Article
Immunology
M. A. Clements, A. J. Kwilasz, S. T. Litwiler, Z. Sents, B. J. Woodall, K. Hayashida, L. R. Watkins
Summary: Intrathecal delivery of IL-10 gene therapy is effective in relieving neuropathic pain, as demonstrated by behavioral tests in rodents. A new maze task, called the Two-Arm Rodent Somatosensory (TARS) task, has been developed to assess the development and resolution of pain behavior. This study provides evidence that intrathecal IL-10 gene therapy can improve neuropathic pain through supraspinally-mediated behavioral tasks.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Anesthesiology
Dominic Anthony Friston, Joshua Cuddihy, Jessica Souza Luiz, An Hoai Truong, Laptin Ho, Meirvaan Basra, Peter Santha, Orsolya Oszlacs, Joao de Sousa Valente, Tim Marczylo, Sini Junttila, Helen Laycock, Declan Collins, Marcela Vizcaychipi, Attila Gyenesei, Zoltan Takats, Gabor Jancso, Elizabeth Want, Istvan Nagy
Summary: Tissue injuries, including burns, release intracellular molecules and induce inflammatory reactions, leading to persistent pain. This study reveals that 18:0 LPC, a lysophosphatidylcholine, plays a significant role in burn injury-induced pain. It activates pain-sensing neurons and causes hypersensitivities through the transient receptor potential ion channel. These findings have implications for improving patient care.
Article
Biochemistry & Molecular Biology
Krishna Ghosh, Guang-Fen Zhang, Hong Chen, Shao-Rui Chen, Hui-Lin Pan
Summary: This study found that nerve injury leads to an increase in CB2 expression, which reduces neuropathic pain by modulating nociceptive transmission. This upregulation of CB2 may be achieved through histone modifications in epigenetics.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Anesthesiology
Xiaoyan Zhu, Wenrui Xie, Jingdong Zhang, Judith A. Strong, Jun-Ming Zhang
Summary: The study demonstrates the close association between local sympathetic effects and neuropathic pain, with CCL2 playing a key role in regulating the regeneration process.
Article
Neurosciences
Damien C. Boorman, Kevin A. Keay
Summary: Placebo analgesia shows potential in treating chronic pain, and an experiment on rats with neuropathic injury identified both placebo reactors and non-reactors, with specific nuclei showing activity during the analgesic process. Despite the presence of placebo reactions in some rats, there was no evidence of increased activity in the nuclei involved in the traditional analgesic pathways.
Article
Behavioral Sciences
Nisar Ahmad, Fazal Subhan, Nazar Ul Islam, Muhammad Shahid, Naseem Ullah, Rahim Ullah, Shehla Akbar, Muhammad Usman Amin, Muhammad Khurram, Ihsan Ullah, Robert D. E. Sewell
Summary: In comparison to Gabapentin, the synthesized GABA analogue showed higher efficacy in treating neuropathic pain induced by chronic constriction injury without causing adverse motor effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Immunology
Francis Desire Tatsinkou Bomba, Telesphore Benoit Nguelefack, Gangadhar Matharasala, Ram Kumar Mishra, Madhu Babu Battu, Dharmarajan Sriram, Albert Kamanyi, Perumal Yogeeswari
Summary: The study found that stem bark extracts of P. macrocarpus have a potent anti-hypernociceptive effect on CCI neuropathic pain, possibly achieved through inhibition of the nitric oxide pathway and reduction of NF-kappa B and TNF-alpha gene expression in the brain.
