Article
Chemistry, Medicinal
Rayanne Poletti Guimaraes, Danilo Leandro Ribeiro, Keila Bariotto Dos Santos, Carlos Henrique Zanello Talarico, Livea Dornela Godoy, Fernando E. Padovan-Neto
Summary: The inhibition of striatal phosphodiesterase 10A (PDE10A) can modulate L-DOPA-induced dyskinesia (LID) by regulating corticostriatal activity. The facilitation of corticostriatal transmission likely contributes to the expression of abnormal involuntary movements (AIMs). Manipulation of cyclic nucleotides is an essential target for controlling LID.
Review
Neurosciences
Lisa Z. Fang, Meaghan C. Creed
Summary: This article provides an overview of the neurochemical and molecular diversity of striatal and pallidal neurons, as well as recent studies on circuit connectivity in rodents. The authors highlight the anatomical organizational principles of the dorsal and ventral basal ganglia pathways. Future research integrating the molecular and anatomical properties of specific subpopulations may help resolve controversies related to the function of basal ganglia networks.
NATURE NEUROSCIENCE
(2023)
Article
Cell Biology
Violeta G. Lopez-Huerta, Jai A. Denton, Yoko Nakano, Omar Jaidar, Marianela Garcia-Munoz, Gordon W. Arbuthnott
Summary: The research shows that D1 and D2 neurons have different roles in controlling motor behavior, with D1 neurons having a greater impact on overall kinematics results and D2 neurons being more involved in controlling target accuracy. Practice of movements changes synaptic patterns between neurons.
Article
Biochemistry & Molecular Biology
Joshua R. Enck, Eric C. Olson
Summary: This study confirms that Cajal-Retzius neurons in the cortical marginal zone can influence the development of cortical projection neurons by releasing glutamate and glycine, providing insight into the observation that many autism-linked genes are expressed in the developing cortex before the appearance of synapses and functional circuits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Lucero Aceves-Serrano, Jason L. Neva, Jonathan Munro, Martin Parent, Lara A. Boyd, Doris J. Doudet
Summary: The long-term therapeutic effects of TBS may be facilitated through the modulation of neurotransmission systems beyond the dopamine system.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vahid Esmaeili, Anastasiia Oryshchuk, Reza Asri, Keita Tamura, Georgios Foustoukos, Yanqi Liu, Romain Guiet, Sylvain Crochet, Carl C. H. Petersen
Summary: This study explores the changes in the activity of excitatory and inhibitory neurons in the mouse sensorimotor cortex before and after learning a whisker detection task. The results indicate that the changes in whisker-evoked activity of these neurons differ in primary and secondary whisker motor cortices, but show similar patterns in primary and secondary orofacial motor cortices. These findings suggest that the balance of excitation and inhibition in local circuits, along with changes in long-range synaptic inputs, may contribute to the performance of delayed sensory-to-motor transformation.
Review
Cell Biology
Brik A. Kochoian, Cassandra Bure, Stella M. Papa
Summary: A lot of research has been focused on therapeutic strategies for controlling L-DOPA-induced dyskinesias (LIDs) in Parkinson's disease. The only FDA-approved treatment for LIDs is amantadine, but there is a need for novel therapies with improved pharmacological profiles.
Article
Multidisciplinary Sciences
Jaeeon Lee, Bernardo L. Sabatini
Summary: The study reveals that indirect striatal projection neurons in the basal ganglia contribute to action selection and exploration by modulating the superior colliculus, highlighting a competitive interaction between hemispheres of the superior colliculus in triggering motor actions.
Article
Neurosciences
Ted Maldonado, Trevor Bryan Jackson, Jessica A. Bernard
Summary: This study investigated the impact of transcranial direct current stimulation on cerebellar and cortical activation. The findings showed that anodal stimulation worsened task performance and increased cortical activation in parietal and frontal regions.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Abid Bhat, Vanessa Tan, Benjamin Heng, Sharron Chow, Salundi Basappa, Musthafa M. Essas, Saravana B. Chidambaram, Gilles J. Guillemin
Summary: Phosphodiesterase-10A (PDE10A) plays a critical role in the progression of neurodegenerative diseases, and this study investigated the neuroprotective effects of papaverine (PAP) against quinolinic acid (QUIN)-induced excitotoxicity. The results showed that pre-treatment with PAP reduced oxidative stress and protected synaptic proteins by up-regulating the cAMP signaling cascade in QUIN-exposed neurons, demonstrating neuroprotection.
