Article
Oncology
Nushin Mirzaei, Fredrik Waernberg, Pontus Zaar, Henrik Leonhardt, Roger Olofsson Bagge
Summary: This study aimed to determine the feasibility of detecting sentinel lymph nodes (SLNs) in breast cancer patients using an ultra-low dose of superparamagnetic iron oxide nanoparticles (SPIO). SPIO was injected intradermally 4 days before surgery, and SLNs were detected using a handheld magnetometer during surgery. The results showed that SLNs were successfully detected in all patients using the ultra-low dose of SPIO.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Chemistry, Physical
Xiang-Yang Lou, Roberto Boada, Laura Simonelli, Manuel Valiente
Summary: The supported superparamagnetic iron oxide nanoparticles (SPION) show significantly improved adsorption performance for removing arsenic from polluted water compared to unsupported SPION, with approximately 14 times higher adsorption capacity. The adsorption-oxidation mechanism partially converts the adsorbed As(III) to less toxic As(V) through hydroxyl free radicals (.OH) generated by Fe(III) species and hydroxyl groups.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Zuzanna Z. Janczuk, Agnieszka Jedrych, Sylwia Parzyszek, Anita Gardias, Jacek Szczytko, Michal Wojcik, Paola Tiberto
Summary: This study reports the preparation of MNPs composites using excess liquid crystal-like ligands, which allows for precise and reversible control of magnetic nanoparticles in thin films, showing great potential for various applications.
Article
Chemistry, Physical
Idoia Castellanos-Rubio, Oihane Arriortua, Lourdes Marcano, Irati Rodrigo, Daniela Iglesias-Rojas, Ander Baron, Ane Olazagoitia-Garmendia, Luca Olivi, Fernando Plazaola, M. Luisa Fdez-Gubieda, Ainara Castellanos-Rubio, Jose S. Garitaonandia, Inaki Orue, Maite Insausti
Summary: A new chemical route for synthesizing Zn-doped magnetite nanoparticles has been developed, allowing for control over size, morphology, and zinc content to achieve high saturation magnetization. Coating the nanoparticles with PEG ensures good biocompatibility and colloidal stability under physiological conditions.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leening P. Liu, Nadav Shapira, Andrew A. Chen, Russell T. Shinohara, Pooyan Sahbaee, Mitchell Schnall, Harold Litt, Peter B. Noel
Summary: This study compared the image characteristics of a first-generation dual-source photon-counting computed tomography (PCCT) and a dual-source dual-energy CT (DECT) scanner at ultra-low radiation dose levels. The results showed that PCCT had high precision in Hounsfield unit (HU) measurements at various radiation dose levels, outperforming DECT at low doses and significantly reducing electronic background noise.
EUROPEAN RADIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mona Kappes, Bernhard Friedrich, Felix Pfister, Christian Huber, Ralf Phillipp Friedrich, Rene Stein, Christian Braun, Julia Band, Eveline Schreiber, Christoph Alexiou, Christina Janko
Summary: Noncontact manipulation of cells in regenerative medicine using superparamagnetic iron oxide nanoparticles (SPIONs) allows for new possibilities in tissue engineering. SPIONs can be used as drug transporters, contrast agents, or to make cells maneuverable by magnetic forces. Different SPION coatings, such as PAM and citrate, show good cellular loading and magnetic controllability of cells. This research demonstrates the potential for using SPIONs in 3D cell cultures and highlights their ability to accelerate spheroid formation and micropatterning.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Korobi Konwar, Niyorjyoti Sharma, Pranjali Pranjali, Anupam Guleria, Som Datta Kaushik, Anupam Dutta, Rupak Mukhopadhyay, Debasis Sen, Weibo Gao, Pritam Deb
Summary: The study aims to explore the relationship between structure and relaxivity by observing transverse relaxivity enhancement in MRI of differently organized superparamagnetic complex ensembles. The spatial arrangement of nanoparticles, magnetic easy axes, and anisotropy energy landscape were found to affect transverse relaxation. The research simplifies the limitation of the quantum mechanical outer-sphere diffusion model of MR relaxivity.
