Article
Pharmacology & Pharmacy
Gajendra Singh Thakur, Charu Misra, Nagarani Thotakura, Ahmed Al Saqr, Saud Almawash, Simran Preet, Kaisar Raza
Summary: The study developed a novel chitosan-based nanoconjugate for intravenous drug delivery to enhance the therapeutic efficacy of docetaxel. The system showed superior efficacy on cancer cells compared to the naive drug, improved drug bioavailability, and enhanced hemocompatibility.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Baode Shen, Chengying Shen, Weifeng Zhu, Hailong Yuan
Summary: The study revealed that the size of the nanoparticles affects the absorption and biodistribution of the drug, with smaller particles being more easily absorbed but dissolving faster in vivo, leading to higher drug distribution but lower accumulation of integral nanocrystals in the liver. Larger particles, on the other hand, show slower dissolution and higher liver distribution due to enhanced recognition by RES. The absolute exposure of integral nanocrystals to oral bioavailability enhancement was unexpectedly high, indicating a significant difference in absorption and biodistribution between integral nanocrystals and overall drugs following oral and intravenous administration.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Chemistry, Multidisciplinary
Sarfaraz Ahmad Ejazi, Rebecca Louisthelmy, Katharina Maisel
Summary: Oral drug administration is popular but faces challenges in the harsh gastrointestinal environment. Nanoparticles can enhance drug bioavailability by protecting against degradation, promoting absorption, and facilitating drug transport across the intestinal epithelium. This review focuses on the components of intestinal barriers, various nanoparticles developed for oral delivery, and the intracellular pathways involved in nanoparticle internalization and transport. Understanding these factors may lead to the development of more effective nanoparticles for drug delivery.
Article
Chemistry, Multidisciplinary
Sherif Ashraf Fahmy, Soad Nasr, Asmaa Ramzy, Abdelhameed S. Dawood, Anwar Abdelnaser, Hassan Mohamed El-Said Azzazy
Summary: Loading ascorbic acid (AA) and geranium oil (GO) into niosomal nanovesicles can improve their physicochemical properties and enhance their cytotoxic effects on breast cancer cells. The AA-GO niosomal vesicles showed higher inhibitory effects on cancer cell growth and induced apoptosis compared to free AA or GO, suggesting their potential as a treatment strategy for breast cancer.
Review
Pharmacology & Pharmacy
Daniel Andres Real, Karen Bolanos, Josefina Priotti, Nicolas Yutronic, Marcelo J. Kogan, Rodrigo Sierpe, Orlando Donoso-Gonzalez
Summary: This review focuses on the application of CD-modified or CD-based nanomaterials in drug delivery, highlighting their potential in formulating new systems and achieving controlled drug release and increased bioavailability in in vivo studies.
Article
Pharmacology & Pharmacy
Lie Yun Kok, Pauric Bannigan, Forugh Sanaee, James C. Evans, Michael Dunne, Maximilian Regenold, Lubabah Ahmed, David Dubins, Christine Allen
Summary: The number of lipophilic drug candidates in pharmaceutical discovery pipelines has increased, leading to the need for improved formulation strategies. In this study, self-nanoemulsifying drug delivery systems (SNEDDS) were used to enhance the oral bioavailability of cannabidiol (CBD). The results showed that the SNEDDS formulations led to more rapid absorption and improved systemic exposure of CBD compared to traditional oil-based formulations.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Kyoung Sub Kim, Kun Na, You Han Bae
Summary: Oral administration of pharmaceuticals is challenging due to solubility, size, enzymes, and transporters. Efforts have been made to enhance oral bioavailability using nanoparticles with specific and nonspecific uptake pathways. However, translating results from animal models to humans is difficult and inconsistent. Parameters for translational potential in designing oral nanoparticles are discussed in this review.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Pharmacology & Pharmacy
Alessandra T. Zizzari, Dimanthi Pliatsika, Flavio M. Gall, Thomas Fischer, Rainer Riedl
Summary: Peptides, due to their structural diversity, are considered a unique source of innovative active ingredients, but face challenges in development due to their disadvantageous pharmacokinetic properties. Recent efforts have focused on improving the oral bioavailability of peptide drugs, with the latest findings expected to influence future approaches in developing more efficient and safer orally delivered peptides by pharmaceutical companies.