NEUROTOXICITY RESEARCH
(2021)
Article
Cell Biology
Fran van Heusden, Anezka Macey-Dare, Jack Gordon, Rohan Krajeski, Andrew Sharott, Tommas Ellender
Summary: This study investigates how distinct embryonic neural progenitor pools contribute to neuronal diversity and synaptic circuit connectivity in the mouse striatum. The results show that embryonic progenitor origin plays a significant role in shaping the neuronal and circuit properties of the postnatal striatum, particularly in the strength of excitatory inputs from cortical areas.
Article
Cell Biology
M. Felicia Davatolhagh, Marc Fuccillo
Summary: In the striatal circuitry, dysregulation of Nrxn1α specifically affects synaptic strength onto the indirect pathway SPNs, while thalamic excitatory inputs to DMS exhibit relatively normal excitatory synaptic strength despite changes in synaptic NMDAR content. This suggests that Nrxn1α modulates striatal function in an input- and target-specific manner.
Article
Cell Biology
Heng Kang Yao, Alexandre Guet-McCreight, Frank Mazza, Homeira Moradi Chameh, Thomas D. Prevot, John D. Griffiths, Shreejoy J. Tripathy, Taufik A. Valiante, Etienne Sibille, Etay Hay
Summary: This study investigated the impact of reduced somatostatin interneuron-mediated inhibition on cortical processing in human neuronal microcircuits using a data-driven computational approach. The findings demonstrate a decreased signal-to-noise ratio and increased false detection of stimuli in depression due to higher baseline activity. Ultimately, this research provides mechanistic insights into how reduced inhibition impairs cortical processing in depression and its quantitative links to cognitive deficits.
Correction
Clinical Neurology
Shirin Z. Birjandi, Nora Abduljawad, Shyama Nair, Morteza Dehghani, Kazunori Suzuki, Haruhide Kimura, S. Thomas Carmichael
Summary: The original version of this article was revised due to retrospective Open Access.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Erica Butti, Stefano Cattaneo, Marco Bacigaluppi, Marco Cambiaghi, Giulia Maria Scotti, Elena Brambilla, Francesca Ruffini, Giacomo Sferruzza, Maddalena Ripamonti, Fabio Simeoni, Laura Cacciaguerra, Aurora Zanghi, Angelo Quattrini, Riccardo Fesce, Paola Panina-Bordignon, Francesca Giannese, Davide Cittaro, Tanja Kuhlmann, Patrizia D'Adamo, Maria Assunta Rocca, Stefano Taverna, Gianvito Martino
Summary: In this study, the researchers provide evidence that adult neural stem/precursor cells in the brain regulate striatal function and support cognitive functions through the secretion of IGFBPL1.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Kenneth A. Jones, Frank S. Menniti, Digavalli V. Sivarao
TRANSLATIONAL NEUROSCIENCE IN PSYCHIATRY
(2015)
Article
Neurosciences
David Nagy, Milan Stoiljkovic, Frank S. Menniti, Mihaly Hajos
NEUROPSYCHOPHARMACOLOGY
(2016)
Article
Neurosciences
Kristina E. Hogue, Shannon R. Blume, Stephen Sammut, Anthony R. West
Article
Multidisciplinary Sciences
Robert A. Volkmann, Christopher M. Fanger, David R. Anderson, Venkata Ramana Sirivolu, Kathy Paschetto, Earl Gordon, Caterina Virginio, Melanie Gleyzes, Bruno Buisson, Esther Steidl, Susanna B. Mierau, Michela Fagiolini, Frank S. Menniti
Article
Neurosciences
Christina Camilleri, Rebecca M. Beiter, Lisett Puentes, Paula Aracena-Sherck, Stephen Sammut
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Mark D. Condon, Nicola J. Platt, Yan-Feng Zhang, Bradley M. Roberts, Michael A. Clements, Stefania Vietti-Michelina, Min-Yee Tseu, Katherine R. Brimblecombe, Sarah Threlfell, Edward O. Mann, Stephanie J. Cragg
NATURE COMMUNICATIONS
(2019)
Article
Neurosciences
Feng Yi, Nirvan Rouzbeh, Kasper B. Hansen, Yuelian Xu, Christopher M. Fanger, Earl Gordon, Kathy Paschetto, Frank S. Menniti, Robert A. Volkmann
Article
Reproductive Biology
Christina Camilleri, Cara Buskmiller, Stephen Sammut
Summary: This study aimed to investigate the potential long-term changes in uterine vasculature and horn length in postpartum rats. Results showed significant differences between previously-pregnant and virgin rats at 3 weeks postpartum, but not at 8-9 and 13 weeks postpartum. Significant differences were observed in venous diameter and mesometrial segmental vessel length at all measured timepoints.
