期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 100, 期 1, 页码 75-93出版社
WILEY-BLACKWELL
DOI: 10.1002/jps.22272
关键词
membrane emulsification; drug delivery systems; multiple emulsion; micro/nano particulate; uniform size; controlled release
资金
- National Basic Research Program of China [2007CB935800]
- Key Technology R&D Program of Hubei Province of China [2006AA304A07]
Much attention has in recent years been paid to fine applications of drug delivery systems, such as multiple emulsions, micro/nano solid lipid and polymer particles (spheres or capsules). Precise control of particle size and size distribution is especially important in such fine applications. Membrane emulsification can be used to prepare uniform-sized multiple emulsions and micro/nano particulates for drug delivery. It is a promising technique because of the better control of size and size distribution, the mildness of the process, the low energy consumption, easy operation and simple equipment, and amendable for large scale production. This review describes the state of the art of membrane emulsification in the preparation of monodisperse multiple emulsions and micro/nano particulates for drug delivery in recent years. The principles, influence of process parameters, advantages and disadvantages, and applications in preparing different types of drug delivery systems are reviewed. It can be concluded that the membrane emulsification technique in preparing emulsion/particulate products for drug delivery will further expand in the near future in conjunction with more basic investigations on this technique. (C) 2010 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 100:75-93, 2011
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据