Review
Biochemistry & Molecular Biology
Sobhi Gaba, Anjali Saini, Gurpreet Singh, Vikramdeep Monga
Summary: Berberine, a plant-derived isoquinoline alkaloid, has shown remarkable therapeutic diversity and potential for the discovery of new therapeutic agents. Despite its clinical utility being compromised by undesirable pharmacokinetic properties, structural modifications have been made to improve its therapeutic efficacy, leading to significant advancements in its medicinal chemistry. This review provides a comprehensive overview of recent advancements in the field and serves as a valuable guide for the rational design of berberine-based compounds.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Sneha Singh, Nandini Pathak, Eram Fatima, Arvind Singh Negi
Summary: Isoquinoline alkaloids are important plant bioactives with diverse structures and various biological activities, including anticancer, antidiabetic, anti-inflammatory, and antimicrobial effects. Berberine, as one of the most prominent bioactive compounds in this class, possesses broad-spectrum pharmacological activities and is widely researched.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sagar Satpathi, Tamaki Endoh, Peter Podbevsek, Janez Plavec, Naoki Sugimoto
Summary: The study demonstrates detailed interaction analysis between PCs and RNAs to verify the impact of PCs on RNA functions, using berberine as a model PC. It identifies a minimal RNA motif interacting with berberine and highlights the importance of electrostatic and stacking interactions for sequence selective interaction and RNA stabilization. This selective interaction with a relatively small RNA motif based on a chemical structure of a planer heterocyclic highlights the biological activities of various PCs mediated by interactions with functional RNAs.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Viriyanata Wijaya, Ondrej Jandourek, Jana Kroustkova, Katerina Hradiska-Breiterova, Jan Korabecny, Katerina Sobolova, Eliska Kohelova, Anna Hostalkova, Klara Konecna, Marcela Safratova, Rudolf Vrabec, Jiri Kunes, Lubomir Opletal, Jakub Chlebek, Lucie Cahlikova
Summary: A study found that alkaloids isolated from the plant Dicranostigma franchetianum showed moderate anti-tuberculosis activity, and further development and testing of semi-synthetic derivatives of these alkaloids showed significantly enhanced activity. All compounds exhibited lower cytotoxicity in a liver cancer cell line.
Article
Biochemistry & Molecular Biology
Chengqing Zhang, Xiaohua Liu, Lifeng Tan
Summary: In this study, two different η(6)-arene Ru(II) complexes, Ru1 and Ru2, with fluorine substituent positions were synthesized and characterized for their binding with poly(U)*poly(A)·poly(U) triplex. It was found that Ru2 exhibited slightly higher binding affinity than Ru1, and both complexes similarly increased the stabilization of the third strand without affecting the template duplex stability significantly.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Takumi Makiura, Yutaka Nishigaichi
Summary: Photochemical and selective synthesis of 1-benzyl-1,2-dihydroisoquinolines was achieved using isoquinolines, methyl chloroformate, and electron-rich benzyltrifluoro-borates, with the presence of pyridine inhibiting the formation of cyclized pavine type products. The benzyl adducts were successfully transformed into berberine type skeletons through carbamate moiety cyclization.
Article
Multidisciplinary Sciences
Zhaoyang Xie, Sunuo Zhang, Yi Wu, Jinling Liang, Wenbin Yao, Ruoning Qu, Xiaole Tong, Guang Zhang, Hongmei Yang
Summary: In this study, the interactions between bioactive isoquinoline alkaloids and DNA triplexes were characterized using ESI-MS and various spectroscopic techniques. The sequence selectivity and preference of binding to TC and TTT triplex DNA structures were investigated. The alkaloids berberrubine, fangchinoline, coptisine, columbamine, and epiberberine showed a preference for TC rich DNA sequences, and the interaction between alkaloid-DNA had diverse mechanisms including electrostatic binding and intercalation binding.
Article
Chemistry, Applied
Xuanbin Wang, Xiaohua Liu, Lifeng Tan
Summary: Two new chiral ruthenium (II) complexes, A-1 and A-1, have been synthesized and characterized. The study reveals that A-1 has a weaker binding affinity towards the RNA triplex compared to A-1. Viscosity experiments show that both enantiomers can intercalate into the triplex, but A-1 is a better intercalator than A-1. Thermal denaturation experiments demonstrate that A-1 can more selectively stabilize the Watson-Crick base-paired duplex and the Hoogsteen base-paired third strand of the triplex, and its overall triplex stabilization is stronger than A-1.
