Article
Chemistry, Medicinal
Qi Wang, Fuqiang Wang, Xiangze Li, Zhi Ma, Dapeng Jiang
Summary: This study investigated the effect of quercetin treatment on renal fibrosis and its mechanism. The results showed that quercetin can alleviate fibrosis, inflammation, oxidative stress, and cell apoptosis. Quercetin alleviates fibrosis by inhibiting the activation of AREG/EGFR signaling.
PHYTOTHERAPY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kunihiro Nakai, Minato Umehara, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Tomohiro Nakata, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Tomoharu Ida, Noriyuki Yamashita, Michitsugu Kamezaki, Yuhei Kirita, Eiichi Konishi, Hiroaki Yasuda, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Summary: Streptozotocin (STZ) is an anti-cancer drug used to treat neuroendocrine tumors (NETs). It enters pancreatic beta-cells or proximal tubular epithelial cells through GLUT2. This study demonstrated the cytotoxic effects of STZ on kidney cells and identified DNA damage and p53 signaling as underlying mechanisms. Inhibition of p53 and SGLT2 mitigated kidney injury caused by STZ, but the cytotoxic effects on pancreatic beta-cells were not affected. These findings suggest the potential use of SGLT2 inhibitors as preventive treatments for kidney injury in NET patients treated with STZ.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Glory Ranches, Maximilian Zeidler, Roman Kessler, Martina Hoelzl, Michael W. Hess, Jonathan Vosper, Paul Perco, Herbert Schramek, Kai K. Kummer, Michaela Kress, Anne Krogsdam, Michael Rudnicki, Gert Mayer, Alexander Huettenhofer
Summary: Exosomes are valuable biomarkers for studying chronic kidney disease (CKD). Urinary exosomes and exosomes derived from renal proximal tubular epithelial cells (RPTECs) were analyzed for microRNA (miRNA) profiles. Dysregulated exosomal miRNAs associated with pro-inflammatory and pro-fibrotic pathways were identified in RPTECs, suggesting their potential use in predicting CKD pathogenesis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Cell Biology
Ting Xie, Zunen Xia, Wei Wang, Xiangjun Zhou, Changgeng Xu
Summary: BMPER inhibits tubular dedifferentiation and fibroblast activation induced by TGF-beta 1, showing therapeutic potential for tubulointerstitial fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Min Chen, Xiangchen Gu
Summary: Endocytosis plays a crucial role in kidney diseases, particularly in renal fibrosis, and is affected by other diseases and factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alia M. Zeid, Joseph O. Lamontagne, Hui Zhang, Alexander G. Marneros
Summary: Deficiency of EGF can lead to severe renal diseases, including glomerular abnormalities, tubular degeneration, and kidney fibrosis. These pathological abnormalities are only observed in a subset of EGF-deficient mice, suggesting the involvement of strain-specific modifier alleles.
Article
Cell Biology
Bohao Liu, Tianshi Sun, Huiling Li, Shuangfa Qiu, Yijian Li, Dongshan Zhang
Summary: This study reveals that RAGE plays a crucial role in renal fibrosis by promoting autophagy through the upregulation of the Stat3/Atg7 axis. The expression of RAGE is increased in proximal tubular cells upon TGF-beta 1 treatment and unilateral ureteral obstruction (UUO), leading to enhanced renal fibrosis. The findings were confirmed in kidney samples from patients with obstructive nephropathy.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Elena Daveri, Ana M. Adamo, Eugenia Alfine, Wei Zhu, Patricia Oteiza
Summary: The study found that hexameric PAC can inhibit proliferation and promote apoptosis of colorectal cancer cells by reducing the activity of the EGFR signaling pathway. It affects EGFR localization, promotes EGFR internalization, and synergizes with EGFR-targeted drugs, demonstrating anti-CRC effects.
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shayan Poursharif, Shereen Hamza, Branko Braam
Summary: This review paper discusses the renal protective effects of SGLT2 inhibitors in diabetic nephropathy and their mechanisms. The authors point out that the activation of tubuloglomerular feedback mechanism can only partially explain the renoprotective effects of SGLT2 inhibitors, and there are other factors affecting proximal tubular reabsorption and TGF response. The review also considers the physiological basis of SGLT2 inhibitors in early and advanced diabetic nephropathy, as well as the effects of their combination use with other drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Samuel Shin, Eugenia Awuah Boadi, Saloni Shah, Madison Ezell, Peijun Li, Bidhan C. Bandyopadhyay
Summary: Renal tubular epithelial cells can synthesize interleukins in response to inflammation, and elevated levels of interleukins have been found in patients with nephritic diseases. This study shows that L-arginine plays an immunological signaling role in renal tubular epithelial cells through the activation of CaSR and TRPC channel. This signaling pathway has a potential protective effect on the kidneys.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ziyan Lin, Ai Chen, Hongwang Cui, Ruihua Shang, Tian Su, Xiaoyan Li, Kekun Wang, Jing Yang, Keli Gao, Jie Lv, Jie Shen, Shanzhi Wang, Yonghui Qi, Minghao Guo, Yongjun Zhu
Summary: This study identified the occurrence of renal tubular epithelial cell necroptosis in CKD patients, especially in stages 2 and 3a CKD. Renal tubular epithelial cell necroptosis mediates renal tubulointerstitial fibrosis in patients with chronic kidney disease, which is related to the TGF-beta 1/Smad3 signaling pathway.