INFLAMMOPHARMACOLOGY
(2021)
Article
Neurosciences
Diego N. Messina, Emanuel D. Peralta, Cristian G. Acosta
Summary: The expression of the K2P channel TREK2 in neurons is regulated by GDNF, and this finding may have therapeutic potential in the treatment of chronic pain.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Clara Hoebart, Attila Kiss, Patrick M. Pilz, Petra L. Szabo, Bruno K. Podesser, Michael J. M. Fischer, Stefan Heber
Summary: This study aims to investigate the effects of TRPA1 activation, inhibition, or absence on infarcts and explore the underlying mechanisms. In vivo experiments showed no significant differences in infarct size among different TRPA1 activation or inhibition groups compared to the control group. In vitro experiments demonstrated that the presence of sensory neurons, partly dependent on TRPA1, increased the survival probability of cardiomyocytes challenged by ischemia-reperfusion. These findings raise doubts about the potential of TRPA1 as a promising target for reducing myocardial damage within a 24-hour period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jaisan Islam, Elina Kc, Kyoung Ha So, Soochong Kim, Hyong Kyu Kim, Yoon Young Park, Young Seok Park
Summary: Our study found that optogenetic inhibition of the posterior hypothalamus significantly improved behavioral responses in trigeminal neuropathic pain (TNP) animals. We also observed increased firing activity in the ventrolateral periaqueductal gray and decreased firing activity in the ventral posteromedial thalamus during optogenetic inhibition of the posterior hypothalamus. By modulating these areas, inhibiting the posterior hypothalamus can attenuate trigeminal pain signal transmission, providing evidence of its therapeutic potential in TNP management.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Xiaodan Song, Yuchen Wang, Wei Yang, Yingji Wang, Chunjuan Yang, Zhiyong Chen
Summary: Patients with vascular dementia experience more pain than healthy elders, potentially due to the presence of central neuropathic pain. In this study, a rat model of vascular dementia was induced by permanently occluding the common carotid arteries bilaterally (2-VO). The results indicate that neuropathic pain behaviors developed in the rat model of vascular dementia, and abnormal spontaneous discharges of primary sensory neurons may play a crucial role in the development of pain after vascular dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Martin E. Gosnell, Vasiliki Staikopoulos, Ayad G. Anwer, Saabah B. Mahbub, Mark R. Hutchinson, Sanam Mustafa, Ewa M. Goldys
Summary: This study successfully validated the feasibility of using hyperspectral autofluorescence imaging and deep learning techniques as a tool to differentiate tissues from nerve injured vs non-injured mice, providing important research and clinical applications prospects.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Engineering, Biomedical
Luis Vargas, He (Helen) Huang, Yong Zhu, Xiaogang Hu
Summary: The study investigated the recognition of static and dynamic components of proprioception using vibrotactile feedback, finding that subjects were able to accurately perceive these informations, with rotational amplitude recognition achieving the highest accuracy. Experimental results indicated that the implemented vibrotactile encoding scheme effectively provided proprioceptive information to users.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Cell Biology
Noosha Yousefpour, Samantha Locke, Haley Deamond, Chengyang Wang, Lucas Marques, Manon St-Louis, Johanne Ouellette, Arkady Khoutorsky, Yves De Koninck, Alfredo Ribeiro-da-Silva
Summary: Neuropathic pain is a debilitating condition caused by nerve system damage, and the imbalance of spinal excitation and inhibition is believed to contribute to it. Little is known about the structural basis of this imbalance. Through a preclinical model of neuropathic pain, researchers have found that microglia selectively engulf spinal synapses of central neurons but not peripheral sensory neurons. They also discovered that the removal of inhibitory and excitatory synapses occurs in different temporal patterns, with microglia-mediated inhibitory synapse removal happening before excitatory synapse removal. Additionally, they observed a gradual increase in complement depositions on dorsal horn synapses, which corresponds to the temporal pattern of microglial synapse pruning activity and specific synapse loss.
Article
Biochemistry & Molecular Biology
Shima Abtin, Rasoul Ghasemi, Homa Manaheji
Summary: Recent studies have shown that the ephrin/Eph signaling pathway may contribute to the pathology of neuropathic pain. Progesterone, administered after nerve injury, can alleviate neuropathic pain by suppressing the activation of ephrin-B2. The expression of spinal ephrin-B2 increased after nerve injury, and the administration of progesterone decreased mechanical allodynia, thermal hyperalgesia, and the expression of ephrin-B2.