Article
Behavioral Sciences
Yingchun Xiang, Yumiao Niu, Yacong Xie, Shishuo Chen, Feng Zhu, Weida Shen, Ling-Hui Zeng
Summary: The study investigated the phosphorylation levels of the RhoA/Rho kinase pathway in response to KA treatment, and found that KA induces activation of the pathway leading to inhibition of neurite outgrowth. Pretreatment with fasudil reversed this effect, suggesting that inhibiting the RhoA/Rho kinase pathway may be a potential treatment for seizure-induced neurite injury.
BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Mengwei Li, Limei Zhang, Xinyan Liu, Guoqiang Wang, Jian Lu, Jifeng Guo, Hongjie Wang, Jinpeng Xu, Yi Zhang, Na Li, You Zhou
Summary: This study found that low-intensity exercise training can improve the heart function and structure of spontaneously hypertensive rats by inhibiting the RhoA/ROCK signaling pathway, providing further evidence for this protective effect.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yongtao Yang, Lianyong Li, Huan He, Mengyang Shi, Lanying He, Shuwen Liang, Jun Qi, Weiqing Chen
Summary: Numb regulates cell proliferation, differentiation, migration, and apoptosis through the RhoA/ROCK signaling pathway in colorectal cancer. Its expression is correlated with prognosis and provides a new theoretical molecular basis for understanding the pathogenesis of colorectal cancer.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Behavioral Sciences
RuoLan Cai, YangYang Wang, ZhenTing Huang, Qian Zou, YinShuang Pu, Changyin Yu, Zhiyou Cai
Summary: ROCK activation can promote the occurrence of Alzheimer's disease and may involve a positive feedback loop between Aβ and ROCK. Additionally, ROCK can also promote the formation of neurofibrillary tangles and exacerbate neuroinflammatory responses.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Medicine, Research & Experimental
Liyan Bai, Hae Jin Kee, Sin Young Choi, Young Mi Seok, Gwi Ran Kim, Seung-Jung Kee, Hyun Kook, Myung Ho Jeong
Summary: The genetic deletion of HDAC5 and treatment with class IIa HDAC inhibitors can prevent increases in blood pressure and arterial wall thickness induced by Ang II. HDAC5 plays a role in vascular contraction and hypertrophy, and its inhibition may be a potential target for hypertension treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Chensheng Le, Xin Hu, Lusha Tong, Xianghua Ye, Junyi Zhang, Jun Yan, Prativa Sherchan, John H. Zhang, Feng Gao, Jiping Tang
Summary: This study investigated the role of LAR in neuroinflammation after intracerebral hemorrhage (ICH) using a mouse model. The results showed that LAR contributed to neuroinflammation after ICH via the RhoA/IRS-1 pathway, and the inhibitor ELP may be a potential therapeutic strategy to attenuate LAR-mediated neuroinflammation after ICH.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
Qian Liu, Qu-Dong Lu, Bi-Shao Sun, Jiang Zhao, Fan He, Jing-Zhen Zhu
Summary: The activation of U-II/UT signaling promotes the development of cystitis-associated bladder hyperactivity by targeting the RhoA/Rho-kinase pathway, indicating that U-II/UT signaling could serve as a novel target for the treatment of interstitial cystitis/bladder pain syndrome.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Genetics & Heredity
Guangzhao Guan, Richard D. D. Cannon, Dawn E. E. Coates, Li Mei
Summary: The mechanical properties of cells play an important role in tissue homeostasis and various cellular processes. These properties are determined by the cytoskeleton, which is a complex and dynamic network of microfilaments, intermediate filaments, and microtubules. The Rho-kinase/ROCK signaling pathway regulates the architecture of this cytoskeletal network, influencing cell behavior.
Review
Cell Biology
Sissel Ida Schmidt, Morten Blaabjerg, Kristine Freude, Morten Meyer
Summary: RhoA, a small GTPase involved in multiple signal transduction pathways, plays a crucial role in neurodegenerative diseases. Understanding the regulation of RhoA and its downstream cellular functions is important for elucidating the mechanisms of neurodegenerative diseases and exploring potential therapeutic interventions.
Article
Biochemistry & Molecular Biology
Hiroshi Senoo, Daisuke Murata, May Wai, Kenta Arai, Wakiko Iwata, Hiromi Sesaki, Miho Iijima
Summary: AKT, a serine/threonine kinase, plays a crucial role in metabolism, cell growth, and cytoskeletal dynamics, and is activated by PDK1 and mTORC2. Research has uncovered that insulin activates mTORC2 towards AKT by forming a supercomplex KARATE with KRAS4B and RHOA GTPases, revealing a fundamental mechanism in insulin-regulated glucose homeostasis.