Article
Biochemistry & Molecular Biology
Sylwia Nakonieczna, Aneta Grabarska, Kinga Gawel, Paula Wroblewska-Luczka, Arkadiusz Czerwonka, Andrzej Stepulak, Wirginia Kukula-Koch
Summary: This study investigated the anti-cancer effects of compounds from Coptis chinensis on gastric cancer cells and found that coptisine showed the highest efficacy. The combination of coptisine with cisplatin exhibited synergistic and additive interactions in vitro, and coptisine was safe for developing zebrafish in vivo. Further studies are warranted to explore the detailed mechanisms of these bioactive compounds in inhibiting gastric cancer cell survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Feng Yuan, Xiaohua Liu, Juan Li, Lifeng Tan
Summary: Two arene ruthenium(II) complexes (Ru1 and Ru2) with different ligands were synthesized and characterized. The binding properties of Ru1 and Ru2 with triple helix RNA were investigated, and it was found that both complexes bind through intercalation. Ru2 has a stronger binding affinity than Ru1. The stabilizing effects of Ru1 and Ru2 on the triple helix differ, with Ru2 stabilizing both the template duplex and the third strand. The planarity of the intercalative ligands plays an important role in the stabilization of the triple helix by arene Ru(II) complexes.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Bingxin Wen, Xiaohua Liu, Lifeng Tan
Summary: Two chiral ruthenium(II) polypyridyl complexes, Lambda-[Ru(bpy)(2)(dppx)](2+) and Delta-[Ru(bpy)(2)(dppx)](2+), were synthesized and characterized. Their interactions with RNA triplex poly(U)center dot poly(A)*poly(U) were investigated. The binding strengths and stabilizing effects of the enantiomers differed slightly, but Delta-1 showed a more marked light switch effect and a significantly different stabilizing effect on the triplex compared to Lambda-1. The chiralities of Ru(II) polypyridine complexes played an important role in their binding and stabilizing effects on the triplex.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)
Article
Plant Sciences
Nekpen Erhunse, Surekha Kumari, Pooja Anmol, Pooja Singh, Ehimwenma Sheena Omoregie, Agam Prasad Singh, Upendra Sharma, Dinkar Sahal
Summary: This study identified the specialized metabolites responsible for the antiplasmodial activity of Annickia affinis, finding that protoberberine alkaloids isolated from the plant showed excellent antiplasmodial activity, particularly against the blood-stage malaria parasite. Additionally, these compounds also exhibited promising activity against the liver-stage malaria parasite.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Analytical
Shuzhen Peng, Yun Chang, Xingli Zeng, Rong Lai, Mujing Yang, Dandan Wang, Xiaoshun Zhou, Yong Shao
Summary: We successfully programmed polyadenine DNA into a parallel duplex assembly using a polyvalent-binding assembler called nitidine (NIT) at neutral pH. The molecule planarity of natural isoquinoline alkaloids (NIAs) was found to be a determining factor in this assembly process. We also developed a gold nanoparticles-based colorimetric method to screen NIT out of NIAs for constructing the polyadenine assembly. Our work will inspire further interest in developing switches and sensors based on polyadenine by concentrating NIT within the parallel assembly.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
John M. Talbott, Brandon R. Tessier, Emily E. Harding, Grant D. Walby, Kyle J. Hess, Vladislavs Baskevics, Martins Katkevics, Eriks Rozners, James A. Mackay
Summary: Four new isoorotamide (Io)-containing PNA nucleobases have been designed for A-U recognition of double helical RNA. The experiments showed that these new PNA nucleobases have strong binding affinity, which will contribute to the future design of nucleobases capable of recognizing any sequence of double helical RNA.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Longlong Gao, Rui Tian, Yong Shao
Summary: DNAzymes, including G-quadruplexes, have been widely used in gene tools, therapies, and biosensors. This study develops a photocatalytic DNAzyme by introducing an abasic site (AP site) into a duplex structure, allowing for the activation of the DNAzyme's photocatalytic activity. The in situ photogenerated singlet oxygen (1O2) serves as a readout for the DNAzyme's activity.
