Article
Polymer Science
Mona Ebadi, Saifullah Bullo, Kalaivani Buskaran, Mohd Zobir Hussein, Sharida Fakurazi, Giorgia Pastorin
Summary: Iron oxide nanoparticles coated with a polymeric carrier and loaded with an anti-cancer drug showed stronger activity against liver cancer cells and no cytotoxicity towards fibroblast cell lines, demonstrating the potential of a nano delivery system for cancer treatment.
Article
Polymer Science
Azhar Mahmood, Bolin Zhao, Muhammad Sufyan Javed, Dequan He, Weng-Chon Cheong, Dongxue Han, Li Niu
Summary: A unique synthetic strategy based on polyaniline (PANI) doped 2D cobalt-iron layered double hydroxide (CoFe-LDH/P) nanomaterials is designed, and pores are formed at low temperature. This method increases the active surface area of CoFe-LDH/P and enhances its potential applications in energy storage devices.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Antonio J. S. Fernandes Junior, Welton C. Sodre, Barbara E. C. F. Soares, Cicero W. B. Bezerra, Alex Rojas, Javier Perez-Carvajal, Ana C. S. Alcantara
Summary: Global concerns over the future consequences of uncontrolled industrial development have led to the emergence of sustainable materials composed of earth abundant elements. A new type of heterostructured material has been synthesized by assembling inexpensive metals on synthetic silicates, showing promising performance in catalytic reactions. The study indicates that the presence of particular metal-oxide nanoparticles supported on specific materials can enhance photocatalytic activity and stability.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Wenhui Wang, Hongwei Yan, Utkarsh Anand, Utkur Mirsaidov
Summary: The study reveals the process of MOF nanoparticles converting into LDH nanostructures using liquid-phase transmission electron microscopy. The findings show that maintaining comparable etching and growth rates is crucial for forming hollow nanostructures with the shape of underlying MOF NP template.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Nanoscience & Nanotechnology
Lakshya Kumar, Purna K. Boruah, Sukanya Borthakur, Lakshi Saikia, Manash R. Das, Sasanka Deka
Summary: A flexible high-performance supercapacitor cell using nanostructured CuCo-layered double hydroxide (LDH) as electrode material is reported for the first time, showing specific capacity, capacitance, cell voltage, energy density, and power density values. The flexible cell offers long-term stability and Coulombic efficiency, while providing valuable concepts for understanding its exceptional charge storage characteristics.
ACS APPLIED NANO MATERIALS
(2021)
Review
Environmental Sciences
Roshanak Tarrahi, Sepideh Mahjouri, Alireza Khataee
Summary: This article summarizes the results of toxicological studies on the interactions between NMs and plants, discussing the toxic mechanisms of NMs on plants and highlighting the various factors that influence the impact of NMs on plants. The importance of dose metrics for assessing toxicity and the need for standardized methodologies for accurate dose delivery of NMs to plants in the laboratory are emphasized.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Sepideh Yoosefi, Amir Rakhshani, Vahideh Montazeri, Mohamadreza Tavakoli, Amin Aliabadi, Yousef Fatahi, Helia Behrouzfar, Shadi Keihankhadiv, Behzad Darbasizadeh, Hamidreza Motasadizadeh, Hassan Farhadnejad
Summary: The present study aimed to improve wound healing rate using LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats. The fabricated mats showed sustained drug release and no cytotoxicity, and could accelerate the wound healing process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nanoscience & Nanotechnology
Wenwen Song, Yanqi Xu, Xiangli Xie, Cunjun Li, Wenfeng Zhu, Qiankun Xiang, Wei Chen, Ningli Tang, Linjiang Wang
Summary: In this study, a Pd/Co1Fe3-LDH/NF electrocatalyst for ethanol oxidation reaction (EOR) in direct ethanol fuel cells was prepared using a two-step synthetic strategy. The metal-oxygen bonds formed between Pd nanoparticles and Co1Fe3-LDH/NF ensured structural stability and sufficient exposure of surface-active sites. The charge transfer of the Pd-O-Co-(Fe) bridge effectively modulated the electrical structure of hybrids, enhancing the absorption of OH- radicals and oxidation of COads. The specific activity of Pd/Co1Fe3-LDH/NF (17.46 mA cm(-2)) was 97 and 73 times higher than that of commercial Pd/C (20%) (0.18 mA cm(-2)) and Pt/C (20%) (0.24 mA cm(-2)), respectively. The j (f)/j (r) ratio representing the resistance to catalyst poisoning in the Pd/Co1Fe3-LDH/NF catalytic system was 1.92. These findings provide insights for optimizing the electronic interaction between metals and electrocatalyst supports for EOR.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Shiwen Zhang, Siyan Pang, Wenhao Pei, Haitao Zhu, Yingxiang Shi, Ziyang Liu, Lingyu Mao, Xiuru Shi, Shuang Tao, Chenchen Geng, Sulian Chen, Linnan Yang, Changjie Chen, Qingling Yang, Wenrui Wang
Summary: In this study, layered double hydroxides (LDH) nanomaterials were synthesized and used as carriers to deliver the suppressor oncogene miR-30a for breast cancer therapy. LDH@miR30a was able to escape the lysosomal pathway, be phagocytosed by breast cancer cells, and remain stable in the cells. In vitro experiments showed that LDH@miR30a inhibited proliferation and induced cell cycle arrest in breast cancer cells, as well as regulated the EMT process and inhibited cell migration and invasion. In vivo experiments demonstrated that LDH@miR30a treatment significantly reduced solid tumors without causing significant impairment to vital organs. Therefore, LDH@miR30a is an effective drug delivery system for breast cancer treatment.
