Article
Chemistry, Inorganic & Nuclear
Sebastian Reese, Peter Kaden, Corey J. Taylor, Roger Kloditz, Moritz Schmidt
Summary: The complexation of small organic ligands with metal ions under different pH conditions results in varied structures and stability. Cm3+ and Eu3+ form 1:1 complexes with glucuronic acid, while Y3+ prefers a different coordination geometry with the same ligand. The differences in stability among the metal ions are related to the ring strain induced by smaller cations, with stronger complexes detected at higher pH due to deprotonation of a coordinating group.
INORGANIC CHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Brandon S. McKeon, Xinyu Liu, Jacek K. Furdyna, David J. Smith
Summary: The structure of misfit dislocations (MDs) at heterovalent II-VI/III-V (001) compound semiconductor interfaces has been determined using aberration-corrected electron microscopy. The study revealed that MDs at interfaces with different lattice mismatches exhibit different dislocation structures and core compositions, as well as substantial interfacial intermixing.
ACS APPLIED ELECTRONIC MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Satendra Kumar, S. Maji, K. Sundararajan
Summary: This study investigated the complex formation between uranyl and carboxylate ligands and found stable and enhanced luminescent tris(carboxylato) uranyl(vi) complexes. Quantum chemical calculations verified the experimental results, and an energy transfer from uranyl to Eu(iii) was observed, enabling the detection of europium at trace levels.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Jiaxu Zhang, Jing Wang, Jie Li, Tushar Debnath, Rui Zhou, Zhiqiang Wang, Liuhong Xu, Xiang Wang, Chaochao Qin, Dingguo Xu, Sirui Yang, Ming-De Li, Dong-Sheng Li, Tao Wu
Summary: This study investigates the effects of the local manganese environment on the photophysical properties of II-VI quantum dots. Structurally well-defined metal chalcogenide supertetrahedral clusters are used as ideal models to explore the influence of external environments on photoluminescence and excited-state dynamics. The study provides insight into the precise nanochemistry of II-III-VI d-dots.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Inorganic & Nuclear
Nisha Kamboj, Ayan Dey, Prem Lama, Moumita Majumder, Srijan Sengupta, Ramesh K. Metre
Summary: Closed-shell phenalenyl (PLY) systems are increasingly attractive as building blocks for catalysts and electrode materials due to their ability to accept electrons and participate in redox reactions. In this study, a PLY-based dinuclear [FeIII2(hmbh-PLY)3] complex was synthesized and used as a cathode material in a H2O2 fuel cell, exhibiting exceptional power density compared to previously reported Fe-based complexes. DFT studies were performed to gain insights into the catalytic reduction of H2O2 by the Fe-center of the complex.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Yonghoon Kwon, Do-Hyeon Kim, Min Gyu Jeong, Minh-Triet Hong, Soyeon Park, Yeonho Chang, Kai Zhou, Seung-Yeol Park, Jin Zhang, Sung Ho Ryu
Summary: This study reveals the importance of dimerization of the β2-adrenergic receptor for generating inverse agonism and identifies cholesterol as a specific regulator in this process.
CELL CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Gennady M. Verkhivker, Steve Agajanian, Deniz Yasar Oztas, Grace Gupta
Summary: This study combines atomistic simulations with ensemble-based mutational profiling to identify dynamic and binding affinity fingerprints of SARS-CoV-2 complexes with a variety of nanobodies. The research characterizes the binding energy hotspots in the SARS-CoV-2 protein and complexes with nanobodies, showing how nanobody combinations and biparatopic nanobodies can potentially increase binding affinity and resilience to escaping mutants.
Article
Biochemistry & Molecular Biology
Jing Chen, Xin Cai, Maocai Yan, Zhengwen Wang, Zhitong Lv, Chunmei Wang
Summary: By combining experimental and calculation approaches, the study successfully identified and characterized the interfaces of GPCR receptor dimers, and constructed atomic resolution models.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ingrid Hartl, Veronika Brumovska, Yasmin Striedner, Atena Yasari, Gerhard J. Schuetz, Eva Sevcsik, Irene Tiemann-Boege
Summary: This study utilized micropatterning to enrich FGFR3 in specific areas of the cell membrane, and quantified receptor activation by observing the recruitment of downstream signaling molecule GRB2 to FGFR3 micropatterns. The results showed that mutations in FGFR3 altered receptor activity, with increased activity in G380R and K650Q mutants upon ligand addition, while decreased activity in K650E mutant. These findings provide further insight into the functional effects of mutations to FGFR3.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Anna-Roza Dimogkioka, Jamie Lees, Erik Lacko, Kostas Tokatlidis
Summary: Mitochondria play a central role in cellular metabolism, with 99% of their proteins encoded by nuclear genes and imported into the organelle through well-studied pathways. Proper folding of these proteins is ensured by a system of chaperones and co-chaperones, critical for maintaining cell homeostasis and response to stress. Understanding the targeting signals and folding mechanisms in mitochondria remains a key area of research.
