Article
Microbiology
Xiaoju Liu, Yanpeng Xiong, Yiyi Shi, Xiangbin Deng, Qiwen Deng, Yansong Liu, Zhijian Yu, Duoyun Li, Jinxin Zheng, Peiyu Li
Summary: This study found that licochalcone A has antibacterial effects on Enterococcus faecalis and significantly inhibits biofilm formation. Through genetic mutation analysis, it is suggested that licochalcone A may act by regulating transcription factor genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Jianyan Qi, Min Gong, Rui Zhang, Yumeng Song, Qian Liu, Hongyan Zhou, Jue Wang, Yufeng Mei
Summary: Tea tree essential oil (TTO) is known for its traditional medicinal uses and earlier research has shown its effectiveness in inhibiting oral microorganisms. This study found that TTO can destroy cell membrane, inhibit biofilm formation, and eliminate mature biofilms of E. faecalis, suggesting its potential as a novel antibacterial drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Magdalena Moryl, Aleksandra Palatynska-Ulatowska, