Coupling biorelevant dissolution methods with physiologically based pharmacokinetic modelling to forecast in-vivo performance of solid oral dosage forms

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Precipitation in the small intestine may play a more important role in the in vivo performance of poorly soluble weak bases in the fasted state: Case example nelfinavir

(2011) Yasushi Shono et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In vitro vs. canine data for assessing early exposure of doxazosin base and its mesylate salt

(2011) Marijana Erceg et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions

(2011) Kirstin Thelen et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug

(2010) Sandra Klein   AAPS Journal

Forecasting in vivo oral absorption and food effect of micronized and nanosized aprepitant formulations in humans

(2010) Yasushi Shono et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development and Application of a Biorelevant Dissolution Method Using USP Apparatus 4 in Early Phase Formulation Development

(2010) Jiang B. Fang et al.   MOLECULAR PHARMACEUTICS

Quantitative Analysis of the Effect of Supersaturation on in Vivo Drug Absorption

(2010) Ryusuke Takano et al.   MOLECULAR PHARMACEUTICS

Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility

(2010) Maria Vertzoni et al.   PHARMACEUTICAL RESEARCH

Predicting Pharmacokinetics of Drugs Using Physiologically Based Modeling—Application to Food Effects

(2009) N. Parrott et al.   AAPS Journal

Population-Based Mechanistic Prediction of Oral Drug Absorption

(2009) Masoud Jamei et al.   AAPS Journal

Application of biorelevant dissolution tests to the prediction of in vivo performance of diclofenac sodium from an oral modified-release pellet dosage form

(2009) Ekarat Jantratid et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A comparative study of different release apparatus in generating in vitro–in vivo correlations for extended release formulations

(2009) N. Fotaki et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prediction of food effects on the absorption of celecoxib based on biorelevant dissolution testing coupled with physiologically based pharmacokinetic modeling

(2009) Yasushi Shono et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Whole-body physiologically based pharmacokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption

(2009) Stefan Willmann et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Computer simulations using GastroPlus™ to justify a biowaiver for etoricoxib solid oral drug products

(2008) Arthur Okumu et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

Lipid-based Formulations for Danazol Containing a Digestible Surfactant, Labrafil M2125CS: In Vivo Bioavailability and Dynamic In Vitro Lipolysis

(2008) Anne Larsen et al.   PHARMACEUTICAL RESEARCH

Dynamic Dissolution Testing To Establish In Vitro/In Vivo Correlations for Montelukast Sodium, a Poorly Soluble Drug

(2008) Arthur Okumu et al.   PHARMACEUTICAL RESEARCH

Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update

(2008) Ekarat Jantratid et al.   PHARMACEUTICAL RESEARCH

Designing biorelevant dissolution tests for lipid formulations: Case example – Lipid suspension of RZ-50

(2007) Ekarat Jantratid et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Cogrinding enhances the oral bioavailability of EMD 57033, a poorly water soluble drug, in dogs

(2007) Markus Vogt et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS