Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

(2010) Jason S. Lee et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

The humanHIF(hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction

(2009) Tetsuhiro Tanaka et al.   BIOCHEMICAL JOURNAL

Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice

(2009) Takeshi Inagaki et al.   GENES TO CELLS

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

(2009) Keisuke Tateishi et al.   NATURE

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Hypoxia upregulates the histone demethylase JMJD1A via HIF-1

(2008) Sven Wellmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Mechanisms involved in the regulation of histone lysine demethylases

(2008) Fei Lan et al.   CURRENT OPINION IN CELL BIOLOGY

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease

(2008) P. A.C. Cloos et al.   GENES & DEVELOPMENT

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

(2008) Amber Buescher Johnson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS