期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 56, 期 1, 页码 16-22出版社
ELSEVIER
DOI: 10.1016/j.jpba.2011.04.017
关键词
Valsartan; Potential impurities; Structural elucidation; Photodegradation; NMR spectroscopic analysis
资金
- Secretary of Science and Technology (SECyT-UNR)
- Argentine National Research Council (CONICET)
- Santa Fe's Secretary of Science, Technology and Innovation (SECTel)
- National Agency for Promotion of Science and Technology (ANPCyT)
A photostability study of Valsartan (VAL) is reported. Exposure of the drug to UV-vis radiation (lambda > 320 nm) yielded two previously unknown compounds, which were detected by HPLC. Preparative amounts of the new potential degradation products (DP-1 and DP-2) were obtained by submitting VAL bulk drug to extensive photodegradation. The impurities were isolated by preparative normal phase column chromatography. Analytical information from the infrared, nuclear magnetic resonance and mass spectral data of the degradation products revealed their structures as N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N-isobutylpentanamide (DP-1) and N-(diazirino[1,3-f]phenanthridin-4-ylmethyl)-N-isobutylpentanamide (DP-2). DP-1 arose from decarboxylation of VAL, while DP-2 results from further loss of nitrogen from the tetrazole motif of DP-1, with concomitant cyclization to yield a tetracyclic diazacyclopropene derivative. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据