Article
Engineering, Environmental
Choe Earn Choong, Kien Tiek Wong, Seok Byum Jang, Pichiah Saravanan, Chulhwan Park, Sang-Hyoun Kim, Byong-Hun Jeon, Jaeyoung Choi, Yeomin Yoon, Min Jang
Summary: The study focused on controlling the particle size and aggregation of nanosheet layers in LDHs for effective As(III) and As(V) removal. The PAM(40)/PVA(30)-LDH showed higher affinity and maximum adsorption capacities for As(III) and As(V) compared to LDH alone. X-ray photoelectron spectroscopy analysis revealed the mechanisms of As(III) and As(V) removal on PAM(40)/PVA(30)-LDH, making it a promising adsorbent for arsenic-polluted wastewater treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Joana Lopes, Tania Ferreira-Goncalves, Lia Ascensao, Ana S. Viana, Lina Carvalho, Jose Catarino, Pedro Faisca, Abel Oliva, Dragana P. C. de Barros, Cecilia M. P. Rodrigues, Maria Manuela Gaspar, Catarina Pinto Reis
Summary: Gold nanoparticles (AuNPs) have attracted the interest of researchers due to their unique properties, and are being explored for diagnostics and therapy, particularly in cancer cell ablation. Safety is a crucial factor for medical applications, so the physicochemical properties and morphology of AuNPs coated with different materials were characterized. The safety of the developed AuNPs was evaluated in various cell lines, skin models, and biosafety assays, showing no significant toxicity.
Article
Chemistry, Physical
Zolfaghar Rezvani, Leila Jafari Foruzin, Kamellia Nejati
Summary: This paper presents the preparation of a dual-color emitting nanohybrid based on ZnAl-layered double hydroxide (LDH), where Mordant Orange 1 (MO1) is intercalated into the interlayer space of LDH using the microwave-assisted ion-exchange method. The nanohybrid is characterized by various techniques and exhibits dual-color photoluminescence emission due to fluorescence resonance energy transfer (FRET). This study demonstrates the potential of using the microwave-assisted ion-exchange method to design inorganic-organic matrices with two-color emission and high stability for optoelectronic and dual-color optical devices.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Nanoscience & Nanotechnology
Fang Xian, Lulu Jia, Yoshiyuki Sugahara, Hairong Xue, Yusuke Yamauchi, Takayoshi Sasaki, Renzhi Ma
Summary: Researchers prepared a composite membrane by mixing nanoparticles and nanosheets, which improved the conductivity of the anion-exchange membrane. By altering the arrangement of LDH nanosheets, diversified ion-conducting pathways and networks were formed in the membrane, leading to a significant improvement in conductivity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Emre Ozgenc, Merve Karpuz, Ege Arzuk, Marta Gonzalez-Alvarez, Marival Bermejo Sanz, Evren Gundogdu, Isabel Gonzalez-Alvarez
Summary: This study prepared radiolabeled trastuzumab loaded solid lipid nanoparticles and investigated their biocompatibility, cellular uptake, and apoptosis induction capacity. The results showed that these nanoparticles exhibited favorable physicochemical properties and pharmacokinetic profiles.
