Article
Engineering, Biomedical
Yanjun Li, Jingbo Yang, Ying Zheng, Rui Ye, Bin Liu, Yong Huang, Wei Zhou, Lelun Jiang
Summary: The study introduced a novel iontophoresis-driven porous MA patch (IDPMAP) and a portable iontophoresis-driven device for active transdermal delivery of charged liquid drugs. IDPMAP showed robust drug delivery ability with more advanced controllability and efficiency compared to pristine MA or iontophoresis, offering a platform technique for effective drug delivery in an active-controlled manner.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Ahlam Zaid Alkilani, Jehad Nasereddin, Rania Hamed, Sukaina Nimrawi, Ghaid Hussein, Hadeel Abo-Zour, Ryan F. Donnelly
Summary: Transdermal drug delivery (TDD) is a non-invasive approach that is convenient and easy to use, especially for vulnerable age groups. However, its applicability is limited to drugs with specific physicochemical properties due to the barrier posed by the skin. Various techniques, including chemical and passive methods, have been investigated to enhance drug permeability across the skin. Hybrid approaches combining chemical penetration enhancement technologies with physical technologies are also being intensely researched.
Article
Pharmacology & Pharmacy
Anna-Lena Elksnat, Paula Zscherpe, Karina Klein, Jessika Maximiliane Cavalleri, Jessica Meissner
Summary: The study demonstrates that the use of an oxygen-based medical device can enhance the permeation of drugs, particularly for drugs with lower molecular weight.
Article
Materials Science, Multidisciplinary
Goeen Jeong, Hyung-Seop Han, Hojeong Jeon, Yu-Chan Kim, Ho Won Jang, Myoung-Ryul Ok
Summary: Although metallic microneedles (MNs) and iontophoresis have been extensively studied, the use of biodegradable metals for transdermal drug delivery has not received much attention. In this study, Mg was employed as a promising candidate for an MN electrode due to its metallic properties and the hydrogen gas generated during Mg corrosion. The Mg MN electrode was fabricated using a nanosecond laser, and the hydrogen gas produced during iontophoresis was measured at various applied potentials. The results demonstrate an optimal potential range for iontophoresis based on the combined effect of enhanced drug diffusion and impediment from hydrogen generation.
METALS AND MATERIALS INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Kamchai Saepang, S. Kevin Li, Doungdaw Chantasart
Summary: The study explored the potential of skin microchannels created by polymer microneedle patches for enhancing transdermal drug delivery of pramipexole dihydrochloride. Results showed that drug-loaded dissolving microneedle (DMN) patches greatly improved PXCl transdermal delivery compared to conventional methods, while hydrogel-forming microneedle (HGMN) patches provided more sustained drug delivery. Electromigration was identified as the main mechanism for iontophoresis of PXCl through microchannels, with HGMN patches showing greater flux enhancement than DMN patches. The study indicates the potential application of microneedle patches, either alone or in combination with iontophoresis, as an alternative method for PXCl administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Tae Hyeon Kim, Na Yeon Kim, Hee Uk Lee, Ji Wook Choi, Taewook Kang, Bong Geun Chung
Summary: Cancer is a leading cause of death worldwide, and conventional cancer therapy has limitations. To address these issues, a transdermal drug delivery system based on iontophoresis has been developed. Controlled by a smartphone application, this system significantly enhances drug permeation at the tumor site and reduces systemic side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Instruments & Instrumentation
Yu Wang, Lijuan Zeng, Wenting Song, Jianping Liu
Summary: The stratum corneum of skin poses a strong barrier to most molecules, limiting transdermal drug delivery. Iontophoresis technology has emerged as an effective method to enhance drug permeation through the skin, providing a more efficient, noninvasive, and patient-friendly approach while widening the scope of drugs for transdermal delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Tatsuro Amano, Naoto Fujii, Ying-Shu Quan, Glen P. Kenny, Narihiko Kondo, Hirofumi Yamashita, Yoshimitsu Inoue
Summary: Emotional stress-induced sweating in glabrous skin of the palm and sole has a negative impact on quality of life. This study investigated the effectiveness of using microneedles to enhance iontophoretic delivery of pilocarpine to modulate sweat production. The microneedle array enhanced skin permeability and sweat production on the palm without increasing pilocarpine delivery, suggesting its potential use in understanding and treating conditions such as hyperhidrosis.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Mahadi Hasan, Anowara Khatun, Kentaro Kogure
Summary: Biological macromolecular drugs have become a significant therapeutic modality for various diseases due to their high specificity and safety profiles. However, their oral bioavailability and half-lives are limited. Iontophoresis, a method that uses low-level electricity for skin permeation, has been explored for the noninvasive transdermal delivery of these drugs.