Article
Chemistry, Medicinal
Olmo Martin-Camara, Angel Cores, Pilar Lopez-Alvarado, J. Carlos Menendez
Summary: The morphology of synaptic spines is controlled by Rac1, Cdc42, and RhoA, with RhoA/ROCK playing a crucial role in stabilizing actin formation and preventing the generation of new protrusions. The RhoA/ROCK pathway influences plasticity processes and is implicated in various brain-related pathologies, highlighting its importance in drug discovery for neurodegenerative diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Toshio Kaneda, Farida Ifadotunnikmah, Alfarius Eko Nugroho, Sae Koshikawa, Sasaki Tadahiro, Yusuke Hirasawa, Hiroshi Morita
Summary: This study demonstrated that CA-A induces vasorelaxation through an indirectly activated PKA-MYPT1 pathway caused by inhibition of PI3K activity.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Pharmacology & Pharmacy
Robert Eckenstaler, Michael Hauke, Ralf A. Benndorf
Summary: RhoA, RhoB, and RhoC are key regulators of signal transduction in cell biology and have significant roles in tumor biology and vascular biology, regulating various cellular processes and disease pathogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Lianxin Li, Jinge Xin, Hesong Wang, Yadong Wang, Weiqi Peng, Ning Sun, Haonan Huang, Yanxi Zhou, Xingmei Liu, Yu Lin, Jing Fang, Bo Jing, Kangcheng Pan, Yan Zeng, Dong Zeng, Xiang Qin, Yang Bai, Xueqin Ni
Summary: Fluoride is a common contaminant that poses challenges to animal and human health. This study investigates the role of the cytoskeleton in fluoride-induced barrier dysfunction and provides potential therapeutic targets for fluoride-induced intestinal injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Cheng Ju, Yue Wang, Caixia Zang, Hui Liu, Fangyu Yuan, Jingwen Ning, Meiyu Shang, Jingwei Ma, Gen Li, Yang Yang, Xiuqi Bao, Dan Zhang
Summary: This study investigated the role of Dyrk1A in regulating neuroinflammation and found that inhibiting Dyrk1A can reduce neuroinflammation and the production of proinflammatory factors.
Article
Engineering, Environmental
Muhammad Qadir, Anwar Hussain, Mohib Shah, In Jung Lee, Amjad Iqbal, Muhammad Irshad, Ismail, Aqib Sayyed, Husna, Ayaz Ahmad, Muhammad Hamayun
Summary: The study demonstrated that Pantoea conspicua and Aspergillus niger can resist high concentrations of Cr+6 and transform it into non-toxic forms, helping sunflowers to recover growth. These microbes can also modulate plant hormone production and enhance the antioxidant system, improving plant tolerance to chromium.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Sajjad Asaf, Waqar Ahmad, Ahmed Al-Harrasi, Abdul Latif Khan
Summary: The study sequenced and analyzed the complete chloroplast genome of Ziziphus hajarensis, revealing its genetic features and providing insights into its evolution and phylogenetic position among Rhamnaceae species.
Article
Engineering, Environmental
Abdul Latif Khan, Muhammad Numan, Saqib Bilal, Sajjad Asaf, Kerri Crafword, Muhammad Imran, Ahmed Al-Harrasi, Jamal Nasser Al-Sabahi, Najeeb Ur Rehman, Ahmed A-Rawahi, In-Jung Lee
Summary: This study found that the association between mangrove seedlings and specific bacteria can reprogram the host's growth, physiology, and ability to degrade diesel. The presence of certain bacterial strains also led to higher soil-enzyme activities and essential metabolites in the rhizosphere.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Hussah Abdullah Alshwyeh, Sahar Khamees Aldosary, Muna Abdulsalam Ilowefah, Raheem Shahzad, Adeeb Shehzad, Saqib Bilal, In-Jung Lee, Jannah Ahmed Al Mater, Fatima Najf Al-Shakhoari, Waad Abdulrahman Alqahtani, Nurkhalida Kamal, Ahmed Mediani
Summary: Nigella species, particularly the roasted seeds, have been found to have various health benefits due to the presence of bioactive components. This study investigated the effect of roasting on the composition and biological activities of Nigella arvensis and Nigella sativa seed extracts. The results showed that roasted seeds exhibited strong antimicrobial activities and extracts significantly decreased cancer cell viability.
Article
Environmental Sciences
Ismail Ismail, Muhammad Hamayun, Anwar Hussain, Amjad Iqbal, Sumera Afzal Khan, Ayaz Ahmad, Sarah Gul, Ho-Youn Kim, In-Jung Lee
Summary: Endophytic fungi isolated from a wild plant species have been found to improve the physicochemical characteristics of sunflower and soybean exposed to high temperature stress, promoting chlorophyll contents, total biomass and plant height, inhibiting ROS production and lipid peroxidation, and increasing the levels of antioxidants, sugars, proteins, lipids and phenolics.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2022)
Article
Environmental Sciences
Raid Ali, Humaira Gul, Muhammad Hamayun, Mamoona Rauf, Amjad Iqbal, Anwar Hussain, In-Jung Lee
Summary: This study analyzed the physiological and biochemical parameters of maize plants exposed to salt stress with or without fungal association. The results showed that salinity had negative effects on maize growth and biochemical parameters, but fungal association improved growth parameters and reduced lipid-peroxidation under salt stress.
