Article
Engineering, Environmental
Soomin Jeong, Soogyeong Jang, Seong Soon Kim, Myung Ae Bae, Junnyung Shin, Ki-Baek Lee, Ki-Tae Kim
Summary: The study found that 10μm polystyrene microplastics can cause an increase in seizure-like events in zebrafish, resulting in inhibited swimming behavior, which is attributed to the dysregulation of cholinergic, dopaminergic, and GABAergic systems.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Plant Sciences
Weiwei Zhang, Xu Geng, Qing Dong, Xiuhan Li, Ping Ye, Mengyuan Lin, Bin Xu, Hong Jiang
Summary: This study investigated the mechanism of realgar-induced neurotoxicity and its effects on autophagy and the Keap1-Nrf2-ARE pathway. The results showed that arsenic from realgar accumulated in the brain and blood, leading to neuronal and synaptic damage, decreased exploratory behavior and spontaneous movement, and impaired memory ability in rats. The mechanism may involve realgar-mediated autophagy impairment and continuous activation of the Nrf2 pathway. However, the activation of the Nrf2 pathway was insufficient to counteract oxidative damage, resulting in aggravated apoptosis in the cerebral cortex.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Electrochemistry
A. R. M. Rosli, M. S. Noorashikin, F. Yusoff
Summary: A novel electrochemical sensing platform based on Fe3O4, silver nanoparticles (AgNPs), and reduced graphene oxide (rGO) composite was synthesized for sensitive dopamine (DA) detection in human urine samples. The optimized composite-modified electrode showed anodic peak of DA at 0.20 V vs Ag/AgCl and detection limits of 3.98 nM, with a linear range from 0.015 μM to 100 μM. The sensor offers advantages such as ease of preparation, low cost, and rapid response.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Neurosciences
Rui Feng, Jieyu Liu, Zhao Yang, Tiantian Yao, Ping Ye, Xiuhan Li, Jiaxin Zhang, Hong Jiang
Summary: Realgar, a traditional Chinese medicine containing arsenic, has been found to cause central nervous system toxicity. This study reveals that realgar accumulation in the brain impairs neuronal structure, disrupts autophagic flux, and amplifies the p62-NRF2 feedback loop, leading to apoptosis and neurotoxicity. These findings highlight the mechanism of realgar-induced neurotoxicity.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Environmental Sciences
Bin He, Yan Wang, Shuang Li, Yuwei Zhao, Xiaolong Ma, Weicheng Wang, Xinran Li, Yanshu Zhang
Summary: The study revealed significant relationships between heavy metal exposure and neurotransmitters, as well as between neurotransmitters and neurobehavior. Specifically, Ser, Glu, Gly, and GABA were found to have a specific mediating effect between blood heavy metals and neurobehavior. This provides valuable information for the prevention and management of metal-related neurological disorders in preschool children.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Peng Chen, Matthew L. Scarpelli, Debbie R. Healey, Shwetal Mehta, C. Chad Quarles
Summary: This study compares the performance of [18F]fluciclovine PET and MRI in detecting the whole brain tumor burden. The results show that PET and MRI have similar sensitivity, but the combination of PET and MRI has higher sensitivity and lower specificity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Environmental Sciences
Jie Gu, Min Guo, Xiaogang Yin, Caoxing Huang, Lingling Qian, Linjun Zhou, Zhen Wang, Lei Wang, Lili Shi, Guixiang Ji
Summary: The study compared the neurotoxicity of four BPs on zebrafish and found that BPAF, BPF, and BPA exposure significantly reduced locomotor activity in the larvae. Additionally, BPAF adversely affected motor neuron axon length and CNS neurogenesis. BPAF displayed the strongest effects on neurotransmitters levels, followed by BPF and BPA, while BPS showed the weakest effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Jie Gu, Yuanhui Zhu, Min Guo, Xiaogang Yin, Mengyuan Liang, Xinyu Lou, Jingrong Chen, Linjun Zhou, Deling Fan, Lili Shi, Guocheng Hu, Guixiang Ji
Summary: This study evaluated the neurotoxicity of BPF and uncovered a novel mechanism involving disturbance of neurotransmitter metabolism and gut dysbiosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agricultural Engineering
R. S. Sowmya, Vishal G. Warke, Girish B. Mahajan, Uday S. Annapure
