Article
Biochemistry & Molecular Biology
Liurong Huang, Lulu Qu, Shifang Jia, Shuang Ding, Jun Zhao, Feng Li
Summary: The study found that allicin affects the fluorescence properties of bovine serum albumin, the number of binding sites, binding constants, and leads to changes in its structure, including instability in secondary and tertiary structure and exposure of more hydrophobic groups.
PROCESS BIOCHEMISTRY
(2022)
Article
Spectroscopy
Ye Li, Hongrui Liu, Chunyu Mu, Jiali Gu, Chun Li
Summary: This study investigated the interaction mechanism between ethoxyquin (EQ) and transporter protein before and after beta-cyclodextrin (beta-CD) encapsulation. The results showed that EQ formed complexes with bovine serum albumin (BSA) and affected its structure and environment. However, encapsulation in beta-CD reduced the binding ability of EQ to BSA and prevented adverse effects on BSA conformation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Biochemistry & Molecular Biology
Mojtaba Azari-Anpar, Kambiz Jahanbin, Pascal Degraeve, Farideh Tabatabaei Yazdi, Isabelle Adt, Nadia Oulahal, Didier Le Cerf
Summary: This paper describes the structural elucidation of Leuconostoc mesenteroides P35 exopolysaccharide (EPS-LM) produced by a goat cheese isolate. The analysis included determination of optical rotation degree, macromolecular characterization, sugar units and methylation analyses, FT-IR, 1D NMR spectroscopy, and 2D NMR spectroscopy. EPS-LM was found to be a high molecular weight dextran composed of D-glucose units with α(1 → 6) linkages and α(1 → 3) branches. The interaction between EPS-LM and bovine serum albumin was investigated using surface plasmon resonance, revealing the involvement of van der Waals and hydrogen binding forces. The findings suggest potential applications of Ln. mesenteroides P35α-D-glucan in the biopolymer, medical, and food industries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Spectroscopy
Jie Bai, Xuekai Sun, Bing Geng, Xiping Ma
Summary: FTIR, fluorescence, and UV-vis absorption techniques were used to study the interaction between Cu+ and Cu2+ and bovine serum albumin (BSA) under simulated physiological conditions. The spectroscopic analysis showed that Cu+/Cu2+ could quench the intrinsic fluorescence emitted by BSA through static quenching with binding sites of 0.88 and 1.12 for Cu+ and Cu2+ respectively. The interaction was mainly driven by electrostatic force, as indicated by the negative ΔH and positive ΔS values. This study provides insight into the toxicological effects of different speciation of copper at the molecular level.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Dilshad, Afzal Shah, Shamsa Munir
Summary: In this study, a sensitive, selective, cost-effective, and environmentally benign electrochemical probe was developed for the detection of ibuprofen (IBP) using a glassy carbon electrode modified with Ag-ZnO and MWCNTs. The designed sensing platform was able to detect IBP down to a limit of detection of 28 nM under optimized conditions. The interaction between IBP and bovine serum albumin (BSA) was also investigated, revealing a strong complex formation with a binding constant of 8.7 x 10(13). This is the first reported example of IBP detection and its complexation with BSA.
Article
Chemistry, Applied
Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang
Summary: This study investigates the binding of six flavonoids with BSA containing Cu2+ using UV-vis, fluorescence, and molecular docking. The results show that the complexation of Cu2+ significantly affects the binding of flavonoids with BSA.
Article
Chemistry, Multidisciplinary
Wei Xu, Yuli Ning, Shiwan Cao, Guanchen Wu, Haomin Sun, Liwen Chai, Shuping Wu, Jingyi Li, Denglin Luo
Summary: The interaction mechanism between bovine serum albumin (BSA) and tannic acid (TA) was investigated using spectroscopic and computational approaches, and validated by circular dichroism (CD), differential scanning calorimetry (DSC), and molecular docking techniques. The fluorescence spectra and molecular docking results indicated that TA bound to BSA and caused static quenching at a single binding site. The interaction between BSA and TA was dose-dependent. Thermodynamic analysis showed that hydrophobic forces played a dominant role in the BSA-TA interaction. The stability of the BSA-TA complex was enhanced, as evidenced by changes in secondary structure and increased melting temperature and enthalpy.
