Article
Cardiac & Cardiovascular Systems
Silvia Lee, Patricia P. Wadowski, Timothy Hoberstorfer, Constantin Weikert, Joseph Pultar, Christoph W. Kopp, Simon Panzer, Thomas Gremmel
Summary: The study found that hyperuricemia is associated with increased residual platelet reactivity in patients treated with clopidogrel and prasugrel, but not in those treated with ticagrelor.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Christiane Franz, Lara Bender, Christoph Dorn, Thorsten Sichtermann, Jan Minkenberg, Maximilian Franko, Martin Wiesmann, Andrea Stockero, Omid Nikoubashman, Rebecca May, Hani Ridwan
Summary: Knowledge of platelet function in pigs and the effectiveness of antiplatelet therapy is important for the transferability of animal studies to humans. This study characterized the baseline platelet function of Aachen minipigs, compared it with Gottingen minipigs, and evaluated platelet inhibition after intravenous administration of acetylsalicylic acid (ASA). The results showed differences in baseline platelet function between the two pig breeds and immediate platelet inhibition after ASA administration in Aachen minipigs.
Article
Hematology
Freek W. A. Verheugt, Kurt Huber, Peter Clemmensen, Jean-Philippe Collet, Thomas Cuisset, Felicita Andreotti
Summary: Antiplatelet therapy is crucial for preventing secondary ischemic heart disease. After PCI, temporary DAPT, which consists of aspirin and an oral P2Y12 receptor blocker, is recommended. However, long-term DAPT increases the risk of bleeding compared to aspirin monotherapy. To reduce bleeding, shorter DAPT duration or switching to P2Y12 inhibitor monotherapy have been suggested. This survey reviews the evidence and provides clinical guidance on the use of P2Y12 inhibitor monotherapy after DAPT cessation following PCI.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Peripheral Vascular Disease
Yuichi Saito, Takeshi Nishi, Shinichi Wakabayashi, Yuji Ohno, Hideki Kitahara, Noritaka Ariyoshi, Yoshio Kobayashi
Summary: This study found that clinical and genetic factors have differential effects on P2Y12 inhibitor reactivity with clopidogrel and prasugrel in patients with coronary artery disease. The severity of these factors also has a different impact on high platelet reactivity (HPR).
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Article
Pharmacology & Pharmacy
Bing Chen, Hao-Qiang Shi, Meihua Rose Feng, Xi-Han Wang, Xiao-Mei Cao, Wei-Min Cai
Summary: This study established a population pharmacokinetic model for INH and AcINH in Chinese population, evaluating the impact of NAT2 genotype on drug transformation and metabolism, which may be beneficial for individualized therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bing Chen, Hao-Qiang Shi, Meihua Rose Feng, Xi-Han Wang, Xiao-Mei Cao, Wei-Min Cai
Summary: This study aimed to establish a population pharmacokinetic model for isoniazid (INH) and its major metabolite Acetylisoniazid (AcINH) in Chinese participants and tuberculosis patients, and to assess the role of the NAT2 genotype on the transformation of INH to AcINH. The study also estimated the INH exposure required to achieve 90% effective concentration (EC90) in patients with different NAT2 genotypes. The results showed that NAT2 genotypes had different effects on the metabolism of INH and AcINH, and the probability of target attainment of INH EC90 varied among patients with different NAT2 genotypes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Hematology
Tatiana Mencarini, Yana Roka-Moiia, Silvia Bozzi, Alberto Redaelli, Marvin J. Slepian
Summary: This study aimed to evaluate the feasibility of MICELI in platelet aggregation testing in whole blood and found that it had similar effects compared to LTA. Platelet aggregation in whole blood as recorded by EIA was found to be a better model system for evaluating platelet reactivity.
THROMBOSIS RESEARCH
(2021)
Article
Anesthesiology
Marco Tescione, Eugenio Vadala, Graziella Marano, Enzo Battaglia, Andrea Bruni, Eugenio Garofalo, Federico Longhini, Serena Rovida, Nicola Polimeni, Rosalba Squillaci, Stefano Lascala, Gaetana Franco, Demetrio Labate, Massimo Caracciolo, Sebastiano Macheda
Summary: This study suggests that an aggregometry-guided protocol can safely expedite hip fracture surgery in patients taking clopidogrel. Clinicians can opt for neuraxial anesthesia instead of general anesthesia for patients with normal platelet function, reducing the incidence of postoperative delirium and cognitive dysfunction.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Multidisciplinary Sciences
Beenish Ali, Amjad Khan, Hamad S. Alyami, Majeed Ullah, Abdul Wahab, Munair Badshah, Attiqa Naz
Summary: The study investigated the effect of carrier material on clopidogrel release characteristics from liquisolid compacts. Different formulations were developed using various carrier materials, showing that microcrystalline cellulose and starch maize led to faster drug release, while polyvinyl pyrollidone and HPMC resulted in sustained release through gel formation. Proper selection of carrier material can achieve both fast and sustained release of clopidogrel.
