Article
Engineering, Chemical
Satoshi Nogami, Katsuhiko Minoura, Nao Kiminami, Yui Kitaura, Hiromasa Uchiyama, Kazunori Kadota, Yuichi Tozuka
Summary: This study investigated methods to improve the water solubility of curcumin and maintain its supersaturated state. Experimental results indicate that the addition of alpha-cyclodextrin can help inhibit the nucleation and crystal growth of curcumin.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Engineering, Chemical
Yuna Nitta, Haruna Sato, Rina Yamamoto, Hiroyuki Imanaka, Naoyuki Ishida, Koreyoshi Imamura
Summary: In this study, powderization of flavoring substances using an ASD technique was investigated. Various conditions for drying and storage were examined and compared. The results demonstrated that vacuum-foam-drying with polyvinylpyrrolidone minimized flavor loss during drying and storage. Vacuum-foam-drying with alpha-maltose or palatinose also showed better flavor retention compared to the typical O/W emulsification-based powderization method.
Article
Medicine, Research & Experimental
Sien Dedroog, Peter Adriaensens, Guy van den Mooter
Summary: Spray drying is a commonly used manufacturing technique for amorphous solid dispersions (ASDs), and this study investigates the relation between solvent evaporation rate and the kinetic stabilization of highly drug-loaded ASDs. The process parameters of spray drying were adjusted to alter the evaporation rate, which affects the phase behavior of FNB and NAP ASDs.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Marika Nespi, Robert Kuhn, Chun-Wan Yen, Joseph W. Lubach, Dennis Leung
Summary: Spray-drying dispersion (SDD) is a well-established manufacturing technique for preparing amorphous solid dispersions (ASDs). This study aims to identify optimized preset parameters for SDD to support early ASDs development. A mini-DoE study was conducted, and it was found that a 5% solid load and 35 mm height atomizing spray gas flow were the most optimized parameters. These parameters were applicable to different formulations and drug loadings, resulting in good yields and consistent particle size distribution.
Article
Pharmacology & Pharmacy
Lena Karin Mueller, Laura Halstenberg, Nicole Di Gallo, Thomas Kipping
Summary: Amorphous solid dispersions can improve the solubility of poorly soluble drugs, and stable formulations can be achieved by using polymers as excipients. This study demonstrates the applicability of polyvinyl alcohol in spray-dried solid dispersions, which can generate ASDs with targeted dissolution profiles and enhanced drug-loading capacity.
Article
Chemistry, Applied
Alberto Baldelli, Diana Yumeng Liang, Yigong Guo, Anubhav Pratap-Singh
Summary: Iron fortification through spray-dried microparticles can alleviate iron deficiency. The optimal formulation consists of equal weight percentages of iron compound, bulk material, and wall material, resulting in small particle size and high bioavailability. Encapsulation of iron gluconate reduces toxicity, while encapsulated iron fumarate decreases absorption.
FOOD HYDROCOLLOIDS
(2023)
Article
Thermodynamics
Chun Luo, Sha Mi, Naijun Zhou, Zhiqiang Liu, Lingling Cai
Summary: A model based on non-equilibrium formulation was established in this paper to study spray freeze drying. The accuracy of the model was compared with that based on equilibrium formulation, and the history of temperature, vapor concentration, and ice saturation was investigated. The simulation results showed good agreement with experimental data and provided insights for process design and optimization.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Article
Pharmacology & Pharmacy
Monika Bhalodiya, Jayant Chavda, Dhaval Mori, Nilesh Patel, Ravi Manek, Kiran Dudhat
Summary: The study aimed to prepare an amorphous solid dispersion of methanolic extract of Boerhaavia diffusa root powder to improve its dissolution properties. The results showed significant improvement in the release of phytoconstituents from all prepared batches, and the stability studies indicated that the formulations were able to maintain the phytoconstituents in amorphous/molecularly dispersed form within the polymer matrix for 6 months.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Debora Santonocito, Maria Grazia Sarpietro, Francesco Castelli, Maria Rosaria Lauro, Cristina Torrisi, Stefano Russo, Carmelo Puglia
Summary: The aim of the project was to find suitable methods to obtain a dry powder formulation from an SLN suspension. Freeze-drying and spray-drying techniques were used to dry the nanoparticle suspension. Results showed that freeze-drying under optimized conditions produced a dry powder with good reconstitution properties and similar technological parameters.
Review
Pharmacology & Pharmacy
Mohamed S. Attia, Ahmed Elshahat, Ahmed Hamdy, Ayman M. Fathi, Mahmoud Emad-Eldin, Fakhr-Eldin S. Ghazy, Hitesh Chopra, Tarek M. Ibrahim
Summary: Since the emergence of Soluplus (R) (SOL), several publications have highlighted its potential as a solubilizing excipient for poorly water-soluble drugs. Various drug formulation strategies, such as solid dispersions, nanosuspensions, nanomicelles, and selfnanoemulsions, have been utilized to improve the bioavailability of SOL-based products. This review summarizes the current applications of SOL in different pharmaceutical formulations and emphasizes the available forms of drug delivery systems and applicable formulation strategies.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Somayeh Mojtabavi, Maryam Torshabi, Kambiz Gilani, Nasrin Samadi, Mohammad Reza Khoshayand, Mohammad Reza Fazeli, Mohammad Ali Faramarzi
Summary: This study successfully produced an active laccase mouthwash dry powder using spray drying technique and optimized the processing conditions. The laccase mouthwash showed good residual activity and yield, and the native structure of laccase was largely restored upon reconstitution. Furthermore, the laccase mouthwash effectively inhibited the growth of bacteria and exhibited promising tooth whitening effect with lower cytotoxicity compared to chemical mouthwash.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Chemical
Aldo Benavides-Moran, Alfonso Cubillos, Alexander Gomez
Summary: This paper introduces a CFD approach to model the spray-drying of guava juice formulation, incorporating the characteristic drying rate curve. The computational domain is based on a small production spray-dryer, and the URANS k-omega SST and Scale-Adapted Simulation turbulence models are used to compute the flow field. Calibrating the model with experimental data is crucial for accurate simulations.
Article
Pharmacology & Pharmacy
Han Cong Seow, Qiuying Liao, Andy T. Y. Lau, Susan W. S. Leung, Shuofeng Yuan, Jenny K. W. Lam
Summary: This study aimed to develop a dual targeting powder formulation that can simultaneously target the nasal cavity and the lung through a single administration route. Spray freeze drying and spray drying techniques were used to prepare tamibarotene powder formulations, and the powder mixing ratio could be adjusted to modulate the aerosol deposition in the nasal and pulmonary regions. The formulated powder exhibited spherical structures, amorphous characteristics, and improved dissolution profile.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Chemical
Alberto Baldelli, Hale Oguzlu, Diana Yumeng Liang, Alison Subiantoro, Meng Wai Woo, Anubhav Pratap-Singh
Summary: This study proposes the use of spray freeze drying technology to improve the re-dispersibility of milk powders in aqueous systems. The formulation of the dairy products was found to influence their re-dispersibility, with higher fat percentages and the presence of maltodextrin additive decreasing the re-dispersibility.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Xiaoting Yuan, Si Lin, Kang Zhao, Yingchao Han
Summary: A new ultrasonic spray-assisted emulsion method was developed for preparing PLA microspheres, reducing preparation time and enhancing control over microsphere morphology, which provides technical assistance for microsphere preparation in tissue engineering.