Article
Clinical Neurology
Arne Herring, Nirup K. Kurapati, Sofia Krebs, Nils Grammon, Luisa M. Scholz, Gerrit Voss, Muhammad R. Miah, Vanessa Budny, Fabian Mairinger, Katharina Haase, Sarah Teuber-Hanselmann, Celia Dobersalske, Sara Schramm, Karl-Heinz Joeckel, Yvonne Muenster, Kathy Keyvani
Summary: Genetic knockdown of Klk8 in transgenic mice showed significant reduction of Aβ and tau pathology, improvement of neuroplasticity, enhanced Aβ phagocytosis and resistance, as well as improved memory performance. These findings suggest KLK8 as a potential therapeutic target in Alzheimer's disease.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Neurosciences
Ashutosh Tripathi, Henry A. Nasrallah, Anilkumar Pillai
Summary: The study suggests that the therapeutic effectiveness of Pimavanserin in Parkinson's Disease psychosis may be related to its ability to increase mature BDNF levels.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Qinxi Li, Bangcheng Zhao, Wanxin Li, Yao He, Xun Tang, Ting Zhang, Zhihui Zhong, Qiangwen Pan, Yingqian Zhang
Summary: Mental disorders have a high incidence and recurrence rate, and some patients do not respond to drug medication. The study found that different methods of drug administration have varying effects on behaviors and drug efficacy. Gastric administration induces CUMS-like behaviors that negatively affect drug efficacy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Giovanni Polverino, Upama Aich, Jack A. Brand, Michael G. Bertram, Jake M. Martin, Hung Tan, Vrishin R. Soman, Rachel T. Mason, Bob B. M. Wong
Summary: The pharmaceutical contaminant fluoxetine, commonly known as Prozac, is found in freshwater systems globally. It has been found to have different effects on the behavioral variability of male and female guppies. This research highlights the potential impact of psychoactive pollutants on wildlife and the importance of considering sex-specific effects.
BEHAVIORAL ECOLOGY
(2023)
Article
Multidisciplinary Sciences
Maarouf Baghdadi, Andrea Mesaros, Martin Purrio, Linda Partridge
Summary: The Cre-loxP system is widely used to generate specific mutations in mice, allowing researchers to study the biological mechanisms of disease. This study characterized the behavioral, morphological, and metabolic phenotypes of Syn1Cre mice and found that they exhibit specific traits. Moreover, over-expression of Syn1Cre results in reduced body weight and femur length in males.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Seona D. Patel, Lindsay P. Cameron, David E. Olson
Summary: The study highlights the importance of social housing conditions in evaluating stress-induced behavioral phenotypes. Mixed cages of GH and CORT animals yield the greatest difference between treatment groups, suggesting implications for identifying therapeutics capable of rescuing stress-induced behavioral deficits in the FST.
Article
Clinical Neurology
Iris Dalhuisen, Eveline Ackermans, Lieke Martens, Peter Mulders, Joey Bartholomeus, Alex de Bruijn, Jan Spijker, Philip van Eijndhoven, Indira Tendolkar
Summary: This study investigated the longitudinal effects of rTMS on the volumes of the hippocampus and amygdala as well as cortical thickness in patients with chronic treatment-resistant depression. The results suggest that rTMS can induce neuroplastic changes, especially in cortical thickness, independent of treatment response. Additionally, longitudinal changes in amygdala volume were observed in males.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Neurosciences
Felipe A. Olave, Felipe Aguayo, Luciano P. Roman-Albasini, Wladimir A. Corrales, Juan P. Silva, Pablo Gonzalez, Sara Lagos, Maria A. Garcia, Matias Alarcon-Mardones, Paulina S. Rojas, Xiaojiang Xu, John A. Cidlowski, Esteban Aliaga, Jenny Fiedler
Summary: Stress-related disorders display differences between males and females. This study found that chronic restraint stress produces different somatic responses in adult male and female rats. The molecular responses in the hippocampus also showed sex-specific differences, with the signaling pathways mainly influenced by sex rather than stress. The study suggests that female rats are resilient and males are susceptible to stress exposure, while the activity of canonical signaling pathways is primarily determined by sex in the hippocampus.
