Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Cell Biology
Yuanxi Yang, Xin Ran, Hefei Wang, Yingsheng Chen, Shuang Hou, Zhanqing Yang, Shoupeng Fu, Juxiong Liu, Guiqiu Hu, Wenjin Guo
Summary: Evodiamine was found to significantly alleviate pathological injury and pro-inflammatory cytokine production in breast tissue, as well as inhibit the activation of inflammation-related pathways.
Article
Biotechnology & Applied Microbiology
Jingya Yang, Jing Li, Lanzhu Yang, Ruohui Guo
Summary: This research found that Alkannin attenuated LPS-induced inflammation by inhibiting NF-kappa B and MAPK signaling. This finding may provide a new theoretical basis for exploring new strategies against rheumatoid arthritis.
Article
Immunology
Binjie Lu, Xiaolei Chen, Hua Chen, Qian Li, Hongwei Li, Yue Xu, Yuwei Li, Xiaofeng Shen, Rilei Jiang
Summary: Demethoxycurcumin (DMC) can reduce the production of inflammatory cytokines in nucleus pulposus (NP) cells induced by inflammatory radicular pain, and this effect is mediated by inhibiting the activation of MAPKs and NF-kappa B signaling pathway. Further experiments in LDH model rats confirmed the in vitro results. These studies expand our knowledge of the effect of DMC on LDH, suggesting that DMC may be a viable alternative for the treatment of LDH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Applied
Jinyang Cai, Xin Li, Xing Wang, Chengfei Jiang, Dan Shen, Xianwei Cui, Kaipeng Xie, Chenbo Ji, Yan Cao
Summary: In this study, a novel peptide named BCCY-1 corresponding to human beta-casein sequence was identified in human milk, showing immunomodulatory activity by enhancing monocyte migration. BCCY-1 exerts its effects by activating NF-κB and MAPK signaling pathways.
Article
Chemistry, Multidisciplinary
Qian Li, Yu-Heng Zhao, Cheng Xu, Ye-Lin Liang, Yin Zhao, Qing-Mei He, Jun-Yan Li, Kai-Lin Chen, Han Qiao, Na Liu, Jun Ma, Lei Chen, Ying-Qin Li
Summary: This study reveals that circWDR37 deficiency limits the proliferation, migration, and invasion of senescent NPC cells induced by cisplatin or gemcitabine. Mechanistically, circWDR37 binds and dimerizes PKR, leading to PKR autophosphorylation and activation. Activated PKR phosphorylates IKKβ, releasing RELA from IκBα and activating NF-κB, thus promoting the transcription of CCND1 and senescence-associated secretory phenotype component genes in a circWDR37-dependent manner. Low circWDR37 levels are associated with favorable survival and chemotherapy response in NPC patients treated with gemcitabine or cisplatin induction chemotherapy.
Review
Pharmacology & Pharmacy
Xin-Fang Leong, Ker Woon Choy, Aspalilah Alias
Summary: Atherosclerosis poses serious health problems and requires long-term medication for prevention. Thymoquinone, a bioactive compound from Nigella sativa L., shows potential anti-inflammatory effects in atherosclerosis, but further studies are needed to determine its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiyue Zhang, Li Du, Jinrong Zhang, Chunyan Li, Jie Zhang, Xuejiao Lv
Summary: The study found that hordenine (Hor) can inhibit lipopolysaccharide-induced acute lung injury (ALI) by alleviating the disease through anti-inflammatory mechanisms. Hor can suppress the increase in inflammatory cytokine levels and exert its effects by regulating multiple signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Min Gun Kim, Sojin Kim, Kyung-Hwan Boo, Jae-Hoon Kim, Chang Sook Kim
Summary: This study investigated the anti-inflammatory effects of immature Citrus unshiu fruit extract, finding that the ethyl acetate fraction showed the highest inhibition of NO production and pro-inflammatory cytokine production. Additionally, it inhibited the expression of inflammation-related proteins and the activity of NF-kappa B and MAPK signaling pathways. Furthermore, three major anti-inflammatory components, beta-sitosterol, campesterol, and isoferulic acid, were identified in the ethyl acetate fraction.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fengmao An, Xinran Xuan, Zheng Liu, Ming Bian, Qingkun Shen, Zheshan Quan, Guowei Zhang, Chengxi Wei
Summary: In this study, the potential of a compound called W112 for the treatment of Alzheimer's disease (AD) was investigated. The results showed that W112 has neuroprotective effects against AD-like pathology, improving learning and memory abilities in AD-induced rats and reversing tau hyperphosphorylation. It also reduced the production of proinflammatory cytokines in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Xiao-Yu Zhang, Zhuo-Chang Chen, Nan Li, Zhi-Hua Wang, Ya-Li Guo, Cui-Jie Tian, Dong-Jun Cheng, Xue-Yi Tang, Luo-Xian Zhang
Summary: Activated neutrophil-derived CRNDE is transferred to ASMCs through exosomes, activating the NF-kappa B pathway and promoting the proliferation and migration of ASMCs, which contributes to airway remodeling in asthma.
