Article
Pediatrics
Kamil Javorka, Katarina Haskova, Barbora Czippelova, Mirko Zibolen, Michal Javorka
Summary: The study found that as premature babies mature, spontaneous short-term blood pressure variability decreases while baroreflex sensitivity significantly increases, with these effects being more attributable to gestational age than postnatal age. Mean blood pressure, diastolic blood pressure, and heart rate also showed increases during maturation, while respiratory rate decreased.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Neil J. McMillan, Rogerio N. Soares, Jennifer L. Harper, Brian Shariffi, Alfonso Moreno-Cabanas, Timothy B. Curry, Camila Manrique-Acevedo, Jaume Padilla, Jacqueline K. Limberg
Summary: This study examines whether peripheral vasodilation induced by insulin contributes to increased muscle sympathetic nerve activity (MSNA) via arterial baroreflex-mediated mechanisms. The results show that insulin-induced peripheral vasodilation plays a role in the increase of MSNA during hyperinsulinemia.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Review
Urology & Nephrology
Christian Ott, Roland E. Schmieder
Summary: In the past 4 years, guidelines for the management of arterial hypertension have been published with mostly concordant recommendations but some discordant opinions. Accurate blood pressure measurement is crucial for diagnosis, and out-of-office measurements are also important. Simplified antihypertensive drug treatment and personalized goals are emphasized. Renal denervation is supported for uncontrolled and treatment-resistant hypertension.
KIDNEY INTERNATIONAL
(2022)
Review
Physiology
Bojana Savic, David Murphy, Nina Japundzic-Zigon
Summary: The paraventricular nucleus (PVN) is a crucial structure in the hypothalamus that plays a key role in regulating cardiovascular and osmotic balance. It is divided into neuroendocrine and autonomic compartments, both equally important for hormone production and autonomous regulation. Additionally, the PVN interacts with other regions to modulate blood pressure and its variability.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Andy Schumann, Christian Gaser, Rassoul Sabeghi, P. Christian Schulze, Sven Festag, Cord Spreckelsen, Karl-Juergen Baer
Summary: This study used machine learning to estimate participants' age based on autonomic cardiovascular indices. The Gaussian process regression model was found to be the most suitable, with a correlation of r=0.81 and a mean absolute error of MAE=5.6 years. The estimated age for obese participants was significantly higher compared to normal-weight controls, indicating advanced cardiovascular aging by 5.7 years.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Liwei Shen, Xiaoli Yang, Wenmei Lu, Weijie Chen, Xiaofei Ye, Danhong Wu
Summary: Abnormal blood pressure regulation is a common feature of autonomic dysfunction in Parkinson's disease patients. This study found significant differences in circadian blood pressure rhythm between different disease stages and subtypes of PD patients, with reverse dipping being more common in advanced PD patients. 24-hour ambulatory blood pressure monitoring is crucial for evaluating blood pressure alterations in PD patients and clinicians should be vigilant about reverse dipping to prevent serious clinical events.
BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Yia-Ping Liu, Chen-Cheng Lin, Yu-Chieh Lin, Shih-Hung Tsai, Che-Se Tung
Summary: This study investigates the role of autonomic baroreflex in modulating the hemodynamic perturbations evoked by paradoxical sleep deprivation (PSD) and aversive cold stress (CS). The results suggest that the baroreflex, combined with other reflex pathways, plays an important role in regulating the vascular and cardiorespiratory responses to PSD and subsequent CS.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Monika Zawadka-Kunikowska, Lukasz Rzepinski, Malgorzata Tafil-Klawe, Jacek J. Klawe, Pawel Zalewski, Joanna Slomko
Summary: This study aimed to evaluate the cardiac and autonomic function in patients with myasthenia gravis (MG) and investigate its relationship with disease outcomes. The results showed that MG patients exhibited altered systolic blood pressure variability, reduced heart rate response to deep breathing test, increased sympathovagal balance after tilt, lower baroreflex sensitivity, and decreased hemodynamic parameters compared to controls. Disease severity was found to be associated with diminished vagal tone and increased sympathetic response. Age and sex were the main predictors of hemodynamic parameters. These findings highlight the importance of evaluating autonomic balance in MG patients, especially those at risk for cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Tan Lai Zhou, Jos P. H. Reulen, Hilde Van der Staaij, Coen D. A. Stehouwer, Marleen Van Greevenbroek, Ronald M. A. Henry, Abraham A. Kroon
Summary: This study found that lower cardiovagal baroreflex sensitivity is associated with higher mean blood pressure in the short- to mid-term range, but not consistently with blood pressure variability. These associations may differ according to sex and (pre)diabetes.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Philippe Gosse, Antoine Cremer, Ajay J. Kirtane, Melvin D. Lobo, Manish Saxena, Joost Daemen, Yale Wang, Johannes Stegbauer, Michael A. Weber, Josephine Abraham, Kazuomi Kario, Sripal Bangalore, Lisa Claude, Yuyin Liu, Michel Azizi
Summary: The study found that baseline nighttime systolic blood pressure and its variability can predict the blood pressure response to renal denervation in patients with hypertension, which is helpful in identifying potential responders.