CHEMISTRY-SWITZERLAND
(2023)
Article
Mechanics
Suresh S. Kumar, Arjun Shyam Sundar, R. Deepak
Summary: The stress intensity factor (SIF) of opposite surface cracks in an un-notched round bar under tension and combined load conditions was determined using a numerical method. The influence of loading modes on SIF was investigated, considering different crack depth ratios and crack aspect ratios. It was found that the SIF distribution changed as the crack depth ratio increased under pure tensile loading, and nonuniform and asymmetric SIF spread was observed when torque was applied. The effect of mode-II and mode-III fractures was more pronounced under combined loading.
MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
(2023)
Article
Mechanics
U. Magarajan, S. Suresh Kumar
Summary: This paper investigates the ballistic performance of AA6061-B4C surface composite targets fabricated by the Friction Stir Processing (FSP) technique. The paper is divided into two stages: stage I focuses on identifying suitable process parameters, while stage II conducts ballistic experiments for single and multiple hit conditions. The results show that FSPed AA6061-B4C targets exhibit better ballistic performance compared to BM targets.
MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
(2023)
Article
Materials Science, Multidisciplinary
Rajendran Praveen, Sajja Rama Koteswara Rao, Saurabh Suresh Kumar, Sundaram Suresh Kumar
Summary: The optimum thickness of aluminium alloy 7075 targets and the influence of heat treatment conditions on their high velocity impact response have been determined. Both experimental and numerical studies show that solution treated targets have higher microhardness and better ballistic performance, making them suitable for armored vehicles.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS
(2023)
Review
Rehabilitation
Yohali Burrola-Mendez, Sureshkumar Kamalakannan, Paula W. Rushton, Selsabil-A. Bouziane, Ed Giesbrecht, R. Lee Kirby, Rosemary J. Gowran, David F. Rusaw, Tomasz Tasiemski, Mary Goldberg, Marco Tofani, Jessica P. Pedersen, Jon Pearlman
Summary: This review summarized the research literature on wheelchair service provision education and found limited information on integrating wheelchair content into professional rehabilitation programs. It suggests prioritizing international partnerships, improving the quality and timeliness of training programs, and providing resources for educators to integrate wheelchair-related content.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Nurfaten Hamzah, Kamarul Imran Musa, Muhammad Hibatullah Romli, Xin Wee Chen, Mohd Zulkifli Abdul Rahim, Jafri Malin Abdullah, Mohd Azmi Suliman, Mohd Ismail Ibrahim, Tengku Alina Tengku Ismail, Iliatha Papachristou Nadal, Suresh Kumar Kamalakannan
Summary: The study aimed to translate and validate the CAFU instrument into Malay and test its validity and reliability among informal stroke caregivers in Malaysia. The results showed that the Malay-CAFU questionnaire had good relevancy, satisfactory item-level CVI, and high internal consistency. Therefore, the Malay-CAFU questionnaire is a valid and reliable instrument to assess the dependence level of stroke survivors and the upset level of informal stroke caregivers in Malaysia.
Review
Crystallography
Madunuri Chandra Sekhar, Eshwarappa Veena, Nagasamudram Suresh Kumar, Kadiyala Chandra Babu Naidu, Allam Mallikarjuna, Dudekula Baba Basha
Summary: This paper provides a review on recent advancements in piezoelectric materials and their applications in various fields such as catalysis, energy harvesting, and sensors. It also discusses the limitations of piezoelectric materials.
CRYSTAL RESEARCH AND TECHNOLOGY
(2023)
Article
Clinical Neurology
Sureshkumar Kamalakannan, Vijay Karunakaran, Ashwin Balaji, Aadi Sai Vijaykaran, Sivakumar Ramachandran, Ramakumar Nagarajan
Summary: ReWin, a digital therapeutics platform for stroke rehabilitation, was found to be feasible and acceptable in an Indian context through two phases of pilot testing. About 76% of participants used ReWin for more than half of the intervention period, and 90% of stroke care providers and 60% of stroke survivors and caregivers found the content of ReWin to be very relevant. Based on overall credibility, usability, and user-friendliness, 40% of stroke survivors and caregivers as well as 90% of stroke care providers rated the ReWin intervention as excellent.