HUMAN MOLECULAR GENETICS
(2022)
Article
Veterinary Sciences
Jingjing Cao, Yanhui Ni, Huaxing Zhang, Xiaoran Ning, Xiaoyong Qi
Summary: RA is an autoimmune disease that can cause joint inflammation and destruction. KLF7 expression was found to be upregulated in synovial tissues of rats with arthritis, and its loss suppressed cell proliferation, pro-inflammatory factors, and MMP expression in FLSs through inhibition of NF-kappa B and JNK pathways. miR-9a-5p negatively regulated KLF7 expression, suggesting a potential role for KLF7 as a therapeutic target for RA.
EXPERIMENTAL ANIMALS
(2021)
Article
Biochemistry & Molecular Biology
Naomi C. Bosch, Lena-Marie Martin, Caroline J. Voskens, Carola Berking, Barbara Seliger, Gerold Schuler, Niels Schaft, Jan Doerrie
Summary: NK cells play a crucial role in tumor cell rejection, and activating NK cells along with other immune cells can lead to a more comprehensive cellular response. Dendritic cells are capable of enhancing immune responses by activating NK cells and producing IL-12, while IL-15 serves as an important NK cell activator as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Otorhinolaryngology
Si-Youn Song, Hyung Gyun Na, So Young Kwak, Yoon Seok Choi, Chang Hoon Bae, Yong-Dae Kim
Summary: The impact of e-cigarettes on human health remains controversial, with research showing that e-cigarette vapor can stimulate the expression of MUC5AC in respiratory epithelial cells, mediated through the activation of multiple signaling pathways.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2021)
Article
Chemistry, Medicinal
Do T M Dung, Nguyen V Huan, Do M Cam, Dao C Hieu, Pham-The Hai, Le-Thi-Thu Huong, Jisung Kim, Jeong E. Choi, Jong S. Kang, Sang-Bae Han, Nguyen-Hai Nam
MEDICINAL CHEMISTRY
(2018)
Article
Oncology
Duong T Anh, Nguyen T Thuan, Pham-The Hai, Le-Thi-Thu Huong, Nguyen T K Yen, Byung W Han, Eun J. Park, Yeo J. Choi, Jong S. Kang, Van T M Hue, Sang-Bae Han, Nguyen-Hai Nam
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2019)
Article
Biochemical Research Methods
Kyeong-Ryoon Lee, Song-Hee Chae, Min Ju Kim, Yoon-Jee Chae, Myung Yeol Lee, Chang Woo Lee, Jong Soon Kang, Won-Kee Yoon, Young-Suk Won, Kihoon Lee, Og-Sung Moon, Young-Kook Kim, Hyoung-Chin Kim
BIOMEDICAL CHROMATOGRAPHY
(2019)
Article
Biochemistry & Molecular Biology
Le Cong Huan, Cao Viet Phuong, Le Cong Truc, Vo Nguyen Thanh, Hai Pham-The, Le-Thi-Thu Huong, Nguyen Thi Thuan, Eun Jae Park, A. Young Ji, Jong Soon Kang, Sang-Bae Han, Phuong-Thao Tran, Nguyen-Hai Nam
