Review
Pharmacology & Pharmacy
Olimpia Dumitriu Buzia, Ana Maria Paduraru, Claudia Simona Stefan, Monica Dinu, Dorin Ioan Cocos, Lawrence Chukwudi Nwabudike, Alin Laurentiu Tatu
Summary: In this work, various strategies to enhance transdermal drug delivery, such as iontophoresis, sonophoresis, electroporation and micron, are explored. A review on transdermal patches and their medical applications is also presented. The paper introduces new approaches for controlled drug release including niosomes, microemulsions, transfersomes, ethosomes, as well as hybrid approaches such as nanoemulsions and microns. The novelty of this review lies in the combination of strategies to improve transdermal drug administration with their applications in medicine, in the context of pharmaceutical technological advancements.
Article
Acoustics
Hao Wu, Cheng Zhou, Yuanyuan Li, Yongzhen Jin, Xiaochen Lai, Claus-Dieter Ohl, Dachao Li, Haixia Yu
Summary: Sonophoresis, as a safe and effective method for systemic transdermal drug delivery, has attracted much attention. This study reveals the influence of skin properties on the dynamics of single cavitation bubbles (SCBs), including the collapse time and the velocity of microjets. The elasticity, hydrophilicity, and texture of the skin all affect the behavior of SCBs.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Health Care Sciences & Services
Francisco Javier Martin-Vega, Maria Jesus Vinolo-Gil, Veronica Perez-Cabezas, Manuel Rodriguez-Huguet, Cristina Garcia-Munoz, Gloria Gonzalez Medina
Summary: This study conducted a meta-analysis to compare the use of phonophoresis with corticosteroids to other non-surgical treatment methods for carpal tunnel syndrome. The results showed that phonophoresis with corticosteroids may be an effective treatment method for reducing pain and improving motor and sensory nerve conduction in mild to moderate cases of carpal tunnel syndrome.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Antonio Galarreta, Pablo Valledor, Patricia Ubieto-Capella, Vanesa Lafarga, Eduardo Zarzuela, Javier Munoz, Marcos Malumbres, Emilio Lecona, Oscar Fernandez-Capetillo
Summary: Inhibitors of USP7 lead to widespread activation of CDK1 throughout the cell cycle, causing DNA damage and toxicity to mammalian cells. Additionally, USP7 interacts with the phosphatase PP2A, facilitating its active localization in the cytoplasm, and inhibition of USP7 or PP2A results in similar changes in the phosphoproteome, including increased phosphorylation of CDK1 targets.
Article
Pediatrics
Nicolle F. Dyess, Megan L. Albertz, Michael E. Murphy, John P. Kinsella
Summary: This case highlights the possibility of severe and persistent bronchoconstriction following the administration of neuromuscular blocking agents, serving as a reminder of the potentially life-threatening reactions that can occur.
JOURNAL OF PEDIATRICS
(2021)
Article
Pharmacology & Pharmacy
Tatiana Aparecida Pereira, Danielle Nishida Ramos, Lays Martin Sobral, Yugo Araujo Martins, Raquel Petrilli, Marcia de Abreu Carvalho Fantini, Andreia Machado Leopoldino, Renata Fonseca Vianna Lopez
Summary: This study investigated the potential of low-frequency ultrasound (LFU) combined with nanotechnology-based formulations in improving topical treatment of skin tumors. The results show that hydrophilic nanogels coupled with LFU achieved larger localized transport regions (LTR), while solid lipid nanoparticles hindered drug penetration. LFU treatment with nanogel significantly inhibited tumor growth. These findings suggest the importance of optimizing nanoparticle-based formulations and LFU parameters for the clinical application of LFU technology in skin tumor treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Junhua Xu, Hongwei Cai, Zhuhao Wu, Xiang Li, Chunhui Tian, Zheng Ao, Vivian C. Niu, Xiao Xiao, Lei Jiang, Marat Khodoun, Marc Rothenberg, Ken Mackie, Jun Chen, Luke P. Lee, Feng Guo
Summary: We have developed an active acoustic metamaterials-driven transdermal drug delivery method for rapid and on-demand management of acute diseases. This method integrates compact therapeutic patches with precise control of drug dosage and release kinetics, providing better delivery performance than subcutaneous injection. As a proof-of-concept, our method successfully reverses acute allergic reactions in a mouse model, demonstrating its potential for personalized medicine.
