Article
Biochemistry & Molecular Biology
Chaohui Bao, Shan Wang, Lulu Jiang, Zhongcheng Fang, Kexin Zou, James Lin, Saijuan Chen, Hai Fang
Summary: How to effectively convert genomic summary data into downstream knowledge discovery is a major challenge in human genomics research. We have developed OpenXGR, a web server that offers almost real-time enrichment and subnetwork analyses for user-input genes, SNPs, or genomic regions. It leverages ontologies, networks, and functional genomic datasets to link SNPs or genomic regions to candidate genes. OpenXGR provides a user-friendly and all-in-one platform for interpreting summary data on the human genome, enabling integrated and effective knowledge discovery.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Patricia Wollstadt, Mariusz Bujny, Satchit Ramnath, Jami J. J. Shah, Duane Detwiler, Stefan Menzel
Summary: This article introduces an industry-grade automobile hood dataset called CarHoods10k, which includes over 10,000 shapes and mechanical performance data. It provides researchers and practitioners with the opportunity to develop novel methods. The study demonstrates the effectiveness of machine learning in building metamodels and design optimization.
IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION
(2022)
Review
Construction & Building Technology
Jiaxin Ling, Xiaojun Li, Haijiang Li, Yi Shen, Yi Rui, Hehua Zhu
Summary: Support design is crucial for the safety of rock tunnel construction. IoT and other information technologies have been used to collect monitoring data in real time. This review identifies three research gaps and proposes key indicators for tunnel support design. A conceptual framework is proposed to guide the most appropriate and efficient methods for just-in-time tunnel support design.
AUTOMATION IN CONSTRUCTION
(2022)
Article
Materials Science, Multidisciplinary
M. G. Brik, A. M. Srivastava, A. Popov
Summary: Proper presentation and interpretation of experimental spectroscopic data is crucial for understanding luminescence in solids. Errors in interpreting spectroscopic data, such as estimating band gaps, locating defect levels, decomposing spectral bands, and comparing FWHM, are prevalent in scientific reports. Citing these issues can help researchers avoid these common mistakes in data interpretation.
Article
Computer Science, Theory & Methods
Rodrigo Cataldo, Ramon Fernandes, Kevin J. M. Martin, Jarbas Silveira, Gustavo Sanchez, Johanna Sepulveda, Cesar Marcon, Jean-Phillipe Diguet
Summary: The decrease in performance gain due to Moore's Law has led to the development of manycore architectures, which require parallel applications to be distributed across multiple cores for optimal performance. Developing parallel applications is more challenging than sequential ones, as synchronization primitives must be used to ensure data integrity.
IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
(2021)
Article
Multidisciplinary Sciences
Herbert Formayer, Imran Nadeem, David Leidinger, Philipp Maier, Franziska Schoeniger, Demet Suna, Gustav Resch, Gerhard Totschnig, Fabian Lehner
Summary: The modelling of electricity production and demand requires specific and comprehensive meteorological data at high temporal frequency. The European electricity market's high connectivity necessitates considering the entire European Union (EU) area, and the spatial resolution must accurately represent thermal conditions, especially in mountainous regions. To meet these requirements, the SECURES-Met dataset was developed, with hourly temporal resolution, covering the EU and selected European countries, and considering high spatial variability.
Review
Environmental Sciences
Monika Nehra, Neeraj Dilbaghi, Rajesh Kumar, Sunita Srivastava, K. Tankeshwar, Ki-Hyun Kim, Sandeep Kumar
Summary: Phosphorene, a two-dimensional material composed of a single atomic layer of black phosphorus, has great potential in catalytic applications due to its unique structural features and properties. This review provides a comprehensive overview of the current status of phosphorene as a catalyst, including its synthesis strategies, structural features, and catalytic properties, based on both computational and experimental results.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Automation & Control Systems
Azad Ghaffari
Summary: Maintaining the safety of unmanned aerial vehicles is essential, with system properties and constraints affecting maneuverability; transforming safety envelopes into input-constrained barriers can guarantee safety and stability; the proposed safety design seamlessly integrates with an existing motion control algorithm and handles UAV complexity using super-twisting control.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2021)
Article
Chemistry, Multidisciplinary
Mariia Matveieva, Pavel Polishchuk
Summary: The interpretation of QSAR models is crucial for understanding complex processes and guiding model validation. This study develops benchmark datasets for evaluating interpretation methods of different complexity levels, proposing quantitative metrics for performance assessment. These benchmarks are applied to various models and neural networks, aiding in the evaluation and investigation of decision-making in complex black box models.