Article
Pharmacology & Pharmacy
Amruta A. Dandekar, Madhura Kale, Harsha T. Garimella, Ajay K. Banga
Summary: Application of drugs on compromised skin can alter drug permeation and lead to increased adverse effects. This study examined the in vitro delivery of diclofenac sodium from different brands and generic formulations across normal and compromised skin using microneedles and iontophoresis. The results showed that compromised skin had higher delivery of diclofenac sodium, suggesting increased absorption and systemic exposure of the drug.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Tais Gratieri, Rhita Zarhloule, Sachin Dubey, Yogeshvar N. Kalia
Summary: The study found that skin barrier impairment affects the iontophoretic transport of both low and high molecular weight permeants, with removal of the stratum corneum not always leading to increased iontophoretic delivery. The decrease of electroosmotic flow and facilitated transport of ions impacted cation delivery by anodal iontophoresis, but the effects were partly offset by enhanced passive diffusion. Decreased electroosmosis favored cathodal electrotransport.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Zehua Li, Ranran Wu, Ke Chen, Wei Gu, Yi-Heng PJ. Zhang, Zhiguang Zhu
Summary: Recent advancements in enzymatic biofuel cells (EBFCs) have shown great potential in health monitoring and powering medical applications such as drug delivery. In this study, an EBFC was combined with a facial mask to enhance the transdermal permeability of target molecules using microcurrents. The results demonstrated a significant increase in drug permeation compared to non-iontophoretic transdermal drug delivery.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Pharmacology & Pharmacy
Changzhao Jiang, Xiumei Jiang, Xiumin Wang, Jiaxu Shen, Mengjie Zhang, Leilei Jiang, Rui Ma, Tingting Gan, Yingbiao Gong, Jincui Ye, Wenyan Gao
Summary: This study successfully established a transdermal iontophoresis delivery system for terazosin hydrochloride and investigated the impact of factors such as current intensity, TEH concentration, and pH on its penetration rate. Results showed that IDDS-TEH had a higher blood concentration and antihypertensive effects compared to passive diffusion. Further clinical studies are needed to develop a therapeutically useful protocol based on these findings.
Review
Pharmacology & Pharmacy
Abdelrahman M. Helmy
Summary: Iontophoresis has evolved over the years from studying delivery-enhancing mechanisms to include new target tissues and organs, such as the suprachoroidal space, nibbles, and intestinal mucosa. The combination of iontophoresis with other drug delivery approaches and the development of smart iontophoretic devices have further optimized drug delivery. Moreover, significant progress in mathematical and computational simulations has enabled the prediction of iontophoretic drug delivery across different tissues.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ana Claudia Sueiro, Erica Mendes dos Santos, Louise Lacalendola Tundisi, Ana Laura Masquetti Fava, Luiza Aparecida Luna Silverio, Julia Cedran Coco, Janaina Artem Ataide, Ana Claudia Paiva-Santos, Priscila Gava Mazzola
Summary: This article reviews transdermal delivery systems for migraine treatment, emphasizing their advantages over oral administration and discussing the lack of transdermal drugs available on the market.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Li Chen, Hamad Alrbyawi, Ishwor Poudel, Robert D. Arnold, R. Jayachandra Babu
Article
Biochemical Research Methods
Vanisree Mulabagal, Manjusha Annaji, Sharmila Kurapati, Ranjeet Prasad Dash, Nuggehally R. Srinivas, Amit K. Tiwari, R. Jayachandra Babu
BIOMEDICAL CHROMATOGRAPHY
(2020)
Article
Pharmacology & Pharmacy
Hamad Alrbyawi, Ishwor Poudel, Manjusha Annaji, Sai H. S. Boddu, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu
Summary: In this study, a pH-sensitive liposomal system was used to deliver daunorubicin to melanoma cells, resulting in enhanced cytotoxic effects. The liposomes exhibited high drug encapsulation efficiency and rapid release at acidic pH, leading to significantly higher cytotoxicity compared to conventional daunorubicin or liposomes.
