Article
Biotechnology & Applied Microbiology
Meng Du, Ting Wang, Renjie Feng, Penghui Zeng, Zhiyi Chen
Summary: Bacteria-driven biohybrid microbots have potential in cancer treatment, but the precise control of drug release at the tumor site remains a challenge. To overcome this, the ultrasound-responsive SonoBacteriaBot (DOX-PFP-PLGA@EcM) was proposed. It showed high tumor-targeting efficiency, controlled drug release capability, and ultrasound imaging. DOX-PFP-PLGA@EcM can efficiently accumulate in tumors and has significant potential applications for therapeutic drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Chemistry, Physical
Urmila Saha, Ranjit De, Bijan Das
Summary: The efficacy of drugs is often challenged by issues such as premature degradation, low solubility, side effects, and rapid clearance from the circulatory system. Surfactants play a pivotal role in solubilizing a wide variety of drug molecules through micellization in physiologically relevant fluids. They offer advantages over conventional liposomes and phospholipid-based formulations, including higher micellar stability, ease of formation, and lower maintenance expenses. This review critically analyzes the interactions between loaded drugs and surfactants in micellar delivery systems, highlighting the need for a better understanding of these interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Fasih Bintang Ilhami, Kai-Chen Peng, Yi-Shiuan Chang, Yihalem Abebe Alemayehu, Hsieh-Chih Tsai, Juin-Yih Lai, Yu-Hsuan Chiao, Chen-Yu Kao, Chih-Chia Cheng
Summary: The newly developed DOX/5-ALA-loaded A-PPG micelles exhibited excellent light and pH-responsive behavior, allowing rapid drug release within 1-2 minutes of laser irradiation. This led to enhanced cellular uptake and rapid production of reactive oxygen species in cancer cells, ultimately inducing apoptotic cell death through endocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Marie Piantino, Masahiko Nakamoto, Michiya Matsusaki
Summary: Efficient and selective drug delivery systems (DDS) in cancer therapy remain a major challenge. A recent study introduced a molecular block (MB) therapy targeting the cancer cell microenvironment, which induced cancer cell death through self-aggregation and cell membrane disruption. The optimized MB showed increased sensitivity to the cancer microenvironment and avoided off-target accumulation in the bloodstream, making it a promising approach for improved cancer cell targeting.
Article
Chemistry, Multidisciplinary
Shuaidong Huo, Zhihuan Liao, Pengkun Zhao, Yu Zhou, Robert Goestl, Andreas Herrmann
Summary: Mechanochemistry-based strategies provide new avenues to improve drug selectivity and overcome side effects and drug resistance. In this study, a mechano-responsive nanoswitch was constructed for the selective activation of drugs to inhibit cancer cell proliferation.
Review
Biology
Lulu Zhang, Zhuohua Lin, Lan Zeng, Fan Zhang, Lihong Sun, Suhui Sun, Ping Wang, Menghong Xu, Jinxia Zhang, Xiaolong Liang, Huiyu Ge
Summary: This review comprehensively discusses the mechanisms and factors influencing ultrasound-induced drug delivery, highlighting the biophysical effects of ultrasound and their applications in enhancing drug delivery efficiency. The review also covers recent advances in ultrasound-triggered drug delivery, safety issues, optimization strategies, current progress, and future directions in the field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Max L. Wang, Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, Amin Arbabian
Summary: On-demand drug delivery systems combined with wireless implants can control drug release, reducing dosage and side effects. Researchers designed a release system based on a modified electroresponsive polypyrrole nanoparticulate film for negatively charged compounds. They also developed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system in vivo. The feasibility of wireless, controllable drug release was demonstrated through in vitro and in vivo characterization using fluorescein as a model drug.
Article
Chemistry, Multidisciplinary
Yuqiang Li, Yitong Jiang, Ziyan Zheng, Nan Du, Shuli Guan, Wenxuan Guo, Xiaohu Tang, Jiajunzi Cui, Lanqiong Zhang, Kunpeng Liu, Qingsong Yu, Zhihua Gan
Summary: The limited availability of anticancer drugs and drug resistance have made monotherapy-based cancer therapy challenging. Combination therapy using currently available drugs is a potential alternative, but the barrier between in vitro screening and in vivo delivery hinders its application. This study proposes a precise drug delivery strategy using engineered nanomedicine to overcome this limitation and facilitate individualized combination therapy.
