Article
Pharmacology & Pharmacy
Yi Hsuan Ou, Wei Jiang Goh, Seng Han Lim
Summary: This study developed an adjustable and controllable release dosage form of budesonide using 3D printing technology, aiming to reduce off-target adverse effects and potentially replace the use of invasive enemas. In vitro tests showed that the 3D printed tablets effectively delivered budesonide to targeted sites along the gastrointestinal tract. The tablets demonstrated comparable dose accuracy and quality to commercial tablets while enhancing drug delivery to the colon region. Overall, this study provides proof of concept for controllable targeting of oral therapeutics along the gastrointestinal tract using 3D printing technologies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
S. Spoorthi Shetty, Praveen Halagali, Asha P. Johnson, K. M. Asha Spandana, H. V. Gangadharappa
Summary: Diabetes Mellitus is a condition characterized by high blood sugar levels that can be caused by the destruction of beta cells or insulin resistance. Insulin is a hormone that regulates the metabolism of carbohydrates, proteins, and fats. Type 1 Diabetes Mellitus requires insulin for management, but invasive methods of administration may reduce patient adherence. This article discusses the potential of oral insulin as a non-invasive alternative with advantages such as patient compliance and cost reduction, as well as strategies to overcome gastrointestinal barriers.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Xiyuan Yi, Yong Luo, Qi Zhou, Jun Wang, Zengtao Yang
Summary: Insulin therapy is the most effective way to control blood glucose in diabetic patients, and subcutaneous injection is the most effective administration route. Chitosan poly-acrylic acid nanobubbles were developed as drug carriers for insulin, achieving visually controlled pulsatile release triggered by focused ultrasound. The release of insulin from nanobubbles could be accurately controlled under ultrasound guidance, significantly reducing the injection frequency of insulin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Tyler P. P. Graf, Sherry Yue Qiu, Dhruv Varshney, Mei-Li Laracuente, Erin M. M. Euliano, Pujita Munnangi, Brett H. H. Pogostin, Tsvetelina Baryakova, Arnav Garyali, Kevin J. J. McHugh
Summary: PULSED is a novel drug delivery system that provides a sequence of doses in a single injection, improving patient adherence and therapeutic efficacy. It utilizes high-resolution 3D printing and soft lithography to form biodegradable polymeric microstructures with an open cavity, which are filled with drug and sealed using contactless heating. The system exhibits versatility and compatibility with various drugs, with the potential to simplify drug formulations at a low cost and scale effectively.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanfang Wang, Pengbo Chen, Wei Liu, Xiangqian Wei, Juan Zhang, Xinwei Wei, Yun Liu, Luxuan Rao, Shiming Zhang, Jicheng Yu, Xiao Ye, Jinqiang Wang, Zhen Gu
Summary: Researchers have developed a novel insulin nanocarrier system that can effectively and safely control blood glucose levels in type 1 diabetes patients for an extended period of time.
Article
Pharmacology & Pharmacy
Alireza Ghannad Sabzevari, Hossein Sabahi, Mohsen Nikbakht, Steven J. P. McInnes
Summary: An oral controlled-release formulation of epigallocatechin-3-gallate (EGCG) was developed by intercalating EGCG into mucoadhesive montmorillonite (Mt) nanolayers. The EGCG-loaded Mt showed sustained release of EGCG in a pH-dependent manner, making it a potential nanocarrier for oral administration of EGCG. The study provided valuable insights into the release mechanism and application of EGCG in oral drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Shaimaa S. Ibrahim
Summary: The aim of this study was to develop nanostructured lipid carriers (NLC) to improve the therapeutic outcome of prednisolone acetate (PA) by altering its pharmacokinetic profile and/or allowing preferential targeting to inflammatory tissues. Optimized PA-loaded NLCs showed superior anti-inflammatory activity and good stability.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Arne Matteo Joergensen, Christian Steinbring, Daniel Stengel, Dennis To, Pascal Schmid, Andreas Bernkop-Schnuerch
Summary: This study developed self-emulsifying drug delivery systems containing dry reverse micelles (SEDDS-dRMsPMB) loaded with the model peptide drug polymyxin B (PMB) using anionic (AOT), cationic (DODAB), amphoteric (SL), or non-ionic (P85) surfactants. These systems showed high payload, efficient cellular uptake, and maintained antimicrobial activity, suggesting a potential game-changing strategy for oral peptide drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Tovi Shapira-Furman, Abraham J. Domb
Summary: This report introduces a novel approach of nano formulation using stereo-interaction mechanism with poly(D-lactide)-polyethylene glycol (D-PLA-PEG) to address the challenges of controlled drug delivery for peptide and protein therapeutics. The study demonstrates that nano particles formed by the interaction between water-soluble D-PLA-PEG and insulin can achieve sustained release of insulin, showing potential application in diabetes treatment.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Caitlin L. Maikawa, Peyton C. Chen, Eric T. Vuong, Leslee T. Nguyen, Joseph L. Mann, Andrea D'Aquino, Rayhan A. Lal, David M. Maahs, Bruce A. Buckingham, Eric A. Appel
Summary: The study successfully created a stable co-formulation of monomeric insulin and amylin analogues using amphiphilic acrylamide copolymers, with synchronous pharmacokinetics and ultra-rapid action, offering potential to improve glucose management in patients with diabetes.