Article
Chemistry, Physical
Mengjie Liu, Kyung-Ah Min, Byungchan Han, Lawrence Yoon Suk Lee
Summary: Surface engineering of transition metal layered double hydroxides (LDHs) can enhance their catalytic activity for the oxygen evolution reaction (OER). The study on Ce-doped NiFe-LDHs and Ce(OH)(3) interfaced NiFe-LDHs reveals that Ce and Fe atoms facilitate the oxidation of Ni3+/4+ in NiFe-LDH, resulting in superior catalytic activity for water oxidation. The enhanced electron transfer between Ce(OH)(3) and the matrix in Ce@NiFe-LDH leads to better catalytic activity compared to CeNiFe-LDH, as demonstrated by first-principles density functional theory (DFT) calculations.
ADVANCED ENERGY MATERIALS
(2021)
Article
Materials Science, Composites
Yousof Ghazzawi, Andres F. Osorio, Darren Martin, Asanka P. Basnayake, Michael T. Heitzmann
Summary: The study on fibre-reinforced polypropylene showed that continuous glass fibre reinforcement exhibited the best fire performance at 20 kW m(-2), while 3 mm fibres performed the best at 35 kW m(-2), with 12 mm fibres exhibiting the lowest performance. Melic-anhydride modified PP increased the heat release rate and time to ignition, suggesting improved fibre adhesion plays a role in the fire performance of glass fibre-reinforced PP.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2022)
Article
Chemistry, Physical
Peiyao Yan, Wei Zhao, Samuel J. Tonkin, Justin M. Chalker, Tara L. Schiller, Tom Hasell
Summary: Inverse vulcanized polymer materials have attracted attention due to their use of sulfur as a starting material, and their unique structure makes them suitable for applications such as infrared imaging, energy storage, and heavy metal capture. However, synthesizing flexible sulfur polymers with high strength, high elongation, and high toughness remains a challenge. This study successfully synthesized cross-linked sulfur polymers with high tensile elongation and toughness, and demonstrated their solvent tolerance. The chemical and thermal recycling performance of these materials was also retained.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jordan Pennells, Vincent Mellor, Darren J. Martin
Summary: One of the key challenges in the industrial translation of cellulose nanofiber (CNF) materials is the appropriate characterization and evaluation of product quality. The study explores the development of statistical methodologies to investigate quality and sustainability, including a visualization tool for processing sustainability evaluation, correlation analysis of biomass composition with processing sustainability and nanopaper performance, and a user-defined quality ranking methodology. The versatile framework enhances data analysis and assists researchers in elucidating material performance relationships and advancing the industrial translation of CNF products.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Polymer Science
Hima Haridevan, Celine Chaleat, Liam Pooley, David A. C. Evans, Peter J. Halley, Darren J. Martin, Pratheep K. Annamalai
Summary: This study investigated the mechanical and viscoelastic properties of a polyether polyol filled with long thin cellulose nanofibres (CNF), revealing insights into the influence of loading levels on mechanisms of dispersion, interaction, and gelation behavior. The study found that the addition of CNF affected the rheological behavior and mechanical properties of the polyol, providing important information for optimizing product performance.
Article
Pharmacology & Pharmacy
Fatemeh Movahedi, Jie Liu, Bing Sun, Pei Cao, Luyao Sun, Christopher Howard, Wenyi Gu, Zhi Ping Xu
Summary: Co-loaded dual-targeting LCP nanoparticles with ABZ and OTS show synergistic cytotoxicity against skin cancer cells and completely suppress skin tumor growth at low doses through targeting PD-L1 and folate receptor.
Article
Green & Sustainable Science & Technology
Diana Cafiso, Athanasia Amanda Septevani, Camilla Noe, Tara Schiller, Candido Fabrizio Pirri, Ignazio Roppolo, Annalisa Chiappone
Summary: In this study, natural-based composite hydrogel inks for DLP 3D printing have been developed using cellulose-based materials. The addition of cellulose nanocrystals derived from oil palm empty fruit bunch improves the printability and mechanical properties of the hydrogels while maintaining their photocuring properties. These printable hydrogels exhibit intriguing characteristics such as controlled swelling and pH sensitivity, opening up new possibilities in fields such as sensors, biomedical, and soft robotics.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Article
Polymer Science
Clement Matthew Chan, Darren Martin, Emilie Gauthier, Paul Jensen, Bronwyn Laycock, Steven Pratt
Summary: Paunch, a solid residue from processed cattle stomachs, is an untapped waste stream that shows potential as a valuable source of fibers for the production of sustainable biocomposite materials. In this study, the characteristics of paunch fibers were compared to wood flour and ground buffel grass, and composites of the biopolymer PHBV and ground paunch were successfully produced. Mechanical property analysis showed that the composites had comparable properties to those with ground buffel grass.