ADVANCED MATERIALS
(2022)
Article
Acoustics
Osamah Alghazwat, Somayeh Talebzadeh, Jeremiah Oyer, Alicja Copik, Yi Liao
Summary: A study developed an ultrasound responsive micelle for localized CO delivery, demonstrating its significant therapeutic effects in prostate cancer cells.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Chemistry, Physical
Dmitriy Moreira, Oren Regev, Nuno Basilio, Eduardo F. Marques
Summary: This study develops a delivery system based on dual light and pH responsive vesicles, which can achieve precise drug release. By adjusting the acid and base conditions and UV irradiation, the release of the drug is successfully controlled, demonstrating the potential application of vesicles as nano-carriers in acidic environments such as tumors.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Qiutong Jin, Zhuang Liu, Qian Chen
Summary: Cancer immunotherapy is a promising therapeutic strategy, but systemic administration of immunotherapeutic agents may lead to severe side effects, necessitating the development of local delivery systems to avoid this issue. Advances in biomaterials, biotechnology, nanomedicine, and engineering have facilitated the development of such systems, which can effectively inhibit cancer recurrence and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Qinghao Zhou, Fathelrahman Mohammed, Yuheng Wang, Jingbo Wang, Nannan Lu, Junjie Li, Zhishen Ge
Summary: The study highlights the important influence of the inherent hypoxic microenvironment of solid tumors on tumor growth and spread. By preparing a polyprodrug, a complementary photodynamic-chemotherapy strategy can be achieved, effectively suppressing tumor growth through a combination of photodynamic therapy and chemotherapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Yuting Yuan, Zhenhua Wang, Shengjia Su, Yingqi Mi, Qing Li, Fang Dong, Wenqiang Tan, Zhanyong Guo
Summary: Amphiphilic low molecular weight chitosan-lipoic acid (LC-LA) conjugates with different degrees of substitution (DS) of LA were synthesized by N, N'-carbonyldiimidazole (CDI) catalysis to self-assemble into redox-sensitive micelles. The blank micelles showed excellent biocompatibility and redox-sensitive behavior with low critical micelle concentration (CMC), nano-scale size, and positive zeta potential. Doxorubicin (Dox) loaded micelles exhibited redox-trigger behavior, strong antitumor activity, and increased cellular uptake efficiency against A549 cell.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Article
Pharmacology & Pharmacy
Ji Luo, Shuguang Zhang, Peiyao Zhu, Wenke Liu, Jiang Du
Summary: In this study, pH/redox dual-responsive mixed polyprodrug micelles (MPPMs) were prepared for enhanced anticancer drug delivery. The MPPMs showed reasonable size and uniform dispersion, and exhibited pH and redox responsiveness. In vitro and in vivo experiments demonstrated that these MPPMs effectively released the drug and inhibited tumor growth, resulting in improved therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Nour M. AlSawaftah, Vinod Paul, Doua Kosaji, Leen Khabbaz, Nahid S. Awad, Ghaleb A. Husseini
Summary: Targeted liposomes deliver chemotherapeutics to tumours and reduce systemic side effects. Low-frequency ultrasound can trigger drug release from liposomes, and targeted liposomes are more susceptible to ultrasound. Targeting also enhances cellular uptake of the drug and is further enhanced by ultrasound.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Rouba D. Al Bostami, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: Cancer therapies have made significant advancements in the past decade, but there are still barriers to their success. Nanomedicines that deliver multiple drugs and genes simultaneously have shown improved effectiveness and synergistic effects. However, the development of co-delivery systems faces limitations and challenges and requires a better understanding of the therapeutic agent ratio and heterogeneity of cancer cells.
Review
Chemistry, Multidisciplinary
Wafa N. Bahutair, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: Smart drug delivery systems utilizing nanoparticles as drug carriers have shown great potential in enhancing the targetability of anticancer agents and limiting their side effects. Liposomes, as one of the most investigated nanoplatforms, have the capability of encapsulating different types of drugs and good biocompatibility. Liposomal nanodrug systems can release drugs at targeted diseased sites, sparing normal cells from undesired cytotoxic effects. Ultrasound-triggered liposomal nanodrug systems have proven to be effective in spatially and temporally controlling and stimulating drug release in cancer therapy.
Review
Chemistry, Multidisciplinary
Heba F. Abed, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: This paper explores the physiological and biochemical basis of redox-responsive drug delivery systems as a potential cancer treatment, and reviews recent advances in the chemical composition and design of these systems. It discusses five main redox-responsive chemical entities, focusing on the most commonly used disulfide bonds and their incorporation into liposomes, polymeric micelles, and nanogels.
Review
Chemistry, Multidisciplinary
Amaal Abdulraqeb Ali, Waad H. Abuwatfa, Mohammad H. Al-Sayah, Ghaleb A. Husseini
Summary: Researchers believe that gold nanoparticle (GNP) hybrid nanostructures are promising multimodal candidates for cancer therapy, as they can achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. However, there is currently a lack of reviews summarizing the use of GNP nanohybrids for cancer treatment. Therefore, this review provides a critical analysis of GNP nanohybrid use in cancer therapy, with a focus on synergistic approaches.