POLISH JOURNAL OF ENVIRONMENTAL STUDIES
(2022)
Article
Plant Sciences
Muhammad Junaid Yousaf, Anwar Hussain, Muhammad Hamayun, Amjad Iqbal, In-Jung Lee
Summary: Gibberellins, particularly GA4, play a significant role in the plant-pathogen interactions between Triticum aestivum and Bipolaris sorokiniana. The elevated GA4 level triggers a hypersensitive response in T. aestivum seedlings, leading to an increase in HR-inducing signaling compounds. This response also decreases the levels of IAA and TZn in the seedlings. However, the application of uniconazole inhibits GA4 biosynthesis and promotes the colonization of BIPOL in the roots of T. aestivum seedlings, resulting in enhanced seedling growth.
JOURNAL OF PLANT INTERACTIONS
(2022)
Article
Plant Sciences
Arjun Adhikari, Muhammad Aaqil Khan, Muhammad Imran, Ko-Eun Lee, Sang-Mo Kang, Jin Y. Shin, Gil-Jae Joo, Murtaza Khan, Byung-Wook Yun, In-Jung Lee
Summary: The co-application of biochar, chemical fertilizers, and the strain AR11 effectively improved the growth of rice under salt and drought stresses. It also reduced the content of abscisic acid, increased the levels of silicon, phosphorus, and potassium, and decreased the concentration of sodium ions.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rahmatullah Jan, Muhammad-Aaqil Khan, Sajjad Asaf, Lubna, Muhammad Waqas, Jae-Ryoung Park, Saleem Asif, Nan Kim, In-Jung Lee, Kyung-Min Kim
Summary: Drought and UV radiation are environmental factors that negatively affect plant growth. In this study, kaempferol and quercetin were found to enhance tolerance to these stresses in rice plants.
Review
Plant Sciences
Shifa Shaffique, Muhamad Aaqil Khan, Muhamad Imran, Sang-Mo Kang, Yong-Sung Park, Shabir Hussain Wani, In-Jung Lee
Summary: Plants defend themselves against ecological stresses including drought, and microbial associations play a potential role in mediating plant protection responses to drought.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Microbiology
Husna, Anwar Hussain, Mohib Shah, Muhammad Hamayun, Amjad Iqbal, Muhammad Qadir, Abed Alataway, Ahmed Z. Dewidar, Hosam O. Elansary, In -Jung Lee
Summary: The aim of this research was to utilize plant growth promoting rhizobacteria for the sequestration and biotransformation of toxic forms of chromium and arsenic into non-toxic forms. The study found that the isolated rhizobacteria strains were able to tolerate high levels of chromate and arsenate, and convert them into least toxic forms. Additionally, they released stress-related metabolites and plant hormones, benefiting the soybean seedlings.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Microbiology
Sang-Mo Kang, Arjun Adhikari, Yu-Na Kim, In-Jung Lee
Summary: This study investigated the effects of Paclobutrazol (PBZ) and Variovorax sp. YNA59 on Chinese cabbage. The results showed that both YNA59 and PBZ treatments significantly increased plant biomass under drought conditions. YNA59 had a more pronounced effect on the physiological attributes of the plants, especially under drought stress.
MICROBIOLOGY RESEARCH
(2023)
Article
Horticulture
Muhammad Aaqil Khan, Kalsoom, Muhammad Imran, Lubna, Shifa Shaffique, Eun-Hae Kwon, Sang-Mo Kang, Seong-Heon Kim, Muhammad Hamayun, In-Jung Lee
Summary: In this study, halotolerant rhizobacteria isolated from Pohang beach were able to neutralize the negative impact of food waste-related salt stress on plant growth, significantly enhancing Chinese cabbage plant growth parameters and reducing abscisic acid content.
Article
Green & Sustainable Science & Technology
Sang-Mo Kang, Arjun Adhikari, Dibya Bhatta, Ho-Jun Gam, Min-Ji Gim, Joon-Ik Son, Jin Y. Shin, In-Jung Lee
Summary: The high rate of food waste production has negative effects on the environment and socio-economic conditions. However, it can be used as an efficient and safe source of fertilizer in agriculture practice, potentially replacing chemical fertilizers and improving plant growth and yield.
Article
Environmental Sciences
Laila Aziz, Muhammad Hamayun, Mamoona Rauf, Humaira Gul, Muhammad Arif, Amjad Iqbal, Sarah Gul, Hamida Bibi, Khushnood Ur Rehman, In-Jung Lee
Summary: Continued industrialization poses a major threat to agricultural soil, particularly due to contamination by heavy metals, which adversely impact crop production. This study explores the potential use of plant growth-promoting microbes as a bioremediation tool for combating heavy metal pollution. The results demonstrate that certain endophytic fungi exhibit both resistance to heavy metals and the ability to promote plant growth, making them valuable candidates for improving crop growth in Cd and Cr polluted soils.
FRESENIUS ENVIRONMENTAL BULLETIN
(2022)