期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 114, 期 20, 页码 6850-6854出版社
AMER CHEMICAL SOC
DOI: 10.1021/jp9109207
关键词
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资金
- National Office for Research and Technology (NKTH, Hungary) [NKFP07a-NANODRUG]
- European Community [FP7/2007-2013, 226716]
The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize the hydrophilic shell of the polyethylene glycol chains. Using a Gaussian model for describing the electron density profile along the normal of the bilayer, we got an asymmetric distribution of PEGylated lipids in accordance with theoretical considerations. Moreover, we used anomalous X-ray scattering to study the localization of a hydrophobic drug (a kinase inhibitor), which revealed that these molecules are mainly located in the hydrocarbon chain region of the phospholipid bilayer.
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