Article
Chemistry, Physical
Eszter Fliszar-Nyul, Zelma Faisal, Violetta Mohos, Diana Derdak, Beata Lemli, Tamas Kalai, Cecilia Sar, Balazs Z. Zsido, Csaba Hetenyi, Adam Horvath, Zsuzsanna Helyes, Ruth Deme, Dora Bogdan, Andrea Czompa, Peter Matyus, Miklos Poor
Summary: SZV 1287 is a novel multi-target analgesic with promising potential for treating neuropathic pain. Studies have shown that SZV 1287 and its metabolites form stable complexes with albumin and exhibit activity in animal models. The interaction of SZV 1287 with albumin may play a crucial role in determining its pharmacokinetic properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Zhe-Ying Hu, Wan-Jun Wang, Lu Hu, Jie-Hua Shi, Shao-Liang Jiang
Summary: Dacomitinib, a tyrosine kinase inhibitor, was found to quench the endogenous fluorescence of bovine serum albumin (BSA) through static quenching. It preferentially inserted into the hydrophobic cavity of the BSA subdomain IA (site III), forming a 1:1 DAC-BSA complex. DAC had a higher affinity for BSA, and non-radiative energy transfer occurred between them. Hydrogen bonds, van der Waals forces, and hydrophobic forces played a significant role in the insertion of DAC into the hydrophobic cavity of BSA. DAC affected the secondary structure of BSA, leading to a slight decrease in the alpha-helix content. The microenvironment around tyrosine residues was affected by the DAC-BSA combination, while the microenvironment around tryptophan residues remained unaffected. Molecular docking and molecular dynamics simulation confirmed the insertion of DAC into site III of BSA, with hydrogen energy and van der Waals energy contributing to the stability of the DAC-BSA complex. The influence of metal ions on the system's affinity was also explored.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Xin Qi, Duoxia Xu, Jinjin Zhu, Shaojia Wang, Jingwei Peng, Wei Gao, Yanping Cao
Summary: The interaction between lutein dipalmitate and BSA was found to be static with a binding stoichiometry of 1:1. Thermodynamic study and molecular docking confirmed that lutein dipalmitate spontaneously bound to BSA through hydrogen bonds, van der Waals forces, and hydrophobic interactions. The addition of lutein dipalmitate led to a decrease in the alpha-helix content of BSA, as observed through CD analysis.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Physical
Paulina Tworek, Kamil Rakowski, Magdalena Szota, Malgorzata Lekka, Barbara Jachimska
Summary: This study investigates the structural modifications of bovine serum albumin (BSA) when adhering to a gold surface. The adsorbed molecules display increased levels of disordered structures and beta-turns, with a preference for a planar orientation. The interaction between exposed cysteines and the gold surface plays a vital role in the structural transformation.
Article
Multidisciplinary Sciences
Ashima Thakur, Jayant Patwa, Suyash Pant, Abha Sharma, S. J. S. Flora
Summary: The study investigated the interaction between MiADMSA and BSA, finding that MiADMSA can influence the conformation of BSA, and the interaction is spontaneous, endothermic, and involves hydrophobic forces. Experimental and computational studies demonstrated the effective binding of MiADMSA with BSA, essential for drug transportation and elimination from the body.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Yifan Wang, Si Chen, Xin Yang, Shuang Zhang, Chunying Cui
Summary: Optimizing the preparation of BSA NPs, the study found that BSA NPs/siRNA showed stable efficacy both in vitro and in vivo, showing promise as an effective system for siRNA-based gene therapy.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Applied
Hui Zhang, Yanzhen Zhang, Yongqi Huang, Ling Wu, Qianwan Guo, Qi Wang, Li Liang, Katsuyoshi Nishinari, Meng Zhao
Summary: The study revealed the weak interaction between COS2-6 and BSA, primarily stabilized by electrostatic and hydrophobic forces, providing important insights into the potential of COS in food applications.