Article
Environmental Sciences
Mohammad AlShurbaji, Lamis Abdul Kader, Hadia Hannan, Maruf Mortula, Ghaleb A. Husseini
Summary: Diabetes is a global silent epidemic that poses a growing threat to public health. This paper focuses on a mathematical model called the diabetes complication (DC) model, using various numerical methods to analyze and monitor the diabetic population over time. The model's parameters and convergence are discussed, with the Runge-Kutta method providing the highest accuracy. The results provide a comprehensive understanding of diabetes complications and can be utilized to improve overall public health through effective strategies for screening and treatment.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Pharmacology & Pharmacy
Mah Noor Zafar, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: In order to improve current cancer treatments, nanomaterials are used as smart drug delivery vehicles that can be designed to specifically target cancer cells and respond to stimulation. These nanocarriers can encapsulate chemotherapy drugs and deliver them to the affected area, reducing the side effects associated with conventional systemic administration. Different sonosensitive liposomal formulations that can be stimulated using acoustic methods are discussed in this review. Emulsion liposomes (eLiposomes) are highlighted for their ability to promote drug release at low intensities and short exposure times compared to regular liposomes. Other formulations incorporating microbubbles and nanobubbles are also explored.
Article
Mathematics
Ghinwa El Masri, Asma Ali, Waad H. Abuwatfa, Maruf Mortula, Ghaleb A. Husseini
Summary: This research compares two methods for estimating the behavior of neurons using the leaky integrate and fire model. The findings show that Heun's method is faster and more accurate, making it more suitable for this model.
Review
Biochemistry & Molecular Biology
Paul Kawak, Nour M. Al Sawaftah, William G. Pitt, Ghaleb A. Husseini, Christian Celia, Chiara Laezza
Summary: Glioblastoma (GBM) is a highly aggressive brain tumor with limited treatment options due to the blood-brain barrier (BBB). Liposomes offer potential solutions to the limitations of chemotherapy, but passive targeting strategies have been ineffective. The upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics, which show promise in GBM therapy. This review discusses the role of Tf-conjugated liposomes in GBM therapy, recent studies on their drug delivery efficiency, challenges faced, and potential improvements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Baraa A. K. Al-Sakaji, Ghaleb A. Husseini, Naif A. Darwish
Summary: This work investigates the impact of fixed charge density of ion exchange membranes and ionic strength of treated aqueous NaCl solution on the Donnan potential. The study confirms the importance of high fixed charge density in counterbalancing membrane selectivity deterioration in high-salinity systems. The Debye-Huckel model is suitable for predicting Donnan potential up to 0.1 M, while the Meissner model provides better predictions at higher compositions.
Review
Chemistry, Multidisciplinary
Aisha Hamidu, William G. Pitt, Ghaleb A. Husseini
Summary: Cancer, one of the leading causes of death worldwide, presents challenges in diagnosis and treatment. Advances in nanomedicine have enabled the detection and investigation of tumor cells at a cellular level using quantum dots, showcasing their potential for various applications.
Review
Chemistry, Medicinal
Richu Raju, Waad H. Abuwatfa, William G. Pitt, Ghaleb A. Husseini
Summary: Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood-brain barrier (BBB). This review paper consolidates relevant literature regarding the delivery to the brain using nanocarriers, particularly liposomes, and discusses the challenges and potential of using liposomal systems to treat brain tumors.
Review
Biochemistry & Molecular Biology
Waad H. Abuwatfa, Nour AlSawaftah, Naif Darwish, William G. Pitt, Ghaleb A. Husseini
Summary: Membrane fouling is a major challenge for pressure-driven membrane processes. Various factors affect membrane fouling, and several models, including artificial neural networks (ANNs), have been developed to predict fouling. ANNs are powerful tools for nonlinear mapping and can capture complex relationships between input and output variables. This review focuses on the use of ANNs for membrane fouling prediction, providing insights into their strengths, weaknesses, potential, and areas of improvement.
Review
Nanoscience & Nanotechnology
Saniha Aysha Ajith, Omnia Mohamed, Rana Sabouni, Ghaleb Husseini, Abdollah Karami, Renu Geetha Bai
Summary: Nanotechnology is a rapidly growing industry where the use of nanomaterials in various fields raises concerns about their potential impact on human health. This review focuses on the health implications of several commonly used nanoparticles, discussing their routes of exposure and cytotoxicity profiles, with the aim of providing guidelines for safe usage.
Article
Nanoscience & Nanotechnology
Nour M. AlSawaftah, Vinod Paul, Nahid S. Awad, Ghaleb A. Husseini
Summary: Delivering highly toxic drugs inside a safe carrier to tumors while achieving controlled and effective drug release at the targeted sites represents an attractive approach to enhance drug efficiency while reducing its undesirable side effects. Functionalization of highly biocompatible nanocarriers such as liposomes conjugated with targeting moieties enhances their ability to target specific cancer cells overexpressing the targeted receptors. Furthermore, upon their accumulation at the target site, high-frequency ultrasound (HFUS) can be used to stimulate the controlled release of the loaded drugs. Pegylation was found to enhance liposomal sensitivity to HFUS. In addition, targeted pegylated liposomes were more susceptible to HFUS than non-targeted pegylated (control) liposomes.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