JOURNAL OF CHEMINFORMATICS
(2021)
Article
Computer Science, Information Systems
Shixin Wang, Lixin Wang, Min Guo, Yuanzhe Li, Bowang Li
Summary: This paper presents a novel double node upset (DNU) self-recoverable and single event transient (SET) pulse filterable latch design in 28 nm CMOS technology. The loop structure formed by C-elements (CEs) ensures that the latch can self-recover from the DNUs. A Schmitt trigger at the output can filter out transient pulses from anywhere in the circuit. A clock-controlled inverter channel that connects the input to the output reduces the transmission latency. The simulation results show that the proposed design is completely immune to DNUs, and the delay power area product (DPAP) is reduced by more than 50% compared with the previous design.
Article
Pharmacology & Pharmacy
Pei Ma, Rong Zhang, Lijia Xu, Haibo Liu, Peigen Xiao
Summary: This study utilized network pharmacology to investigate the potential molecular mechanism and new therapeutic opportunities of Coreopsis tinctoria. The results showed that it may have neuroprotective effects by targeting multiple key factors related to apoptosis, particularly through the BCL-2 and AKT signaling pathways. This study provides a theoretical basis for further research on the neuroprotective effects of Coreopsis tinctoria.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Computer Science, Information Systems
Nancy Kumari, D. P. Acharjya
Summary: Digitization is important in improving people's physical health, and healthcare organizations are focusing on precise disease diagnosis and patient care to enhance living standards. However, the vast amount of data generated through digitization contains uncertainties and impreciseness, requiring the application of computational intelligence techniques for analysis and processing.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Mathematics
Bahram Farhadinia, Francisco Chiclana
Summary: This paper introduces the innovative concept of extended fuzzy set (E-FS) and explores its features and relationships with fuzzy set, intuitionistic fuzzy set, Pythagorean fuzzy set, and p-rung orthopair fuzzy set.
Article
Engineering, Electrical & Electronic
Khaldoun Alkhalifeh, Vaclav Valenta, Christophe Craeye
Summary: Antenna test caps are used to test transmit and receive functionality of RF space systems outside anechoic environment. These caps consist of two cylinders, with the upper one containing a probe and a tuning screw, and the lower one containing absorbing material and the antenna under test. A complete design and experimental validation of the test caps for a Martian X-band radio science payload are presented.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2022)
Article
Engineering, Chemical
Giulia Lo Dico, Borja Munoz, Veronica Carcelen, Maciej Haranczyk
Summary: This study introduces an alternative approach using high-throughput virtual experiments to discover high-performing clay-polymer rheological agent formulations. By developing customized feature vectors and combining them with Random Forest models, the formulations with optimal rheological properties are identified in a cost- and time-efficient manner. Three high-performing formulations are selected and their gel strength for engineering operations is verified.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Biochemical Research Methods
Petra Riasova, Jaroslav Jenco, David Moreno-Gonzalez, Yvan Vander Heyden, Debby Mangelings, Miroslav Polasek, Pavel Jac
Summary: A capillary electrophoresis (CE) method was developed and validated for the baseline separation of structurally similar flavonolignans in silymarin complex. The method showed good separation efficiency, linear calibration curves, and accurate results under the experimental conditions. The CE analysis results were comparable to the reference HPLC method for determining flavonolignans in dietary supplements.
