Article
Chemistry, Analytical
Yingying Chen, Ying He, Jinwen Zhao, Jin Zhang, Ruo Yuan, Shihong Chen
Summary: This study developed a novel hydrophobic localized enrichment strategy using beta-cyclodextrin (beta-CD) to improve the sensitivity of electrochemiluminescence (ECL) detection. The biosensor constructed with TDBA-beta-CD-Pt nanocomposite and PDP PNPs achieved highly sensitive detection of ncovNP. This research provides a promising and sensitive ECL platform for ncovNP detection.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Dat Thinh Ha, Van-Thuan Nguyen, Moon-Soo Kim
Summary: The research developed a one-step FRET technology based on engineered ZFPs and GO, enabling rapid and quantitative detection of ARG with a detection limit of 1 nM.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Tomasz Fas, Maciej Sciesiek, Wojciech Pacuski, Andrzej Golnik, Jan Suffczynski
Summary: Hybrid exciton-polaritons are demonstrated in a structure comprising semimagnetic and nonmagnetic quantum wells coupled via the microcavity optical mode, with the emerging states acquiring magnetic properties due to the susceptibility of excitons in the magnetic quantum well. External magnetic fields enable control over the degree of hybridization, tuning of the ratio of excitonic to photonic components, and alteration of energy transfer between excitonic states in magnetic and nonmagnetic quantum wells. The possibility of hybridizing a semimagnetic exciton with an exciton in a material lacking meaningful magnetic effects holds promise for systems with strong magnetooptical properties.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Analytical
Zi-yue Wang, Huimin Yuan, Dong-ling Li, Juan Hu, Jian-Ge Qiu, Chun-yang Zhang
Summary: This study develops a nanosensor for quantification of 5hmC modification in cancer cells, which shows high specificity and amplification efficiency.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qiuyan Huang, Jiyeon Kim, Kun Wang, Simon Vecchioni, Yoel P. Ohayon, Nadrian C. Seeman, Natasa Jonoska, Ruojie Sha
Summary: The use of DNA triplex association, combined with toehold-mediated strand displacement, allows for the reconfiguration of dynamic DNA nanostructures through pH alteration. This study demonstrates that pH changes can enable a DNA duplex, with toehold assistance, to displace TFOs from another DNA duplex. The dependence of this process on toehold length is examined, and oscillatory conformational changes between two molecular formations are observed.
Article
Biophysics
Daniel Shoup, Andrew Roth, Rajan Thapa, Jason Puchalla, Hays S. Rye
Summary: The development of multicolor BAS provides a powerful and flexible approach to studying hidden properties of important biological particles like viruses and protein aggregates.
BIOPHYSICAL JOURNAL
(2021)
Article
Chemistry, Physical
Yu Wang, Wenjie Dou
Summary: In this study, we convert the Floquet classical master equation (FCME) into a Floquet Fokker-Planck equation in the limit of fast Floquet driving and fast electron motion compared to nuclear motion. We solve the Fokker-Planck equation using Langevin dynamics and observe the violation of the second fluctuation-dissipation theorem and resulting heating effects due to Floquet driving.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Agriculture, Multidisciplinary
Liling Hao, Mengqiu Li, Kaimin Peng, Tai Ye, Xiuxiu Wu, Min Yuan, Hui Cao, Fengqin Yin, Huajie Gu, Fei Xu
Summary: This study proposes a simple and novel strategy to improve the sensitivity of FRET aptasensors by using DNA tetrahedron and gold nanorods. The method exhibits linear detection sensitivity in the concentration range of 0.01-10 ng/mL, with a limit of detection of 0.005 ng/mL. The developed biosensor demonstrates efficient specificity, good accuracy and stability, and performs well in real samples.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Physical