Article
Computer Science, Interdisciplinary Applications
A. Chao-Ecija, M. S. Dawid-Milner
Summary: This study proposes a new tool called BaroWavelet for evaluating baroreflex sensitivity using wavelet analysis methods. The effectiveness of the tool was validated through analysis of simulated data and recordings from actual patients. Results demonstrated that BaroWavelet accurately detected changes in baroreflex sensitivity and provided additional information about baroreflex dynamics.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Physiology
Rabie Fadil, Asenath X. A. Huether, Ajay K. Verma, Robert Brunnemer, Andrew P. Blaber, Jau-Shin Lou, Kouhyar Tavakolian
Summary: This study investigated the involvement of cardiac baroreflex and muscle-pump function in maintaining blood pressure in Parkinson's patients during an orthostatic challenge. The findings showed impaired cardiac baroreflex and mechanical heart effect on blood pressure in Parkinson's patients, as well as muscle-pump dysfunction.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Shoou-Jeng Yeh, Chi-Wen Lung, Yih-Kuen Jan, Ben-Yi Liau
Summary: Diabetes is a chronic disease that causes damage to various organs in the body. This study proposes a new method to detect autonomic neuropathy in diabetes patients by analyzing the changes in blood pressure and heart rate. The results show that this method can differentiate between different types of diabetes and uncover hidden changes in blood pressure control.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Yun-Kai Lee, Sara Mazzucco, Peter M. Rothwell, Stephen J. Payne, Alastair J. S. Webb
Summary: The reduction of blood pressure complexity can distinguish beat-to-beat blood pressure variability caused by pathological failure of compensatory mechanisms, potentially serving as a less confounded and modifiable risk factor for stroke.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Medicine, General & Internal
Sofie Brouwers, Isabella Sudano, Yoshihiro Kokubo, Elisabeth M. Sulaica
Summary: Arterial hypertension is a major contributor to the global burden of disease, but disease control remains poor. Diagnosis and treatment of hypertension should be based on a combination of various guidelines, with equal emphasis on pharmacological treatment and lifestyle adjustments. Device-based therapies such as renal denervation are rapidly evolving to expand therapeutic options.
