Article
Materials Science, Biomaterials
Keuna Jeon, Nesha May O. Andoy, Christian W. Schmitt, Yilei Xue, Leonie Barner, Ruby May A. Sullan
Summary: By manipulating the base systems and solution pH, researchers have influenced the formation rate and particle size of polyserotonin-based nanoparticles, improving the efficiency of nanoparticle synthesis. Synthesizing at elevated temperatures has dramatically reduced synthesis time from days to hours, making the application of PSeNP more convenient. Furthermore, the similarity between PSeNP and serotonin in free radical scavenging property demonstrates the potential of PSeNP in antioxidative therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Nutrition & Dietetics
Yinpeng Ma, Piqi Zhang, Xiaodong Dai, Xiuge Yao, Shuyang Zhou, Qingfang Ma, Jianing Liu, Shuang Tian, Jianan Zhu, Jiechi Zhang, Xianghui Kong, Yihong Bao
Summary: This study investigated the effects of alkali-soluble pH, acid precipitation pH, and microwave time on the extraction yield of Auricularia heimuer melanin (AHM) from fermentation. The optimized extraction conditions were alkali-soluble pH of 12.3, acid precipitation pH of 3.1, and microwave time of 53 min, resulting in an AHM extraction yield of 0.4042%. AHM exhibited similar absorption properties to melanin from other sources and showed strong free radical scavenging activities.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Zhi Li, Hui Heng, Qiqian Qin, Lanchun Chen, Yuedi Wang, Zeyang Zhou
Summary: This study reports the presence of melanin produced by Ascosphaera apis, which exhibits antioxidant activity and metal ion chelating properties, and is located on the spore wall. However, melanin does not enhance the virulence of A. apis spores.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Review
Biochemistry & Molecular Biology
Heba A. S. El-Nashar, Mariam I. Gamal El-Din, Lucian Hritcu, Omayma A. Eldahshan
Summary: Tyrosinase is a crucial enzyme in melanin synthesis, while excessive accumulation of melanin or overexpression of tyrosinase can lead to skin disorders. Flavonoids, a diverse natural class of compounds, exhibit antioxidant and tyrosinase inhibitor activities with a variety of mechanistic approaches.
Article
Chemistry, Applied
Alice Cariola, Madeleine El Chami, Jonathan Granatieri, Luca Valgimigli
Summary: Bakuchiol is a potent tyrosinase inhibitor for treating skin photoaging. It exhibits competitive inhibition against mushroom tyrosinase with average K-i constants of 6.71 +/- 1.23 jiM and 1.15 +/- 0.34 jiM for monophenolase and diphenolase reactions respectively. It also shows good antioxidant activity, making it a potential natural food preservative against oxidation and food-browning.
Article
Biochemistry & Molecular Biology
Jieun Lee, Hye Soo Park, Hee Jin Jung, Yu Jung Park, Min Kyung Kang, Hye Jin Kim, Dahye Yoon, Sultan Ullah, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Summary: Ten 2-mercaptobenzimidazole analogs were synthesized and found to be potent tyrosinase inhibitors and antioxidants. They effectively delayed browning of apple slices and could be potential anti-browning agents in foods.
Article
Food Science & Technology
Wangchen Zhao, Ziyu Liu, Xiaoyun Liang, Siqi Wang, Jie Ding, Zhuozhu Li, Longfeng Wang, Yun Jiang
Summary: Epigallocatechin gallate loaded melanin nanoparticles (EGCG@MNPs) were prepared as eco-friendly food preservation nanomaterials with good thermal stability, antioxidant, and antibacterial activity. The nanoparticles had a uniform spherical structure below 100 nm in diameter, and exhibited superior thermal stability and antioxidant properties. EGCG@MNPs showed higher scavenging ratios for DPPH and ABTS(+) compared to pure EGCG, with lower minimum inhibitory concentration and minimum bactericidal concentration for Escherichia coli and Staphylococcus aureus.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zekai Gou, Zhibo Peng, Shiyu Wang, Liuyang Chen, Zhicong Ma, Yifan Kang, Liang Sun, Rui Wang, Hong Xu, Yian Gu, Dafeng Sun, Peng Lei
Summary: In this study, SPG-producing strains of S. commune from different provinces in China were screened. A candidate strain (NTU-1) with a high SPG yield was chosen, and the fermentation conditions were optimized. The highest reported SPG concentration of 21.3 g/L was obtained in a 5-L bioreactor with a reduced fermentation cycle of five days.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Daniel Bosch, Jun Wang, Lluis Blancafort
Summary: This study successfully models the stability and optical absorption of Eumelanin using deep neural networks, addressing the structural challenge of Eumelanin.
