Review
Pharmacology & Pharmacy
Liang Lou, Shizhe Zhou, Sijia Tan, Menghua Xiang, Wei Wang, Chuang Yuan, Liqian Gao, Qicai Xiao
Summary: ALA is a clinically approved prodrug that can be used to synthesize the natural photosensitizer PpIX. However, its weak lipophilicity, low stability, and poor bioavailability limit its clinical performance. Nanotechnology offers a solution to improve the therapeutic outcomes of ALA-based prodrugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hung Wei Lai, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura
Summary: The study demonstrated that ALA-PDT is more effective in cancer cells of higher malignancy, with increased PpIX production, upregulation of ALA uptake transporters and YAP expression in correlation with higher cancer cell density.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Review
Chemistry, Medicinal
Yo Shinoda, Daitetsu Kato, Ryosuke Ando, Hikaru Endo, Tsutomu Takahashi, Yayoi Tsuneoka, Yasuyuki Fujiwara
Summary: The study reviewed and analyzed the effectiveness of 5-ALA PDT in vitro experiments for different cancer cell types, finding that the sensitivity to 5-ALA PDT varies across cancer classifications, with stomach cancer showing significantly higher sensitivity compared to other cancers. The analysis suggests the need for a standardized in vitro experimental protocol for 5-ALA PDT in future research.
Article
Pharmacology & Pharmacy
Airong Li, Chenglin Liang, Lihua Xu, Yiyang Wang, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi
Summary: A liposomal nanomedicine with iron ion regulation property has been developed to enhance the photodynamic therapy of 5-ALA. By co-encapsulating 5-ALA and DFO into membrane fusion liposomes, the drug delivery efficiency to tumor cells was improved, leading to the accumulation of photosensitive substances and aggravated DNA damage through iron ion inhibition.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Oncology
Jacob Bickels, Yair Gortzak, Amir Sternheim
Summary: The use of 5-ALA photodynamic therapy can decrease the likelihood of local tumor recurrence in fibroblastic soft-tissue tumors.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Abel Ferres, Alberto Di Somma, Alejandra Mosteiro, Thomaz Eduardo Topczewski, Pedro Roldan, Leire Pedrosa, Dioulde Diao, Estela Pineda, Angels Sierra, Joaquim Ensenat, Jose Juan Gonzalez-Sanchez
Summary: In this study, an inadvertent effect of 5-ALA-mediated photodynamic therapy has been detected in vivo. This finding opens up possibilities for further research on this promising therapeutic tool.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Nian Chen, Xia Lei, Qionghui Cheng
Summary: This article reports a case of intractable Queyrat erythroplasia involving the urethral meatus. The study suggests that 5-aminolaevulinic acid photodynamic therapy is effective and safe in the treatment of Queyrat erythroplasia, providing a new choice for patients with poor therapeutic effect.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Oncology
Sankha Bhattacharya, Bhuphendra G. Prajapati, Sudarshan Singh, Md Meraj Anjum
Summary: Photodynamic therapy (PDT) is a promising cancer treatment that selectively kills cancer cells using photosensitizers and specific light wavelengths. 5-aminolevulinic acid (5-ALA) is a widely used photosensitizer, but its limited penetration and targeting hinder its efficacy. Scholars have investigated nano-delivery techniques to improve 5-ALA administration and efficacy in PDT. This review summarizes recent advances in 5-ALA production pathways and highlights the potential of various nano-delivery modalities in treating different cancers. However, further research is needed to overcome challenges and improve targeting and efficacy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Linglin Zhang, Zijun Zhao, Peiru Wang, Guolong Zhang, Bo Wang, Lei Shi, Xiaojing Liu, Zhongxia Zhou, Xiuli Wang
Summary: In this study, the long-term improvement effect of ALA-PDT on photoaging in AK patients was evaluated. Results showed significant improvements in fine lines and mottled pigmentation, with no relapse observed during the 24-month follow-up period. However, the small sample size was a limitation, and further research is needed to confirm the reliability of the results.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Qingyu Zeng, Jiayi Yang, Jie Ji, Peiru Wang, Linglin Zhang, Guorong Yan, Yuhao Wu, Qi Chen, Jia Liu, Guolong Zhang, Xiuli Wang
Summary: The study found that PD-L1 blockade enhances the antitumor effects of ALA-PDT in cSCC and optimizes the tumor microenvironment. The combination therapy of antibody and photodynamic therapy induces immunogenic cell death and stimulates systemic immune response, preventing tumor recurrence. Additionally, the combination therapy can recruit lymphoid aggregates and promote tumor-infiltrating lymphocyte-mediated antitumor immunity.
