Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of adding bypass holes in a dry powder inhaler on aerosol particle characteristics. The direction, size, and position of the bypass holes in the inhaler passage were found to significantly influence the spray output. Adding bypass holes decreased the mean penetration length of drug particles by 12%, but simultaneously increased the spray angle by 35%, resulting in a significant decrease in forward particle momentum.
Article
Engineering, Chemical
Hyeonkang Park, Chang-Soo Han, Chun-Woong Park, Kibum Kim
Summary: This study investigates the effects of mouthpiece designs in carrier-based dry powder inhalation on aerosol particle characteristics. It is found that a mouthpiece with a spiral channel and mixing chamber is effective in delivering drug particles uniformly to the peripheral target regions of the respiratory system under low flow velocities.
Article
Chemistry, Multidisciplinary
Damiano La Zara, Feilong Sun, Fuweng Zhang, Frans Franek, Kinga Balogh Sivars, Jenny Horndahl, Stephanie Bates, Marie Brannstrom, Par Ewing, Michael J. Quayle, Gunilla Petersson, Staffan Folestad, J. Ruud van Ommen
Summary: Surface nanoengineering using atomic layer deposition (ALD) on micronized budesonide particles can effectively tailor the drug release and lung deposition characteristics, providing promising opportunities for the next generation of controlled pulmonary drug delivery systems.
Article
Biochemistry & Molecular Biology
Azin Jahangiri, Ali Nokhodchi, Kofi Asare-Addo, Erfan Salehzadeh, Shahram Emami, Shadi Yaqoubi, Hamed Hamishehkar
Summary: The study aimed to develop carrier-free inhalable CLX microparticles for dry powder inhalation (DPI) using electrospraying. The results showed that electrosprayed particles prepared from the ethanol-acetone solvent mixture at a drug concentration of 3% exhibited the best in vitro aerosolization properties.
Review
Pharmacology & Pharmacy
Abhinav Ram Mohan, Qiang Wang, Sneha Dhapare, Elizabeth Bielski, Anubhav Kaviratna, Liangfeng Han, Susan Boc, Bryan Newman
Summary: This review provides a comprehensive understanding of the complexity of dry powder inhalers and explores the implications of advancements in formulation and device design for generic drug development.
Review
Pharmacology & Pharmacy
Anne Haaije de Boer, Paul Hagedoorn, Floris Grasmeijer
Summary: This article discusses the manufacturing and development of modern dry powder inhalers (DPIs), and highlights the limitations of current DPIs and areas for improvement.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Jiayi Li, Sibo Ma, Ying Sun, Ruxiao Song, Baoli Cai, Hao Li, Ying Chen, Xin Zhang, Jian Guan, Shirui Mao
Summary: Rheological properties are an effective tool for predicting the deposition behavior of dry powder inhalers (DPIs) in both single and combined systems.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Shalaleh Zendehdel Baher, Shadi Yaqoubi, Kofi Asare-Addo, Hamed Hamishehkar, Ali Nokhodchi
Summary: This study aimed to formulate a simvastatin nanoparticle dry powder inhalation (DPI) formulation for the local treatment of pulmonary arterial hypertension (PAH). The results confirmed that the spray drying technique can be used to obtain inhalable simvastatin nanoparticles with suitable inhalation performance.
Article
Engineering, Chemical
Neetu Varun, Arnab Dutta, Chinmay Ghoroi
Summary: This study investigates the drug-excipient incompatibility in physical mixtures and its impact on properties of dry powder inhalers. The findings reveal the formation of condensed or addition compound due to interaction between drug and excipient in solid-state. The study also suggests that surface modification of excipient can improve the performance of the mixtures.