NATURE COMMUNICATIONS
(2023)
Article
Family Studies
Inae Dutra Valerio, Ana Luiza G. Soares, Ana Maria Baptista Menezes, Fernando Cesar Wehrmeister, Helen Goncalves
Summary: The study found that child maltreatment is associated with the use of psychoactive substances in adolescence and early adulthood, with the strength of the association decreasing over time. When gender differences were evident, stronger associations were observed among females.
CHILD ABUSE & NEGLECT
(2022)
Article
Immunology
Austin E. Coye, Kasha J. Bornstein, Tyler S. Bartholomew, Hua Li, Stanley Wong, Naveed Z. Janjua, Hansel E. Tookes, Joan E. St Onge
Summary: This study utilized an algorithm based on ICD-10 to estimate hospitalized PWID populations, assess overall morbidity for IRIs among this group, and calculate associated costs of care.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Endocrinology & Metabolism
Ioannis A. Charitos, Roberto Gagliano-Candela, Luigi Santacroce, Lucrezia Bottalico
Summary: This study provides a comprehensive assessment of the historical significance and medical applications of cannabis, tracing its origins back to ancient civilizations where it was used for various purposes. From ancient Oriental medicine to modern times, cannabis has evolved in its therapeutic uses for physical and mental disorders over the centuries.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Review
Obstetrics & Gynecology
Zhaoxia Ren, Andrew A. Bremer, Aaron C. Pawlyk
Summary: Many pregnant women use medication during pregnancy without clear information on the safety and appropriate dosing of these drugs. The FDA plays a crucial role in approving drugs for obstetrical use to ensure the public health of pregnant women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Anita K. Patel, Jiaxiang Gai, Eduardo Trujillo-Rivera, Farhana Faruqe, Dongkyu Kim, James E. Bost, Murray M. Pollack
Summary: The adoption of multimodal pain regimens that incorporate nonopioid analgesic medications can prevent serious opioid-related adverse effects in children. This study found that IV acetaminophen administered prior to IV opioids was associated with a 15.5% reduction in IV opioid duration in pediatric inpatients.
Review
Biochemistry & Molecular Biology
Maria Gabriela Corrales-Hernandez, Sebastian Kurt Villarroel-Hagemann, Isabella Esther Mendoza-Rodelo, Leonardo Palacios-Sanchez, Mariana Gaviria-Carrillo, Natalia Buitrago-Ricaurte, Santiago Espinosa-Lugo, Carlos-Alberto Calderon-Ospina, Jesus Hernan Rodriguez-Quintana
Summary: This article provides a comprehensive narrative review of the history of antiepileptic drugs (AEDs) and their development over time. It explores the role of serendipity in the discovery of essential AEDs and delves into the progression of preclinical models used in AED development. The article also provides an overview of the clinical advancement of major AEDs and discusses the contributions of artificial intelligence.
Article
Pharmacology & Pharmacy
Sonia N. Pedro, Maria S. M. Mendes, Bruno M. Neves, Isabel Filipa Almeida, Paulo Costa, Ines Correia-Sa, Carla Vilela, Mara G. Freire, Armando J. D. Silvestre, Carmen S. R. Freire
Summary: This study found that aqueous solutions of bio-based deep eutectic solvents (DES) can significantly improve the solubility of nonsteroidal anti-inflammatory drug ibuprofen. These solutions showed no toxicity to cells and preserved the anti-inflammatory action of the drug. Incorporation into alginate-based hydrogels resulted in materials with a regular structure and high flexibility, and demonstrated sustained release of the drug.
