期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 112, 期 -, 页码 7-15出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2012.03.013
关键词
Antioxidant; Oxidative damage; Protein carbonylation; Stratum corneum
资金
- Ministry of Education of Taiwan
- We-Win Applied Biotech CO., Ltd.
- Meiho University [99853088]
We present an in vivo test platform to evaluate the antioxidative capability of seven frequently used dermocosmetic antioxidants on the human stratum corneum (SC). It has been reported that the protein carbonylation could be used as a biomarker for oxidative stress. The current study detects the change of the level of exposed protein carbonyl group in the most outer layer of human SC. The concentration of the antioxidant in each subject emulsion formulation was 0.5% (w/w). The data indicated that alpha-tocopherol (alpha-Vit E) and ascorbic acid (Vit C) have excellent antioxidative capability and alpha-Vit E-acetate possesses better than the average antioxidative capability. The bioconversion of alpha-Vit E-acetate to alpha-Vit E may occur in the human SC during a less than 2 weeks time course test. Lipoic acid possessed moderate antioxidative capability. Ascorbyl 6-palmitate had a low antioxidative capability. Ascorbic acid 2-glucoside represented an insignificant antioxidative capability. Glutathion (GSH) had no effect on reducing oxidative damage to human SC proteins, implying that the GSH recycling system could be absent in human SC. This test platform is an useful tool to evaluate the antioxidative efficiency of antioxidants on human SC proteins. Crown Copyright (c) 2012 Published by Elsevier B.V. All rights reserved.
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