期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 89, 期 -, 页码 111-117出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2013.10.040
关键词
Molecular imprinting; Interval recognition; Solid phase extraction; Pharmaceutical; Sulpiride
资金
- Environment Research and Technology Development Fund of the Ministry of the Environment, Japan [B-0806]
- Japan Society for the Promotion of Science [24350039]
- SENTAN, Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [24750068] Funding Source: KAKEN
We report an effective and a quantitative analysis method for one of pharmaceuticals, sulpiride, in river water by online solid phase extraction (SPE) connected with liquid chromatography-mass spectrometry (LC-MS) using a molecularly imprinted polymer as a preconcentration medium. The polymer prepared with a pseudo template molecule showed the selective retention ability based on the interval recognition of functional groups in sulpiride. Also, the imprinted polymer provided an effective concentration of a trace level of sulpiride in offline SPE with dual washing processes using water and acetonitrile, although another imprinted polymer prepared by an authentic method using sulpiride and methacrylic acid as a template and a functional monomer, respectively, showed the selective adsorption only in organic solvents. Furthermore, we employed the imprinted polymer as the preconcentration column of online SPE-LC-MS and the results supposed that the proposed system allowed the quantitative analysis of sulpiride with high sensitivity and recovery (10 ng/L at 96%). Additionally, the determination of sulpiride in real river water without an additional spiking was effectively achieved by the system. (C) 2013 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据