Article
Chemistry, Multidisciplinary
Anusha Basaiahgari, Ramesh L. Gardas
Summary: Ionic liquid (IL)-based aqueous biphasic systems (ABSs) have attracted significant interest for extraction and separation of value-added compounds, serving as alternative solvents for non-biocompatible volatile organic compounds. Significant developments have been made in phase constituting components, temperature, pH, and extraction mechanisms in the field of IL-based ABS.
CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY
(2021)
Article
Engineering, Chemical
Ana R. F. Carreira, Ana M. Ferreira, Mafalda R. Almeida, Joao A. P. Coutinho, Tania E. Sintra
Summary: The commercialization of chiral drugs is a growing concern in pharmacology due to the potential issues with the pharmacological activities of enantiomers in racemates. This study aimed to develop a platform for the resolution of propranolol using chiral selectors in biphasic systems, with a focus on enantioselective liquid-liquid extraction (ELLE) systems. The most efficient biphasic system identified involved 1,2-dichloroethane-water, dipentyl-L-tartrate, and boric acid as chiral selectors, achieving an enantioselectivity of 2.54.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Engineering, Chemical
Ana R. F. Carreira, Helena Passos, Nicolas Schaeffer, Lenka Svecova, Nicolas Papaiconomou, Isabelle Billard, Joao A. P. Coutinho
Summary: This study systematically evaluated the factors influencing metal partition in acidic aqueous biphasic systems containing phosphonium-based ILs. The results showed that the IL counter anion, acid concentration, temperature, and other factors had an impact on metal extraction. The extraction efficiency of the metals was influenced by the properties of the metal-complex, temperature and ionic strength changes, and the dissociation degree of the acid.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Engineering, Chemical
Sladana Maric, Ana Jocic, Aleksandar Krstic, Milos Momcilovic, Ljubisa Ignjatovic, Aleksandra Dimitrijevic
Summary: This study aimed to investigate and propose a new integrated extraction technology for valorization of active pharmaceutical ingredients (APIs) from unused/expired pharmaceuticals by using eco-friendly components. The results showed that citrate-based ABS induced the strongest salting-out effect for extracting APIs with high recovery efficiencies, while ionic liquid/PL6200-based ABS was used for fractionating acetaminophen and caffeine towards opposite phases. These findings demonstrate the viability and adjustability of PL6200-based ABSs as a sustainable and efficient alternative platform on a larger scale.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Applied
Lili Zhang, Yan Li, Jing Gao
Summary: In this study, a novel aqueous biphasic system composed of tributyloctylphosphine chloride and choline chloride:D-fructose was developed for the selective extraction of Ast(1) and Ast(2) from Haematococcus pluvialis. The system showed excellent performance, with a high yield and partition coefficient of astaxanthin, as well as selective separation of Ast(1) and Ast(2) with a high coefficient of specificity.
Article
Chemistry, Multidisciplinary
Ana F. C. S. Rufino, Joana M. Bola, Joao A. . P. Coutinho, Francisca A. . E. Silva, Mara G. Freire, Emanuel Capela
Summary: Aqueous biphasic systems (ABS) have the potential to enhance separation processes by integrating multiple unit operations and operating under continuous mode. This study proposes the use of ionic liquids (ILs) as components of double-stimuli-responsive ABS, showing simultaneous responsiveness to temperature and pH. The findings inspire the development of customizable separation techniques, improving the performance and sustainability of separation processes.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Thermodynamics
Sholeh Hamzehzadeh, Malihe Fardshirayeh
Summary: This study evaluated the extractive potential of various aqueous biphasic systems for biomolecules, showing that the salting-out strength of salts, PEG molecular weight, and ABS composition affect the partition coefficients of biomolecules.