Article
Materials Science, Multidisciplinary
K. R. Preethy, Ponesakki Ganesan, M. Chamundeeswari
Summary: In this research, superparamagnetic graphene composites were produced using leaf extracts of Melia dubia and Prosopis juliflora. Commercial graphite was replaced with low-cost raw bio source, Pennisetum glaucum panicle waste for graphene oxide production. The composites exhibited enhanced surface area, good conductivity, and high loading capacity.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2023)
Article
Biophysics
E. V. Dukhopelnykov, Yu. N. Blyzniuk, A. A. Skuratovska, E. G. Bereznyak, N. A. Gladkovskaya
Summary: This study investigated the interaction between superparamagnetic iron oxide nanoparticles (SPIONs) and doxorubicin (DOX) and DNA. The results showed that the nanoparticles do not interact with DNA, but can load a large number of DOX molecules. At high DNA concentrations, almost all DOX molecules bind to DNA.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Physical
Dei Erwina, Heryanto Heryanto, Dahlang Tahir
Summary: A cellulose/Fe3O4/Cu composite was synthesized and applied as an X-ray radiation apron. The composition of the composite was varied by adjusting the levels of cellulose and Cu, and the crystal phase and functional group formed were analyzed. The performance of the composite as a radiation shield was evaluated, and the composition with 2 wt% cellulose and 4 wt% Cu showed the best values for various parameters. Additionally, surface analysis revealed a resemblance to Brassica oleracea, indicating advantageous properties.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Review
Nanoscience & Nanotechnology
Hao Wei, Yangnan Hu, Junguo Wang, Xia Gao, Xiaoyun Qian, Mingliang Tang
Summary: Superparamagnetic iron oxide nanoparticles (SPIONs) are extensively studied and utilized in biomedicine due to their superb superparamagnetic properties and reliable traceability. However, different SPIONs exhibit variations in cytotoxicity, metabolism, and cellular behaviors. A comprehensive review of the construction and application of SPIONs is necessary to address these differences.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Zichao Luo, Yayun Wu, Yuenan Wang, Dehong Hu, Duyang Gao, Yongshuai Ge, Zonghai Sheng, Xiaogang Liu, Hairong Zheng
Summary: Radiation dose verification is crucial in radiotherapy to ensure accurate delivery to the targeted tissue while minimizing harm to normal tissue. Traditional dosimeters face limitations in determining topographic radiation dose profiles. This study presents a robust technique using reusable, flexible scintillating films with lanthanide-doped persistent luminescent nanoparticles for visualizing and verifying clinical doses. The nanoparticle-based films outperform commercially available radiochromic films in their linear response to irradiation doses. Complex clinical dose distributions can be accurately recorded using this technique for dose verification and radiotherapy planning.
Article
Multidisciplinary Sciences
James A. Pollock, Kaye S. Morgan, Linda C. P. Croton, Michelle K. Croughan, Gary Ruben, Naoto Yagi, Hiroshi Sekiguchi, Marcus J. Kitchen
Summary: The text discusses the ill-posed problem of phase retrieval in optics and the use of discrete mathematics to improve the accuracy of algorithms for propagation-based phase-contrast X-ray imaging. Experimental measurements show that detectors with single pixel PSF characteristics can significantly improve spatial resolution by up to 17%.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Clara Emer, Laura S. Hildebrand, Bernhard Friedrich, Rainer Tietze, Rainer Fietkau, Luitpold V. Distel
Summary: This study investigates the influence of (3-Aminopropyle)-Triethoxysilane-coated superparamagnetic iron oxide nanoparticles (SPION-APTES) on head and neck squamous cell carcinoma (HNSCC) cell lines, as well as their suitability as a radiosensitizer. The results show that APTES-SPIONs are well taken up by the cancer cells and have a moderate influence on cell growth and colony formation without significant cytotoxic effects. The effects of APTES-SPIONs vary between different cell lines but do not significantly alter the radiation effect.
Article
Cell Biology
Mareike F. Bauer, Laura S. Hildebrand, Marie-Charlotte Rosahl, Ramona Erber, Soren Schnellhardt, Maike Buettner-Herold, Florian Putz, Oliver J. Ott, Carolin C. Hack, Rainer Fietkau, Luitpold Distel
Summary: Cell-in-cell (CIC) structures in early hormone-sensitive breast cancer were studied. In vitro experiments showed that breast cancer cell lines had higher phagocytic capacity compared to primary human fibroblasts. Tissue analysis from 147 patients in a clinical trial revealed that CIC structures were associated with favorable local recurrence-free survival and disease-free survival, but unfavorable for metastasis-free survival. CIC had the highest prognostic value in young breast cancer patients.
Article
Cell Biology
Alexander Grabenbauer, Thomas Aigner, Holger Goebel, Bernhard J. J. Leibl, Christof Lamberti, Gerhard G. G. Grabenbauer, Luitpold V. V. Distel
Summary: This study evaluated the benefit of additional administration of oxaliplatin during neoadjuvant radiochemotherapy in patients with advanced rectal cancer. The results showed that adding oxaliplatin significantly improved the pathologic complete remission rate, but did not have an impact on survival.
