Article
Materials Science, Multidisciplinary
Dongsheng Zhang, Ling-Ya Peng, Kun-Xu Teng, Li-Ya Niu, Ganglong Cui, Qing-Zheng Yang
Summary: In this study, researchers achieved modulation of singlet oxygen generation by controlling the self-assembly behaviors of heavy-atom-free BODIPY derivatives. Different assembly behaviors significantly altered the structures and ISC efficiencies of the nanoassemblies, leading to a remarkable distinction in singlet oxygen generation efficiency.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Ryan P. Connelly, Pedro F. Madalozzo, Jack E. Mordeson, Andrew D. Pratt, Yulia Gerasimova
Summary: The research demonstrates the conversion of a dapoxyl DNA aptamer into a sensor generating fluorescence signal at different wavelengths for detecting drug-resistant tuberculosis gene fragments. The promiscuity of the aptamer in binding to fluorogenic dyes has been discovered, laying the foundation for its application as a versatile sensing platform.
CHEMICAL COMMUNICATIONS
(2021)
Article
Surgery
Matthew Albert, Leticia Delgado-Herrera, Jennifer Paruch, Pauline Gerritsen-van Schieveen, Tomoyoshi Kishimoto, Shin Takusagawa, Na Cai, John Fengler, Jeffrey Raizer
Summary: In this study, researchers successfully achieved ureter visualization using a near-infrared fluorescence imaging technique, providing assistance for laparoscopic colorectal surgery. The drug pudexacianinium showed good efficacy at doses of 1.0 and 3.0 mg, and its safety and tolerability were confirmed.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Chemistry, Multidisciplinary
Yuta Kudoh, Emi Suzuki, Hikari Ochiai, Kakeru Ise, Yoshifumi Kimura, Mao Minoura, Haruyuki Nakano, Yoshihiro Matano
Summary: The properties of azaporphyrins can be modulated by changing the number of meso-nitrogen atoms. This study reports the synthesis of the first examples of 5,10,15,20-tetraaryl-5-azaporphyrinium (MTAMAP) salts. The inclusion of one meso-nitrogen atom significantly changes the properties of the porphyrin ring, making MTAMAP salts promising for the development of new fluorophores and photosensitizers.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Pengfei Zhang, Rui Wang, Zijian Wan, Xinyu Zhou, Guangzhong Ma, Jayeeta Kolay, Jiapei Jiang, Shaopeng Wang
Summary: The article introduces a total internal reflection-based evanescent scattering microscopy technique that can detect single proteins without labeling and provides a high-precision measurement method for protein binding kinetics.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jeongbin Park, Wonyl Choi, Sebastian Tiesmeyer, Brian Long, Lars E. Borm, Emma Garren, Thuc Nghi Nguyen, Bosiljka Tasic, Simone Codeluppi, Tobias Graf, Matthias Schlesner, Oliver Stegle, Roland Eils, Naveed Ishaque
Summary: SSAM is a computational framework for identifying cell types and tissue domains without the need for cell segmentation, applicable to various in situ transcriptomics techniques. Applied to mouse brain tissue images, SSAM can detect regions occupied by known cell types that were previously missed and discover new cell types.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Biomaterials
Helen R. Salinas, Dominie L. Miyasato, Olga E. Eremina, Rodolfo Perez, Karen L. Gonzalez, Alexander T. Czaja, Sean Burkitt, Arjun Aron, Augusta Fernando, Lauro S. Ojeda, Kimberly N. Larson, Ahmed W. Mohamed, Jos L. Campbell, Beth A. Goins, Cristina Zavaleta
Summary: This study evaluated the optical properties of common dyes and pigments, discovering that certain optical inks exhibited superior imaging contrast compared to clinically approved imaging dyes. The research could lead to the development of more sensitive imaging contrast agents for improved early cancer detection and guiding tumor resection, ultimately enhancing patient survival.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Physical
Jurick Lahiri, Shawn Sandhu, Benjamin G. Levine, Marcos Dantus