FRONTIERS IN NEUROLOGY
(2023)
Review
Public, Environmental & Occupational Health
Tiago S. Jesus, Sureshkumar Kamalakannan, Sutanuka Bhattacharjya, Janet Prvu Bettger, Karen Jacobs, Helen Hoenig
Summary: This study describes a protocol for a mixed-methods systematic review aimed at identifying the usage and implementation of telerehabilitation in the delivery of rehabilitation services. The review will search six databases for relevant literature and use a framework synthesis approach to analyze the data. The results can inform future implementation efforts.
WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
(2023)
Article
Health Policy & Services
Tiago S. Jesus, Karthik Mani, Sutanuka Bhattacharjya, Sureshkumar Kamalakannan, Claudia von Zweck, Ritchard Ledgerd
Summary: Occupational therapy workforce needs global strategy for strengthening, as there is a lack of research and resources, as well as various challenges and threats that need to be addressed.
INTERNATIONAL JOURNAL OF HEALTH PLANNING AND MANAGEMENT
(2023)
Article
Pediatrics
Manisha Shrestha, Gopal Bhandari, M. Optom, Sureshkumar Kamalakannan, Gudlavalleti Venkata Satyanarayana Murthy, Suresh Kumar Rathi, Anirudh Gaurang Gudlavalleti, Varun Agiwal, Hira Pant, Binod Pandey, Ramesh Ghimire, Daman Ale, Sajani Kayastha, Rakshya Karki, Daya Shankar Chaudhary, Raghunandan Byanju
Summary: This study aimed to evaluate the effectiveness of counseling and SMS/text messaging and phone calls to improve the follow-up rates among pediatric patients. The results showed that these interventions did not have a significant effect on improving the follow-up rate. However, the study provides useful insights for improving the follow-up rate among children with visual disabilities in Nepal and similar contexts.
JMIR PEDIATRICS AND PARENTING
(2023)
Article
Chemistry, Multidisciplinary
Rajapriya Pandy, Senthuran Suresh Kumar, Perumal Suresh, Jamespandi Annaraj, Mohan Pandi, Shanmugaiah Vellasamy, Suresh Sagadevan
Summary: In this study, seven endophytic fungi from Millingtonia hortensis were screened and five of them were found to produce taxol. The fungal taxol showed significant antibacterial and antifungal activities against human and fungal pathogens. Moreover, it exhibited cytotoxic effects against human liver cancer cells, suggesting its potential as an anticancer agent.
Meeting Abstract
Surgery
Joohyun Kim, Suresh Kumar, Yongqiang Yang, Seung-Keun Hong, Johnny Hong
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Clinical Neurology
Dimple Dawar, Sureshkumar Kamalakannan, Nistara S. Chawla, Jibil T. Mathew, Esha Mehmood, Unnati Bhatnagar, Jeyaraj Durai Pandian
Summary: The study reviewed the intervention and outcome measures for post-stroke cognitive impairments. It found that there is diversity and heterogeneity in the interventions and measures used. While technology is replacing conventional approaches, there is limited data on scalable solutions. Future research is needed for evidence-based assessment and management of cognitive impairments in post-stroke rehabilitation.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2023)
Article
Chemistry, Applied
Jhilmil Swapnalin, Suresh N. Kumar, Kadiyala Chandra Babu Naidu, Prasun Banerjee
Summary: This review investigates the applications of Electron paramagnetic resonance (EPR) in biological systems, discussing its latest developments in areas such as photosynthesis, metalloproteins, radical enzymes, and phospholipid membranes. By utilizing EPR spectroscopy, the dynamics and structure of biological systems can be calculated, providing a better understanding of the radical state of proteins compared to XRD or NMR techniques.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Review
Rehabilitation
Sureshkumar Kamalakannan, Paula W. Rushton, Ed Giesbrecht, David F. Rusaw, Selsabil-A Bouziane, Melodie Nadeau, Jennifer McKee, Rosemary J. Gowran, R. Lee Kirby, Jessica P. Pedersen, Tomasz Tasiemski, Yohali Burrola-Mendez, Marco Tofanin, Mary Goldberg, Jon Pearlman
Summary: This planned scoping review aims to examine and synthesize the global literature on wheelchair service provision education for healthcare professional students, healthcare personnel and educators. The review will provide insights into the organization, content, evaluation, and integration models of wheelchair service provision education on a global scale.
DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
(2023)