REPRODUCTIVE BIOLOGY
(2021)
Article
Psychiatry
Christina Camilleri, Cole S. Fogle, Kathryn G. O'Brien, Stephen Sammut
Summary: Mental health issues among university students have been on the rise globally, with the COVID-19 pandemic exacerbating this problem. Coping mechanisms have been found to mediate the relationship between stressors and mental health. However, our study suggests that positive coping strategies have a limited buffering influence on negative mental health outcomes during the COVID-19 pandemic, highlighting the need for further interventions to improve the mental well-being of university students.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Neurosciences
Jesse E. Hanson, Hongjie Yuan, Riley E. Perszyk, Tue G. Banke, Hao Xing, Ming-Chi Tsai, Frank S. Menniti, Stephen F. Traynelis
Summary: N-methyl-D-aspartate (NMDA) receptors play a role in excitatory synaptic transmission, are present throughout the central nervous system, and are involved in synaptic plasticity. NMDA receptor modulators have shown potential in treating psychiatric disorders, neurodevelopmental disorders, and neurodegenerative conditions. Recent research has discovered that certain NMDA receptor inhibitors can rapidly and significantly alleviate depression by inducing long-lasting changes in the brain. This has led to new studies exploring the therapeutic applications of NMDA receptor antagonists. Positive allosteric modulators of NMDA receptors are also being investigated for enhancing synaptic function in diseases with NMDA receptor dysfunction. However, the use of NMDA receptor modulators comes with potential risks. Therefore, further research is needed to fully understand and harness the therapeutic potential of targeting this important receptor class.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Christina Camilleri, Stephen Sammut
Summary: Globally, a significant number of pregnancies are terminated through induced abortion. However, there is also a percentage of women who seek assistance in reversing the medication-induced abortion. Our study explored the potential of using progesterone to reverse the medication-induced pregnancy termination in a rat model. The results showed that progesterone administration successfully reversed the process in 81% of rats, indicating the need for further investigation in the implications for humans.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Multidisciplinary
Christina Camilleri, Justin T. Perry, Stephen Sammut
Summary: The study found that over half of university students have used pornography, with a significantly higher proportion of males than females. Compulsive pornography use significantly affects mental health parameters such as depression, anxiety, and stress. Faith, morals, and personal motivation are reported as primary factors in reducing pornography use.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Paul D. Williams, William M. Hunter, Elizabeth Seyer, Stephen Sammut, Matthew M. Breuninger
MENTAL HEALTH RELIGION & CULTURE
(2019)
Article
Neurosciences
Katherine R. Brimblecombe, Sarah Threlfell, Daniel Dautan, Polina Kosillo, Juan Mena-Segovia, Stephanie J. Cragg
Article
Psychology, Clinical
Kelsey Porada, Stephen Sammut, Milo Milburn
JOURNAL OF RATIONAL-EMOTIVE AND COGNITIVE-BEHAVIOR THERAPY
(2018)