Summary: Cyanine molecules have high fluorescence yield in the near-infrared region and show enhanced emission upon binding to human serum albumin (HSA). Spectroscopic analysis and calculations reveal that the enhanced emission is associated with a twisted polymethine chain configuration. Moreover, this configuration is more stable at higher HSA concentrations. The formation of HSA dimers at concentrations above 10 μM is confirmed by spectroscopic changes and anisotropy measurements. These findings suggest that the longer-lived S-2 state configuration can be utilized for more efficient phototherapy agents, and cyanine S-2 spectroscopy can be a useful tool to determine the oligomerization state of HSA.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Multidisciplinary Sciences
Yi Yu, Suman Mallick, Mao Wang, Karl Borjesson
Summary: Strong light-matter coupling can challenge traditional chemistry rules, leading to the inversion of singlet and triplet excited states and enabling higher quantum efficiency. Manipulating energy flow in molecular systems through strong light-matter coupling may promote the development of organic optoelectronics devices.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Anna S. Efimova, Mariya A. Ustimova, Nelly S. Chmelyuk, Maxim A. Abakumov, Yury V. Fedorov, Olga A. Fedorova
Summary: This study synthesized new styryl dyes with N-methylpyridine or N-methylquinoline scaffolds and examined their binding affinity for DNA in cell-free solution. The substitution of heterocyclic residue from pyridine to quinoline and variation in the phenyl part greatly influenced their binding modes, binding affinities, and spectroscopic responses. Biological experiments demonstrated the low toxicity of the synthesized dyes and their ability to selectively stain mitochondria in living cells.
Article
Chemistry, Multidisciplinary
Roman A. Barmin, Polina G. Rudakovskaya, Olga Gusliakova, Olga A. Sindeeva, Ekaterina S. Prikhozhdenko, Elizaveta A. Maksimova, Ekaterina N. Obukhova, Vasiliy S. Chernyshev, Boris N. Khlebtsov, Alexander A. Solovev, Gleb B. Sukhorukov, Dmitry A. Gorin
Summary: Microbubbles with hybrid structures containing albumin, albumin-coated gold nanoparticles, and photodynamic dyes were successfully developed for multimodal imaging and potential applications in photodynamic therapy. The combination of gold nanoparticles and photodynamic dyes enhanced the stability and fluorescent signal of the probes, showcasing their potential in theranostics.
Article
Pediatrics
Irene Paraboschi, Paolo De Coppi, Danail Stoyanov, John Anderson, Stefano Giuliani
Summary: Fluorescence-guided surgery has shown promising results in guiding tumor resection and improving surgical accuracy, especially in areas such as hepatoblastoma and biliary tree imaging. Despite the limited clinical studies in pediatric surgery, the potential benefits of fluorescence imaging technology are evident in improving outcomes for young patients.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Virology
Joseph R. Gould, Shihong Qiu, Qiao Shang, Terje Dokland, Tomoaki Ogino, Chad M. Petit, Todd J. Green
Summary: VSV, a member of Mononegavirales, plays a vital role in molecular biology research with its RNA polymerase composed of L and P proteins. Phosphorylation of P-NTD modulates its interaction with L and affects the conformation of L during infection; this study is the first to detail the effects of phosphorylation on protein-protein interactions, providing important insights into mononegavirus RNA synthesis.
JOURNAL OF VIROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kirill S. Sadovnikov, Dmitry A. Vasilenko, Yulia A. Gracheva, Yuri K. Grishin, Vitaly A. Roznyatovsky, Victor A. Tafeenko, Nadezhda E. Astakhova, Ivan D. Burtsev, Elena R. Milaeva, Elena B. Averina
Summary: A simple two-step protocol was developed for the synthesis of 3-aryl/hetaryl-4-nitro-5-styrylisoxazole, resulting in a large series of novel 5-styrylisoxazoles with various substituents. These compounds exhibited fluorescent properties in the visible region, with emission maximum up to 610nm. Additionally, they demonstrated solvatochromism and chemosensor properties towards multiple metal cations. Cytotoxic activity against various cancer cell lines was tested, showing toxicity for some compounds in the concentration range of 10-100 μM.
