Article
Biochemistry & Molecular Biology
Mohammad Khavani, Aliyeh Mehranfar, Mohammad R. K. Mofrad
Summary: The interactions between 10 short peptides and gold nanoparticles of different diameters have been studied using molecular dynamics simulations. The results show that gold nanoparticles significantly affect the stability and conformational properties of the peptides. The size of the gold nanoparticles and the amino acid sequences of the peptides play important roles in the stability of the peptide-gold nanoparticle complexes. The study provides new insight into peptide interaction with gold nanoparticles from a molecular viewpoint, which can be valuable for designing biomaterials based on peptides and gold nanoparticles.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Food Science & Technology
Duanquan Lin, Le-Chang Sun, Wei-Sen Huo, Ling-Jing Zhang, Yu-Lei Chen, Song Miao, Min-Jie Cao
Summary: This paper provides a comprehensive review of the covalent and non-covalent interactions between peptides and polyphenols, and discusses the influence of these interactions on the bioactivity, antimicrobial property, sensitivity, and emulsifying property of peptides. The key findings suggest that non-covalent interactions are achieved through hydrophobic interactions, hydrogen bonds, electrostatic interactions, and van der Waals interactions. The properties of peptides and polyphenols, ratio of peptide/polyphenol, and environmental conditions are the main factors influencing these interactions. Additionally, the formation of peptide-polyphenol complexes can have synergistic or subtractive effects on bioactive peptides through various mechanisms, improving the stability of peptide-stabilized emulsions.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jahar Dey, Sang-Jo Lee, Jiwhan Kim, Sung-Hwan Lim, Jae-Min Ha, Min-Jae Lee, Sung-Min Choi
Summary: This study introduces a method for forming nanoparticle supercrystals driven by covalent bonding interactions, which provide stronger structural stability compared to traditional intermolecular forces. The versatility and cost-effectiveness of the covalent bonding approach make it highly practical for various applications.
Article
Nanoscience & Nanotechnology
Devi Wahyuningtyas, Wen-Hao Chen, Ruei-Yu He, Yung-An Huang, Chia-Kang Tsao, Yu-Jung He, Chu-Yi Yu, Po-Chao Lu, Yu-Cai Chen, Sheng-Hann Wang, Ka Chon Ng, Bryan Po-Wen Chen, Pei-Kuen Wei, Jiun-Jie Shie, Chun-Hong Kuo, Y. Henry Sun, Joseph Jen-Tse Huang
Summary: The researchers designed and synthesized a polyglutamine-specific gold nanoparticle complex that targeted mHtt and alleviated its toxicity. The complex was able to disassociate fibrillary aggregates from polyQ peptides and reduce beta-sheet content in a concentration-dependent manner. Additionally, the complex was shown to penetrate cells, bind to cytosolic mHtt proteins, dissociate mHtt inclusions, reduce mHtt oligomers, and ameliorate mHtt-induced toxicity, suggesting potential therapeutic strategies against Huntington's disease.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Masayoshi Tanaka, Mirei Hayashi, Lucien Roach, Yuka Kiriki, Tetsuya Kadonosono, Takahiro Nomoto, Nobuhiro Nishiyama, Jonghoon Choi, Kevin Critchley, Stephen D. Evans, Mina Okochi
Summary: The study explored the synthesis of triangular gold nanoplates using peptides, demonstrating control over nanoplate size and properties by adjusting peptide concentration. These nanoplates showed promising potential as photothermal therapeutic agents and indicated the feasibility of synthesizing circular gold nanoplates using peptides.
ACTA BIOMATERIALIA
(2021)
Article
Nanoscience & Nanotechnology
Mohammad Akrami, Shabnam Samimi, Mohsen Alipour, Hassan Bardania, Sorour Ramezanpour, Niayesh Najafi, Saman Hosseinkhani, Mojtaba Kamankesh, Ismaeil Haririan, Fatemeh Hassanshahi
Summary: The study successfully developed a cancer-targeting nanoparticle platform with higher affinity to breast cancer cells by combining peptides with AuNPs, showing improved uptake and anti-tumor efficiency in vivo.