Article
Biochemistry & Molecular Biology
Hamad Alrbyawi, Sai H. S. Boddu, Ishwor Poudel, Manjusha Annaji, Nur Mita, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study developed a co-delivery system of daunorubicin and cardiolipin encapsulated in thermosensitive liposomes for the treatment of breast cancer. The liposomes exhibited high drug encapsulation efficiency, small size, and rapid release under mild hyperthermia, resulting in significantly higher cytotoxicity against breast cancer cells compared to daunorubicin or conventional liposomes. This research lays the foundation for future development of liposomal co-delivery systems for breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chanchal Kiran Thakur, Rabin Neupane, Chandrabose Karthikeyan, Charles R. Ashby, R. Jayachandra Babu, Sai H. S. Boddu, Amit K. Tiwari, Narayana Subbiah Hari Narayana Moorthy
Summary: A simple and cost-effective method was reported to functionalize MWCNTs with carbohydrate ligands using lysine as a linker. The results showed that carbohydrate-modified MWCNTs had higher drug loading capacity and improved anticancer efficacy.
Article
Pharmacology & Pharmacy
Manjusha Annaji, Nur Mita, Shivani Rangari, Mohammed F. Aldawsari, Ahmed Alsaqr, Ishwor Poudel, Oladiran Fasina, R. Jayachandra Babu
Summary: In this study, a topical gel formulation containing acyclovir and lidocaine was tested for its skin permeation properties. The results showed that the gel had significantly higher transdermal flux and skin retention compared to commercial formulations. It also showed increased permeation across microporated skin.
Article
Biochemistry & Molecular Biology
Ishwor Poudel, Manjusha Annaji, Fajar Setyo Wibowo, Robert D. Arnold, Oladiran Fasina, Brian Via, Vijaya Rangari, Maria Soledad Peresin, Forrest Smith, Muralikrishnan Dhanasekaran, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study investigates the preparation of an inclusion complex of Hispolon with Sulfobutylether-beta-cyclodextrin (SBE beta CD) and the formulation of Hispolon-SBE beta CD trapped within sterically stabilized liposomes (HSC-SL). The results show that HSC-SL exhibits enhanced anticancer activity against melanoma cell lines and sustained drug release compared to Hispolon liposomes and Hispolon-SBE beta CD liposomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Chanchal Kiran Thakur, Chandrabose Karthikeyan, Mariam Sami Abou-Dahech, Moawia Mohd A. M. Altabakha, Moayad Jamal Saeed Al Shahwan, Charles R. R. Ashby Jr, Amit K. Tiwari, R. Jayachandra Babu, Narayana Subbiah Hari Narayana Moorthy
Summary: Microwave-assisted synthetic methods are commonly used for the surface modification and functionalization of multi-walled carbon nanotubes (MWCNTs) in diverse drug delivery applications. Microwave-induced functionalization of MWCNTs offers high efficiency and shorter reaction time compared to conventional techniques. Microwave methods are simple, fast, and effective for the covalent and noncovalent conjugation of MWCNTs with various biomolecules and polymers. This review focuses on the synthesis and drug delivery applications of microwave irradiation techniques (MITs) for the functionalization of MWCNTs using amino acids, vitamins, proteins, epoxy moieties, metal nanoparticles, and polymers.
