Article
Biochemistry & Molecular Biology
Senty Vun-Sang, Kenneth Francis Rodrigues, Urban J. A. Dsouza, Mohammad Iqbal
Summary: The study found that the leaf extract of Ficus lepicarpa B. has antioxidant, anti-inflammatory, and free-radical scavenging activities, which can protect the liver from carbon tetrachloride-induced damage.
Article
Medicine, Research & Experimental
Neelum Iqbal, Hafiz Muhammad Zubair, Mikhlid H. Almutairi, Muhammad Abbas, Muhammad Furqan Akhtar, Lotfi Aleya, Mohamed Kamel, Ammara Saleem, Qaiser Jabeen, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Mohamed M. Abdel-Daim
Summary: Cordia rothii Roem. & Schult. possesses strong antioxidant and hepatoprotective activities, which may involve the Nrf2-NF kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Ting Chen, Zhigang Huang, Wei Chen, Ru Ding, Na Li, Haiming Cui, Feng Wu, Chun Liang, Xiaoliang Cong
Summary: This study investigated the effect of bupropion on cirrhotic cardiomyopathy induced by carbon tetrachloride. The results showed that bupropion attenuated the inflammatory and oxidative condition, improved liver damage, and enhanced cardiac contractility.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Libor Vitek
Summary: The liver has evolved defense systems to protect against harmful stimuli, including antioxidant substances and enzymes, anti-inflammatory tools, enzymatic biotransformation systems, and metabolic pathways. Recent research indicates the significant role of the heme catabolic pathway in regulating the pathogenesis of liver and other diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Valeria Sorrenti, Agata Grazia D'Amico, Ignazio Barbagallo, Valeria Consoli, Salvo Grosso, Luca Vanella
Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.
Article
Plant Sciences
Olajumoke Olufunlayo Nwaechefu, Tomilola Debby Olaolu, Ifeoluwa Racheal Akinwunmi, Omotunde Oluwaseyi Ojezele, Olufunso Olabode Olorunsogo
Summary: The leaf extract of Cajanus cajan has a protective effect on CCl4-induced liver injury by inhibiting the opening of mitochondrial permeability transition pore, preventing intracellular oxidative stress, and suppressing inflammatory response, indicating its potential value in chemoprevention of liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hossam Ebaid, Jameel Al-Tamimi, Mohamed Habila, Iftekhar Hassan, Ahmed Rady, Ibrahim M. Alhazza
Summary: This study assessed the protective effects of silver nanoparticles with curcumin against CCl4-induced kidney injury in mice. The results showed significant restoration of oxidative balance and kidney structure and function by AgNP-curcumin, with a decrease in DNA damage.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Article
Multidisciplinary Sciences
David Nemecek, Eva Chmelikova, Jaroslav Petr, Tomas Kott, Marketa Sedmikova
Summary: The gasotransmitter carbon monoxide (CO) has antioxidant properties in porcine oocytes and may be involved in the regulation of meiotic maturation, but exogenously delivered CO at higher concentrations may inhibit meiotic maturation.
Review
Biochemistry & Molecular Biology
Jose Angel Alonso-Pineiro, Almudena Gonzalez-Rovira, Ismael Sanchez-Gomar, Juan Antonio Moreno, Ma Carmen Duran-Ruiz
Summary: Atherosclerosis, the underlying cause of cardiovascular diseases and high mortality rates, progresses with the formation of atherosclerotic plaques due to oxidative stress. Strategies aimed at reducing oxidative damage, including the use of antioxidant molecules such as Nrf2 and HO-1, have been studied to inhibit the progression of atherosclerosis.
Article
Psychiatry
Thomas Bertrand, Ayda Tavitian, Julia M. Galindez, Vimal Kothari, Shrisha Mohit, Carmela Galindez, Adrienne Liberman, Judy Glass, Ana M. Velly, Mervyn Gornitsky, Karl Looper, Soham Rej, Hyman M. Schipper
Summary: This study found that higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode compared to control participants, and this overexpression was positively associated with psychiatric symptom severity and disability. The results suggest that overexpression of HO-1 in saliva may serve as a potential biomarker for psychosis and should be explored further in larger clinical trials.
PSYCHIATRY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Anne Grunenwald, Lubka T. Roumenina, Marie Frimat
Summary: The incidence of kidney disease is increasing, posing a significant burden on healthcare systems and underscoring the need for new therapeutic targets. The HO system, specifically HO-1, has shown promise in protecting against various kidney injuries, but despite preclinical data, clinical translation has not yet been achieved. Future research may focus on identifying potential therapeutic interventions targeting HO-1 in kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hamid Reza Ghasemi Basir, Ashkan Karbasi, Alireza Pouyandeh Ravan, Roghayeh Abbasalipourkabir, Mahdi Bahmani
Summary: This study evaluated the therapeutic effects of human umbilical cord MSC-derived conditioned medium (hMSC-CM) on CCl4-induced acute liver injury (ALI). The results suggest that hMSC-CM may improve CCl4-induced ALI through its antioxidant and anti-inflammatory effects.
Article
Multidisciplinary Sciences
Alyaa Farid, Valina Michael, Gehan Safwat
Summary: This study aimed to create Melatonin-loaded nanoparticles to alleviate liver damage caused by a chemical substance, CCL4. The nanoparticles exhibited good antioxidant, anti-inflammatory, and anticoagulant effects in vitro. Treatment with the nanoparticles improved histopathological changes in liver tissues, restored the levels of liver function enzymes, inflammatory cytokines, and matrix metalloproteinases to normal levels. These nanoparticles significantly protected the liver from the toxicity of CCL4.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Jia-Jing Lu, Ayitila Abudukeyoumu, Xing Zhang, Li-Bing Liu, Ming-Qing Li, Feng Xie
Summary: This review summarizes the different effects of HO-1 under normal and diseased conditions, with implications on the diagnosis and treatment of gynecological cancers, suggesting its potential role in cell proliferation, metastasis, immune regulation, and angiogenesis as an oncogene.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Liping Zou, Guiping Cheng, Chengcheng Xu, Heyu Liu, Yingying Wang, Nianyu Li, Xiaorong Fan, Changhong Zhu, Wei Xia
Summary: CuNPs induce oxidative stress in human ovarian granulosa cells, possibly through the MAPK14-Nrf2 signaling pathway to induce HO-1 expression, but HO-1 can protect cells from oxidative stress induced by CuNPs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)