Article
Food Science & Technology
Shraddha Rahi, Vikram Lanjekar, Vandana Ghormade
Summary: In this study, a rapid and user-friendly dot-blot assay for the detection of ochratoxin A was developed using peptide conjugated gold nanoparticles as a detection agent. The assay exhibited high binding affinity towards ochratoxin A and had a low limit of detection. The dot-blot assay showed comparable results with the conventional high performance liquid chromatography in the detection of ochratoxin A in wheat samples. This portable and easy-to-use assay has the potential for application at different stages of food production and distribution to ensure safe and healthy food.
Article
Chemistry, Physical
Tao Chen, Sha Yang, Qinzhen Li, Yongbo Song, Guang Li, Jinsong Chai, Manzhou Zhu
Summary: Hierarchical assemblies of a new silver nanocluster, Ag-70-TPP, have been synthesized and characterized, showing a highly space-efficient double helical 4H close packing pattern directed by ligands. The chirality of Ag-70-TPP and van der Waals forces interactions between ligands play a key role in driving its arrangement, with observed interlocking of phosphine ligands contributing to the structure. This work provides important and unprecedented insights into the internal structure and crystallographic arrangement of nanoclusters.
NANOSCALE HORIZONS
(2021)
Article
Biotechnology & Applied Microbiology
Meihua Fan, Zhi Liao, JianXin Wang, Xiaolin Zhang, Peng Li, Mengxiong Yin
Summary: The study systematically investigated the cellular metabolism profile of Ulva prolifera exposed to HAuCl4, revealing significant changes in metabolites and specific metabolic pathways associated with cellular stress response and AuNP synthesis. The analysis identified novel metabolic pathways specifically regulated by HAuCl4, shedding light on the toxicity mechanisms and synthesis of AuNPs in macroalgae.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tania Patino, Joaquin Llacer-Wintle, Silvia Pujals, Lorenzo Albertazzi, Samuel Sanchez
Summary: This study characterized the formation of a protein corona around enzyme-powered nanomotors using super resolution microscopy STORM. The results showed a significant decrease and different composition of the protein corona formation, but did not hinder the motion capabilities of the nanomotors.
Article
Chemistry, Multidisciplinary
Marc Pretze, Valeska von Kiedrowski, Roswitha Runge, Robert Freudenberg, Rene Hubner, Gullu Davarci, Ralf Schirrmacher, Carmen Wangler, Bjorn Waengler
Summary: This study developed tumor-specific gold nanoparticles for targeted accumulation and detection of tumor angiogenesis, as well as potential therapeutic applications. The nanoparticles showed favorable diagnostic properties both in vitro and in vivo, and could potentially be used as radiosensitizers in future therapeutic concepts.
Article
Engineering, Environmental
Xiaojin Zhang, Shijun Lin, Yichuan Wang, Fan Xia, Yu Dai
Summary: This study constructed cofactor-free organic nanozyme through self-assembly, which reduces the activation energy and increases the reaction rate. The catalysis of organic nanozyme mainly comes from the ordered assembly of peptide chains on the support surface and the assembly and disassembly caused by photoisomerization.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Physical
Franklin O. Egemole, Faith M. Eyimegwu, Jaehan Yun, Wongi Jang, Hongsik Byun, Jian Hou, Jun-Hyun Kim
Summary: This work demonstrates that the crosslinking density of PNIPAM particles greatly influences the size, distribution, and catalytic activity of in situ formed AuNPs. Decreasing crosslinking density leads to smaller and more uniform AuNPs with superior catalytic activity.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Multidisciplinary
Ashwani Kumar Singh, Praveen Malik
Summary: This study demonstrates the influence of citrate buffer stabilised gold nanoparticles (AuNPs) on the morphological, optical, and dielectric properties of polymer-dispersed liquid crystal (PDLC) composites. The dispersion of AuNPs improved the relative transmission and contrast, while lowering the threshold voltage of the doped composite. AuNPs concentration had a minor effect on the threshold voltage and transmission. Moreover, low AuNPs concentration showed better optical responses.
Article
Chemistry, Applied
Wongi Jang, Jaehan Yun, Pascal N. Eyimegwu, Jian Hou, Hongsik Byun, Jun-Hyun Kim
Summary: In this study, the reduction of gold ions using mild reducing agents in the presence of poly(n-isopropylacrylamide) particles was investigated. The controlled formation of physically encapsulated gold nanoparticles was achieved through the manipulation of concentration ratios. The encapsulated gold nanoparticles showed high selectivity and the rate of reaction was influenced by the encapsulation method.