Article
Biochemistry & Molecular Biology
Anallely Lopez-Yerena, Anna Vallverdu-Queralt, Olga Jauregui, Xavier Garcia-Sala, Rosa M. Lamuela-Raventos, Elvira Escribano-Ferrer
Summary: This study investigated the distribution of oleocanthal and its metabolites in rat plasma and tissues after the ingestion of refined olive oil. Oleocanthal was mainly detected in the stomach and intestine samples, with concentrations decreasing over time. Ten metabolites were identified, with the small intestine and liver serving as the most important metabolizing organs. The main circulating metabolites were identified as OLC + OH + CH3 and OLC + H2O + glucuronic acid, which may contribute to the health benefits associated with the regular consumption of extra virgin olive oil. Additional research is needed to determine the concentrations and molecular structures of these metabolites in human plasma and tissues.
Article
Green & Sustainable Science & Technology
Vasiliki Boti, Vasiliki Toli, Christina Efthymiou, Triantafyllos Albanis
Summary: This study aimed to optimize, validate, and apply a solid-phase extraction (SPE) method in combination with liquid chromatography (LC)-LTQ/Orbitrap mass spectrometry to determine the most commonly used antibiotics in waters sampled from fish farms in Greece. The presence of oxytetracycline and trimethoprim traces was detected, and an assessment of the environmental risk posed by these antibiotics was performed, indicating a medium to low risk.
Article
Chemistry, Applied
Hong Duan, Wei Wang, Yongxiang Li, Ghulam Jilany Khan, Yuan Chen, Tianci Shen, Nina Bao, Jing Hua, Zhenglian Xue, Kefeng Zhai, Zhaojun Wei
Summary: The study identified 18 compounds in the stem of Premna microphylla Turcz., with 6 compounds being identified for the first time within this genus and plant. These compounds highlight the strong therapeutic potential of Premna microphylla Turcz. stem extract against oxidation-related diseases.
Article
Food Science & Technology
Xiaoya Sun, Shujuan Xue, Yongxia Cui, Meng Li, Suiqing Chen, Jingyang Yue, Zhining Gao
Summary: Corni Fructus (CF) is a widely used traditional medicine and food, but its chemical profile and the impact of storage periods on indicative components have not been systematically studied. In this study, UHPLC-LTQ-Orbitrap-MS was used to investigate the fragmentation behaviors of multiple compounds from CF and the content variety of its indicative components for different storage periods. A total of 130 components, including 47 potentially new compounds, were identified. The storage period studies indicated that the contents of 19 indicative components in CF changed differently with the prolongation of the storage period.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Chemistry, Applied
Jiangyi Luo, Ling Liang, Qinling Xie, Yixing Qiu, Sai Jiang, Yupei Yang, Lijuan Zhu, Yangfen Fu, Shenghuang Chen, Wei Wang, Hanwen Yuan
Summary: This study explored the differences in phytochemical composition, bioactive properties, and antioxidant activity of five citrus by-products in China. Essential compounds for identification were established, and the spectrum-effect relationship analysis revealed the differential markers contributing to the antioxidant activity. The results highlight the potential for enhancing and utilizing citrus by-products.
Article
Plant Sciences
Xiaoya Wang, Kejun Cheng, Zhiyong Liu, Yong Sun, Lifen Zhou, Mengtian Xu, Xiuxiu Dai, Yaokun Xiong, Hua Zhang
Summary: The study revealed that the extract of Mosla chinensis Maxim. cv. Jiangxiangru has anti-inflammatory and antioxidant properties, showing potential therapeutic effects on inflammatory bowel disease.
Article
Plant Sciences
Irena Brcic Karaconji, Karlo Jurica, Uros Gasic, Aleksandra Dramicanin, Zivoslav Tesic, Dusanka Milojkovic Opsenica
Summary: This study compared the phenolic profiles, total phenolic content, and radical scavenging activity of strawberry tree leaves and fruits collected in two locations in Croatia. The results showed that both leaves and fruits contained a wide range of phenolic compounds and exhibited strong antioxidant activity, indicating the potential health-promoting properties of the strawberry tree.