ADVANCED POWDER TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hend I. Shahin, Lipika Chablani
Summary: Dry powder inhalers (DPIs) are attractive drug delivery systems for the lungs, but designing them with suitable physicochemical properties is challenging. The development of novel DPIs requires the selection of appropriate particle engineering techniques, carriers, and excipients. Optimizing the physicochemical properties of these systems is crucial for efficient drug delivery. This review focuses on recent advances in inhalable dry powder formulations, including current particle engineering techniques, challenges in DPI development, carrier and excipient selection, and factors influencing aerosolization. It also discusses the current and emerging applications of DPIs for local and systemic drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Francesca Buttini, Eride Quarta, Chiara Allegrini, Federico Lavorini
Summary: Pulmonary drug delivery is focused on directing drugs to lung disease sites for maximum therapeutic benefit, with capsule-based dry powder inhalers (cDPIs) being a popular and convenient option for treating a variety of diseases. cDPI technology is relatively simple, cost-effective, and has a lower carbon footprint compared to other inhaler devices.
Article
Pharmacology & Pharmacy
Connor Howe, Mohammad A. M. Momin, Ghali Aladwani, Sarah Strickler, Michael Hindle, Worth Longest
Summary: This study focused on the development of an infant air-jet dry powder inhaler (DPI) that could be actuated multiple times with minimal user interaction. The metering system, consisting of a powder delivery tube (PDT) and a powder supporting shelf, could be tuned for individual powder formulations to maintain high efficiency lung delivery. The optimized infant air-jet DPI provided efficient and consistent lung delivery of aerosols based on in vitro testing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Chemical
Karl Bass, Dale Farkas, Amr Hassan, Serena Bonasera, Michael Hindle, P. Worth Longest
Summary: Recent advancements have been made in technologies such as nose-to-lung administration, active positive-pressure devices, structures to reduce turbulence and jet momentum, and highly dispersible excipient enhanced growth particle formulations, which can significantly improve the efficiency and reproducibility of dry powder inhaler (DPI) use in children. These advancements have the potential to overcome current limitations and improve lung delivery efficiency in pediatric subjects as young as two years old.
JOURNAL OF AEROSOL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Malihe Karimi, Hossein Kamali, Marzieh Mohammadi, Mohsen Tafaghodi
Summary: Therapeutic proteins and peptides have gained attention for chronic diseases, and pulmonary drug administration is a promising alternative with acceptable bioavailability and stability. Stabilizing proteins through drying techniques is critical, and various methods have been used to prepare inhalable powders.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Oncology
Wei-Ren Ke, Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Patricia Tang, Lan Chen, Donghao Chen, Hak-Kim Chan
Summary: Inhaled drugs are commonly used for respiratory-supported patients, with pressurized metered dose inhalers and nebulizers being the main platforms. However, dry powder inhalers (DPIs) are underutilized due to lack of in vivo data and misconceptions about their efficacy in warm and humidified inspiratory air. Recent studies have shown successful delivery of dry powders through humidified circuits, highlighting the advantages of DPIs in terms of rapid delivery and high dose.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Ye Zhang, Hanieh Gholizadeh, Paul Young, Daniela Traini, Ming Li, Hui Xin Ong, Shaokoon Cheng
Summary: This study demonstrates the real-time and noninvasive monitoring of P. aeruginosa biofilm growth using a novel microfluidic device. It shows that P. aeruginosa biofilm developed on the air-liquid interface continuously produces the compound PYO, and the amount of PYO produced is proportional to its viable cell numbers. Results also indicate that treating the biofilm directly on its surface is more effective in reducing PYO and killing the biofilm.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Ye Zhang, Chun Yuen Jerry Wong, Hanieh Gholizadeh, Annalisa Aluigi, Mattia Tiboni, Luca Casettari, Paul Young, Daniela Traini, Ming Li, Shaokoon Cheng, Hui Xin Ong