DRUG DISCOVERY TODAY
(2021)
Review
Pharmacology & Pharmacy
Anjali K. Pandya, Vandana B. Patravale
Summary: Proteins and peptides are highly sought-after biomolecules due to their therapeutic potential, but oral delivery remains a challenge. Computer-aided drug design (CADD) plays a key role in studying molecular interactions and designing formulations.
DRUG DISCOVERY TODAY
(2021)
Article
Chemistry, Applied
Li Wang, Wenqiang Jia, Qilei Yang, Hongda Cai, Xiuhua Zhao
Summary: This study successfully fabricated apigenin-casein nanoparticles (AP-Cas-NPs) to improve the water solubility and bioavailability of apigenin, enhancing its pharmacological effects such as antioxidant, anti-inflammatory, anticancer, and antidiabetic activities. AP-Cas-NPs also demonstrated good gastrointestinal stability and hypoglycemic activity.
FOOD HYDROCOLLOIDS
(2024)
Review
Biochemistry & Molecular Biology
Neslihan Ustundag Okur, Panoraia Siafaka, Evren Homan Gokce
Summary: Oral drug delivery faces challenges due to limitations in the physicochemical properties of drug molecules, leading to low bioavailability. Lipid-based nanoparticles, such as solid lipid nanoparticles and nanostructured lipid carriers, show promise in improving oral bioavailability by increasing solubility and simplifying intestinal absorption.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Gianni Pecorini, Elisabetta Ferraro, Dario Puppi
Summary: This article provides an updated overview of scientific literature on polymeric systems developed for the controlled release of flavonoids. It describes different classes of flavonoids and commonly used polymers for drug delivery. Representative drug delivery systems and their preparation techniques are discussed. The flavonoids investigated for polymer system encapsulation are presented with their main source of extraction and biological properties. Relevant literature on their employment in targeted pharmacological and biomedical applications is reviewed.
Review
Nanoscience & Nanotechnology
Yuehong Ren, Linghui Nie, Shiping Zhu, Xingwang Zhang
Summary: This article explores the significance of oral drug delivery and the role of nanovesicles in enhancing bioavailability. The study discusses the classification, preparative processes, intestinal transport mechanisms, in vivo fate, and design rationale of nanovesicles. By encapsulating drugs in nanoscale vesicles, the efficiency of oral drug delivery can be greatly improved.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Materials Science, Biomaterials
Shuying Li, Yanjuan Wu, Siyuan Liu, Ting Wu, Guozheng Liu, Tianduo Li, Zhaowei Chen
Summary: This work developed an innovative nanoplatform based on a Pt(iv) prodrug and a near-infrared photosensitizer, which can achieve multifunctional cancer therapy and diagnosis. The nanoplatform allows real-time tracking of nanodrugs and has dual effects of photothermal therapy and chemotherapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Biochemistry & Molecular Biology
Neera Raghav, Chanchal Vashisth, Nitika Mor, Priyanka Arya, Manishita R. Sharma, Ravinder Kaur, Surender P. Bhatti, John F. Kennedy
Summary: Polymers-based drug delivery systems are actively studied in the medicinal and pharmaceutical industries. Properties of polymers have been modified to enhance solubility, release kinetics, targeted action site, absorption, and therapeutic efficacy. Natural polymers are preferred due to their easy availability, accessibility, and non-toxicity. This review focuses on oral drug delivery systems using four natural polymers, cellulose, pectin, carrageenan, and alginate, and provides a concise and tabulated summary of relevant literature from the last five years.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Raghu Ganugula, Meenakshi Arora, Prabhjot Saini, Melissa Guada, Majeti N. V. Ravi Kumar