Article
Polymer Science
Mohammad F. Bayan, Saeed M. Marji, Mutaz S. Salem, M. Yasmin Begum, Kumarappan Chidambaram, Balakumar Chandrasekaran
Summary: The study aims to develop a smart drug delivery system based on pH-sensitive polymeric formulations. The system can delay the release of drugs in the stomach and small intestine, while releasing them in the colon, showing promising potential for application.
Article
Chemistry, Multidisciplinary
Rashmi Mannu, Vaithinathan Karthikeyan, Nandakumar Velu, Chandravadhana Arumugam, Vellaisamy A. L. Roy, Anantha-Iyengar Gopalan, Gopalan Saianand, Prashant Sonar, Kwang-Pill Lee, Wha-Jung Kim, Dong-Eun Lee, Venkatramanan Kannan
Summary: Magnetic nanoparticles (MNPs) are commonly used in biomedical applications due to their unique properties. This study introduces the drug loading/release capability of MNPs formulated with methoxy polyethylene glycol (PEG) in aqueous fluid, potentially advancing biomedical applications such as hyperthermia treatment and drug delivery. The experiment compared different MNPs coated with PEG and their efficacy in loading/releasing an anticancer drug, presenting new possibilities for biomedical applications.
Article
Instruments & Instrumentation
Saliha Moutaharrik, Gabriele Meroni, Alessio Soggiu, Anastasia Foppoli, Matteo Cerea, Luca Palugan, Francesca Caloni, Piera Anna Martino, Andrea Gazzaniga, Alessandra Maroni
Summary: This study developed a double-coated delivery system that leverages intestinal microbiota, pH, and transit time for reliable colonic release. The system demonstrated feasibility and the ability of guar gum to trigger release in the presence of colon bacteria without impairing the barrier properties of the coating.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Lijun Cai, Guopu Chen, Lingyu Sun, Shuangshuang Miao, Luoran Shang, Yuanjin Zhao, Lingyun Sun
Summary: A novel micromotor delivery system with rocket-like architecture and effervescent-tablets-derived fuel was developed for efficient oral macromolecule delivery. The micromotors, inspired by rockets, feature sharp needle tips for loading and efficient penetrating, and tail wings for loading effervescent powders and avoiding perforation. When exposed to a water environment, the effervescent fuel generates CO2 bubbles to propel the micromotors, allowing them to inject into the surrounding mucosa for drug release. These micromotors showed efficacy in regulating blood sugar glucose in a diabetic rabbit model, indicating their potential for clinical oral delivery of macromolecules.
ADVANCED MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Phuong H. L. Tran, Thao T. D. Tran
Summary: Mucoadhesive formulations have shown to be efficient drug delivery systems with advantages of increased local retention and sustained drug release. Recent studies have focused on colon-targeted, orally administered drugs with controlled release, resulting in promising applications from mucoadhesive cores to particles.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Pharmacology & Pharmacy
Alice Melocchi, Francesco Briatico-Vangosa, Marco Uboldi, Federico Parietti, Maximilian Turchi, Didier von Zeppelin, Alessandra Maroni, Lucia Zema, Andrea Gazzaniga, Ahmed Zidan
Summary: 3D printing technology, particularly FDM, has rapidly become a hot topic in pharmaceutical research and media attention, with significant growth expected in 2020. Further development of FDM 2.0 process is needed to ensure the production of safe, high-quality personalized drug products.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Alice Melocchi, Marco Uboldi, Matteo Cerea, Anastasia Foppoli, Alessandra Maroni, Saliha Moutaharrik, Luca Palugan, Lucia Zema, Andrea Gazzaniga
Summary: Shape memory materials (SMMs) can recover their original shape in response to external stimuli, which could bring significant innovations in the pharmaceutical field. 4D printing, involving SMMs and 3D printing, adds shape evolution possibilities to manufacturing technology.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Alice Melocchi, Marco Uboldi, Francesco Briatico-Vangosa, Saliha Moutaharrik, Matteo Cerea, Anastasia Foppoli, Alessandra Maroni, Luca Palugan, Lucia Zema, Andrea Gazzaniga
Summary: The study focused on evaluating 3D printing for the Chronotopic(TM) system and testing various multiple-step manufacturing processes, aiming to explore the feasibility of the system's different parts.