Summary: Respiratory tract infections are a leading cause of death globally, and liposomal antibiotic nano-systems delivered via inhalation have shown promise in targeting infections with reduced systemic exposure and side effects. This study evaluated the antibiofilm efficacy of two different-sized liposomal ciprofloxacin formulations using a 3D-printed microfluidic chip, and the results suggest that these formulations can effectively control drug release and offer potential treatment for respiratory infections.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Oncology
Hiu Ting Chan, Satoshi Nagayama, Masumi Otaki, Yoon Ming Chin, Yosuke Fukunaga, Masashi Ueno, Yusuke Nakamura, Siew-Kee Low
Summary: This study compared the clinical utility and sensitivity of two different approaches to ctDNA analyses in colorectal cancer patients. It found that tumor-informed ctDNA analysis was more accurate in monitoring genetic mutations compared to tumor-agnostic analysis. Serial monitoring of ctDNA allowed for the early detection of disease recurrence, with a median of 5 months earlier than radiological imaging.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mathew N. Leslie, Nirmal Marasini, Zara Sheikh, Paul M. Young, Daniela Traini, Hui Xin Ong
Summary: A central characteristic of emphysematous progression is the continuous destruction of the lung extracellular matrix (ECM). Our study aims to repurpose Nitrofurantoin (NF) as an inhalable therapeutic strategy to upregulate ECM expression, thereby reversing the disease progression within the emphysematous lung. Spray-dried (SD) formulations of NF were prepared using different nozzles (2FN and 3FN) and characterized for their physicochemical properties and efficacy on human lung fibroblasts. The 2FN formulation displayed better aerodynamic properties and higher drug release, leading to significantly enhanced ECM protein expression compared to the 3FN formulation.
Article
Biophysics
Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Daniela Traini, Paul Young, Zara Sheikh, Hui Xin Ong
Summary: The current organ-on-chip platforms for respiratory drug delivery research have limitations in administering aerosol drugs and studying their interaction with the respiratory tract barrier. This study developed a human nasal epithelial mucosa (NEM)-on-a-chip that can deposit nasal aerosol formulations under realistic shear stresses. The NEM-on-a-chip demonstrated varying aerosol deposition and particle size distributions under different dynamic conditions, as well as adverse effects on cell viability at higher shear stress.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Chemical
Vishal Chaugule, Larissa Gomes dos Reis, David F. Fletcher, Paul M. Young, Daniela Traini, Julio Soria
Summary: A novel design concept for a dry powder inhaler is proposed to improve its aerosol performance and achieve higher lung deposition. The design includes a varying inner cross-section of the device, resulting in improved flow characteristics and an increased fine particle fraction. This design concept was further adapted with the use of a honeycomb grid, which showed a reduction in fine particle fraction when placed after the tangential inlets but had no significant effect on throat deposition when placed at the mouthpiece exit.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Ching-Yee Loo, Daniela Traini, Paul M. Young, Thaigarajan Parumasivam, Wing-Hin Lee
Summary: The delivery of polyphenols, such as curcumin and quercetin, via inhalation can effectively treat lung cancer by increasing drug concentration in tumor cells. However, their applications have been limited by poor solubility and stability. In this study, inhaled curcumin nanoparticles and quercetin nanoparticles were shown to have enhanced anti-cancer activity in A549 cells compared to their individual formulations. Higher ratios of quercetin in the combination formulations induced more apoptosis, reduced ATP levels, generated more ROS, and caused MMP loss in A549 cells. The combination formulations also increased the expression of pro-apoptotic protein Bax. The toxicity of the formulations followed the trend: Cur-NPs: Que-NPs (1:4) > Cur-NPs: Que-NPs (2:3) > Cur-NPs: Que-NPs (3:2) > Cur-NPs: Que-NPs (4:1) > Cur-NPs only > Que-NPs only. Furthermore, both Cur-NPs and Que-NPs were internalized by cells through clathrin-mediated endocytosis. Overall, the combination of Cur-NPs and Que-NPs delivered via inhalation may serve as an alternative treatment for lung cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Zara Sheikh, Antonella Granata, Ye Zhang, Hanieh Mohammad Gholizadeh Mahvizani, Dina Silva, Paul M. M. Young, Luca Casettari, Hui Xin Ong, Daniela Traini