Article
Engineering, Biomedical
Yu-Tsung Chen, Yun-Jhen Lin, Chang-Cheng Chang, Po-Heng Liu, Yung-Hsueh Huang, Jia-Wei Shen, Meng-En Lu, Hsiu-Mei Chiang, Bor-Shyh Lin
Summary: This study investigated the effects of non-ablative Q-switched 1064-nm Nd:YAG laser-assisted 2% ALA-PDT on the treatment of acne vulgaris. The results showed that combined therapy can significantly improve sebum secretion and maintain its effectiveness for 24 weeks. However, the combined group had more severe melanin index and erythema index after treatment.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Dermatology
Jon Chim Bai-Habelski, Annette Ko, Christoph Ortland, Marcus Stocker, Andrea Ebeling, Uwe Reinhold
Summary: Photodynamic therapy with 5-aminolevulinic acid hydrochloride is an established method for treating actinic keratosis (AK). Occlusion during ALA incubation can improve the clinical outcome of PDT for AK on hands and arms. Two PD P 506 A-PDT sessions 1-2 weeks apart are an efficacious treatment for AK on hands and arms.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Oncology
Xinying Li, Huiling Kou, Chuanqi Zhao, Fengjun Zhu, Yunchuan Yang, Yuangang Lu
Summary: This study evaluated the safety and efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of diabetic foot ulcers (DFUs) with infection. The results showed that ALA-PDT treatment effectively controlled DFUs with infection and had no recurrence.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Lei Shi, Qianqian Wu, Jin Yang, Jingwen Tan, Hong Yang, Chan Hu, Yunfeng Zhang, Haiyan Zhang, Linglin Zhang, Yeqiang Liu, Lianjuan Yang, Xiuli Wang
Summary: ALA-PDT is a potentially effective noninvasive method for the treatment of Majocchi's granuloma, with mechanisms of direct killing of fungal cells and CD4(+) T cell-mediated immune response.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Oncology
Lei Li, Yang Yang, Zengjun Yang, Mengxue Zheng, Gaoxing Luo, Weifeng He, Rui Yin
Summary: This study demonstrates that ALA-PDT can promote wound healing by regulating the formation of granulation tissue, inflammatory process, and M1/M2 macrophages differentiation. In vitro, ALA-PDT can modulate the ratio of M2 polarization to M1 polarization via the NF-KB signaling pathway.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Diana Ram, Maria Laura Hermida, Andrea Braun Jerozolimsky, Or-Yan Slav, Hao-Yu Wang, Florencia Puig Abbate, Ana Lorente Rodriguez, Cristina Cuadros-Fernandez, Roberto Vofovics Leon, Esti Davidovich
JOURNAL OF CLINICAL PEDIATRIC DENTISTRY
(2018)
Article
Microbiology
Mirian A. A. Freitas, Andre H. C. Pereira, Juliana G. Pinto, Adriana Casas, Juliana Ferreira-Strixino
FUTURE MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Gustavo H. Calvo, Vanina A. Cosenza, Daniel A. Saenz, Diego A. Navarro, Carlos A. Stortz, Mariela A. Cespedes, Leandro A. Mamone, Adriana G. Casas, Gabriela M. Di Venosa
SCIENTIFIC REPORTS
(2019)
Article
Materials Science, Multidisciplinary
Vanesa Munoz, Fabian Buffa, Fabricio Molinari, Laura G. Hermida, Juan J. Garcia, Gustavo A. Abraham
Article
Pharmacology & Pharmacy
Gabriela Cervini Bohm, Lautaro Gandara, Gabriela Di Venosa, Leandro Mamone, Fernanda Buzzola, Adriana Casas
