavior. This study focuses on the performance of a magnetic nanocomposite as a contrast agent for magnetic resonance imaging (MRI) and a effector for magnetic hyperthermia (MH), and examines the effects of stabilizing agents and magnetic loading on the physicochemical and functional properties.
ACS APPLIED NANO MATERIALS
(2022)
Article
Polymer Science
Luis M. Araque, Claudio J. Perez, Antonia Infantes-Molina, Enrique Rodriguez-Castellon, Guillermo J. Copello, Juan M. Lazaro-Martinez
Summary: Two responsive PEI hydrogels (P1.5E and P2E) with different cross-linking degrees were synthesized using a click reaction and without organic solvents. The hydrogel's swelling and rheological behavior were dependent on the cross-linking degree, and the hydrogels showed stimuli-responsive behavior to pH or ionic strength changes. The hydrogels also exhibited adsorption capacity for methyl orange (MO) dye and Cu2+ ions, with P1.5E showing higher sorption capacities. Germination experiments with lettuce seeds confirmed that the hydrogels did not release toxic molecules.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Eliezer Velasquez, Cristian Patino Vidal, Guillermo Copello, Carol Lopez de Dicastillo, C. J. Perez, Abel Guarda, Maria Jose Galotto
Summary: This study determined the effect of incorporating fumed nanosilica on the processability improvement of post-consumer recycled flexible polypropylene. The addition of nanosilica increased the thermal stability and crystallinity of the polymer, improving the processability of the nanocomposites. However, it did not affect the crystallization and melting temperatures of the polymer.
Article
Cell Biology
Susanna Kemppainen, Nadine Huber, Roosa-Maria Willman, Ana Zamora, Petra Makinen, Henna Martiskainen, Mari Takalo, Annakaisa Haapasalo, Tomas Sobrino, Manuel Antonio Gonzalez Gomez, Yolanda Pineiro, Jose Rivas, Uwe Himmelreich, Mikko Hiltunen
Summary: Organotypic slice culture models, especially those derived from adult tissue, provide a valuable tool for studying neurodegenerative diseases such as tauopathies. In this study, hippocampal slice cultures from adult transgenic mice were used to investigate the effects of a novel antibody on hyperphosphorylated TAU. The adult-originating slices retained key cellular components and exhibited tau pathology, making them a suitable model for studying TAU pathology in the adult brain without the interference of the blood-brain barrier.
Article
Chemistry, Inorganic & Nuclear
Manuel A. Gonzalez-Gomez, Roman Seco-Gudina, Pelayo Garcia-Acevedo, Angela Arnosa-Prieto, Lisandra de Castro-Alves, Yolanda Pineiro, Jose Rivas
Summary: In recent years, nanotechnology has made significant advancements in cancer therapy through the use of magnetic resonance contrast agents, nano-delivery systems, and magnetic hyperthermia treatments. By exploiting the small size and properties of nanoparticles, such as superparamagnetism, these theragnostic tools offer new possibilities for not only theragnosis, but also biotech procedures. One particular application is the use of bioconjugated magnetic nanoparticles in genetic engineering processes, which have shown enhanced efficiency, specificity, and speed in gene transfer systems compared to conventional methods.
Article
Engineering, Electrical & Electronic
Federico Schipani, Julieta Puig, Gustavo M. Morales, Hernan E. Romeo
Summary: Non-noble metal nanoparticle-free reduced graphene oxide (rGO) sensors were prepared and tested against hydrogen (H2) at room temperature (21 °C) with high humidity conditions (above 90% r.h.). The reduction of graphene oxide (GO) to rGO shape the sensing response, which scales with the sp2 carbon (Csp2) content of the rGO structure. The top-performance rGO sensor showed a superior response to H2 with a negligible cross-sensitivity to other gases.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Physical
Shahana Huseyinova, Jose M. Blanco Trillo, Jose M. Ramallo-Lopez, Felix G. Requejo, David Buceta, M. Arturo Lopez-Quintela
Summary: We report an easily scalable synthesis method for the preparation of cysteine-capped Cu-10 clusters through the reduction of Cu(ii) ions with NaBH4, using Cu-5 clusters as catalysts. The presence of such catalytic clusters allows controlling the formation of the larger Cu-10 clusters and prevents the production of copper oxides or Cu(i)-cysteine complexes. The visible light-absorbing Cu-10 clusters, obtained by the cluster-catalysed method, display high photocatalytic activities for the decomposition of methyl orange with visible light.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Beatriz Brito, Maria Rosaria Ruggiero, Thomas W. Price, Milene da Costa Silva, Nuria Genicio, Annah J. Wilson, Olga Tyurina, Veronika Rosecker, Thomas R. Eykyn, Manuel Banobre-Lopez, Graeme J. Stasiuk, Juan Gallo
Summary: Manganese dioxide (MnO2)-based nanostructures were prepared using a one-pot reaction, and Pt(iv) prodrugs were used as redox-responsive theranostics for cancer therapy. The cytotoxicity of these nanostructures was evaluated and found to be as effective as the clinical chemotherapeutic drug cisplatin in 3D cell models. The nanostructures also exhibited strong ON/OFF magnetic resonance (MR) contrast in response to reducing agents and induced a significant and long-lasting T-1 signal enhancement in tumor-bearing mice.
Article
Chemistry, Applied
Ana Raquel Bertao, Viktoriya Ivasiv, Cristina Almeida-Aguiar, Patricia R. Correia, Antonio M. Fonseca, Manuel Banobre-Lopez, Fatima Baltazar, Isabel C. Neves
Summary: This study developed a zeolite-based delivery system (ZDS) using silver and 5-Fluorouracil as antimicrobial and antineoplastic agents. The ZDS was characterized and its antimicrobial properties were investigated, showing better antibacterial effectiveness for the ZDS containing both silver and 5-FU.
MICROPOROUS AND MESOPOROUS MATERIALS
(2024)