Kyriacos Georgiou, Kirsty E. McGhee, Rahul Jayaprakash, David G. Lidzey
Summary: Researchers have fabricated organic semiconductor microcavities containing J-aggregates of a cyanine dye with an extended optical path-length, and studied the structures using optical-reflectivity, finding a transition from normal strong coupling to decoupled photon-modes by changing the effective oscillator strength within the cavity. Both coupled and decoupled structures were compared in terms of the distribution of the confined optical field using an eight-level modified Hamiltonian.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Biophysics
Ling Liang, Yong Jian Jiang, Long Chuan Zhang, Hui Liu, Yuan Fang Li, Chun Mei Li, Cheng Zhi Huang
Summary: In this study, a two-dimensional DNA walking nanomachine with high working efficiency and low cost was easily assembled using GO as the working platform. The nanomachine showed simple operation, high cost-performance ratio, and low background signal, making it highly promising for biosensing applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Wen-Xiu Ren, Fei Kong, Yu-Qing Shao, Qing-Yun Huang, Long-Fei Sun, Jie Feng, Yu-Bin Dong
Summary: External light-independent antitumor photodynamic therapy has been successfully achieved using a covalent organic framework (COF)-based host-guest nanosystem. Its highly effective antitumor behavior is fully demonstrated in both H2O2-overexpressed 4T1 and H2O2-less expressed HCT116 and MCF-7 xenograft models.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Geping Zhang, Longyue Yu, Jingfei Chen, Renhao Dong, Nicolas Godbert, Hongguang Li, Jingcheng Hao
Summary: Artificial light-harvesting systems (ALHSs)are one of the most attractive scientific topics in recent decades. This study reports a new type of binary ALHS using an ionic derivative as a donor, which achieves efficient FRET and can be used for color tuning and various applications.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Hongguang Li, Jingcheng Hao, Geping Zhang, Longyue Yu, Jingfei Chen, Renhao Dong, Nicolas Godbert
Summary: Artificial light-harvesting systems (ALHSs) are an attractive scientific topic, and a new type of binary ALHS using an ionic naphthalimide (NPI) derivative as a donor has been reported, which shows efficient energy transfer and tunable color by adjusting the acceptor/donor ratio.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Laura Kacenauskaite, Stine G. Stenspil, Andrew H. Olsson, Amar H. Flood, Bo W. Laursen
Summary: Brightly fluorescent solid-state materials are highly desirable for various applications. However, the close contact between pi-systems often leads to quenching. In this study, small-molecule ionic isolation lattices (SMILES) are developed to efficiently isolate fluorophores and ensure high densities of dyes. By intentionally introducing fluorescent dopants, FRET effects are exploited and superior fluorescent solid-state materials are created with freely tunable spectroscopic properties.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Chengcheng Wang, Tao Wu, Xiangmin Miao, Po Wang, Qiumei Feng
Summary: In this study, a dual-stimuli responsive electrochemiluminescence (ECL) sensor was developed for the detection and sterilization of Staphylococcus aureus (S. aureus). The sensor utilized silver nanoclusters labeled hairpin DNA (H-Ag NCs) as the energy acceptor of ECL emission from CdS quantum dots (CdS QDs), generating resonance energy transfer (RET) and quenching ECL signal. The proposed method showed excellent performance in the detection of S. aureus in foods, with a linear range of 5-108 CFU/mL.