BIOCHEMICAL PHARMACOLOGY
(2020)
Review
Oncology
Adriana Casas
Article
Biochemistry & Molecular Biology
Maria Laura Mugas, Gustavo Calvo, Juliana Marioni, Mariela Cespedes, Florencia Martinez, Daniel Saenz, Gabriela Di Venosa, Jose L. Cabrera, Susana Nunez Montoya, Adriana Casas
Summary: PTN isolated from the lichen Teoloschistes nodulifer showed promising potential as a photosensitiser for PDT in treating superficial malignancies. The uptake of PTN by tumor cells mainly through passive diffusion and significant cell death under blue light irradiation were observed.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)
Article
Chemistry, Applied
Cristian M. Pis Diez, Mariela Cespedes, Gabriela M. Di Venosa, Gustavo Calvo, Esteban Avigliano, Adriana G. Casas, Jorge A. Palermo
Summary: In this study, eleven new derivatives of the alkaloid olivacine were synthesized, showing increased cytotoxicity towards cell lines and some exhibiting indications of lysosomal apoptosis. The subcellular localization of olivacine and its synthetic derivatives was studied, revealing a different profile of cell distribution among the phases of the cycle for some of the new compounds compared to olivacine.
NATURAL PRODUCT RESEARCH
(2022)
Article
Oncology
Pablo Vallecorsa, Gabriela Di Venosa, M. Belen Ballatore, Dario Ferreyra, Leandro Mamone, Daniel Saenz, Gustavo Calvo, Edgardo Durantini, Adriana Casas
Summary: The study evaluated the photoactivity of four meso-substituted porphyrins and a porphyrin coupled to a fullerene in vitro. The PS with the best photokilling activity was administered to mice bearing the LM3 subcutaneously implanted adenocarcinoma. The results showed high photoactivity against LM3 mammary carcinoma cells for TAPP, DAPP, TEMCC4+ and TEMCP4+, with TAPP being the most active.
Article
Medicine, General & Internal
Santiago N. Piombi-Adanza, Maria C. Baretto, Flavia A. Echaide, Josefina Arias-Mahiques, Matias Carreras, Eliana Hidalgo-Fredez, Luciana M. Vignolo, Noel Parodi, Tomas Dominguez-Moncla, Jimena del Carlos, Maria F. Padula, Santiago Haedo, Mariana Sigman, Laura Hermida, Maria J. Padilla, Francisco Paulin
Summary: The study found that the Sat/RR index and NEWS2 score have a good capacity to discriminate patients at risk of clinical worsening, with the Sat/RR index being simpler and easier to calculate.
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Laura Hermida Bruno, Ana Paula Taboada Sobral, Marcela Leticia Leal Goncalves, Ana Laura Fossati, Elaine Marcilio Santos, Juliana Maria Altavista Sagretti Gallo, Elza Padilha Ferri, Pamella de Barros Motta, Renato Araujo Prates, Alessandro Melo Deana, Anna Carolina Ratto Tempestini Horliana, Lara Jansiski Motta, Sandra Kalil Bussadori
Summary: This study aims to determine the effectiveness of antimicrobial photodynamic therapy (aPDT) and probiotics in treating halitosis in mouth-breathing children. A total of 52 children between 7 and 12 years old with mouth breathing and halitosis will receive different treatments, and the results will be evaluated through breath meter measurements and microbiological analysis.