Summary: A novel 3D-printed throat model integrated with the Detroit 562 ALI model was developed to investigate drug transport in the oro-pharyngeal region by optimizing the culture conditions.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Sabrina Sciabica, Riccardo Barbari, Riccardo Fontana, Giovanni Tafuro, Alessandra Semenzato, Daniela Traini, Dina M. Silva, Larissa Gomes Dos Reis, Luisa Canilli, Massimo Terno, Peggy Marconi, Anna Baldisserotto, Silvia Vertuani, Stefano Manfredini
Summary: Hyaluronic acid (HA) is a polymer with unique biological properties that has various applications in pharmaceutical, cosmetic, and biomedical fields; however, its short half-life has limited its widespread use. A new cross-linked hyaluronic acid was designed and characterized using a natural and safe cross-linking agent, arginine methyl ester, which showed improved resistance to enzymatic action compared to linear polymers. The new derivative demonstrated effective antibacterial activity against S. aureus and P. acnes, making it a promising candidate for cosmetic formulations and skin applications, and its tolerability on lung cells suggests its suitability for respiratory tract applications.
Review
Biochemical Research Methods
Ye Zhang, Paul Young, Daniela Traini, Ming Li, Hui Xin Ong, Shaokoon Cheng
Summary: Biofilms are structured communities of bacterial cells encased in a self-produced polymeric matrix, exhibiting temporal responses to stimuli. They have both beneficial and detrimental impacts in various fields, but comprehensive understanding of their properties remains a challenge.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Computer Science, Interdisciplinary Applications
Zhiwei Shen, Jingliang Dong, Liam Milton-McGurk, Xinyu Cai, Hanieh Gholizadeh, Hak-Kim Chan, Ann Lee, Agisilaos Kourmatzis, Shaokoon Cheng
Summary: Understanding the effects of anatomical structures on nasal flow and particle deposition is important for drug delivery optimization and assessing the impact of pollutants and toxins inhalation. This study found that simplifying the geometry of the nasal cavity had minimal effect on airflow but influenced the location and quantity of particle deposition.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Qixuan Zhu, Maziar Kakhi, Chandana Jayasundara, Ross Walenga, Srinivas Ravindra Babu Behara, Hak-Kim Chan, Runyu Yang
Summary: This study develops a numerical model to investigate the effect of aperture size on powder dispersion in dry powder inhalers. The results show that larger apertures can reduce the emptying time of the capsule and increase the particle evacuation velocity. However, the impact energy of collisions is not significantly affected by aperture size. It is also found that inside the capsule, particle-particle collisions are more frequent, while outside the capsule, particle-wall collisions are more frequent.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ching-Yee Loo, Charles Gnanaraj, Daniela Traini, Paul M. Young, Wing-Hin Lee
Summary: This study evaluated the use of polyvinylpyrrolidone (PVP) as a co-stabilizer and coating material to improve the stability and bioavailability of curcumin (CUR) and quercetin (QUE) nanoparticles (NPs). The NPs showed anomalous Non-Fickian release behavior when co-stabilized with different concentrations of PVP. The NPs maintained their physical stability and drug content under different pH conditions and demonstrated enhanced cellular uptake and stability during storage when higher concentrations of PVP were used.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Daniel J. Duke, Lingzhe Rao, Alan Kastengren, Benjamin Myatt, Phil Cocks, Stephen Stein, Nirmal Marasini, Hui Xin Ong, Paul Young
Summary: This study used X-ray fluorescence spectroscopy to examine the distribution of drugs inside the canister and actuator in different pMDI formulations. The results indicate that new propellants have a significant impact on drug distribution, particularly for low-GWP formulations where chemistry changes play a major role.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)