Article
Pharmacology & Pharmacy
Camila Fabiani, Brunella Biscussi, Juan P. Munafo, Ana P. Murray, Jeremias Corradi, Silvia S. Antollini
Summary: This study synthesized caffeine derivatives that can inhibit acetylcholinesterase and activate both muscle and a7 nicotinic acetylcholine receptors (nAChRs) with higher potency than caffeine. These analogs can be divided into two groups: non-desensitizing and desensitizing nAChR groups. Among the non-desensitizing nAChR group, compound 11 is proposed as the most interesting analog for further studies as it inhibits acetylcholinesterase with the highest potency and activates nAChRs in the picomolar range without inducing receptor desensitization.
MOLECULAR PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Jadesola Temitope Olayinka, Akanksha Nagarkar, Diana Junyue Ma, Neil B. Wong, Andrew Romasco, Cesar Piedra-Mora, Linda Wrijil, Clement N. David, Heather L. Gardner, Nicholas A. Robinson, Kelly L. Hughes, Bruce Barton, Cheryl A. London, Ramon M. Almela, Jillian M. Richmond
Summary: This study compares canine epitheliotropic lymphoma (EL) with human cutaneous T-cell lymphoma (CTCL) through transcriptomics analysis, identifying similarities and potential biomarkers for distinguishing EL from other forms of interface dermatitis. The results have implications for the development of targeted therapies and drug repurposing in veterinary and human medicine.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Virology
Mette M. Rosenkilde, Naotaka Tsutsumi, Julius M. Knerr, Dagmar F. Kildedal, K. Christopher Garcia
Summary: Herpesviruses have evolved gene capture as a strategy to evade immune surveillance, enhance virus spreading, and manipulate host cells. This review focuses on the viral G protein-coupled receptors (vGPCRs) encoded by human beta- and gamma-herpesviruses. The study discusses the ligand binding, signaling, and structures of these vGPCRs, highlighting their differences from endogenous receptors. Additionally, potential therapeutic targeting of vGPCRs for the treatment of acute and chronic herpesvirus infections is briefly discussed.
ANNUAL REVIEW OF VIROLOGY
(2022)
Article
Allergy
Xiao Tang, Elin Ronnberg, Jesper Safholm, Madhuranayaki Thulasingam, Mette Trauelsen, Thue W. Schwartz, Craig E. Wheelock, Sven-Erik Dahlen, Gunnar Nilsson, Jesper Z. Haeggstrom
Summary: SUCNR1 amplifies IgE-receptor-induced mast cell activation and allergic bronchoconstriction, suggesting a role for this pathway in aggravation of allergic asthma. Pharmacologically targeting protein kinase C and extracellular signal-regulated kinase can modulate succinate-potentiated mast cell reactivity.
Article
Endocrinology & Metabolism
Vasiliki Vana, Michelle K. Laerke, Jens F. Rehfeld, Myrtha Arnold, Oksana Dmytriyeva, Wolfgang Langhans, Thue W. Schwartz, Harald S. Hansen
Summary: Research suggests that exogenous CCK interacts with endogenous GLP-1 to promote satiety, and activation of the FFA1 receptor can initiate this interaction by stimulating the release of CCK.