Article
Chemistry, Multidisciplinary
Yang Sun, Zhen Qin, Qi Li, Jing-jing Wan, Ming-he Cheng, Peng-yuan Wang, Ding-feng Su, Jian-guang Yu, Xia Liu
ACTA PHARMACOLOGICA SINICA
(2016)
Article
Neurosciences
Bo-Shi Fan, En-Hui Zhang, Ming-He Cheng, Zhao-Tang Wu, Bing Han, Jian-Guang Yu
CNS NEUROSCIENCE & THERAPEUTICS
(2016)
Article
Neurosciences
Hao-Qiang Shi, Ying Zhang, Ming-He Cheng, Bo-Shi Fan, Jia-Sheng Tian, Jian-Guang Yu, Bing Chen
CNS NEUROSCIENCE & THERAPEUTICS
(2016)
Article
Pharmacology & Pharmacy
Bo-Shi Fan, En-Hui Zhang, Miao Wu, Jin-Min Guo, Ding-Feng Su, Xia Liu, Jian-Guang Yu
FRONTIERS IN PHARMACOLOGY
(2016)
Article
Pharmacology & Pharmacy
Yang Sun, Dong-Ping Xu, Zhen Qin, Peng-Yuan Wang, Bo-Han Hu, Jian-Guang Yu, Yong Zhao, Ben Cai, Yong-Ling Chen, Min Lu, Jian-Guo Liu, Xia Liu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Letter
Neurosciences
Bo-Shi Fan, Yang Sun, Xia Liu, Jian-Guang Yu
CNS NEUROSCIENCE & THERAPEUTICS
(2013)
Article
Cardiac & Cardiovascular Systems
Jian-Guang Yu, Shu-Wei Song, He Shu, Sai-Jun Fan, Ai-Jun Liu, Chong Liu, Wei Guo, Jin-Min Guo, Chao-Yu Miao, Ding-Feng Su
EUROPEAN HEART JOURNAL
(2013)
Article
Pharmacology & Pharmacy
Jian-Guang Yu, Bo-Shi Fan, Jin-Min Guo, Yun-Jie Shen, Ye-Yan Hu, Xia Liu
FRONTIERS IN PHARMACOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
Meng-Wan Zhang, Yun-Jie Shen, Jing Shi, Jian-Guang Yu
Summary: MiR-223-3p plays a crucial role in cardiovascular diseases by modulating various signaling pathways affecting cellular functions, and may serve as a therapeutic target and biomarker for these diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Meng-Wan Zhang, Xiao-Hui Wang, Jing Shi, Jian-Guang Yu
Summary: Cardio-cerebrovascular diseases are a major global health issue, and traditional Chinese medicine, specifically sinomenine, has shown promising pharmacological effects in treating these diseases, including attenuating atherosclerosis, suppressing inflammation, and preventing ischemia-reperfusion injury. Sinomenine has the potential to be a valuable drug for the treatment of hypertension and arrhythmia due to its regulatory effects on vasodilation and electrophysiology.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Meng-Wan Zhang, Bo-Shi Fan, Jian-Guang Yu
Summary: Hypertension is closely related to gastrointestinal function, and gut intervention may play a significant role in regulating blood pressure. After Miles surgery for rectal carcinoma, a patient with long-term hypertension saw a return to normal blood pressure levels, possibly due to modulation of sympathetic tone and the gut microbiota-brain axis. This report provides evidence of the relevance between hypertension and gut intervention, particularly in the colorectal sites, offering insights for investigating the possible mechanisms of hypertension and novel strategies for blood pressure control.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Hematology
Hai-Ni Wen, Qing-Feng He, Xiao-Qiang Xiang, Zheng Jiao, Jian-Guang Yu
Summary: This study investigated the impact of co-administration of dronedarone and apixaban or rivaroxaban on exposure and bleeding risk. The results showed that co-administration of dronedarone increased the exposure of apixaban and rivaroxaban, and might potentiate the risk of major bleeding. Reduced dosing regimens of apixaban and rivaroxaban are recommended when co-administered with dronedarone in patients with atrial fibrillation.
THROMBOSIS RESEARCH
(2022)
Article
Infectious Diseases
Yuejia Cheng, Yong Chen, Xumin Hou, Jianguang Yu, Haini Wen, Jinjie Dai, Yue Zheng
Summary: A nomogram predictive model was successfully established for predicting surgical site infections (SSI) in patients with lung neoplasm who undergo minimally invasive surgeries (MIS).
SURGICAL INFECTIONS
(2022)
Article
Pharmacology & Pharmacy
Wen-Jing Huang, Meng-Wan Zhang, Bei-Yi Li, Xiao-Hui Wang, Chu-Han Zhang, Jian-Guang Yu
Summary: This study conducted a 5S management project in the outpatient-emergency pharmacy to improve pharmaceutical service quality and staff capacity. The project resulted in increased accuracy and efficiency in drug dispensing, as well as higher satisfaction rates among patients and pharmacists. The positive effects of the 5S management method support its potential for use in healthcare system management.
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Article
Biochemistry & Molecular Biology
Yang Sun, Zhen Qin, Jing-Jing Wan, Peng-Yuan Wang, Yi-Li Yang, Jian-Guang Yu, Bo-Han Hu, Ding-Feng Su, Zhu-Min Luo, Xia Liu
EXPERIMENTAL AND MOLECULAR MEDICINE
(2018)