Article
Pharmacology & Pharmacy
Ahmed Al Saqr, Manjusha Annaji, Ishwor Poudel, Mohammed F. Aldawsari, Hamad Alrbyawi, Nur Mita, Muralikrishnan Dhanasekaran, Sai H. S. Boddu, Rabin Neupane, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study aimed to develop a microemulsion formulation for topical delivery of Diacetyl Boldine (DAB) and evaluate its cytotoxicity against melanoma cell line (B16BL6) in vitro. The results showed that the microemulsion formulation exhibited significantly higher skin retention levels than the DAB solution in MCT oil. Additionally, the microemulsion formulations showed substantially higher cytotoxicity toward B16BL6 cell lines than the control formulation.
Review
Pharmacology & Pharmacy
Xuejia Kang, Sanika Jadhav, Manjusha Annaji, Chung-Hui Huang, Rajesh Amin, Jianzhong Shen, Charles R. R. Ashby Jr, Amit K. K. Tiwari, R. Jayachandra Babu, Pengyu Chen
Summary: Disulfiram (DSF) is an approved drug for alcoholism treatment and has shown anticancer efficacy in preclinical studies. Supplementing DSF with copper (CuII) enhances its efficacy. However, clinical trials have not yielded promising results. Understanding the anticancer mechanisms of DSF/Cu (II) may lead to repurposing DSF as a new cancer treatment.
Article
Biochemistry & Molecular Biology
Xuejia Kang, Qi Wang, Siqi Wu, Chuanyu Wang, Manjusha Annaji, Chung-Hui Huang, Jianzhong Shen, Pengyu Chen, R. Jayachandra Babu
Summary: Therapeutic strategies for ARID1A-mutant ovarian cancers are limited. Higher basal ROS and lower basal GSH enhance the aggressive proliferation ability and metastatic property of OCCCs through EMT induction and immunosuppressive microenvironment. However, the aberrant redox homeostasis also increases the sensitivity of DQ-Lipo/Cu in mutant cells. DQ generates DDC in response to ROS, which together with Cu generates ROS cascade and targets GSH vulnerability, disrupting redox homeostasis and causing cancer cell death. The formed Cu(DDC)2 acts as a potent cytotoxic anti-cancer drug inducing immunogenic cell death, providing a promising strategy for managing cancer metastasis and drug resistance.
Review
Chemistry, Medicinal
Qi Wang, Keerthi Atluri, Amit K. Tiwari, R. Jayachandra Babu
Summary: Various formulations of polymeric micelles are being investigated as potential nanomedicines for cancer treatment. They target specific tissues and have prolonged circulation in the body. This review focuses on the different polymeric materials available for micelle synthesis and the ways they can be tailored to be responsive to different stimuli. It also discusses clinical trends, drug delivery applications, and challenges in this field.
Review
Oncology
Suhrud Pathak, Kelsee K. Zajac, Manjusha Annaji, Manoj Govindarajulu, Rishi M. Nadar, Dylan Bowen, R. Jayachandra Babu, Muralikrishnan Dhanasekaran
Summary: Choosing the most effective and least toxic chemotherapy drug is a challenge in cancer treatment. The individual's genetic makeup plays a significant role in drug response, and personalized medication regimens based on pharmacogenomics can optimize treatment outcomes. However, current standardized chemotherapy protocols rarely consider these individual differences. Therefore, integrating personalized medicine with clinical data of different ethnicities can improve treatment outcomes for patients of different ethnic backgrounds.
Article
Medicine, Research & Experimental
Ishwor Poudel, Manjusha Annaji, Chu Zhang, Peter R. Panizzi, Robert D. Arnold, Amal Kaddoumi, Rajesh H. Amin, Seungjong Lee, Nima Shamsaei, R. Jayachandra Babu
Summary: A surgically implantable device is a necessary treatment option for millions worldwide with orthopedic injuries. The use of additive manufacturing has enabled the customized fabrication of orthopedic implants with surface modifications. This study investigates the application of laser powder bed fusion to create 3D-printed implants functionalized with antimicrobial coatings to treat postsurgical infections.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Kyle McIntosh, Jeffrey Sarver, Kristopher Mell, David J. Terrero, Charles R. Ashby, Chris Reddy, Gregory O' Neil, Jayachandra Babu Ramapuram, Amit K. Tiwari
FRONTIERS IN BIOSCIENCE-LANDMARK
(2020)