Summary: Amino acids promote the growth of coriander by improving plant metabolism. This study analyzed the impact of amino acids solution on coriander cultivated hydroponically under different light conditions. Results showed that the incorporation of amino acids into the nutrient solutions significantly affected the growth, elemental content, chlorophyll, carotenoid, amino acids, and essential oils profile of coriander. The use of 100 ppm amino acids solution resulted in morphological changes, increased nutrient content, enhanced chlorophyll and carotenoid content, and higher accumulation of aromatic compounds.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Environmental Sciences
Mohamed A. Awad, Zainab Sabry Othman Ahmed, Huda O. AbuBakr, Gehad Abd El-Fattah Hassan Elbargeesy, Moukhtar H. G. Moussa
Summary: The study demonstrates that FIP can induce oxidative stress in the brain stem and diencephalon, leading to apoptosis and tissue reaction. Over a 45-day period, FIP significantly increased levels of MDA, PCC, and DNA fragmentation, resulting in alterations to the neural tissue in these regions. Additionally, immunoreactivity to GFAP, iNOS, and caspase-3 (active form) was significantly elevated in the FIP-treated group.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Beibei Qi, Chao Wu, Huiling Liang, Kehui Cui, Shah Fahad, Manlian Wang, Baoyu Liu, Lixiao Nie, Jianliang Huang, Hui Tang
Summary: The study developed a method for determining phytohormones using liquid-liquid extraction and HPLC-UV analysis system, with optimized parameters. The method can simultaneously determine 11 phytohormones, showing low detection limits and good recovery rates, suitable for phytohormone determination in rice plants.
Article
Environmental Sciences
Yun Wang, Tingting Gai, Lianfeng Zhang, Liangwen Chen, Shunchang Wang, Tao Ye, Weiru Zhang
Summary: This study used the nematode C. elegans as an animal model to investigate the neurobehavioral and developmental effects of BPA. The results showed that BPA caused neurobehavioral toxicities, decreased growth and survival rate, and damaged neurons in the nematode. In addition, BPA induced oxidative damage. The findings suggest that neurobehavioral and developmental toxicity of BPA may be attributed to neurotransmission abnormality and oxidative damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Shiyi Wei, Fei Wu, Jing Liu, Wenliang Ji, Xiulan He, Ran Liu, Ping Yu, Lanqun Mao
Summary: This study provides the first direct evidence of neurotoxicity induced by nanoplastics, using single-vesicle electrochemistry. The researchers observed cellular uptake of polystyrene nanoplastics, leading to cell viability loss and reductions in vesicular catecholamine content, exocytotic activity, neurotransmitter release, and fusion pore opening-closing speed. Mechanistic investigations suggest that nanoplastics disrupt F-actin assemblies. This research offers important insights into how nanoplastics affect neurotransmitter secretion and neural functions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Singh
Summary: This study aimed to assess the neurotoxicity and underlying biomolecular mechanism of different concentrations of polystyrene microplastics on zebrafish embryos. The results showed that the embryos could ingest and bioaccumulate microplastics without causing morphological changes and lethality. However, microplastic exposure led to altered swimming behavior patterns, increased apoptosis, abnormal neurotransmitter levels, down-regulation of bdnf gene expression, and disrupted downstream apoptotic signaling.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Environmental Sciences
Qing Yang, Ping Deng, Dan Xing, Haoling Liu, Fang Shi, Lian Hu, Xi Zou, Hongyan Nie, Junli Zuo, Zimeng Zhuang, Meiqi Pan, Juan Chen, Guangyu Li
Summary: The fungicide difenoconazole was found to affect the development of the nervous system in zebrafish embryos, leading to inhibitory effects on heart rate and body length, increased malformation rate, and decreased locomotor activity. Difenoconazole treatment also significantly reduced dopamine and acetylcholine levels, while increasing acetylcholinesterase activity. Furthermore, the expression of genes involved in neurodevelopment was significantly altered.
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)