DIABETES OBESITY & METABOLISM
(2022)
Biographical-Item
Biochemistry & Molecular Biology
Jens F. Rehfeld, Jens Hannibal, Jens Juul Holst, Tomas Hokfelt, Ove B. Schaffalitzky de Muckadell, Thue W. Schwartz
Article
Endocrinology & Metabolism
Stephanie Holm, Anna S. Husted, Louise J. Skov, Thomas H. Morville, Christoffer A. Hagemann, Tina Jorsal, Morten Dall, Alexander Jakobsen, Anders B. Klein, Jonas T. Treebak, Filip K. Knop, Thue W. Schwartz, Christoffer Clemmensen, Birgitte Holst
Summary: This study found that LEAP2 is downregulated during states of energy deprivation in both humans and rodents. The recovery period after endurance exercise is associated with increased levels of BHB and decreased levels of LEAP2 in humans. In fasting and ketogenic diet conditions, Leap2 expression in the liver is decreased. Furthermore, oral administration of BHB and direct exposure to BHB in hepatocytes also decrease LEAP2 levels.
Editorial Material
Cell Biology
Jens Lund, Christoffer Clemmensen, Thue W. Schwartz
Summary: In this recent study, Li et al. propose that Lac-Phe, a metabolite derived from lactate released during high-intensity exercise, acts as an exercise hormone that suppresses appetite and obesity.
Article
Endocrinology & Metabolism
Abraham S. Meijnikman, Casper C. van Olden, Omrum Aydin, Hilde Herrema, Dorota Kaminska, Dimitra Lappa, Ville Mannisto, Valentina Tremaroli, Louise E. Olofsson, Maurits de Brauw, Arnold van de Laar, Joanne Verheij, Victor E. A. Gerdes, Thue W. Schwartz, Jens Nielsen, Fredrik Backhed, Paivi Pajukanta, Jussi Pihlajamaki, Tamar Tchkonia, James L. Kirkland, Folkert Kuipers, Max Nieuwdorp, Albert K. Groen
Summary: This article investigates the association between insulin levels and cellular senescence in the human liver and finds a significant correlation between high insulin levels and markers of cellular senescence. The results support the potential benefits of lowering insulin levels in obese individuals with insulin resistance.
Article
Multidisciplinary Sciences
Abraham S. Meijnikman, Dimitra Lappa, Hilde Herrema, Omrum Aydin, Kimberly A. Krautkramer, Valentina Tremaroli, Louise E. Olofsson, Annika Lundqvist, Sjoerd Bruin, Yair Acherman, Joanne Verheij, Siv Hjorth, Victor E. A. Gerdes, Thue W. Schwartz, Albert K. Groen, Fredrik Backhed, Jens Nielsen, Max Nieuwdorp
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with increased risk of mortality driven by extrahepatic cancers and liver and cardiovascular disease. Women with NAFLD have a higher risk of disease progression and worse outcome. Therefore, understanding the pathophysiology of NAFLD in women is critical. This study used a systems biology approach to analyze different organs and revealed differences in metabolites, gene expression, and gut microbial features between patients with and without NAFLD. These findings provide novel strategies for studying the pathophysiology of NAFLD in humans.
Article
Biochemistry & Molecular Biology
Abraham S. Meijnikman, Mark Davids, Hilde Herrema, Omrum Aydin, Valentina Tremaroli, Melany Rios-Morales, Han Levels, Sjoerd Bruin, Maurits de Brauw, Joanne Verheij, Marleen Kemper, Adriaan G. Holleboom, Maarten E. Tushuizen, Thue W. Schwartz, Jens Nielsen, Dees Brandjes, Eveline Dirinck, Jonas Weyler, An Verrijken, Christophe E. M. De Block, Luisa Vonghia, Sven Francque, Ulrich Beuers, Victor E. A. Gerdes, Fredrik Backhed, Albert K. Groen, Max Nieuwdorp
Summary: This study found that microbial ethanol might contribute to pathogenesis in some patients with nonalcoholic fatty liver disease. The research suggests that microbial ethanol could be considered in the pathogenesis of this highly prevalent liver disease.