FLUID PHASE EQUILIBRIA
(2021)
Article
Engineering, Chemical
Ana F. C. S. Rufino, Sara C. Ribeiro, Joao A. P. Coutinho, Francisca A. Silva, Mara G. Freire
Summary: This study proposes the use of triblock copolymers to develop double stimuli-responsive aqueous biphasic systems (ABS) with ionic liquids (ILs). The ABS exhibit a Lower Critical Solution Temperature (LCST)-like behavior and only show a simultaneous response to both pH and temperature when using a specific copolymer. Copolymers with an adequate content of polyethylene oxide (PEO) provide a stronger response to the simultaneous action of pH and temperature compared to the homopolymer polypropylene glycol (PPG). The results highlight the importance of adjusting polymer structure/monomer composition in developing ABS with double response to temperature and pH. The enhanced tailoring ability of the proposed systems is demonstrated through the simultaneous separation of two dyes.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yun Deng, Ian Beadham, Tianyue Yang, Guang Wang, Feiyue Song, Wenquan Ruan
Summary: We have developed a novel approach for palladium (Pd) recovery using the ionic liquid 1-cyanopyl-3-methylimidazolium chloride ([C(3)CNmim][Cl]) and potassium phosphate (K3PO4). The results showed that Pd extraction can reach 100% with a [C(3)CNmim][Cl]-based aqueous biphasic system. Pure palladium was obtained after electrodeposition and calcination. This method offers a more environmentally friendly and efficient way for Pd recovery on an industrial scale.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Engineering, Chemical
Alexandre M. S. Jorge, Joao A. P. Coutinho, Jorge F. B. Pereira
Summary: This study investigates the hydrodynamics of three cholinium chloride-based aqueous biphasic systems (ABS) through analyzing the relationship between mixing time and phase settling time. The results show that phase settling time is independent of mixing time and is influenced by the nature of the phase-forming compounds. The study also defines the best operating region within the liquid-liquid region of [Ch]Cl/salt-based ABS.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Guiping Zhu, Xiaoyu Ma, Qilan Huang, Lingling Zhao, Ru Zhang, Xiangjun Yang, Shixiong Wang
Summary: A green aqueous two-phase system (ATPS) composed of a guanidinium ionic liquid (GIL) and phosphate was constructed and used to extract palladium from an acidic solution. The results show that up to 100% of Pd(II) efficiently migrates from the lower salt-rich phase to the upper GIL-rich phase. Various characterization methods reveal the mechanism of palladium distribution in the GIL-rich phase, and palladium can be successfully recovered from the GIL-rich phase.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Damien Degoulange, Raj Pandya, Michael Deschamps, Dhyllan A. Skiba, Betar M. Gallant, Sylvain Gigan, Hilton B. de Aguiar, Alexis Grimaud
Summary: High-resolution Raman imaging is used to investigate the interface of salt-salt aqueous biphasic systems (ABSs) at a molecular level, revealing a gradual change of environment instead of a sharp molecular interface. This knowledge is of great importance in understanding aqueous interfaces and has significant implications in various biological and technological settings, including novel battery technologies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Sandra C. Bernardo, Emanuel V. Capela, Jorge F. B. Pereira, Sonia P. M. Ventura, Mara G. Freire, Joao A. P. Coutinho
Summary: Cholinium-based ionic liquids were studied as electrolytes in ABS composed of PEG and NaPA, showing both enhancement and decrease in the liquid-liquid demixing ability. The distribution of electrolyte ions between phases and polyelectrolyte ion compartmentalization are key factors influencing the formation of PEG-NaPA-based ABS.
Article
Chemistry, Physical
Petr A. Korchak, Evgenia A. Safonova, Alexey I. Victorov
Summary: This study obtained experimental data on the partitioning of amino acid ionic liquids in aqueous mixtures, showing that they have higher partition coefficients and specificity compared to halide ionic liquids. Hydrogen bonding is likely to play a major role in the partitioning of the solute. These amino acid ionic liquids have high potential for the extraction of small biomolecules.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Paula Berton, Hongzhe Tian, Robin D. Rogers
Summary: This study investigated aqueous biphasic systems (ABS) composed of choline alkanoate ionic liquids mixed with K3PO4 solutions at different pH values. The ability to form ABS varied with different ILs and pH, with decreasing biphasic regions observed as pH increased. Anion exchange between phases in ABS at neutral pH was also observed.