NEUROBIOLOGY OF STRESS
(2022)
Article
Anesthesiology
Magali Millecamps, Susana G. Sotocinal, Jean-Sebastien Austin, Laura S. Stone, Jeffrey S. Mogil
Summary: Human epidemiological studies indicate that chronic pain may increase the risk of mortality. This study on mice reveals sex-specific patterns in pain behavior and suggests that the biology of chronic pain in humans is not adequately represented in current preclinical pain research.
Article
Biochemistry & Molecular Biology
Paulina Misztak, Magdalena Sowa-Kucma, Patrycja Panczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowak
Summary: Chronic stress is a key factor in the development of depressive symptoms. The combination of fluoxetine and zinc induces a more pronounced antidepressant effect in the chronic restraint stress model. Zinc supplementation enhances the effectiveness of fluoxetine and plays a role in epigenetic regulation.
Article
Biochemistry & Molecular Biology
Mauritz Frederick Herselman, Liying Lin, Shayan Luo, Akihiro Yamanaka, Xin-Fu Zhou, Larisa Bobrovskaya
Summary: Anxiety and depressive disorders are closely linked, but their pathophysiology is poorly understood. This study explored the mechanisms involved in anxiety and depression by subjecting mice to chronic stress. The results showed that female mice exhibited more anxiety-like behavior and had reduced synaptic proteins in the hippocampus, while all female mice showed increased synaptic proteins in the prefrontal cortex. These findings highlight the importance of considering sex differences in future studies on chronic stress and depression mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Si-Long Deng, Zhuang-Li Hu, Li Mao, Bo Gao, Qiong Yang, Fang Wang, Jian-Guo Chen
Summary: This study identified that Kctd12 in the DG plays a critical role in regulating stress responses, making it a promising therapeutic target for stress-related psychiatric disorders, including depression.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Min-Kyung Joo, Dong-Hyun Kim
Summary: This study investigated the effects of fluoxetine on anxiety and depression-like behaviors in mice with restraint stress or antibiotics-induced anxiety and depression. The results showed that fluoxetine alleviated these behaviors, but celiac vagotomy attenuated its anti-depressive effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sandrine Bergeron, Romain Barus, Clemence Leboullenger, Florent Auger, Antonino Bongiovanni, Meryem Tardivel, Aurelie Jonneaux, Charlotte Laloux, Camille Potey, Regis Bordet, Yaohua Chen, Sophie Gautier
Summary: Atorvastatin modulates sex-specific cognitive impairment induced by cerebral microhaemorrhages, with beneficial effects on males by improving visuospatial memory and increasing expression of certain factors, while mainly affecting neural development factor and astrocytes in females.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Physiology
Oliver H. Wearing, Graham R. Scott
Summary: This study used physiological telemetry to investigate the effects of chronic exposure to moderate hypoxia on cardiovascular physiology and the differences between sexes. The results showed that chronic hypoxia had sex-specific effects on heart rate, body temperature, and activity in mice during the daytime, but had no effect during the nighttime. Furthermore, chronic hypoxia enhanced the hypoxic ventilatory response in females but not in males.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Editorial Material
Immunology
Georgia E. Hodes
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Meeting Abstract
Neurosciences
Caroline Menard, Madeline Pfau, Georgia Hodes, Veronika Kana, Victoria Wang, Sylvain Bouchard, Aki Takahashi, Meghan Flanigan, Hossein Aleyasin, Katherine LeClair, William Janssen, Benoit Labonte, Eric Parise, Zachary Lorsch, Sam Golden, Mitra Heshmati, Carol Tamminga, Gustavo Turecki, Matthew Campbell, Zahi Fayad, Cheuk Ying Tang, Miriam Merad, Scott Russo
BIOLOGICAL PSYCHIATRY
(2019)
Meeting Abstract
Neurosciences
Jennifer Rainville, Flurin Cathomas, Scott Russo, Georgia Hodes
BIOLOGICAL PSYCHIATRY
(2019)
Article
Neurosciences
Alyssa Johnson, Jennifer R. Rainville, G. Nicole Rivero-Ballon, Katerina Dhimitri, Georgia E. Hodes
Summary: Behavioral sex differences were detected in response to variable stress, with females being more susceptible to 6 days of stress and both sexes susceptible to 28 days of stress. Performance on behavioral tests varied between individuals and sexes, and not all stressed animals showed susceptibility to all behaviors tested.