Article
Food Science & Technology
Di Zhang, Xianrui Chen, Nitong Bu, Liying Huang, Huanglong Lin, Lizhen Zhou, Ruojun Mu, Lin Wang, Jie Pang, Andrea Gomez-Zavaglia
Summary: In this study, a novel nanoscale delivery system for quercetin was successfully constructed using melanin nanoparticles. The system showed improved thermal stability, antioxidant properties, and antibacterial capability. It also exhibited NIR/pH dual-responsive drug release behavior.
Article
Food Science & Technology
Wan Wang, Kai Zhang, Congyu Lin, Shanshan Zhao, Jiaqi Guan, Wei Zhou, Xin Ru, Hua Cong, Qian Yang
Summary: We have identified the transcription factor Cmr1 from the fungus Aureobasidium pullulans Hit-lcy3T, which regulates melanin biosynthesis genes. Gene knockout and overexpression experiments showed that Cmr1 is a key regulator of melanin synthesis in Hit-lcy3(T), and overexpression of Cmr1 enhanced melanin production and the expression of genes involved in melanin biosynthesis. The melanin extracted from Hit-lcy3(T) exhibited antioxidant properties and holds promise as a functional food additive.
Article
Biochemistry & Molecular Biology
Krystian Mokrzynski, Shosuke Ito, Kazumasa Wakamatsu, Theodore G. Camenish, Tadeusz Sarna, Michal Sarna
Summary: The photoreactivity of natural melanins isolated from hair samples of donors with different skin phototypes was studied, with melanins from blond and chestnut hair showing the highest photoreactivity. These melanins also exhibited the highest quantum efficiency of singlet oxygen photogeneration at 332 nm and 365 nm, supporting their potential contribution to UVA-induced melanoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agronomy
Paula Furtado Padua, Quelen de Lima Barcelos, Fernanda Aparecida Castro Pereira, Luanna de Barros Wanderley Gomes, Elaine Aparecida de Souza
Summary: This study evaluated the reaction of 416 germplasm accessions to Pseudocercospora griseola and identified 102 resistant and 314 susceptible accessions. The research showed that Carioca grain type lines have higher resistance to ALS. The discovery of new accessions resistant to P. griseola is crucial for common bean breeding programs.
CROP BREEDING AND APPLIED BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Xiaomin Li, Wenya Wu, Fengpei Zhang, Xin Hu, Yuan Yuan, Xiaoping Wu, Junsheng Fu
Summary: Water-soluble and water-insoluble melanin were obtained from Inonotus hispidus mushrooms, and their chemical composition and structure were found to differ. Water-soluble melanin consists of smaller, well-arranged particles with high amounts of benzene, phenol, and indole compounds, while water-insoluble melanin consists of larger, irregularly arranged particles with more sugar monomers.
Article
Food Science & Technology
Qun Yu, Liuping Fan
Summary: The study found that hydrothermal treatment enhances the antityrosinase and antioxidant activity of asparagus polyphenol extract, while ASEH effectively decreases melanin content and intracellular tyrosinase activity in B16F10 cells.