Article
Pharmacology & Pharmacy
Irene de Jesus Martinez-Segoviano, Adriana Ganem-Rondero
Summary: This study evaluated the effect of two permeation enhancers, sonophoresis and microneedles, on the permeability of AZT through the skin. Results showed that pretreatment of the skin with sonophoresis significantly increased AZT transport, while the use of microneedles further enhanced the flux and total amount permeated compared to sonophoresis. This suggests promising results in promoting AZT transport through the skin using these permeation enhancers.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ramon Andres Pineda-Alvarez, Maria Josefa Bernad-Bernad, Isabel Marlen Rodriguez-Cruz, Jose Juan Escobar-Chavez
Summary: This study aimed to develop and characterize biodegradable polymeric microneedle arrays loaded with losartan potassium. Lecithin/gelatin nanoparticles were prepared and optimized, and a 3D printed mold was used to create the microneedle arrays. The optimized nanoparticle formulation and microneedle arrays showed potential for delivering losartan through the skin, providing an innovative pharmaceutical form for blood pressure control.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Chemistry, Medicinal
Karla Stella Constantino-Gonzalez, Pablo Serrano-Castaneda, Omar Rodrigo Guadarrama-Escobar, Miriam Lopez-Cervantes, Clara Luisa Dominguez-Delgado, Jose Juan Escobar-Chavez
Summary: This study aimed to develop and characterize amikacin sulfate loaded emulgel as a co-adjuvant treatment for mycetoma. Through three stages of experimentation, the emulgel formulation and properties were determined. The formulated emulgel demonstrated appropriate technical characteristics for the treatment of mycetoma.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Ma. Concepcion Pena-Juarez, Omar Rodrigo Guadarrama-Escobar, Jose Juan Escobar-Chavez
Summary: Transdermal drug delivery systems have become increasingly important since the late 1970s when approved by the FDA. They are used as an alternative resource for administering potent drugs in treatments like cancer, diabetes, vaccinations, hormonal disorders, and contraception. The latest technologies in transdermal biomolecule transporters include electrical methods, chemical penetration enhancers, and nanocarriers, allowing for efficient storage, transport, and release of proteins and peptides for better treatment outcomes in various diseases.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Chemistry, Medicinal
Pablo Serrano Castaneda, Lilia Gutierrez Olvera, Maria Josefa Bernad Bernad, Hector Sumano Lopez, Jose Juan Escobar-Chavez
Summary: The developed spectrophotometric method showed a linear regression curve, good precision, high recovery rate, and detection of florfenicol in Eudragit nanocapsules at 270 nm.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Clara Luisa Dominguez-Delgado, Zubia Akhtar, Godfrey Awuah-Mensah, Braden Wu, Hugh David Charles Smyth
Summary: The emulsification-diffusion method for producing polymeric nanoparticles has been improved by using solvent blends as the organic phases, resulting in the successful production of biodegradable or pH-sensitive nanoparticles. Additionally, factors influencing particle size and polydispersity were identified.
Article
Pharmacology & Pharmacy
Omar Rodrigo Guadarrama-Escobar, Ivonne Sanchez-Vazquez, Pablo Serrano-Castaneda, German Alberto Chamorro-Cevallos, Isabel Marlen Rodriguez-Cruz, Adali Yisell Sanchez-Padron, Ericka Anguiano-Almazan, Ma. Concepcion Pena-Juarez, Abraham Mendez-Albores, Clara Luisa Dominguez-Delgado, Crisoforo Mercado-Marquez, Betsabe Rodriguez-Perez, Jose Juan Escobar-Chavez
Summary: Methacrylic acid-ethyl acrylate copolymer nanoparticles were prepared using the solvent displacement method, with optimization based on multiple variables. The optimal nanoparticle formulation exhibited significant therapeutic effects in in vivo experiments.
