期刊
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
卷 98, 期 2, 页码 167-171出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jphotobiol.2009.12.003
关键词
Photodynamic therapy; Mitochondria-targeting; Lipophilic cation
资金
- NNSFC [20772133, 20873170]
- CAS [KJCX2.YW.H08]
Four meso-tetraphenylporphyrin derivatives bearing either triphenylphosphonium ion-(P1 and P2) or triethylammonium ion-(P3 and P4) terminated alkoxy group at either para-(P1 and P3) or meta-(P2 and P4) position of one meso-phenyl group were designed and synthesized. P1-P4 show similar absorption and fluorescence emission spectra and O-1(2) quantum yields. The more lipophilic nature of triphenylphosphonium ion over triethylammonium ion renders P1 and P2 higher octanol/water partition coefficients than P3 and P4. Confocal fluorescence microscopy proved that P1-P4 are all mitochondria-targeting. MTT assay showed that P1-P4 presented significant phototoxicity at the concentrations that dark toxicity is negligible towards human breast cancer cell line MCF-7 cells, displaying their application potential in PDT. (C) 2009 Elsevier B.V. All rights reserved.
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