Article
Chemistry, Physical
Rong-Juan Zhang, Song-Bo Kou, Lu Hu, Li Li, Jie-Hua Shi, Shao-Liang Jiang
Summary: In this study, the interaction between Baricitinib (BRT) and bovine serum albumin (BSA) was investigated. The results showed a weak binding between BRT and BSA, with van der Waals forces and hydrogen bonds playing a critical role in the complexation process. The findings provide important insights for evaluating the pharmacological characteristics of BRT and designing new drugs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Priya Mullick, Gopal Das, Aiyagari Ramesh
Summary: This study demonstrates the use of 2-dodecylmalonic acid as a template in biomineralization-inspired synthesis of hydroxyapatite nanoparticles, showing that it can regulate particle size and shape at different concentrations. The self-assembly of the amphiphilic template plays a nuanced role in the mineralization process, guiding scaffold design for bone tissue engineering applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Engineering, Environmental
Deepa Sachan, Gopal Das
Summary: In this study, a novel nanocomposite material was synthesized for the removal of toxic heavy metals from water. The nanocomposite showed high adsorption efficiency and followed Langmuir adsorption isotherm for copper and zinc. The findings suggest that this nanocomposite has the potential to be an eco-friendly, economical, and alternative adsorbent for heavy metal ions.
JOURNAL OF HAZARDOUS TOXIC AND RADIOACTIVE WASTE
(2022)
Review
Chemistry, Inorganic & Nuclear
Utsab Manna, Gopal Das, Md Alamgir Hossain
Summary: This review provides a comprehensive assessment of examples of neutral receptors binding fluoride, focusing on the structural aspects. It discusses the selective solid-state capture of fluoride by various receptors and also briefly mentions the fluoride selective sensing in solution state.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Environmental Sciences
Deepa Sachan, Arnab Ghosh, Gopal Das
Summary: Salvinia minima proved to be an effective biosorbent for the selective removal of cationic dyes and heavy metal ions. The experimental conditions greatly influenced the adsorption process, and the maximum adsorption capacity for the dyes and heavy metal ions was determined.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Asesh Das, Gopal Das
Summary: This report discusses the specific colorimetric and fluorometric sensing of HSO3- by a pair of chemodosimetric probes, showing excellent responses, selectivity, and detection limits. The reliability of selective sensing was ensured through verification of activated exo-cyclic C=C double bonds. The probes have a wide range of applications, including paper-strip analysis and detection of HSO3- in real environmental samples.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Sagnik De, Gopal Das
Summary: This study compares the aggregation-induced emission properties of two naphthalimidetethered amphiphile and non-amphiphile molecules. It demonstrates that these molecules exhibit intense emission signals in aqueous media and can mimic natural light-harvesting processes, as well as have potential analytical applications in detecting explosives.
Article
Chemistry, Multidisciplinary
Sagnik De, Oiyao Appun Pegu, Gopal Das
Summary: We designed three amphiphilic substituted urea compounds with different chain lengths. These hydrophobic amphiphiles exhibited aggregation-induced emission upon solvent switching. Microscopy was used to provide detailed information about the aggregates. The hydrophobicity of these AIEgens was utilized to create water-repelling fluorescent surfaces. The AIEgen, through photoinduced electron transfer-mediated mechanism, has been employed for the detection of nitroantibiotics. The analytical usefulness of the AIEgen in detecting nitroantibiotics in biofluids is being demonstrated.
Article
Chemistry, Applied
Partha Protim Bakal, Gopal Das
Summary: Potassium carbonate-activated biochar derived from Ricinus communis and Colocasia esculanta stems exhibited efficient removal of Cd2+ and Pb2+ from synthetic wastewater. The adsorption parameters and mechanisms were studied, with the findings indicating that biosorption followed the Freundlich isotherm and the pseudo-second-order kinetic model, and involved physical adsorption. The optimum conditions for Cd2+ and Pb2+ removal were determined, and the adsorption capacity was found to be 55 mg g(-1) for Cd and 76 mg g(-1) for Pb. Thermodynamics showed spontaneous and endothermic adsorption, and desorption studies indicated recyclability up to 5 cycles. These results highlight the potential of RCSB and CESB for efficient removal of heavy metal ions from aqueous environments.