Article
Cell Biology
Qianling Su, Wei Shi, Xianing Huang, Yakun Wan, Guanghui Li, Bengang Xing, Zhi Ping Xu, Hongbo Liu, Bruce D. Hammock, Xiaomei Yang, Shihua Yin, Xiaoling Lu
Summary: This study successfully developed four nanobody strains with significant affinity and specificity against SARS-CoV-2 spike protein receptor binding domain. These findings provide an important foundation for further research and the development of diagnostic and therapeutic tools for SARS-CoV-2.
Article
Engineering, Environmental
Jordan Pennells, Celine Chaleat, Darren J. Martin
Summary: This study presents a benchmarking assessment of cellulose nanofiber (CNF) materials, including biomass sources, mechanical processing methods, and mechanical performance. The results highlight sorghum and banana stem as comparatively sustainable biomass feedstock and identify twin-screw extrusion as a promising fibrillation method with low energy consumption. The nanopaper benchmarking study aids in the visualization of the nanopaper research landscape.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Chandra Choudhury, Courtney E. E. McAleese, Neville J. J. Butcher, Rodney F. F. Minchin
Summary: There are two human arylamine N-acetyltransferases (NAT1 and NAT2) that differ in their substratespecificity and tissue localization. NAT1 can hydrolyze acetyl coenzyme A to coenzyme A in the presence of folate, and it is rapidly inactivated at temperatures above 39 °C. The acetyltransferase activity of NAT1 is also rapidly lost in whole cells, while the hydrolase activity is resistant to heat-induced inactivation due to the stabilizing effect of folate.
Article
Medicine, Research & Experimental
Christopher N. Subasic, Neville J. Butcher, Rodney F. Minchin, Lisa M. Kaminskas
Summary: PEGylated lipid nanoparticle-based Covid-19 vaccines can induce anti-PEG antibodies in humans, which may affect the efficacy of PEGylated therapeutics. This study found that anti-PEG IgM levels can influence the pharmacokinetics of PEGylated liposomal chemotherapy drugs and are dose-dependent. However, the DNA-LNP vaccine has a lesser impact on anti-PEG IgM production and does not alter the pharmacokinetics of chemotherapy drugs.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Rebecca R. Mackley, Steven Huband, Tara L. Schiller
Summary: Atherosclerosis is a complex disease, with unique plaque morphology in each individual. Currently, there is a lack of technique to differentiate stable and unstable plaques and identify those at risk of thromboembolic events. Small-and wide-angle X-ray scattering (SAXS/ WAXS) has the potential to identify key materials in plaques, such as cholesterol species, collagen, LDLs, and hydroxyapatite. Protocols for preparing excised human atherosclerotic tissue have been established, leading to improved sample-to-noise ratio and background subtraction.
Article
Medicine, Research & Experimental
Christopher N. Subasic, Neville J. Butcher, Fiona Simpson, Rodney F. Minchin, Lisa M. Kaminskas
Summary: Dynamin II (dynII) plays a significant role in the internalization pathways of endocytic cells, by allowing membrane invaginations to bud off. However, clinically relevant doses of dynII inhibitors can inhibit the uptake of liposomes by endocytic cells in vitro, but are unlikely to significantly affect the pharmacokinetics of long-circulating, co-administered liposomes, as shown by the study that investigated the impact of phenothiazines, PCZ and thioridazine, on in vitro liposome endocytosis and in vivo liposome pharmacokinetics after PCZ infusion in rats.
MOLECULAR PHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Hima Haridevan, Deborah Barkauskas, Kamil A. Sokolowski, David A. C. Evans, Darren J. Martin, Pratheep K. Annamalai
Summary: This study utilizes X-ray computed microtomographic (X-ray μCT) analysis to investigate the microstructural changes induced by the dispersion of kraft lignin in rigid polyurethane foam. The results show that lignin has a significant impact on the microstructure of the foam. The methodology used in this study can provide valuable insights into the microstructure-property relationship in cellular plastics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Rebecca R. Mackley, Steven Huband, Tara L. Schiller
Summary: Atherosclerosis is a complex disease with unique plaque morphology in each individual. Current techniques lack the ability to differentiate stable and unstable plaques, and identify those at risk of thromboembolic events. Small- and wide-angle X-ray scattering (SAXS/WAXS) shows potential in identifying key materials in plaques. Improved protocols for preparing atherosclerotic tissue samples have enhanced the sample-to-noise ratio and background subtraction.