Article
Biochemical Research Methods
Yasmine Grooten, Quinten Marcelis, Debby Mangelings, Yvan Vander Heyden
Summary: A micellar liquid chromatographic method was developed to model skin permeability of pharmaceutical and cosmetic compounds. The method allowed for analysis of a large test set of compounds with just one mobile-phase composition, providing useful models with similar or even slightly better performance parameters on a monolithic column as compared to a particle-based column. The method on the monolithic column also allowed for faster analysis, making it ideal for estimating skin permeability.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Engineering, Environmental
Sha Yan, Kai Wang, Yahya Al Naggar, Yvan Vander Heyden, Lingling Zhao, Liming Wu, Xiaofeng Xue
Summary: Consumers often believe that natural food is harmless, however naturally occurring toxins in food represent a health risk to humans. Toxic honey, collected by bees from poisonous plants, contains plant toxins such as grayanotoxins and triptolides that can be fatal if consumed. Understanding the toxicity mechanisms of different toxins, preventing toxic honey from entering the food chain, and developing effective antidotes and treatments are critical challenges.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Green & Sustainable Science & Technology
Ben Ahmed Ziyad, Mohamed Yous, Yvan Vander Heyden
Summary: The study investigated the effect of fatty-acid composition and oil accumulation in developing Pistacia atlantica fruits on the resulting biodiesel properties. Samples from Algeria met international standards, showing promising potential for biodiesel production.
Article
Biochemical Research Methods
Mourad Kharbach, Johan Viaene, Huiwen Yu, Rabie Kamal, Ilias Marmouzi, Abdelaziz Bouklouze, Yvan Vander Heyden
Summary: This study investigated the composition and geographical origin of Moroccan Argan kernels using UPLC-MS technology. By analyzing metabolites and using data handling tools, the geographical traceability of Argan kernels was successfully evaluated.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemical Research Methods
Petra Riasova, Pavel Jac, Miroslav Polasek, Yvan Vander Heyden, Debby Mangelings
Summary: Column coupling can improve chromatographic selectivity for the separation of compounds with similar chemical and structural properties. This study proposes a reliable prediction method for the retention behavior of analytes on a coupled column system, and demonstrates the influence of flow rate and back pressure on prediction precision.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Analytical
Xiaoyun Lei, Ting Huang, Xiaoping Wu, Debby Mangelings, Ann Van Eeckhaut, Jana Bongaerts, Herman Terryn, Yvan Vander Heyden
Summary: In this study, a novel molecularly imprinted monolithic column was successfully synthesized for the selective capillary microextraction of neumtensin and neummedin N. The column exhibited excellent adsorption capacity and selectivity towards the target peptides, and the proposed method proved to be effective for the specific analysis of NT and NmN in human plasma samples.
Article
Chemistry, Analytical
Jan P. M. Andries, Gerjen H. Tinnevelt, Yvan Vander Heyden
Summary: This study proposes and evaluates a new approach, CSIV-PLS1, for PLS modelling of low-correlated multiple responses. CSIV-PLS1 combines the characteristics of PLS1 and PLS2, making it more flexible and achieving better selective and predictive abilities.