Article
Chemistry, Multidisciplinary
Vasiliki Boti, Vasiliki Kobothekra, Triantafyllos Albanis, Ioannis Konstantinou
Summary: A simple method for determining Endocrine Disrupting Chemicals (EDCs) in dairy products was developed using QuEChERS extraction and liquid chromatography-mass spectrometry analysis. The method demonstrated excellent sensitivity and accuracy, and experimental design was used to optimize the extraction efficiency. Method validation showed good linearity, precision, and recoveries.
APPLIED SCIENCES-BASEL
(2021)
Article
Veterinary Sciences
Pagona G. Gouletsou, George Th. Tsangaris, Eleni I. Katsarou, Maria V. Bourganou, Mariana S. Barbagianni, Athina P. Venianaki, Efterpi Bouroutzika, Athanasios K. Anagnostopoulos, George C. Fthenakis, Angeliki I. Katsafadou
Summary: Proteomics is used to study the proteins present in a sample and their expression under different conditions. This study used high-throughput technologies to analyze the proteome of dog semen and identified proteins related to sperm maturation and motility. Future research can focus on applying this technique to animals with suboptimal fertility.
VETERINARY SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xiaofan Chen, Jiahui Zhang, Rui Li, Hua Zhang, Yong Sun, Li Jiang, Xiaoya Wang, Yaokun Xiong
Summary: This study demonstrates that extracts from Flos Puerariae and Semen Hoveniae (PHE) can effectively alleviate DSS-induced colitis through inhibition of inflammatory reactions, restoration of antioxidant enzyme activity, and modulation of gut microbiota composition.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Fanghua Guo, Rong Tsao, Xiaoya Wang, Li Jiang, Yong Sun, Hua Xiong
Summary: The study analyzed the chemical profiles, metabolites, and organ distribution of yellow pea hull (YPH) extract, as well as their in vivo antioxidant activities in rats using the D-gal model. Results showed that the distribution of these polyphenol metabolites in plasma and organs may have positive effects on antioxidant enzymes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Aleksandra Cvetanovic Kljakic, Milos Radosavljevic, Gokhan Zengin, Linlin Yan, Uros Gasic, Predrag Kojic, Aleksandra Torbica, Miona Belovic, Zoran Zekovic
Summary: Chamomile is widely used as a medicinal plant and its optimal extraction conditions were determined using an artificial neural network model. The optimized conditions included a solid-to-solvent ratio of 1:80, microwave power of 400 W, and extraction time of 30 min. The extract obtained under these conditions had a rich composition and high biological activity, and showed potential as a growth medium for probiotics. This study contributes to the improvement of extraction techniques using modern statistical designs and modeling.
Article
Biochemistry & Molecular Biology
Paola Montoro, Gilda D'Urso, Adam Kowalczyk, Carlo Ignazio Giovanni Tuberoso
Summary: Through various complex analytical methods, the bitter component in strawberry tree honey was identified as unedone. This study provides important clues for identifying specific flavor substances in honey.
