期刊
JOURNAL OF PHARMACEUTICAL SCIENCES
卷 97, 期 7, 页码 2448-2461出版社
ELSEVIER SCIENCE INC
DOI: 10.1002/jps.21215
关键词
DNA delivery; formulation; gene delivery; microparticles; plasmid DNA; poly(lactide-co-glycolide) (PLGA); polymeric drug delivery systems
资金
- NCI NIH HHS [R21 CA128414, P50 CA097274-04] Funding Source: Medline
Biodegradable poly(lactide-co-glycolide) (PLGA) particles have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including plasmid DNA (pDNA). Here, we survey current approaches to PLGA particle preparation for pDNA delivery and discuss recent progress on optimizing formulation development. (C) 2007 Wiley-Liss, Inc.
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