Article
Pharmacology & Pharmacy
Ting Liu, Liying Hong, Yuan Yang, Xiandong Qiao, Wenyao Cai, Ming Zhong, Menghong Wang, Zeqi Zheng, Yongnan Fu
Summary: Metformin reduces proteinuria induced by long-term high blood pressure in spontaneously hypertensive rats by activating the Hif-2 alpha-VEGF signaling pathway, which increases VEGF-A production in the kidneys and podocytes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Miyuki Nakagawa, Masanori Inoue, Sadahisa Ogasawara, Susumu Maruta, Tomomi Okubo, Norio Itokawa, Yotaro Iino, Masamichi Obu, Yuki Haga, Atsuyoshi Seki, Yasuharu Kikuchi, Tadayoshi Kogure, Sae Yumita, Takamasa Ishino, Keita Ogawa, Kisako Fujiwara, Terunao Iwanaga, Naoto Fujita, Takafumi Sakuma, Ryuta Kojima, Hiroaki Kanzaki, Keisuke Koroki, Takashi Taida, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Takayuki Kondo, Ryo Nakagawa, Shingo Nakamoto, Ryosuke Muroyama, Tetsuhiro Chiba, Ei Itobayashi, Masanori Atsukawa, Yoshihiro Koma, Ryosaku Azemoto, Kenji Ito, Hideaki Mizumoto, Masami Shinozaki, Jun Kato, Naoya Kato
Summary: This study investigated the long-term efficacy and adverse events of atezolizumab plus bevacizumab in patients with advanced hepatocellular carcinoma. It found that the median progression-free survival (PFS) for the first-line treatment group was 8.0 months, while the median PFS for the second- or later-line treatment group was 4.1 months, significantly worse than the first-line treatment group. Interrupted bevacizumab treatment, mainly due to proteinuria, was more common in patients with hypertension and/or diabetes mellitus. The landmark analysis suggested that the interruption of bevacizumab may be associated with impaired efficacy of atezolizumab plus bevacizumab over the long term.
Article
Health Care Sciences & Services
Hyungwoo Lee, Moo-Suk Park, Min Kyoung Kang, Tae-Jin Song
Summary: This study explored the association between changes in proteinuria status and the risk of developing hypertension using data from the Korean National Health Insurance Database. The study found that individuals with chronic proteinuria had the highest risk of hypertension, while those who recovered from proteinuria had a lower risk, and individuals who developed proteinuria had a higher risk compared to those without proteinuria.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Peripheral Vascular Disease
Yoon Jung Park, Pil-Sung Yang, Hee Tae Yu, Tae-Hoon Kim, Eunsun Jang, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y. H. Lip, Boyoung Joung
Summary: Hypertension and/or proteinuria are associated with increased risk of atrial fibrillation, with the greatest risks when both are present.
JOURNAL OF HYPERTENSION
(2022)
Article
Transplantation
Hae Hyuk Jung
Summary: This study evaluated the systolic blood pressure (BP) target for CKD patients using the Korean National Health Information Database. The findings indicate that the systolic BP target for CKD patients with proteinuria should be <= 130 mmHg, while for CKD patients without proteinuria it should be <= 140 mmHg. Moreover, the benefit of intensive BP-lowering may be greater in CKD patients, especially those with proteinuria.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Oncology
Yuma Shibutani, Shinya Suzuki, Atsunobu Sagara, Tomohiro Enokida, Susumu Okano, Takao Fujisawa, Fumiaki Sato, Tetsuro Yumoto, Motohiko Sano, Toshikatsu Kawasaki, Makoto Tahara
Summary: This retrospective study evaluated the association between lenvatinib-induced proteinuria and renal function in patients with thyroid cancer. The results showed that the degree of proteinuria was not associated with renal function. Therefore, treatment with lenvatinib should be continued with attention to renal function, regardless of the degree of proteinuria.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Raluca Ursu, Nina Sopel, Alexandra Ohs, Ramesh Tati, Lisa Buvall, Jenny Nystrom, Mario Schiffer, Janina Mueller-Deile
Summary: In this study, the role of miR-200c in primary podocytopathies was investigated. The upregulation of miR-200c was observed in urine from patients with different renal diseases, as well as in TGF-beta stressed glomerular endothelial cells. MiR-200c overexpression in zebrafish resulted in glomerular damage, possibly through the reduction of podocyte VEGF-A expression. MiR-200c may also influence ZEB expression and epithelial to mesenchymal transition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Transplantation
Claudia Seikrit, Thomas Rauen, Eleni Stamellou, Jurgen Floege
Summary: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide with complex pathophysiology and clinical presentations. Early identification and individualized therapies are crucial for predicting disease progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Peripheral Vascular Disease
Yuta Suzuki, Hidehiro Kaneko, Yuichiro Yano, Akira Okada, Katsuhito Fujiu, Satoshi Matsuoka, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Koichi Node, Hideo Yasunaga, Suzanne Oparil, Issei Komuro
Summary: This study examined the relationship between blood pressure and cardiovascular disease risk in individuals with proteinuria and preserved estimated glomerular filtration rate. The results showed that stage 1 and stage 2 hypertension were associated with an increased risk of cardiovascular disease among medication-naive individuals, while only stage 2 hypertension was associated with an increased risk among those taking blood pressure-lowering medications. This study provides important insights into the cardiovascular disease risk in this population.
