期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 115, 期 14, 页码 3777-3783出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp2003613
关键词
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资金
- East China Normal University [77202201]
- Shanghai Education Commission [10SG27]
- Specialized Research Fund for the Doctoral Program of Higher Education [20093402110041]
Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and DL-Dithiothreitol are described. A competitive redox cleavage and suprarnolecular aggregate formation model is proposed based on PFG NMR and H-1 NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.
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