Review
Pharmacology & Pharmacy
Deepak Kulkarni, Fouad Damiri, Satish Rojekar, Mehrukh Zehravi, Sarker Ramproshad, Dipali Dhoke, Shubham Musale, Ashiya A. Mulani, Pranav Modak, Roshani Paradhi, Jyotsna Vitore, Md Habibur Rahman, Mohammed Berrada, Prabhanjan S. Giram, Simona Cavalu
Summary: Microneedle (MNs) technology is a recent advancement in biomedical science that has gained popularity worldwide due to its multifaceted and broad-spectrum applications in drug delivery. The limitations of conventional drug delivery, such as poor absorption and bioavailability, can be overcome by MN-based drug delivery. Nanotechnology has played a significant role in the fabrication techniques and design of microneedles.
Article
Chemistry, Physical
Beibei Lu, Tianqi Liu, Hao Wang, Chengyu Wu, Hanjun Chen, Zhe Liu, Jiaheng Zhang
Summary: Transdermal drug delivery system has several advantages, and ionic liquids play an important role in transdermal drug delivery.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Kristyna Dvorakova, Petr Stepanek, Jirina Kroupova, Jarmila Zbytovska
Summary: Transdermal drug delivery is a non-invasive method with advantages over conventional routes of administration. However, the skin barrier needs to be modulated with enhancers, and currently there is a lack of enhancers with low toxicity and reversible effects. A study found that a series of new N-alkylmorpholines showed enhanced transdermal and dermal delivery, with the most effective derivatives having 10-14 carbons. The enhancers interacted predominantly with stratum corneum lipids.
Review
Chemistry, Multidisciplinary
Farzaneh Sabbagh, Beom Soo Kim
Summary: Transdermal drug delivery is an effective method with advantages of avoiding liver and gastrointestinal side effects, maintaining a steady rate of drug delivery, and utilizing patches for administration. With effective design and evaluation, a wide range of drugs can now be administered using this valuable advanced technology, which has roots dating back to ancient China.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Kanokwan Singpanna, Chaiyakarn Pornpitchanarong, Prasopchai Patrojanasophon, Theerasak Rojanarata, Tanasait Ngawhirunpat, S. Kevin Li, Praneet Opanasopit
Summary: Transdermal drug delivery via the skin is a promising method, and gold nanoparticles (AuNPs) have emerged as a useful tool in this area. This review provides a comprehensive summary of the properties, synthesis, and applications of AuNPs in transdermal drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Y. Han, Z. Y. Jin, D. S. Zhang, B. B. Hu, Z. Q. Li, Y. S. Jing, S. G. Sun
Summary: The transdermal drug delivery system (TDDS) can increase patient compliance, but many drugs are not easily absorbed through the skin due to the barrier function. Polymers can promote transdermal absorption as a chemical penetration promoter or as a raw material, and this article introduces the structure and mechanism of the skin, as well as the classification of polymers.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Rahman Md Moshikur, Islam Md Shimul, Shihab Uddin, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto
Summary: In this study, we synthesized 12 oil-miscible ionic liquid drugs and found that one formulation containing oleate had 2.6 times higher permeation ability than the traditional levamisole salt. Animal experiments showed that the levamisole ionic liquid had higher plasma concentration and longer elimination half-life compared to the levamisole salt. Additionally, the levamisole ionic liquid demonstrated excellent biocompatibility. Therefore, oil-miscible ionic liquid drugs provide a simple and scalable strategy for the design of effective transdermal drug delivery systems.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Tae Hyeon Kim, Na Yeon Kim, Hee Uk Lee, Ji Wook Choi, Taewook Kang, Bong Geun Chung
Summary: Cancer is a leading cause of death worldwide, and conventional cancer therapy has limitations. To address these issues, a transdermal drug delivery system based on iontophoresis has been developed. Controlled by a smartphone application, this system significantly enhances drug permeation at the tumor site and reduces systemic side effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Atoosa Jafari, Saeid Daneshamouz, Parisa Ghasemiyeh, Soliman Mohammadi-Samani
Summary: In recent years, lipid-based transdermal drug delivery systems, specifically ethosomes, have gained attention due to their high penetration ability and versatility. Ethosomes are innovative, biocompatible, biodegradable and non-toxic lipid-based vesicles that efficiently encapsulate drugs with diverse physicochemical properties.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Zhiguo Li, Xuexun Fang, Dahai Yu
Summary: Transdermal drug delivery (TDD) has emerged as an effective alternative to traditional oral and injection administration, with potential for enhanced anti-obesity drug delivery. Obesity is a global epidemic with significant health threats, requiring more effective drug delivery strategies. Despite most studies being in the animal stage, the application of TDD in anti-obesity drugs could bring safe and effective therapies to obese patients in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Anna-Lena Elksnat, Paula Zscherpe, Karina Klein, Jessika Maximiliane Cavalleri, Jessica Meissner
Summary: The study demonstrates that the use of an oxygen-based medical device can enhance the permeation of drugs, particularly for drugs with lower molecular weight.
Article
Pharmacology & Pharmacy
Mengzhen Xing, Yuning Ma, Xiaocen Wei, Chen Chen, Xueli Peng, Yuxia Ma, Bingwen Liang, Yunhua Gao, Jibiao Wu
Summary: Auxiliary permeable microneedles (AP-MNs) were prepared using polyvinyl alcohol and Eudragit NM30D to enhance transdermal drug delivery. The formulation of AP-MNs was optimized based on swelling properties, skin insertion, solution viscosity, and needle integrity. The AP-MNs exhibited excellent mechanical strength and hydrogel-forming properties, creating a continuous and unblockable network channel. The cumulative permeation of acidic and alkaline model drugs, azelaic acid and matrine, significantly increased after using AP-MNs.
Article
Medicine, General & Internal
Tory R. Spindle, Dennis J. Sholler, Edward J. Cone, Timothy P. Murphy, Mahmoud ElSohly, Ruth E. Winecker, Ronald R. Flegel, Marcel O. Bonn-Miller, Ryan Vandrey
Summary: This study evaluated the accuracy of CBD and THC labeling in topical cannabinoid products and found that they are often inaccurately labeled and many contain THC. These findings suggest the need for clinical studies to determine whether topical cannabinoid products with THC can produce psychoactive effects or positive drug tests for cannabis.
Article
Biochemistry & Molecular Biology
Janonna Kadyrov, Lanie Ruiz-Perez, Heather A. E. Benson, Ricardo L. Mancera
Summary: This study uses molecular dynamics simulations to investigate the mechanism of prodrugs' permeation through the skin, and finds that increased hydrophobicity can enhance drug permeation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Instruments & Instrumentation
Delly Ramadon, Maeliosa T. C. McCrudden, Aaron J. Courtenay, Ryan F. Donnelly
Summary: Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. This article reviews the current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. The use of microneedle technology has shown promising results in improving transdermal delivery systems, with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)