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2019)
Article
Pharmacology & Pharmacy
Yae Jin Yoon, Young-Min Han, Jiyeon Choi, Yu-Jin Lee, Jieun Yun, Su-Kyung Lee, Chang Woo Lee, Jong Soon Kang, Seung-Wook Chi, Jeong Hee Moon, Sangku Lee, Dong Cho Han, Byoung-Mog Kwon
BIOCHEMICAL PHARMACOLOGY
(2019)
Article
Chemistry, Medicinal
Byeoung-Kyu Choi, Hwa-Sun Lee, Jong Soon Kang, Hee Jae Shin
Article
Chemistry, Medicinal
Byeoung-Kyu Choi, Phan Thi Hoai Trinh, Hwa-Sun Lee, Byeong-Woo Choi, Jong Soon Kang, Ngo Thi Duy Ngoc, Tran Thi Thanh Van, Hee Jae Shin
Article
Chemistry, Medicinal
Hwa-Sun Lee, Jong Soon Kang, Byeoung-Kyu Choi, Hyi-Seung Lee, Yeon-Ju Lee, Jihoon Lee, Hee Jae Shin
Article
Biochemistry & Molecular Biology
Le Cong Huan, Phuong-Thao Tran, Cao Viet Phuong, Phan Huy Duc, Duong Tien Anh, Pham The Hai, Le Thi Thu Huong, Nguyen Thi Thuan, Hye Jin Lee, Eun Jae Park, Jong Soon Kang, Nguyen Phuong Linh, Tran Trung Hieu, Dao Thi Kim Oanh, Sang-Bae Han, Nguyen-Hai Nam
BIOORGANIC CHEMISTRY
(2019)
Article
Plant Sciences
Jaeyoung Kwon, Hyaemin Lee, Seung Mok Ryu, Yeongseon Jang, Hak Cheol Kwon, Yuanqiang Guo, Jong Soon Kang, Jae-Jin Kim, Dongho Lee
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Plant Sciences
Byeoung-Kyu Choi, Thi Hoai Trinh Phan, Sunghoon Hwang, Dong-Chan Oh, Jong Soon Kang, Hwa-Sun Lee, Thi Duy Ngoc Ngo, Thi Thanh Van Tran, Hee Jae Shin
JOURNAL OF NATURAL PRODUCTS
(2019)
Article
Cell Biology
Hee Chan Yoo, Seung Joon Park, Miso Nam, Juwon Kang, Kibum Kim, Joo Hye Yeo, Joon-Ki Kim, Yunkyung Heo, Hee Seung Lee, Myeong Youl Lee, Chang Woo Lee, Jong Soon Kang, Yun-Hee Kim, Jinu Lee, Junjeong Choi, Geum-Sook Hwang, Seungmin Bang, Jung Min Han
Article
Biochemistry & Molecular Biology
Le Cong Huan, Duong Tien Anh, Bui Xuan Truong, Phan Huy Duc, Pham-The Hai, Lai Duc-Anh, Le-Thi-Thu Huong, Eun Jae Park, Hye Jin Lee, Jong Soon Kang, Phuong-Thao Tran, Dinh Thi Thanh Hai, Dao Thi Kim Oanh, Sang-Bae Han, Nguyen-Hai Nam
CHEMISTRY & BIODIVERSITY
(2020)
Article
Chemistry, Medicinal
Ta Thu Lan, Duong Tien Anh, Pham-The Hai, Do Thi Mai Dung, Le Thi Thu Huong, Eun Jae Park, Hye Won Jeon, Jong Soon Kang, Nguyen Thi Thuan, Sang-Bae Han, Nguyen-Hai Nam
MEDICINAL CHEMISTRY RESEARCH
(2020)
Article
Environmental Sciences
Ju-Won Jang, Jae-Wook Lee, Yeo Dae Yoon, Jong-Soon Kang, Eun-Yi Moon
ENVIRONMENTAL POLLUTION
(2020)