Article
Endocrinology & Metabolism
Ahmed M. Abdelmoez, Oksana Dmytriyeva, Yasemin-Xiomara Zurke, Mette Trauelsen, Alesandra A. Marica, Mladen Savikj, Jonathon A. B. Smith, Claudia Monaco, Thue W. Schwartz, Anna Krook, Nicolas J. Pillon
Summary: Succinate released by skeletal muscle activates SUCNR1/GPR91, but it is unclear which cell types respond to succinate and the directionality of communication. This study found that SUCNR1 is expressed in macrophages but not in muscle cells, suggesting that the adaptive response of skeletal muscle to exercise is mediated via paracrine mechanisms involving macrophages.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Maria J. Forteza, Martin Berg, Andreas Edsfeldt, Jangming Sun, Roland Baumgartner, Ilona Kareinen, Felipe Beccaria Casagrande, Ulf Hedin, Song Zhang, Ivan Vuckovic, Petras P. Dzeja, Konstantinos A. Polyzos, Anton Gistera, Mette Trauelsen, Thue W. Schwartz, Lea Dib, Joerg Herrmann, Claudia Monaco, Ljubica Matic, Isabel Goncalves, Daniel F. J. Ketelhuth
Summary: Recent studies have shown a link between cellular metabolism and the chronic inflammatory process of atherosclerosis. The PDK/PDH axis has been identified as a major metabolic pathway regulating vascular inflammation and atherogenesis, and targeting it with DCA could be a promising treatment for atherosclerosis.
CARDIOVASCULAR RESEARCH
(2023)
Letter
Endocrinology & Metabolism
Stephanie Kjaerulff Holm, Esben Thyssen Vestergaard, Natasa Brkovic Zubanovic, Sarah Byberg, Christoffer Clemmensen, Birgitte Holst, Henrik Holm Thomsen
DIABETES OBESITY & METABOLISM
(2023)
Article
Gastroenterology & Hepatology
Iain R. Tough, Mari L. Lund, Bhavik A. Patel, Thue W. Schwartz, Helen M. Cox
Summary: This study investigates the efficacy of 5-HT signaling and its interaction with incretin hormones in different regions of the mouse intestine. The results show that 5-HT has the highest levels in the ascending colon mucosa and acts through both 5-HT3 and 5-HT4 receptors. Additionally, GLP-1 and GIP have interactions with 5-HT and affect the colonic mucosa.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Multidisciplinary Sciences
Dimitra M. Lappa, Abraham S. Meijnikman, Kimberly A. Krautkramer, Lisa M. Olsson, Omrum Aydin, Anne-Sophie Van Rijswijk, Yair I. Z. E. Acherman, Maurits De Brauw, Valentina A. Tremaroli, Louise E. Olofsson, Annika Lundqvist, Siv A. K. Hjorth, Boyang W. Ji, Victor E. A. Gerdes, Albert K. Groen, Thue W. Schwartz, Max Nieuwdorp, Fredrik Baeckhed, Jens Nielsen
Summary: Weight loss through bariatric surgery is effective in treating or preventing obesity related diseases, but the long-term weight loss response varies among patients. This study conducted multiple omics analyses on individuals undergoing bariatric surgery to identify metabolic differences and explore their relationship with weight loss response. Five distinct metabotypes were identified based on plasma metabolome analysis, showing differential enrichment in pathways related to immune functions, fatty acid metabolism, protein signaling, and obesity pathogenesis. The gut metagenome of the heavily medicated metabotypes was significantly enriched in Prevotella and Lactobacillus species. Each metabotype responded differently to bariatric surgery in terms of weight loss after 12 months. This study provides a path for patient stratification and improved clinical treatments.
Article
Endocrinology & Metabolism
Jacob Emil Petersen, Maria Hauge Pedersen, Oksana Dmytriyeva, Emilie Nellemose, Tulika Arora, Maja Storm Engelstoft, Wesley B. Asher, Jonathan A. Javitch, Thue W. Schwartz, Mette Trauelsen
Summary: The activation of FFAR1 can induce both IP3/Ca2+ signaling pathway and cAMP signaling pathway, and the co-activation of these two pathways is required for the highly efficient hormone secretion induced by second-generation FFAR1 agonists. Adcy2 gene is highly expressed in enteroendocrine cells of the intestine and may mediate Gq-driven cAMP signaling response.
MOLECULAR METABOLISM
(2023)
Article
Oncology
Kathrine Lundo, Oksana Dmytriyeva, Louise Spohr, Eliana Goncalves-Alves, Jiayi Yao, Laia P. Blasco, Mette Trauelsen, Muthulakshmi Ponniah, Marc Severin, Albin Sandelin, Marie Kveiborg, Thue W. Schwartz, Stine F. Pedersen
Summary: This study reveals the mechanism of lactate receptor GPR81 in breast cancer, which promotes tumor invasiveness by downregulating the Notch pathway ligand DLL4. This finding is of great significance for the treatment of breast cancer.