Article
Neurosciences
Benjamin Kirchweger, Luiz C. Klein-Junior, Dagmar Pretsch, Ya Chen, Sylvian Cretton, Andre L. Gasper, Yvan Vander Heyden, Philippe Christen, Johannes Kirchmair, Amelia T. Henriques, Judith M. Rollinger
Summary: In this study, the compounds Nemorosine A (1) and fargesine (2) were explored for their pharmacological effects on neurodegenerative disorders using a combined in silico-in vitro-in vivo approach. The compounds showed agonistic effects on the 5-HT2A receptor and demonstrated potential in reducing proteotoxicity and neurodegeneration in Caenorhabditis elegans models. These results contribute to the understanding of the compounds' multitarget profiles and support their potential in the treatment of neurodegenerative disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Yasmine Grooten, Debby Mangelings, Yvan Vander Heyden
Summary: Supercritical fluid chromatography (SFC) was investigated as an alternative method to liquid chromatography for predicting the skin permeability of pharmaceutical and cosmetic compounds. Nine different stationary phases were used to screen a test set of 58 compounds. Multiple linear regression (MLR) models were found to perform better than partial least squares (PLS) models. The best correlation with skin permeability data was achieved using retention factors from a cyanopropyl (CN) column. A simple MLR model including the CN-column retention, octanol-water partition coefficient, and number of atoms showed good fit and predictive features.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Jana Bongaerts, Dimitri De Bundel, Ilse Smolders, Debby Mangelings, Yvan Vander Heyden, Ann Van Eeckhaut
Summary: Neuromedin U (NmU) and neuromedin S (NmS) are neuropeptides belonging to the neuro-medin family. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) is the preferred analytical technique for peptide quantification, but quantification limits for these peptides in biological samples remain challenging due to nonspecific binding. This study focuses on solving the adsorption problem and improving the sensitivity of the LC-MS/MS method for NmU and NmS.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Biochemistry & Molecular Biology
Meryeme El Maouardi, Mourad Kharbach, Yahya Cherrah, Kris De Braekeleer, Abdelaziz Bouklouze, Yvan Vander Heyden
Summary: In addition to its nutritional and therapeutic benefits, Argan oil is highly regarded for its unique bio-ecological and botanic characteristics. It has been traditionally used to treat various health issues and is widely commercialized. However, the intentional adulteration of Argan oil with cheaper oils affects its quality and poses potential health risks to consumers. Analytical techniques are employed to ensure the quality, safety, and authenticity of Argan oil. This review provides a comprehensive overview of studies on the quality assessment of Moroccan Argan oil using both targeted and untargeted approaches, coupled with chemometric techniques to detect adulteration.
Article
Biochemistry & Molecular Biology
Meryeme El Maouardi, Mohammed Alaoui Mansouri, Kris De Braekeleer, Abdelaziz Bouklouze, Yvan Vander Heyden
Summary: The aim of this study was to develop an analytical method for determining the geographical origin of Moroccan Argan oil using near-infrared (NIR) or mid-infrared (MIR) spectroscopic fingerprints. Unsupervised and supervised classification methods were evaluated to distinguish between Argan oils from different regions. The use of multivariate filters improved the accuracy of the classification models. The findings suggest that these models can be applied in routine monitoring to identify the geographical origin of Argan oils, reducing analysis costs and time.
Article
Chemistry, Analytical
Pieter De Gauquier, Jordy Peeters, Kenno Vanommeslaeghe, Yvan Vander Heyden, Debby Mangelings
Summary: This study aims to develop models for predicting the retention, separation, and elution sequence of enantiomers in diverse pharmaceuticals. Quantitative Structure Retention Relationships (QSRR) models are built using molecular descriptors and retention. The models show that only achiral descriptors can accurately predict the global retention, while chiral descriptors are not suitable for predicting enantioseparation and elution sequence. Models with both chiral and achiral descriptors can effectively predict retention, but their ability to predict elution sequence and separation varies for different chromatographic systems.
Review
Criminology & Penology
Amorn Slosse, Filip Van Durme, Joy Eliaerts, Nele Samyn, Debby Mangelings, Yvan Vander Heyden
Summary: Cannabis sativa L. is widely used as a recreational drug due to its desired psychotropic effects, and its medical properties have attracted attention. This review discusses the challenges in analyzing herbal Cannabis, and the need for sensitive techniques to identify and quantify the components of interest. It provides detailed information on the analysis of cannabinoids in seizures for forensic purposes, and the advantages and drawbacks of existing methods. The application of chemometrics in interpreting complex data is also explained.
WILEY INTERDISCIPLINARY REVIEWS: FORENSIC SCIENCE
(2023)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