Article
Gastroenterology & Hepatology
Jun-Hao Zheng, Shu-Ting Zhai, Xiao Liang
Summary: The study introduced a novel laparoscopic anatomical liver resection strategy using indocyanine green (ICG) fluorescent dual staining technique for tumor-bearing portal territory hepatectomy. The operative time was 195 min with an estimated blood loss of 100 mL. The patient was discharged without complications on the seventh day post-operation, and no recurrence was observed during the 6-month follow-up period.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Biophysics
Aurora Munoz-Losa, Carles Curutchet, Brent P. Krueger, Lydia R. Hartsell, Benedetta Mennucci
BIOPHYSICAL JOURNAL
(2009)
Article
Chemistry, Physical
Elena Dolghih, Wilfredo Ortiz, Seonah Kim, Brent P. Krueger, Jeffrey L. Krause, Adrian E. Roitberg
JOURNAL OF PHYSICAL CHEMISTRY A
(2009)
Article
Chemistry, Physical
Amy L. Speelman, Aurora Munoz-Losa, Katie L. Hinkle, Darren B. VanBeek, Benedetta Mennucci, Brent P. Krueger
JOURNAL OF PHYSICAL CHEMISTRY A
(2011)
Article
Environmental Sciences
Jonathan W. Peterson, Benjamin M. Fry, Daniel R. Wade, Ford J. Fishman, Jacob T. Stid, Jonas M. Peterson, Cleveland E. Tarp, Randall D. Wade, Sarah A. Brokus, Michael J. Pikaart, Brent P. Krueger, Aaron A. Best
Summary: Metal and metalloid contamination in drinking water sources is a global concern, with arsenic and copper exceeding WHO guidelines in certain sources. The study demonstrated the use of hollow membrane water filters and metal-capturing polyurethane foams for sampling and analysis, with some metal concentrations in source waters above recommended levels. Additionally, other metals were detected, with manganese being the most common.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2021)
Article
Tropical Medicine
Nathan Tintle, Kristin van De Griend, Rachel Ulrich, Randall D. Wade, Tena M. Baar, Emma Boven, Carolyn E. A. Cooper, Olivia Couch, Lauren Eekhoff, Benjamin Fry, Grace K. Goszkowicz, Maya A. Hecksel, Adam Heynen, Jade A. Laughlin, Sydney M. Les, Taylor R. Lombard, B. Daniel Munson, Jonas M. Peterson, Eric Schumann, Daniel J. Settecerri, Jacob E. Spry, Matthew J. Summerfield, Meghana Sunder, Daniel R. Wade, Caden G. Zonnefeld, Sarah A. Brokus, Francesco S. Moen, Adam D. Slater, Jonathan W. Peterson, Michael J. Pikaart, Brent P. Krueger, Aaron A. Best
Summary: Low-cost, in-home, point of use water filtration systems are effective at reducing bacterial-induced diarrhea, but installation of filters in schools did not significantly reduce diarrhea prevalence. There was no evidence of a loss of filter efficacy up to 200 days post-installation. Unfiltered water samples contained potential waterborne bacterial pathogens and heavy metals.
TROPICAL MEDICINE AND HEALTH
(2021)
Article
Chemistry, Multidisciplinary
Matthew C. Zwier, Justin M. Shorb, Brent P. Krueger
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2007)
Article
Chemistry, Physical
JM Jean, BP Krueger
JOURNAL OF PHYSICAL CHEMISTRY B
(2006)
Article
Chemistry, Physical
W Ortiz, BP Krueger, VD Kleiman, JL Krause, AE Roitberg
JOURNAL OF PHYSICAL CHEMISTRY B
(2005)
Article
Physics, Applied
SS Lampoura, BP Krueger, IHM Van Stokkum, JM Salverda, CC Gradinaru, D Rutkauskas, RG Hiller, R Van Grondelle
INTERNATIONAL JOURNAL OF MODERN PHYSICS B
(2001)
Article
Biochemistry & Molecular Biology
BP Krueger, PA Kollman
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2001)
Article
Biophysics
BP Krueger, SS Lampoura, IHM van Stokkum, E Papagiannakis, JM Salverda, CC Gradinaru, D Rutkauskas, RG Hiller, R van Grondelle
BIOPHYSICAL JOURNAL
(2001)
Article
Chemistry, Physical
PJ Walla, J Yom, BP Krueger, GR Fleming
JOURNAL OF PHYSICAL CHEMISTRY B
(2000)
Article
Chemistry, Physical
R Agarwal, BP Krueger, GD Scholes, M Yang, J Yom, L Mets, GR Fleming
JOURNAL OF PHYSICAL CHEMISTRY B
(2000)