期刊
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
卷 48, 期 3, 页码 508-518出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2008.06.022
关键词
Chemiluminescence detection; Process analytical chemistry; Morphine; Codeine; Heroin; Oxycodone; Flow injection analysis; Sequential injection analysis; High-performance liquid chromatography
资金
- Australian Research Council and Deakin University
A review with 98 references. The determination of the opium poppy (Papaver somniferum) alkaloids and their semi-synthetic derivatives has important applications in industrial process monitoring, clinical analysis and forensic science. Liquid-phase chemiluminescence reagents such as tris(2,2'-bipyridyl)ruthenium(II) and acidic potassium permanganate exhibit remarkable sensitivity and complementary selectivity for many P. somniferum alkaloids, which has been exploited in the development of a range of analytical procedures using flow analysis, high-performance liquid chromatography, capillary electrophoresis and microfluidic instrumentation. (C) 2008 Elsevier B.V. All rights reserved.
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