Article
Engineering, Electrical & Electronic
Joel M. Hales, Ani Khachatrian, Stephen Buchner, Adrian Ildefonso, Daniele M. Monahan, Stephen D. Lalumondiere, Dale Mcmorrow
Summary: By scanning the charge-deposition profile produced by a pulsed laser throughout a device, the spatially dependent charge-collection efficiency (CCE) can be determined. The efficiency curves can be applied to charge-deposition curves for heavy ions and pulsed X-rays to calculate collected charge values that show very good agreement with experimental results. The profiles extracted using the laser can help predict charge-collection data from other excitation sources and improve modeling efforts by determining sensitive volumes.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Kaitlyn L. Ryder, Landen D. Ryder, Andrew L. Sternberg, John A. Kozub, En Xia Zhang, Stephen D. LaLumondiere, Daniele M. Monahan, Jeremy P. Bonsall, Ani Khachatrian, Stephen P. Buchner, Dale McMorrow, Joel M. Hales, Yuanfu Zhao, Liang Wang, Chuanmin Wang, Robert A. Weller, Ronald D. Schrimpf, Sharon M. Weiss, Robert A. Reed
Summary: A silicon epitaxial diode is subjected to heavy-ion, focused X-ray, and pulsed laser single-event transient experiments, where collected charge, transient rise times, and transient fall times are compared across different sources. The differences in transient shape characteristics observed between sources can be attributed to basic charge collection mechanisms.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
George N. Tzintzarov, Adrian Ildefonso, Jeffrey W. Teng, Milad Frounchi, Albert Djikeng, Prahlad Iyengar, Patrick S. Goley, Ani Khachatrian, Joel Hales, Ryan Bahr, Stephen P. Buchner, Dale Mcmorrow, John D. Cressler
Summary: Experimental results show that the extinction of optical power in waveguides due to optical single-event transients (OSETs) is dependent on the number of injected electron-hole pairs. The fractional extinction remains constant regardless of the optical power level, raising concerns about using integrated silicon photonics for radiation-intensive applications.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2021)
Review
Materials Science, Multidisciplinary
S. J. Pearton, Assel Aitkaliyeva, Minghan Xian, Fan Ren, Ani Khachatrian, Adrian Ildefonso, Zahabul Islam, Md Abu Jafar Rasel, Aman Haque, A. Y. Polyakov, Jihyun Kim
Summary: Wide bandgap semiconductors such as SiC and GaN face challenges in space and avionic applications due to susceptibility to radiation damage, while ultra-wide bandgap semiconductors like Ga2O3, diamond, and BN show promising radiation resistance characteristics for high-energy applications. More research is needed on the response of these semiconductor materials to radiation, especially in single event effects.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2021)
Review
Materials Science, Multidisciplinary
S. J. Pearton, Aman Haque, Ani Khachatrian, Adrian Ildefonso, Leonid Chernyak, Fan Ren
Summary: Radiation effects play a critical role in the reliability of SiC and GaN power electronics, with single event effects (SEE) being a key concern. Opportunities for comprehensive assessment and mitigation strategies are discussed in this paper.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Adrian Ildefonso, Jacob P. Kimball, Ani Khachatrian, Yaw Mensah, Jeffrey W. Teng, George N. Tzintzarov, Sunil G. Rao, Arya Moradinia, John D. Cressler, Dale McMorrow
Summary: This article applies the k-nearest neighbors algorithm to detect and correct single-event upsets, specifically focusing on the SEUs caused by single-event transients in RF systems carrying modulated data. By performing pulsed-laser measurements and training separate k-NN algorithms, the number of symbol upsets is reduced by 30% and the algorithm achieves a correct classification rate of 99.2%.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Joel M. Hales, Ani Khachatrian, Adrian Ildefonso, Stephen Buchner, Dennis Adams, David Wheeler, Scott Messenger, Codie Mishler, Nicholas Budzinski, Scott Jordan, Roger Van Art, Dale McMorrow
Summary: This study uses pulsed-laser testing to accurately determine the single-event latchup (SEL) thresholds for static random-access memories (SRAMs) on a mixed-signal application-specific integrated circuit (ASIC). It demonstrates two approaches that can be effective tools for evaluating SEL susceptibilities and mitigation strategies.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Sulima, Fuying Li, Jeffrey Brian Morgan, Phong Truong, Joshua F. G. Antoline, Therese Oertel, Rodell C. Barrientos, Oscar B. Torres, Zoltan Beck, Gregory H. Imler, Jeffrey R. Deschamps, Gary R. Matyas, Arthur E. Jacobson, Kenner C. Rice
Summary: This study focuses on the design and synthesis of haptens for anti-heroin vaccines, evaluating their efficacy in inducing protective antibodies against heroin in vivo. The results show that haptens with a linker at the C1 position can induce protective effects, with significant differences in antibody specificity among different haptens.
