期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 118, 期 2, 页码 245-254出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.11123FP
关键词
chrysophanol-8-O-glucoside; anthraquinone derivative; antiplatelet; anticoagulant; rhubarb
资金
- Korea Food and Drug Administration
- Cooperative Research Program for Agriculture Science & Technology Development, Rural Development Administration, Republic of Korea [PJ006986]
- Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea [111093-03-1-SB010]
Rhubarb is a widely used traditional medicine and has been reported to elicit a number of biological effects including anti-inflammatory and antiplatelet effects. In the present study, we investigated the effects of anthraquinone derivatives isolated from rhubarb on platelet activity. Of four anthraquinone derivatives isolated from rhubarb examined, chrysophanol-8-O-glucoside (CP-8-O-glc) was found to have the most potent inhibitory effect on collagen- and thrombin-induced platelet aggregation. CP-8-O-glc treated mice showed significantly prolonged bleeding times. Furthermore, CP-8-O-glc was found to have a significant inhibitory effect on rat platelet aggregation ex vivo and on thromboxane A(2) formation in vitro. In coagulation tests, CP-8-O-glc did not alter prothrombin time, and it prolonged the activated partial thromboplastin time. However, CP-8-O-glc only inhibited platelet phosphatidylserine exposure, but not exert direct inhibition on intrinsic factors. This study demonstrates the antiplatelet and anticoagulant effects of CP-8-O-glc and suggests that this compound might be of therapeutic benefit for the prevention of platelet-related cardiovascular diseases.
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