Article
Pharmacology & Pharmacy
Saliha Moutaharrik, Alessandra Maroni, Alice Melocchi, Lucia Zema, Anastasia Foppoli, Matteo Cerea, Luca Palugan, Christel Neut, Florence Siepmann, Juergen Siepmann, Andrea Gazzaniga
Summary: A novel oral colon delivery platform was proposed, utilizing multiple physiological characteristics of the intestine. The system includes a drug core, a water-swellable/soluble inner layer, and an enteric outer layer, which were studied for release performance in various media. Pulsatile release profiles were observed, with differences in drug release in simulated colonic fluid indicating the role of microbial degradation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Luca Palugan, Matteo Cerea, Carlo Vecchio, Alessandra Maroni, Anastasia Foppoli, Saliha Moutaharrik, Alice Melocchi, Lucia Zema, Andrea Gazzaniga
Summary: This study introduced a new punch design for manufacturing easy-breakable tablets, demonstrating its suitability for orally disintegrating tablets. The experimental results showed that the new punch design could effectively modulate drug dose and intake.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Marco Uboldi, Alice Melocchi, Saliha Moutaharrik, Matteo Cerea, Andrea Gazzaniga, Lucia Zema
Summary: Film-coating is widely used in the pharmaceutical field to improve the appearance and mechanical properties of dosage forms. Recently, it has been applied to the development of 4D printed prolonged-release systems for organ retention. The shape, weight, and surface characteristics of the cores are essential for achieving a homogeneous film during the coating process.
Review
Pharmacology & Pharmacy
Luca Palugan, Matteo Cerea, Micol Cirilli, Saliha Moutaharrik, Alessandra Maroni, Lucia Zema, Alice Melocchi, Marco Uboldi, Ilaria Filippin, Anastasia Foppoli, Andrea Gazzaniga
Summary: Treatment of urinary bladder diseases faces challenges such as local drug delivery, sustained drug concentration, and drug permeability. Proposed solutions such as intravesical delivery systems aim to reduce catheterization procedures and increase drug concentration at the target site.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2021)
Article
Pharmacology & Pharmacy
Luca Palugan, Mattia Spoldi, Francesco Rizzuto, Norberto Guerra, Marco Uboldi, Matteo Cerea, Saliha Moutaharrik, Alice Melocchi, Andrea Gazzaniga, Lucia Zema
Summary: This study evaluated the physico-technological characteristics and performance of commercial cosmetic formulations that are free of E171. A quantitative method based on the CIELab color space was proposed for the first time to study the covering and coloring performance of the coating formulations. The results showed that all the commercially-available E171-free products considered in this study achieved satisfactory covering capability and white color comparable to a standard TiO2-containing reference, without affecting the dissolution performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Marco Uboldi, Alice Melocchi, Saliha Moutaharrik, Luca Palugan, Matteo Cerea, Anastasia Foppoli, Alessandra Maroni, Andrea Gazzaniga, Lucia Zema
Summary: Targeted drug delivery in specific sites of the upper GI tract is crucial for effective treatment, especially in chronic diseases. The traditional gastroretentive systems have been widely used, while the development of novel drug delivery systems focuses on injectable oral administration.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Luca Palugan, Saliha Moutaharrik, Micol Cirilli, Andrea Gelain, Alessandra Maroni, Alice Melocchi, Lucia Zema, Anastasia Foppoli, Matteo Cerea
Summary: Dry granulation by roller compaction is a continuous manufacturing technology used in the pharmaceutical industry to improve bulk density and flowability of powder mixtures or prevent segregation issues. Mannitol, a commonly used excipient, can be successfully granulated using roller compaction, resulting in granules with proper size, increased bulk density, and adequate flow properties, which are suitable for tableting.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Berta Bosch, Saliha Moutaharrik, Andrea Gazzaniga, Kaisa Hiippala, Helder A. Santos, Alessandra Maroni, Reetta Satokari
Summary: The O. splanchnicus 57 strain was successfully formulated for oral colonic release, showing anti-inflammatory properties, which could be used in the treatment of inflammatory bowel disease.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)