Article
Engineering, Electrical & Electronic
Pujan K. C. Mishu, Moon-Kyu Cho, Ani Khachatrian, Stephen P. Buchner, Dale Mcmorrow, Pauline Paki, John D. Cressler, Ickhyun Song
Summary: The advantages and tradeoffs of using inverse-mode SiGe HBT biasing circuitry in RF VCOs were investigated and compared with conventional forward-mode VCOs. The high-frequency performance of the inverse-mode VCOs may be degraded, but they offer acceptable performance at lower frequencies. Additionally, the inverse-mode VCOs show reduced single-event effects and better reliability under radiation compared to conventional VCOs.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Ebrahim M. Al Seragi, Subhra Dash, K. Muthuseenu, John D. Cressler, Hugh J. Barnaby, Ani Khachatrian, Stephen P. Buchner, Dale McMorrow, Saeed Zeinolabedinzadeh
Summary: This article introduces novel radiation hardening design techniques to reduce single-event effects on high-frequency receivers in space. The effectiveness is investigated through modifications to the mixer and matching considerations, with measurements conducted during normal receiver operation. The proposed radiation hardened receiver is validated through simulations and experiments using transient current pulses and a pulsed laser setup.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Xinyi Xia, Jian-Sian Li, Ribhu Sharma, Fan Ren, Md Abu Jafar Rasel, Sergei Stepanoff, Nahid Al-Mamun, Aman Haque, Douglas E. Wolfe, Sushrut Modak, Leonid Chernyak, Mark E. Law, Ani Khachatrian, S. J. Pearton
Summary: This paper presents a review of experimental and simulation radiation damage results in Ga2O3. Ga2O3 is expected to have similar radiation resistance as GaN and SiC, but with orders of magnitude difference compared to GaAs. The study highlights the importance of examining all types of radiation, as Ga2O3 devices may be used in both space and terrestrial applications.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Electrical & Electronic
Tolen Nelson, Daniel G. Georgiev, Michael R. Hontz, Raghav Khanna, Adrian Ildefonso, Andrew D. Koehler, Karl Hobart, Ani Khachatrian, Dale McMorrow
Summary: The study examines the effect of various trapping centers on single-event transients (SETs) in GaN high-electron-mobility transistors (HEMTs) through calibrated technology computer-aided design (TCAD) simulations. A computational model of a single-channel, Schottky-gate HEMT is developed and validated using static characteristics and single-photon absorption laser data. The simulations reveal a 2-D electron gas (2-DEG) enhancement effect in SETs, resulting in additional collected charge beyond the generated charge. The origins of this effect are investigated, showing an increase in the occupation rate of surface donor traps as charge influx develops in the charge track. Variations in trap characteristics are introduced, and their impact on internal charge collection processes is analyzed. It is further demonstrated that the SET drain current closely follows the transient decay of occupation rate back to the original dc level, indicating the dominance of surface donor traps in the SET response.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Joel M. Hales, Adrian Ildefonso, Stephen P. Buchner, Ani Khachatrian, Greg Allen, Dale McMorrow
Summary: A newly developed pulsed-laser testing approach using a quasi-Bessel beam (QBB) is applied to predict the heavy-ion generated single-event transient (SET) response in an LM124 operational amplifier. The QBB accurately reproduces the transient features measured in the broadbeam heavy-ion data, showing strong agreement with worst-case transients. Importantly, the QBB is capable of predicting ion-induced SET response without any fitting or adjustable parameters.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Jeffrey H. Warner, Eric Faraci, Chi Pham, Ani Khachatrian, Dale McMorrow
Summary: The SET response of the RIC7S113 gate driver was characterized using pulsed laser and heavy ion accelerator testing, and the SET response between the two methods were compared.
2022 IEEE RADIATION EFFECTS DATA WORKSHOP (REDW) (IN CONJUNCTION WITH 2022 NSREC)
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Joel M. Hales, Ani Khachatrian, Jeffrey Warner, Stephen Buchner, Dale McMorrow
Summary: This research aims to develop an accurate and simplified approach for quantitative pulsed-laser testing.
2019 19TH EUROPEAN CONFERENCE ON RADIATION AND ITS EFFECTS ON COMPONENTS AND SYSTEMS (RADECS)
(2022)