Article
Chemistry, Inorganic & Nuclear
Jeireimy Domergue, Pawel Guinard, Magali Douillard, Jacques Pecaut, Sarah Hostachy, Olivier Proux, Colette Lebrun, Alan Le Goff, Pascale Maldivi, Carole Duboc, Pascale Delangle
Summary: To control the cellular level of reactive oxygen species (ROS) and prevent pathologies related to oxidative stress, designing antioxidants based on natural enzymes involved in ROS degradation is a promising strategy. In this study, Ni complexes with tripeptides derived from the ATCUN motif were synthesized to mimic the active site of nickel superoxide dismutase (NiSOD). Six different Ni(II) complexes with various coordination modes were characterized and found to exhibit SOD-like activity. The complexes with equilibrium between N-coordination and S-coordination showed the highest efficiency, indicating the beneficial effect of a nearby proton relay. This study also demonstrated that two bound thiolates and two amidates are not prerequisites for the catalytic activity of NiSOD mimics.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Sabah El Mohammad, Olivier Proux, Antonio Aguilar, Jean-Louis Hazemann, Christele Legens, Celine Chizallet, Kim Larmier
Summary: The formation of tungstate-mannose complexes in aqueous solution was characterized using a combination of experimental and theoretical techniques. The structures of the complexes were determined using NMR and X-ray absorption spectroscopy. The study identified new complexes and provided insights into the structure-reactivity relationships of these metal-sugar complexes.
INORGANIC CHEMISTRY
(2023)
Article
Physics, Multidisciplinary
S. Botticelli, R. Chiaraluce, V. Consalvi, G. La Penna, A. Pasquo, M. Petrosino, O. Proux, G. C. Rossi, F. Stellato, S. Morante
Summary: In this study, it is demonstrated that Zn2+ ions are involved in the mechanism of SARS-CoV-2 virus evading immune response mediated by the BST2-tetherin host protein, supported by sequence analysis, molecular dynamics simulations, and X-ray absorption experiments.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Chemistry, Multidisciplinary
Tobias Huempfner, Felix Otto, Roman Forker, Paul Mueller, Torsten Fritz
Summary: The intercalation of potassium into epitaxial bilayer graphene is shown to enable superconductivity with a critical temperature of Tc = 3.6 +/- 0.1 K. The physical mechanisms are analyzed in detail using scanning tunneling microscopy and angle-resolved photoelectron spectroscopy. The data suggest that electron-phonon coupling is the driving force for superconductivity, and multiple energy gaps are observed. Additionally, the low-dimensional effects lead to a gap ratio exceeding the BCS value for conventional superconductors. These findings highlight the significance of reduced dimensionality in determining the superconducting properties of K-intercalated epitaxial bilayer graphene.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Electrochemistry
Ana Marija Damjanovic, Anna Theresa Sophie Freiberg, Armin Siebel, Burak Koyutuerk, Davide Menga, Kevin Krempl, Pankaj Madkikar, Olivier Proux, Hubert Andreas Gasteiger, Michele Piana
Summary: Ex situ and operando X-ray absorption spectroscopy (XAS) were used to investigate the structure and degradation mechanism of Fe-based catalysts for the oxygen reduction reaction (ORR) in proton exchange membrane fuel cells (PEMFCs). The results showed that Fe3+ was incorporated in the ZrO2 structure and significant presence of Fe-N-C-type structures was excluded in the Fe0.07Zr0.93O2-delta/C catalyst. The aging process led to the formation of oxidic Fe clusters and Fe demetalation from the ZrO2 structure. The faster aging of Fe0.07Zr0.93O2-delta compared to Fe-N-C was attributed to improved mass transport to/from active sites.
Article
Biochemistry & Molecular Biology
Benoit Toubhans, Nour Alkafri, Marcos Quintela, David W. James, Caroline Bissardon, Salvatore Gazze, Franziska Knodel, Olivier Proux, Alexandra T. Gourlan, Philipp Rathert, Sylvain Bohic, Deyarina Gonzalez, Lewis W. Francis, Laurent Charlet, R. Steven Conlan
Summary: At physiological levels, selenium is involved in redox reactions and has potential anti-cancer effects. Selenium nanoparticles, coated with serum albumin or chitosan, enhance biocompatibility and bioavailability. In this study, selenium nanoparticles were found to regulate histone methylation in ovarian cancer cell models, leading to increased histone methylation at specific sites. This novel role of selenium in histone methylation is mediated by a decrease in S-adenosylhomocysteine, an endogenous inhibitor of lysine methyltransferases. These findings broaden our understanding of the action of selenium nanoparticles in cancer therapy and other applications.