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Polymer Science
Raghu Ganugula, Meenakshi Arora, Melissa Guada, Prabhjot Saini, Majeti N. V. Ravi Kumar
Article
Biochemistry & Molecular Biology
R. Ganugula, M. Deng, M. Arora, H. -L. Pan, M. N. V. Ravi Kumar
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Caitlin A. Madison, Meenakshi Arora, M. N. V. Ravi Kumar, Shoshana Eitan
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Raghu Ganugula, Meenakshi Arora, Dianxiong Zou, Sandeep K. Agarwal, Chandra Mohan, M. N. V. Ravi Kumar
Article
Multidisciplinary Sciences
R. Ganugula, M. Arora, M. A. Lepiz, Y. Niu, B. K. Mallick, S. C. Pflugfelder, E. M. Scott, M. N. V. Ravi Kumar
Article
Biochemistry & Molecular Biology
Srijayaprakash Uppada, Dianxiong Zou, Erin M. Scott, Gladys Ko, Stephen Pflugfelder, M. N. V. Ravi Kumar, Raghu Ganugula
Summary: Neurovascular eye problems are best prevented rather than managed or treated, but currently there are limited options available. A robust ex vivo rat eye model was introduced in this study to investigate the therapeutic potential of paclitaxel and urolithin A for preventing vascular damage in the retina.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
R. Ganugula, M. Arora, S. Dwivedi, D. S. Chandrashekar, S. Varambally, E. M. Scott, M. N. V. Ravi Kumar
Summary: This study proposes a combination therapy targeting inflammation and hyperglycemia using curcumin-laden nanoparticles and basal insulin to prevent diabetic cataracts and retinopathy. The treatment successfully delayed the progression of the diseases, improved liver function and glucose homeostasis, and protected against retinal vascular damage induced by hyperglycemia. The chronic administration of curcumin-laden nanoparticles was found to be well tolerated, indicating their potential application without nanoparticle toxicity concerns.
Article
Nanoscience & Nanotechnology
Ingrid M. Heyns, Raghu Ganugula, Tanmaykumar Varma, Swetha Allamreddy, Navneet Kumar, Prabha Garg, M. N. V. Ravi Kumar, Meenakshi Arora
Summary: This study reported the design and synthesis of highly functional nanoparticles targeted towards the folate receptor for peroral delivery of insulin. The nanoparticles decorated with naringenin showed increased colocalization with the folate receptor and improved bioavailability compared to unfunctionalized nanoparticles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Urology & Nephrology
Michael W. Holliday Jr, Ravikumar Nagavenkata Majeti, David Sheikh-Hamad
Summary: Chronic interstitial nephritis in agricultural communities (CINAC) is a global epidemic kidney disease with unknown etiology and no specific treatment. It primarily affects agricultural workers in specific tropical and subtropical regions, but can also affect other populations.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Chemistry, Multidisciplinary
R. Ganugula, M. Arora, S. Dwivedi, D. S. Chandrashekar, S. Varambally, E. M. Scott, M. N. V. Ravi Kumar
Summary: A combination therapy targeting inflammation and hyperglycemia is effective in preventing diabetic eye diseases, improving liver function and glucose homeostasis.
Article
Nanoscience & Nanotechnology
M. Arora, R. Ganugula, N. Kumar, G. Kaur, J-P Pellois, P. Garg, M. N. V. Ravi Kumar
ACS APPLIED BIO MATERIALS
(2019)
Article
Chemistry, Multidisciplinary
G. Kaur, M. Arora, R. Ganugula, M. N. V. Ravi Kumar
CHEMICAL COMMUNICATIONS
(2019)
Article
Nanoscience & Nanotechnology
Raghu Ganugula, Meenakshi Arora, Majeti N. V. Ravi Kumar
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Pharmacology & Pharmacy
Raghu Ganugula, Meenakshi Arora, Patcharawalai Jaisamut, Ruedeekorn Wiwattanapatapee, Heather G. Jorgensen, Vinod P. Venkatpurwar, Beiyan Zhou, Aline Rodrigues Hoffmann, Rita Basu, Shaodong Guo, Naga Venkata Ravi Kumar Majeti
BRITISH JOURNAL OF PHARMACOLOGY
(2017)