Article
Biochemical Research Methods
Nina Wiedmaier-Czerny, Walter Vetter
Summary: Furan fatty acids (FuFAs) are important antioxidants for protecting polyunsaturated fatty acids (PUFAs) in biological systems and food. This study developed a screening method using LC-Orbitrap-HRMS to detect FuFA-containing triacylglycerols (TAGs). The method was successfully applied to the analysis of fish oil and mushroom extract samples, and several FuFA-containing TAGs were identified.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Food Science & Technology
Hong Duan, Guo-cheng Wang, Ghulam Jilany Khan, Xiao-hui Su, Su-lan Guo, Yan-ming Niu, Wen-Gen Cao, Wen-ting Wang, Ke-feng Zhai
Summary: A total of 17 compounds were identified in Isodon amethystoides (Benth.) Hara (IA) leaves extract, with 14 of them being novel findings. Flavonoid components exhibited better free radical scavenging ability, and a significant correlation was observed between diterpenoid compounds content and flavonoids activity. These results provide an experimental basis for the extraction and separation of antioxidant chemical constituents of IA.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
G. A. Zou, D. Guo, H. Q. Zhao, H. A. Aisa
CHEMISTRY OF NATURAL COMPOUNDS
(2015)
Article
Chemistry, Medicinal
D. Guo, W. J. Xue, G. A. Zou, H. A. Aisa
CHEMISTRY OF NATURAL COMPOUNDS
(2016)
Article
Plant Sciences
Qi-Bin Chen, Jie Gao, Guo-An Zou, Xue-Lei Xin, Haji Akber Aisa
JOURNAL OF NATURAL PRODUCTS
(2018)
Article
Chemistry, Medicinal
Ch Turghun, M. Bakri, G. A. Zou, Kh M. Bobakulov, H. A. Aisa
CHEMISTRY OF NATURAL COMPOUNDS
(2018)
Article
Chemistry, Medicinal
M. S. Muratova, G. A. Zou, J. Jenis, H. A. Aisa
CHEMISTRY OF NATURAL COMPOUNDS
(2019)
Article
Chemistry, Medicinal
F. Y. Jia, A. Turak, G. A. Zou
CHEMISTRY OF NATURAL COMPOUNDS
(2019)
Article
Chemistry, Multidisciplinary
Mengfei Qiao, Ying Wang, Xamxikamar Mamat, Anran Chen, Guoan Zou, Lei Li, Guangzhi Hu, Shusheng Zhang, Xun Hu, Damien Voiry
Article
Materials Science, Multidisciplinary
Meng-Fei Qiao, Ying Wang, Lei Li, Guang-Zhi Hu, Guo-An Zou, Xamxikamar Mamat, Ye-Min Dong, Xun Hu
Article
Chemistry, Applied
Mengfei Qiao, Ying Wang, Thomas Wagberg, Xamxikamar Mamat, Xun Hu, Guoan Zou, Guangzhi Hu
JOURNAL OF ENERGY CHEMISTRY
(2020)
Article
Chemistry, Medicinal
J. F. Wu, A. Turak, R. Rouzimaimaiti, G. A. Zou, H. A. Aisa
Summary: Ten monoterpenoids, including a new compound seritramentol A, were isolated from Seriphidium transiliense. The structures and absolute configurations of these compounds were elucidated through various analyses. In addition, their antimicrobial, anti-inflammatory, and antioxidant activities were tested.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Article
Chemistry, Applied
Nurfida Ablajan, Bo Zhao, Xue Wenjuan, Jiangyu Zhao, Sh Sh Sagdullaev, Zou Guoan, Haji Akber Aisa
Summary: Nineteen compounds, including seventeen alkaloids and two megastigmane type compounds, were isolated from Aconitum barbatum var. puberulum Ledeb. Compound 5 displayed mild cytotoxicity against Hela cell lines, while compounds 1 and 6 showed strong antibacterial activity against the Gram-positive bacterium, S. aureus.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Aikebaier Jumai, Ruxianguli Rouzimaimaiti, Guo-An Zou, Haji Akber Aisa
Summary: Four undescribed pyrrolizidine alkaloids and two enantiomeric pairs of unusual alkaloids were isolated from whole plant extracts of Jacobaea vulgaris Gaertn. The structures were determined through spectroscopic and X-ray diffraction analysis, with some confirmed by comparison of theoretical and experimental data. These compounds exhibit unique structural features and possess rare natural moieties.
Article
Plant Sciences
Jun-Fang Wu, Ablajan Turak, Deng Zang, Guo-An Zou, Haji Akber Aisa
Summary: Several unique sesquiterpenoids were isolated from the whole plants of Seriphidium transiliense. Compound 7 exhibited potential activity for treating vitiligo.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Yan-rong Zhao, Guo-an Zou, Haji Akber Aisa
Summary: Eight undescribed guaianolides and two known analogues were isolated from Artemisia macrocephala in Xinjiang, China. Their structures were determined through extensive spectroscopic analysis and confirmed by experimental and calculated ECD data, as well as X-ray crystallography. The discovery of unique guaianolides with unprecedented structures in natural sesquiterpenes is significant.
Article
Chemistry, Medicinal
J. Cui, M. Nuermaimaiti, G. Zou, X. Xin
CHEMISTRY OF NATURAL COMPOUNDS
(2020)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)