Review
Chemistry, Multidisciplinary
J. Afonso, A. Mezzetta, I. M. Marrucho, L. Guazzelli
Summary: The establishment of Deep Eutectic Solvents (DESs) as a new class of green solvents was initially based on naive comparisons with Ionic Liquids (ILs), but further research has emphasized the need for a thermodynamic definition and differentiation from other solvents. This perspective review presents experimental and computational data to dispel myths about DESs and make fair comparisons with other solvents, such as ILs, eutectic solvents (ESs), and volatile organic compounds (VOCs). The unique potential of DESs in biopolymer dissolution and treatment is highlighted, along with considerations for recycling and techno-economic aspects.
Article
Biotechnology & Applied Microbiology
Ines P. E. Macario, Telma Veloso, Andreia P. M. Fernandes, Margarida Martins, Silja Frankenbach, Joao Serodio, Fernando J. M. Goncalves, Sonia P. M. Ventura, Joana L. Pereira
Summary: This study evaluated the growth patterns and pigment production of three cyanobacterium species, and found that N. muscorum was the best producer of chlorophyll a and C-phycocyanin.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemical Research Methods
Jean-Baptiste Chagnoleau, Ines L. D. Ryan, Ryan Khedher, Joao AP Coutinho, Thomas Michel, Xavier Fernandez, Nicolas Papaiconomou
Summary: A study was conducted on ternary biphasic systems composed of heptane, 1-butanol or ethyl acetate, and type III or type V deep eutectic solvents based on levulinic acid and choline chloride or thymol. The binodal curves, densities, and phase compositions of the equilibrium phases were determined for seven systems. The partition coefficients of six natural compounds were measured in these systems. Based on the results, a system composed of heptane, 1-butanol, and the deep eutectic solvent choline chloride:levulinic acid at a molar ratio of 1:3 was selected for centrifugal partition chromatography and showed good separation of apigenin, coumarin, beta-ionone, and alpha-tocopherol.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Engineering, Chemical
Emanuel Capela, Jessica Bairos, Augusto Q. Pedro, Marcia C. Neves, M. Raquel Aires-Barros, Ana M. Azevedo, Joao A. P. Coutinho, Ana P. M. Tavares, Mara G. Freire
Summary: This work demonstrates that materials modified with ionic liquids (ILs) can be effectively used for the selective adsorption and purification of antibodies, such as IgG, from complex matrices. The developed strategy showed good purification results in various IgG-containing matrices and preserved the structural integrity and biological activity of IgG. This suggests that ILs have the potential to replace costly chromatographic columns currently used for IgG purification.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Henrique Bastos, Nicolas Schaeffer, Jennifer M. M. Pringle, Joao A. P. Coutinho, Cristina Pozo-Gonzalo
Summary: The study investigates the use of dilute HCl solutions in hydroxylated solvents for dissolving Co, Ni, and Mn oxides in spent lithium-ion batteries. The findings present a simple and greener alternative to current leaching processes, reducing acid consumption and enhancing dissolution efficiency.
Article
Chemistry, Multidisciplinary
Ana F. C. S. Rufino, Joana M. Bola, Joao A. . P. Coutinho, Francisca A. . E. Silva, Mara G. Freire, Emanuel Capela
Summary: Aqueous biphasic systems (ABS) have the potential to enhance separation processes by integrating multiple unit operations and operating under continuous mode. This study proposes the use of ionic liquids (ILs) as components of double-stimuli-responsive ABS, showing simultaneous responsiveness to temperature and pH. The findings inspire the development of customizable separation techniques, improving the performance and sustainability of separation processes.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Engineering, Environmental
Ana R. F. Carreira, Andre Nogueira, Anna P. S. Crema, Helena Passos, Nicolas Schaeffer, Joao A. P. Coutinho
Summary: Recycling spent lithium-ion batteries is crucial for resource recovery and environmental protection. An integrated process for the leaching and separation of metals from spent cathode powder has been developed. By using a hydrophobic deep eutectic solvent, the cathodes can be efficiently leached and specific metals can be precipitated simultaneously. The proposed leaching process can extract cobalt, manganese, and copper completely from the spent batteries, while only extracting a small amount of nickel. Nickel can be easily recovered with high purity through appropriate manipulation. This system shows better atom economy and provides a new mild approach for the simultaneous leaching and separation of metals from lithium-ion batteries.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Energy & Fuels
Matthieu Habrioux, Djamel Nasri, Joao A. P. Coutinho, Jean-Luc Daridon
Summary: This study presents experimental data on the sound velocities and densities of two biodiesel fuels, namely sunflower methyl ester and a blend of Palm, Rapeseed, and Soybean methyl esters. The measurements were conducted at pressures ranging from atmospheric to 200 MPa and temperatures from 293.15 to 393.15 K. The data obtained were compared with existing models to predict the density and sound velocity of biodiesels under high pressure based on their fatty acid ester composition.