HYPERTENSION RESEARCH
(2023)
Article
Transplantation
Kate Wiles, Philip Webster, Paul T. Seed, Katy Bennett-Richards, Kate Bramham, Nigel Brunskill, Sue Carr, Matt Hall, Rehan Khan, Catherine Nelson-Piercy, Louise M. Webster, Lucy C. Chappell, Liz Lightstone
Summary: This study found that pregnancies in women with CKD Stages 3-5 are complicated by high rates of preterm delivery, low birthweight, and maternal renal function loss. Chronic hypertension, pre- or early pregnancy proteinuria, and a gestational fall in serum creatinine of <10% are key predictors of adverse obstetric and renal outcomes. Pregnancy in women with CKD Stages 3-5 advances the need for dialysis or transplantation by 2.5 years.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Oncology
Molly Schiffer, Lejla Zukovic, Sophia Hall, Man Yee Merl
Summary: The study assessed the safety of extending the interval for urine protein monitoring in patients receiving bevacizumab. Results showed that monitoring urine protein every other treatment did not increase the frequency of adverse events.
JOURNAL OF ONCOLOGY PHARMACY PRACTICE
(2021)
Article
Biochemistry & Molecular Biology
Banaz Abbas, Nagwa A. Sabri, Amal A. El-Khouly
Summary: The study aimed to investigate the effects of food and selected single nucleotide polymorphisms in the UGT2B7 gene on the pharmacokinetics and pharmacodynamics behavior of indapamide. The results showed that food had a modest impact on the maximum concentration and absorption time of indapamide, while genetic variations in the UGT2B7 gene had no significant impact on the pharmacokinetic parameters. It was concluded that food had a moderate effect on the pharmacokinetics, but there were no significant differences in safety and efficacy.
Article
Biochemistry & Molecular Biology
Gabriela Chyla-Danil, Kornelia Salaga-Zaleska, Ewelina Kreft, Olaf Stumski, Aleksandra Krzesinska, Monika Sakowicz-Burkiewicz, Agnieszka Kuchta, Maciej Jankowski
Summary: In this study, the long-term effects of suramin in diabetic rats were evaluated. The results showed that suramin can reduce proteinuria and restore the relaxation properties of renal arteries, potentially contributing to the reduction/slowing down of the development of diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Dongjoon Choi, Taesik Yun, Dohee Lee, Yoonhoi Koo, Yeon Chae, Mhan-Pyo Yang, Byeong-Teck Kang, Hakhyun Kim
Summary: This study found that serum concentrations of leptin and adiponectin may be associated with the severity of CKD and proteinuria in dogs.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Review
Transplantation
Jennifer S. Lees, Stephen J. H. Dobbin, Benjamin M. P. Elyan, David F. Gilmour, Laurie P. Tomlinson, Ninian N. Lang, Patrick B. Mark
Summary: This study conducted a systematic review and meta-analysis of intravitreal VEGF inhibitor treatments for retinal diseases. The results showed that there was no increased risk of cardiorenal side effects, but VEGF inhibitor treatment was associated with higher all-cause mortality in patients with diabetic eye disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)