Article
Cell Biology
Sarah Jesse, Lukas Kuhlmann, Laura S. Hildebrand, Henriette Magelssen, Martina Schmaus, Beate Timmermann, Stephanie Andres, Rainer Fietkau, Luitpold V. Distel
Summary: Phelan-McDermid syndrome is a global developmental disorder often associated with autism spectrum disorder. Our study found that most patients with this syndrome have significantly increased radiosensitivity, which is not related to individual genetic findings, clinical course, or disease severity. These findings raise questions about the interpretation of the data and suggest further research is needed to explore possible links between increased radiosensitivity and aging/preaging or neurodegeneration.
Article
Cell Biology
Julia Fleischmann, Laura S. Hildebrand, Lukas Kuhlmann, Rainer Fietkau, Luitpold V. Distel
Summary: The poor prognosis of HNSCC is partly due to treatment resistance. Xevinapant, a SMAC mimetic, shows potential as a targeted therapy for HNSCC by inhibiting cIAP1/2 and XIAP and inducing apoptosis, necroptosis, and inhibition of prosurvival signaling. Combination therapy of Xevinapant with IR could improve treatment efficacy.
Article
Chemistry, Multidisciplinary
Enrico Falcone, Germano Nobili, Michael Okafor, Olivier Proux, Giancarlo Rossi, Silvia Morante, Peter Faller, Francesco Stellato
Summary: The redox activity of Cu ions bound to the amyloid-beta peptide is implicated in oxidative stress in Alzheimer's disease. A low-populated intermediate state, capable of binding Cu in both oxidation states, has been proposed to explain the efficient redox cycling between Cu(II)-Aβ and Cu(I)-Aβ resting states. By using X-ray induced photoreduction and thermal relaxation, a partially reduced Cu-Aβ species different from the resting states was trapped and characterized by X-ray Absorption Spectroscopy (XAS). This approach provides the first direct spectroscopic characterization of an intermediate state.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Oncology
Thomas Weissmann, Sina Mansoorian, Matthias Stefan May, Sebastian Lettmaier, Daniel Hoefler, Lisa Deloch, Stefan Speer, Matthias Balk, Benjamin Frey, Udo S. Gaipl, Christoph Bert, Luitpold Valentin Distel, Franziska Walter, Claus Belka, Sabine Semrau, Heinrich Iro, Rainer Fietkau, Yixing Huang, Florian Putz
Summary: This study introduces two novel methods for automatically analyzing the distribution of nodal metastases in head and neck cancer patients. The deep learning method accurately assigns lymph node metastases to different levels, while the registration-based method allows for the analysis and visualization of the 3D probability distribution of metastases without predefined level boundaries.
Article
Oncology
Luzie Helene Unseld, Laura S. Hildebrand, Florian Putz, Maike Buettner-Herold, Christoph Daniel, Rainer Fietkau, Luitpold Valentin Distel
Summary: Non-professional phagocytosis, specifically cell-in-cell structures, are increasingly studied in malignant melanoma metastasis. This study examined primary melanoma cell lines and tissue samples and found that all primary melanoma cell lines were capable of phagocytosis, with higher rates observed during suspension co-incubation. The presence of cell-in-cell structures was also detected in most tissue samples, indicating that non-professional phagocytosis mechanism is ubiquitous in malignant melanoma.
Article
Chemistry, Multidisciplinary
Caroline Bissardon, Olivier Proux, Salvatore Andrea Gazze, Odile Filhol, Benoit Toubhans, Lucie Sauzeat, Sylvain Bouchet, Aled R. Lewis, Thierry Maffeis, Jean-Louis Hazemann, Sam Bayat, Peter Cloetens, R. Steven Conlan, Laurent Charlet, Sylvain Bohic
Summary: This study investigated the effects of sub-toxic concentrations of functionalized selenium nanoparticles on prostate cancer cells and their intracellular localization and fate. The results showed that monodisperse selenium nanoparticles capped with bovine serum albumin could slow down the migration capacity of aggressive prostate cancer cells compared to polydisperse selenium nanoparticles capped with chitosan. The nanoparticles were found to interact with mitochondria in the cells. These findings provide new insight for further research on the cytotoxic mechanisms of selenium nanoparticles.