Article
Pharmacology & Pharmacy
S. A. Barriga, S. Pena-Corona, S. C. Caballero, M. Gracia, J. Luna del Villar, J. J. Escobar-Ch, M. Rivera, L. Macias, H. Garcia, D. Vargas-Estrada
Summary: This study evaluated the effect of tributyrin on a rat model of chronic diabetes and found that oral supplementation of tributyrin improved blood glucose levels, protected the liver and delayed the progression of kidney disease.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sara Pozos-Nonato, Clara Luisa Dominguez-Delgado, Kenia Areli Campos-Santander, Allyson Amelia Benavides, Sandy Maria Pacheco-Ortin, Rosa Isabel Higuera-Piedrahita, Guillermo Resendiz-Gonzalez, Eva Maria Molina-Trinidad
Summary: This article summarizes and discusses the innovative nanotechnological advances for skin anti-aging and rejuvenation. The study shows that the next generation nanoparticles have an enhanced anti-aging effect and successfully encapsulate various active ingredients for skin rejuvenation. These nanoparticles improve solubility, bioavailability, stability, permeability, and effectiveness, providing controlled drug release with minimized side effects.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Omar Rodrigo Guadarrama-Escobar, Pablo Serrano-Castaneda, Ericka Anguiano-Almazan, Alma Vazquez-Duran, Ma. Concepcion Pena-Juarez, Ricardo Vera-Graziano, Miriam Isabel Morales-Florido, Betsabe Rodriguez-Perez, Isabel Marlen Rodriguez-Cruz, Jorge Esteban Miranda-Calderon, Jose Juan Escobar-Chavez
Summary: The use of nanoparticles as drug delivery systems has become increasingly important in recent decades. Oral administration, despite its disadvantages, is still the most widely used route for therapeutic treatments and controlled-release systems based on nanoparticles synthesized from biodegradable natural polymers have been found to enhance oral delivery. Chitosan, with its various properties and roles in the pharmaceutical and health fields, is capable of encapsulating and transporting drugs within the body, improving drug efficacy, and forming nanoparticles through multiple mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Pablo Serrano-Castaneda, Miguel Alejandro Ochoa Loyo, Cristian Ezequiel Tinoco Hernandez, Brian Miguel Anaya-Ortega, Omar Rodrigo Guadarrama-Escobar, Ericka Anguiano-Almazan, Betsabe Rodriguez-Perez, Ma. Concepcion Pena-Juarez, Alma Vazquez-Duran, Abraham Mendez-Albores, Isabel Marlen Rodriguez-Cruz, Miriam Isabel Morales-Florido, Jose Juan Escobar-Chavez
Summary: This study aimed to develop polymeric dressings, microfibers, and microneedles loaded with ceftriaxone to treat diabetic wounds and promote faster healing. The formulations were optimized and subjected to physicochemical tests. The results showed that the developed dressings, microfibers, and microneedles exhibited favorable bioadhesion, tear strength, erythema, hydration, pH, and drug release properties. In vitro studies demonstrated promising flux, permeation coefficient, and time lag values in wounded skin, and in vivo tests in diabetic rats showed healing time below 14 days. These formulations have great potential for addressing the challenges of chronic wounds, such as diabetic foot, and improving clinical outcomes.
Article
Pharmacology & Pharmacy
Ramon Andres Pineda-Alvarez, Carolina Flores-Avila, Luis Medina-Torres, Jesus Gracia-Mora, Jose Juan Escobar-Chavez, Gerardo Leyva-Gomez, Mohammad-Ali Shahbazi, Maria Josefa Bernad-Bernad
Summary: This study evaluates the performance of Laponite in lecithin/gelatin composites and maltodextrin/sodium ascorbate mixtures. Nanoparticles were prepared using the gelatin desolvation method and turned into films via the solvent-casting method. The optimal composites were developed with 8.8 mg of Laponite, reducing particle size and avoiding agglomeration. Drug release in LGL MAS was fitted to first-order and Korsmeyer-Peppas models.
Review
Polymer Science
Callejas-Quijada Graciela, Escobar-Chavez Jose Juan, Campos-Lozada Gieraldin, Perez-Marroquin Xochitl Alejandra, Aguirre-alvarez Gabriel
Summary: This review provides an overview of the extraction methods and applications of hyaluronic acid (HA). It covers the various methods of HA extraction and its applications in the food industry. It also discusses the penetration routes of HA in the skin and future trends in its application.
Article
Pharmacology & Pharmacy
M. Morales-Florido, J. E. Miranda-Calderon, M. A. Gomez-Samano, J. J. Escobar-Chavez
Summary: This review highlights the promising approach of using microneedles as a painless and convenient method for transdermal drug delivery. It provides examples of materials and methods used for microneedle manufacture and presents an overview of the available clinical trials in Cochrane to demonstrate the growing popularity of this strategy.
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
J. R. Martinez-Rosas, R. Diaz-Torres, P. Ramirez-Noguera, L. D. Lopez-Barrera, J. J. Escobar-Chavez, E. R. Angeles
Article
Pharmacology & Pharmacy
Ericka Anguiano Almazan, Pablo Serrano Castaneda, Roberto Diaz Torres, Jose Juan Escobar-Chaveza
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2020)