Article
Pharmacology & Pharmacy
Urszula Adamiak-Giera, Anna Czerkawska, Szymon Oledzki, Mateusz Kurzawski, Krzysztof Safranow, Maria Jastrzebska, Barbara Gawronska-Szklarz
Summary: The study aimed to correlate platelet aggregation inhibition with the plasma level of the inactive metabolite of clopidogrel in patients after PCI and their associations with genetic polymorphisms. The CYP2C19*2 allele was found to be associated with decreased platelet reactivity during clopidogrel therapy before and after PCI. Simultaneous determination of platelet aggregation and concentration of the inactive clopidogrel metabolite may be useful in clinical practice to identify causes of adverse effects or inadequate treatment in patients on chronic clopidogrel therapy.
PHARMACOLOGICAL REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Tatsuya Fukase, Shinichiro Doi, Tomotaka Dohi, Takuma Koike, Ryota Nishio, Hidetoshi Yasuda, Mitsuhiro Takeuchi, Norihito Takahashi, Yuichi Chikata, Hirohisa Endo, Hiroki Nishiyama, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Hiroyuki Daida, Satoru Suwa, Tohru Minamino, Katsumi Miyauchi
Summary: This study aimed to evaluate the effects of -P2Y12 inhibitors on the -P2Y12 reaction unit (PRU) in the chronic phase after percutaneous coronary intervention (PCI). The results showed that clopidogrel treatment had a higher proportion of ischemic risk than prasugrel 2.5 mg. Prasugrel 2.5 mg also contributed to a decline in bleeding risk with dose reduction.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Jessica Wojciechowski, Bimal K. Malhotra, Xiaoxing Wang, Luke Fostvedt, Hernan Valdez, Timothy Nicholas
Summary: This study provides insights into the impact of Abrocitinib treatment on platelet counts and identifies factors affecting platelet reduction. Overall, the findings support the safety of Abrocitinib and suggest a low probability of thrombocytopenia during treatment.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Feng-Yu Kuo, Cheng-Han Lee, Wei-Ren Lan, Cheng-Huang Su, Wen-Lieng Lee, Yi-Chih Wang, Wei-Shiang Lin, Pao-Hsien Chu, Tse-Min Lu, Ping-Han Lo, Shuji Tsukiyama, Wei-Chen Yang, Li-Chung Cheng, Chien-Lung Huang, Wei-Hsian Yin, Ping-Yen Liu
Summary: This study investigated the impact of CYP2C19 genotype on the pharmacodynamics of Taiwanese ACS patients. The results showed that switching to low-dose prasugrel significantly reduced PRU levels and the proportion of HPR patients, especially in reduced metabolizers.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ilaria Cavallari, Giuseppe Patti, Ernesto Maddaloni, Francesco Veneziano, Fabio Mangiacapra, Elisabetta Ricottini, Raffaella Buzzetti, Gian Paolo Ussia, Francesco Grigioni
Summary: This study investigated the role of low platelet reactivity (LPR) in the bleeding risk stratification of patients who underwent percutaneous coronary intervention (PCI) according to their diabetes mellitus (DM) status. The results showed that LPR provided significant incremental value for predicting bleeding, regardless of DM status. The coexistence of DM and LPR identified the subgroup with the highest bleeding risk.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Hiromi Hagiwara, Hidekatsu Fukuta, Hiroya Hashimoto, Takahiro Niimura, Yoshito Zamami, Keisuke Ishizawa, Takeshi Kamiya, Nobuyuki Ohte
Summary: In Japanese patients undergoing PCI, the safety and effectiveness of prasugrel was found to be comparable to that of clopidogrel in real-world settings, irrespective of whether the procedure was urgent or elective.
JOURNAL OF CARDIOLOGY
(2021)