Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Immunology
Hao Wang, Zengxin Jiang, Zhiying Pang, Guobin Qi, Bingxuan Hua, Zuoqin Yan, Hengfeng Yuan
Summary: Engeletin protects and improves chondrocytes through various mechanisms, alleviating symptoms of osteoarthritis. Both in vitro and in vivo studies have demonstrated its therapeutic efficacy for osteoarthritis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Yi-Ching Lin, Yi-Giien Tsai, Yu-Chih Lin, Chia-Hong Kuo, Mei-Lan Tsai, Chao-Hung Kuo, Wei-Ting Liao
Summary: Acrylamide promoted mitochondria-specific ROS generation, increased gene expression of mitochondrial respiratory chain complex II SDHA, induced histone modifications and upregulated PINK1 expression, leading to a macrophage M2 polarization shift in THP-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wei Guo, Yadi Xing, Xiumei Luo, Fuguang Li, Maozhi Ren, Yiming Liang
Summary: Reactive oxygen species (ROS) are crucial regulators in both plant and human cells, serving as messengers in multiple pathways. While they play a beneficial role in growth and development, excessive ROS can cause oxidative stress and damage cellular functions. This review highlights the current research and mechanisms of ROS in both kingdoms, emphasizing their interactions with other substances and proposing potential opportunities for novel therapeutic strategies and agricultural advancements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Marc Herb, Alexander Gluschko, Michael Schramm
Summary: Reactive oxygen species (ROS) play important roles in cellular processes but can also lead to diseases, their effects depending on cell type and ROS production conditions. Cellular redox balance, like cell pH and calcium levels, is tightly controlled, with evidence showing that cells regulate ROS production by controlling activation and localization factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hee Jin Jung, Dong Chan Choi, Sang Gyun Noh, Heejeong Choi, Inkyu Choi, Il Young Ryu, Hae Young Chung, Hyung Ryong Moon
Summary: Thirteen (Z)-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among these compounds, compounds 1-3 displayed stronger tyrosinase inhibitory activity and could inhibit melanin production through different pathways.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Christina M. Wolff, Juergen F. Kolb, Sander Bekeschus
Summary: In modern oncology, combining different therapies to enhance treatment efficacy is a common approach. The combination of microsecond-pulsed electric fields and cold physical plasma treatment has shown synergistic effects, increasing the accumulation of reactive oxygen species (ROS), enhancing cytotoxicity against cancer cells, and promoting immune responses.
Article
Food Science & Technology
Juanjuan Wei, Yurong Li, Zimao Ye, Yi Li, Zhiqin Zhou
Summary: Citrus carotenoids have antioxidant and anticancer properties, making them potentially effective in the prevention and treatment of breast cancer. Different citrus species contain abundant carotenoids, which exhibit good antioxidant and anticancer activities. Citrus carotenoids can induce cell oxidative stress and regulate cell apoptosis, showing potential for the development of anti-breast cancer products.
Article
Cell Biology
Qian Xu, Xiaoling Liu, Weiwei Liu, Toshihiko Hayashi, Masayuki Yamato, Hitomi Fujisaki, Shunji Hattori, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Xiaoling Liu, Qian Xu, Xinyu Long, Weiwei Liu, Yeli Zhao, Toshihiko Hayashi, Shunji Hattori, Hitomi Fujisaki, Takaaki Ogura, Shin-ichi Tashiro, Satoshi Onodera, Masayuki Yamato, Takashi Ikejima
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Jing Yang, Yue Sun, Fanxing Xu, Weiwei Liu, Yingsi Mai, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Shin-ichi Tashiro, Takashi Ikejima
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Ye-Li Zhao, Xuan Zhang, Wei-Wei Liu, Yu-Ting Yang, Zhuo-Kun Gao, Xiao-Ling Liu, Wei Liu, Toshihiko Hayashi, Masayuki Yamato, Hitomi Fujisaki, Shunji Hattori, Kazunori Mizuno, Yuji Atsuzawa, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima
CONNECTIVE TISSUE RESEARCH
(2019)
Article
Cell Biology
Jing Yang, Yue Sun, Xiaoling Liu, Fanxing Xu, Weiwei Liu, Toshihiko Hayashi, Yasutada Imamura, Kazunori Mizuno, Shunji Hattori, Keisuke Tanaka, Hitomi Fujisaki, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima
CONNECTIVE TISSUE RESEARCH
(2019)
Article
Chemistry, Medicinal
Jing Yang, Yue Sun, Fanxing Xu, Weiwei Liu, Toshihiko Hayashi, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Shin-ichi Tashiro, Takashi Ikejima
PHYTOTHERAPY RESEARCH
(2019)
Article
Cell Biology
Xiaoling Liu, Xinyu Long, Yanfang Gao, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takayuki Ogura, Satoshi Onodera, Dan Ohtan Wang, Takashi Ikejima
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Lingling Si, Jianing Fu, Weiwei Liu, Toshihiko Hayashi, Yuheng Nie, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Satoshi Onodera, Takashi Ikejima
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Lingling Si, Jianing Fu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Satoshi Onodera, Takashi Ikejima
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Jian Li, Jiaojiao Wang, Weiwei Liu, Toshihiko Hayashi, Kikuji Itoh, Satoshi Onodera, Takashi Ikejima
FREE RADICAL RESEARCH
(2020)
Article
Psychology, Biological
Panwen Liu, Lingyu Cui, Bo Liu, Weiwei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Yuko Ushiki-Kaku, Satoshi Onodera, Takashi Ikejima
PHYSIOLOGY & BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Weiwei Liu, Yachao Ji, Yu Sun, Lingling Si, Jianing Fu, Toshihiko Hayashi, Satoshi Onodera, Takashi Ikejima
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Cell Biology
Xinyu Long, Yanfang Gao, Weiwei Liu, Xiaoling Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Takashi Ikejima
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Toxicology
Xiao-Yu Song, Rong-Hua Li, Wei-Wei Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima
Summary: Silibinin does not protect hepatocytes from ethanol-induced injury, but significantly reduces acetaldehyde-induced hepatocyte injury by down-regulating apoptosis and up-regulating autophagy, as demonstrated by cell viability assays and enzyme leakage tests. The study also shows that acetaldehyde induces autophagy in hepatocytes, with autophagy playing a protective role against apoptosis in this context. Silibinin further enhances this protective effect by modulating the levels of caspase-3 and LC3, suggesting a potential therapeutic mechanism for silibinin in preventing acetaldehyde-related liver damage.
TOXICOLOGY IN VITRO
(2021)
Article
Biochemistry & Molecular Biology
Xiaoling Liu, Yanfang Gao, Xinyu Long, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takayuki Ogura, Dan Ohtan Wang, Takashi Ikejima