Article
Engineering, Chemical
Ana M. Ferreira, Maria V. Quental, Mukesh Sharma, Dibyendu Mondal, Augusto Q. Pedro, Joao A. P. Coutinho, Mara G. Freire
Summary: Early infection diagnosis is essential for reducing morbidity and mortality rates. A study investigated the use of aqueous biphasic systems (ABS) composed of polypropylene glycol 400 and cholinium-based ionic liquids (ILs) at different pH values for pre-treating human serum, aiming to separate DNA from human serum albumin (HSA) to improve the accuracy of DNA quantification. The ABS demonstrated high extraction efficiencies of DNA to the IL-rich phase, with minimal DNA loss. It was found that adjusting the pH allowed for selective isolation of DNA from HSA. The IL-rich phase of the ABS was shown to maintain DNA integrity and could potentially serve as a DNA storage medium.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Andre F. M. Nogueira, Ana R. F. Carreira, Silvia J. R. Vargas, Helena Passos, Nicolas Schaeffer, Joao A. P. Coutinho
Summary: In this study, precipitation processes using hydrophilic quaternary ammonium salts were demonstrated as a simple and economical alternative for the recovery of critical metals from ores and electronic wastes. The addition of tetrabutylammonium-based salts resulted in the recovery of over 90% of gold from synthetic solutions. The selectivity of gold precipitation was attributed to the formation of size selective apolar cavity between the cation and anion.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Emanuel Capela, Ilaria Magnis, Ana F. C. S. Rufino, Mario A. Torres-Acosta, M. Raquel Aires-Barros, Joao A. P. Coutinho, Ana M. Azevedo, Francisca A e Silva, Mara G. Freire
Summary: This study proposes a cost-effective approach using a three-phase partitioning system with ionic liquids as adjuvants for the purification and recovery of IgG antibodies from complex biological matrices. Economic analysis shows that the addition of 1% ionic liquids can improve purity/recovery performance and reduce production costs.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
LeticiaS. Contieri, Tania B. Ribeiro, Filipe H. B. Sosa, Barbara M. C. Vaz, Rodrigo S. Pizani, Manuela Pintado, Sonia P. M. Ventura, Leonardo M. de Souza Mesquita, Mauricio A. Rostagno
Summary: A new extraction platform of phenolic compounds from Brazilian green propolis using eutectic solvents was developed, with betaine: citric acid (1:2) and 50 wt % water as the most efficient solvent. The extraction yield was around 100 mg(polyphenol) g(propolis) (-1) using ultrasound-assisted extraction approach (UAE). In vitro biological assays showed that the eutectic solvent enhanced the biological potential of the green propolis extract, paving the way for the development of semi-finished products targeting inflammation biological pathways.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Physical
Jean -Baptiste Chagnoleau, Nicolas Papaiconomou, Xavier Fernandez, Joao A. P. Coutinho
Summary: This study evaluates the potential of the conductor-like screening model for designing biphasic systems for natural compound separation. The model accurately predicts binodal curves and phases composition and shows excellent agreement with experimental data for partition coefficients of natural compounds. The model is able to capture the influence of changes in system composition on partition coefficients.
JOURNAL OF MOLECULAR LIQUIDS
(2024)
Article
Chemistry, Physical
Jordana Benfica, Afonso C. Martins, German Perez-Sanchez, Nicolas Schaeffer, Joao A. P. Coutinho
Summary: The impact of sodium salt anions on the hydrotropic dissolution of syringic acid using an ionic liquid as a hydrotrope was studied. The presence of different sodium salts had different effects on the solubility of syringic acid, with Na[N(CN)2] increasing solubility and Na[SCN] decreasing solubility.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)