期刊
JOURNAL OF PHARMACOLOGICAL SCIENCES
卷 107, 期 2, 页码 159-166出版社
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.08028FP
关键词
Lac-B; histamine signaling; histamine H-1 receptor; histidine decarboxylase; probiotics
It has been shown that probiotic bacteria are effective for the treatment of allergic diseases. As histamine plays a central role in allergic diseases, it is possible that probiotic bacteria affect the allergy-related histamine signaling. Here, we investigated the effect of Lac-B, a mixture of freeze-dried Bifidobacterium infantis and Bifidobacterium longum, on the allergy-related histamine signaling. In the nasal allergy model rats made by sensitization and provocation with toluene 2,4-diisocyanate (TDI) for 3 weeks, TDI provocation caused acute allergy-like behaviors along with significant up-regulation of histamine H-1 receptor (HIR) and histidine decarboxylase (HDC) mRNA expression, increased HDC activity, histamine content, and [H-3]mepyramine binding activity in nasal mucosa. Prolonged treatment with Lac-B (40 mg/rat, p.o.) significantly suppressed both the allergy-like behaviors and all of the above mentioned factors involved in histamine signaling. Our findings indicate that oral administration of Lac-B showed significant anti-allergic effect through suppression of both HIR and HDC gene expression followed by decrease in HIR, HDC protein level, and histamine content. Suppression of histamine signaling may be a novel target of probiotics in preventing allergic diseases.
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