JOURNAL OF WATER CHEMISTRY AND TECHNOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Partha Protim Bakal, Gopal Das
Summary: In this study, low-temperature Ricinus communis stem-activated biochar (RCSB) was synthesized using chemical activation and heating method. The RCSB showed high selective adsorption capability for methylene blue and malachite green, and can be regenerated for reuse. The novelty of this work lies in the low synthesis temperature and cost-effectiveness of the biochar.
WATER CONSERVATION SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Oiyao Appun Pegu, Rubi Moral, Gopal Das
Summary: The dipodal monourea anion receptors BPU-1 and BPU-2 can interact with various geometries of anions. BPU-1 selectively senses SO4 2-/HSO4 - in the aqueous medium, and both receptors undergo anion-induced intramolecular cyclization in the presence of F-/HO-.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Applied
Rubi Moral, Oiyao Appun Pegu, Gopal Das
Summary: Three receptors (L1-3) based on 4-(dimethylamino)cinnamaldehyde were prepared to investigate the influence of aromatic core substitution on self-assembly behavior. The receptors demonstrated different micro/nanostructures depending on solvent polarities and hydrogen-bonding abilities, which significantly affected the supramolecular self-assembly process. The selective sensing of picric acid among nitro-aromatic compounds, known for its high explosiveness, was thoroughly studied in both solid and solution states by the receptors, along with their mechanistic details. Real water samples were used to demonstrate the practical utility of this study, including economical paper-strip applications.
Review
Chemistry, Multidisciplinary
Megha Basak, Gopal Das
Summary: Fresh air and clean water are crucial for humans, fauna, and flora. Due to the high toxicity and widespread presence of NACs and VOCs in the environment, the development of chemosensors for these contaminants has gained significant attention. This review focuses on the latest advancements in fluorescent chemosensors, specifically small molecular frameworks, for NACs and VOCs from 2015 to 2022. The detection methods on various platforms and their potential applications in natural water bodies, vapor phase, and paper strip analysis are also discussed.
Article
Chemistry, Multidisciplinary
Megha Basak, Gopal Das
Summary: A versatile bifunctional probe, L-1, was developed for visualizing and quantitatively analyzing Hg2+ and GSH separately in water. Probe L-1 showed rapid sensing towards Hg2+ (LOD = about 17.35 ppb) and GSH (LOD = about 25.83 ppb) with a significant turn-on fluorescence response and red-shifted emission maxima. The sensing strategy was successfully applied to detect Hg2+ and GSH in contaminated natural water, simulated physiological media, and real biological samples. Affordable test strips for visual and quantitative detection of Hg2+ and GSH may have great potential for rapid preliminary environmental monitoring.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Sagnik De, Gopal Das
Summary: We designed five propellor-shaped molecules based on the quinoxaline scaffold with functional group variation. These molecules exhibit aggregation-induced emission and their responses to different solvents were studied spectroscopically and microscopically. The aggregation facet was analyzed in both solid and solution states. Notably, one of the molecules, L-2, showed specific interaction with a cationic surfactant unlike the other congeners which proceeded via disaggregation. Real sample analysis on freshwater and waste effluent samples demonstrated the analytical and environmental significance of these molecules.
Article
Chemistry, Multidisciplinary
Rubi Moral, Oiyao Appun Pegu, Gopal Das
Summary: This study reports the aggregation and sensing properties of two neutral benzimidazole-based urea receptors. R1 exhibits aggregation-induced emission (AIE) properties, while R2 shows typical aggregation-caused quenching (ACQ) behavior. Both R1 and R2 can sense SO42-/HSO4- in an aqueous medium, although with different binding affinities.
NEW JOURNAL OF CHEMISTRY
(2023)