Article
Neurosciences
Mohit Kumar, Jennifer R. Rainville, Kori Williams, Joshua A. Lile, Georgia E. Hodes, Fair M. Vassoler, Jill R. Turner
Summary: Opioid use disorder is a leading cause of morbidity and mortality in the United States. Research shows that oxycodone exposure and withdrawal have an impact on sex- and region-specific neuroimmune response, leading to elevated levels of pro-inflammatory cytokines.
Review
Neurosciences
Jennifer R. Rainville, Timothy Lipuma, Georgia E. Hodes
Summary: Research over the past decade has shown the existence of sex differences in transcriptional profiles related to stress and mood disorders in the brain. A more systemic and less reductionist approach is needed to explore the purpose of these sex differences. Understanding the relationships between transcriptional changes across different brain regions and the body is crucial for developing personalized medicine in the future.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Aki Takahashi, Hossein Aleyasin, Mihaela A. Stavarache, Long Li, Flurin Cathomas, Lyonna F. Parise, Hsiao-Yun Lin, C. Joseph Burnett, Antonio Aubry, Meghan E. Flanigan, Anna Brancato, Caroline Menard, Madeline L. Pfau, Veronika Kana, Jun Wang, Georgia E. Hodes, Tetsuya Sasaki, Michael G. Kaplitt, Sonoko Ogawa, Bruce S. McEwen, Scott J. Russo
Summary: The study demonstrated the significant role of IL-1 beta in regulating aggression, showing that non-aggressive mice had higher levels of IL-1 beta in the DRN compared to aggressive mice, and pharmacological antagonism or gene knockdown of IL-1 receptors in the DRN increased aggressive behavior. This suggests that modulation of 5-HT neuronal activity by IL-1 beta signaling in the DRN controls the expression of aggressive behavior.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
M. E. Glover, J. L. Cohen, J. R. Singer, M. N. Sabbagh, J. R. Rainville, M. T. Hyland, C. D. Morrow, C. T. Weaver, G. E. Hodes, Ilan A. Kerman, S. M. Clinton
Summary: This study examined the relationships between microbiota, immune markers, and behavior in rats bred for different emotional behavior phenotypes. The findings suggest that antibiotic treatment disrupts the microbiome in rats and affects their behavior.
Article
Neurosciences
Dawson R. Kropp, Georgia E. Hodes
Summary: Depression is a heterogenous disorder with different symptoms across individuals. In some cases, alterations of the immune system are associated with depression onset and symptoms. Women have a higher likelihood of developing depression and a more sensitive immune system compared to men. Sex differences in pattern recognition receptors, release of damage-associated molecular patterns, cell populations, and circulating cytokines contribute to inflammation onset. These immune response differences may explain the higher rate of depression in women.
BRAIN RESEARCH BULLETIN
(2023)
Meeting Abstract
Neurosciences
Georgia Hodes, Margaux Kenwood, Andre Der-Avakian, Eric Nestler, William Carlezon, James Jentsch, Mar Sanchez, Zoe Donaldson, Edythe London, Jill Turner
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Psychiatry
Alisa Huskey, Georgia Hodes, Bruce Friedman
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Neurosciences
Jennifer Rainville, Sadie Riskus, Xianging Xue, Alisa Huskey, James Murrough, Marianne Seney, Georgia Hodes
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
Benedetta Bigio, Danielle Zelli, Paolo de Angelis, Caroline Menard, Georgia Hodes, Catherine Pena, Aleksander Mathe, Michael J. Meaney, Eric Nestler, Scott Russo, Carla Nasca
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
Georgia Hodes
NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Neurosciences
Mariya Tsyglakova, Jennifer Rainville, Georgia Hodes
BIOLOGICAL PSYCHIATRY
(2020)