Article
Medicine, General & Internal
Ana Laura Fossati, Ana Paula Taboada Sobral, Maria Laura Laura Hermida Bruno, Natalia Osorio Viarengo, Maria Roxana Ferreira Sertaje, Elaine Marcilio Santos, Marcela Leticia Leal Goncalves, Raquel Agnelli Mesquita Ferrari, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana, Lara Jansiski Motta, Sandra Kalil Bussadori
Summary: This study aims to determine whether photobiomodulation enhances the results of treatment with glass ionomer sealant on molars with molar incisor hypomineralisation (MIH) that present sensitivity. The study involves two groups, one receiving active photobiomodulation and the other receiving sham treatment. Evaluations will be conducted before and after the procedure at 48 hours and 1 month, assessing various indicators. It is expected that sensitivity will be reduced in both groups after the treatment.
Article
Medicine, General & Internal
Natalia Osorio Viarengo, Marcela Leticia Leal Goncalves, Laura Hermida Bruno, Ana Laura Fossati, Maria Roxana Ferreira Sertaje, Elaine Marcilio Santos, Ana Paula Taboada Sobral, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana, Lara Jansiski Motta, Sandra Kalil Bussadori
Summary: The objective of this study is to evaluate the effect of intravascular irradiation of blood (ILIB) combined with myofunctional exercises for sleep bruxism in pediatrics. A total of 46 patients with sleep bruxism will be recruited and divided into a control group and an ILIB group. The importance of this study lies in being the first to evaluate the effect of ILIB combined with myofunctional exercises for sleep bruxism in pediatrics.
Article
Medicine, General & Internal
Maria Roxana Ferreira Sertaje, Marcela Leticia Leal Goncalves, Andrea Oliver Gomes, Laura Hermida Bruno, Ana Laura Fossati, Natalia Osorio Viarengo, Elaine Marcilio Santos, Ana Paula Taboada Sobral, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes, Anna Carolina Ratto Tempestini Horliana, Lara Jansiski Motta, Sandra Kalil Bussadori
Summary: This study aims to evaluate the effect of intravascular laser irradiation of blood (ILIB) on the range of motion and pain reduction in children and adolescents with temporomandibular disorders (TMD). It will be a blind, randomized, and controlled clinical trial with three groups: ILIB treatment group, placebo laser treatment group, and control group. The outcome measures include TMD diagnosis and pain evaluation using a visual analog scale. Further research is needed due to the limited evidence on the effect of ILIB in children with TMD.
Article
Multidisciplinary Sciences
Juan C. Stockert, Maria C. Carou, Adriana G. Casas, Maria C. Garcia Vior, Sergio D. Ezquerra Riega, Maria M. Blanco, Jesus Espada, Alfonso Blazquez-Castro, Richard W. Horobin, Daniel M. Lombardo
Article
Biochemistry & Molecular Biology
Girgis Obaid, Menitte Eroy, Jie Zhao, Shazia Bano, Mari Mino-Kenudson, Tayyaba Hasan
Summary: The presence of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) is associated with poor treatment outcomes and reduced drug delivery. By analyzing collagen subtypes in PDAC tumors following different treatment regimens, immunofluorescence profiling can predict long-term survival and tumor growth inhibition. This information can aid in personalized treatment and improve patient survival.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Fatemeh Malekpour, Rashin Bahrami, Mahshid Hodjat, Neda Hakimiha, Behnam Bolhari, Aidin Sooratgar, Soheil Niavarzi
Summary: This study investigated the effect of photobiomodulation (PBM) therapy using an 808 nm diode laser on cellular modulation mechanisms in regenerative endodontic procedures (REPs). The results showed that PBM treatment significantly increased cell viability and migration, and enhanced the release of TGF-131 from dentin.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Pranathi Tata, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Thin film coatings with potent antibacterial properties are widely used in medical devices, frequently touched surfaces, and food packaging. However, achieving antibacterial performance under both light and dark conditions remains a challenge. In this study, we successfully prepared AgBr-coated ZnO nanorod thin film architecture using a unique surfactant-mediated solution-phase spin-coating approach. The resulting structures showed dual functionality as antimicrobial agents and photosensitizers, effectively enhancing the visible-light photodisinfection efficacy of ZnO nanorods. The concentration of the surfactant-based precursor solution could be modulated to control the AgBr content. Additionally, components like urea and lactic acid were found to enhance the photocatalytic efficiency of the structures.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2024)