Article
Horticulture
Alejandra Barcena, Corina Graciano, Tomas Luca, Juan J. Guiamet, Lorenza Costa
SCIENTIA HORTICULTURAE
(2019)
Article
Multidisciplinary Sciences
I. Malbran, C. A. Mourelos, P. A. Balatti, G. A. Lori
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2019)
Article
Multidisciplinary Sciences
Andrea V. Toledo, Mario E. E. Franco, Rocio Medina, Ana M. Marino de Remes Lenicov, Pedro A. Balatti
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2019)
Article
Physics, Applied
L. Forzani, A. M. Gennaro, R. R. Koropecki, C. A. Ramos
APPLIED PHYSICS LETTERS
(2020)
Article
Environmental Sciences
Maria Troncozo, Marija Ljesevic, Vladimir P. Beskoski, Boban Andelkovic, Pedro A. Balatti, Mario C. N. Saparrat
Article
Microbiology
Silvina M. Y. Lopez, Graciela N. Pastorino, Antonio J. Fernandez-Gonzalez, Mario E. E. Franco, Manuel Fernandez-Lopez, Pedro A. Balatti
ARCHIVES OF MICROBIOLOGY
(2020)
Article
Agronomy
Alejandra Barcena, Jose Vera Bahima, Victoria Casajus, Gustavo Martinez, Diana Lauff, Juan Jose Guiamet, Lorenza Costa
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2020)
Article
Microbiology
Silvina M. Y. Lopez, Graciela Noemi Pastorino, Pedro Alberto Balatti
Summary: The study investigated the VOCs and secondary metabolites produced by endophytic bacteria isolated from tomato plants, which showed inhibitory effects on the growth of pathogenic fungi. The endophytic bacteria synthesized and released different VOCs, as well as soluble compounds, leading to a range of fungal growth inhibition.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Agronomy
Cesar G. Lucentini, Rocio Medina, Mario E. E. Franco, Mario C. N. Saparrat, Pedro A. Balatti
Summary: This study aims to further investigate the population of Fulvia fulva in Argentina, particularly in terms of genetic diversity, and studied polymorphisms within avr and ecp sequences, which may lead to the development of new races. The results show that the two races affecting Argentine tomato cultivars are under an evolutionary process, with polymorphisms observed mainly in coding sequences of effectors. The evolution of these races in Argentina may be primarily driven by environmental factors and management practices, rather than specific pathogenic or race-related genes.
EUROPEAN JOURNAL OF PLANT PATHOLOGY
(2021)
Article
Mycology
Alejandra Barcena, Rocio Medina, Mario Emilio Ernesto Franco, Lorena Alejandra Eliades, Marta Noemi Cabello, Carlos Pelleschi Taborda, Pedro Alberto Balatti, Mario Carlos Nazareno Saparrat
Summary: This study analyzed the effect of environmental factors on chlamydospore differentiation and pigment biosynthesis in the soil fungus Humicolopsis cephalosporioides. The results showed that temperature did not affect chlamydospore production but altered pigmentation development, which was also influenced by light. The composition of culture media and light modulated chlamydospore differentiation. The main pigment in the chlamydospores of H. cephalosporioides was identified as 1,8 dihydroxynaphthalene (DHN)-melanin-type compound.
MYCOLOGICAL PROGRESS
(2023)
Article
Plant Sciences
Santiago A. Vio, Maria Lina Galar, Maria Cecilia Gortari, Pedro Balatti, Mariana Garbi, Anibal Roberto Lodeiro, Maria Flavia Luna
Summary: The use of multispecies bacterial bio-inputs is a promising strategy for sustainable crop production. This study found that a multispecies bio-input consisting of four bacteria improved lettuce plant growth more effectively than single-species bio-inputs. The bacteria were compatible and persisted on the roots of lettuce plants, resulting in enhanced growth in both controlled conditions and commercial greenhouse production.
Article
Agronomy
V Martinez Alcantara, R. Medina, J. M. Gauna, P. A. Balatti
AGROCIENCIA URUGUAY
(2020)
Article
Multidisciplinary Sciences
Maria E. Brentassi, Rocio Medina, Daniela de la Fuente, Mario EE. Franco, Andrea V. Toledo, Mario CN. Saparrat, Pedro A. Balatti
Article
Multidisciplinary Sciences
Maria Troncozo, Cecilia B. Figoli, Mario E. E. Franco, Maria Mirifico, Alejandra Bosch, Mario Rajchenberg, Pedro A. Balatti, Mario C. N. Saparrat
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2020)
Article
Multidisciplinary Sciences
Alejandra Barcena, Gustavo Martinez, Lorenza Costa
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)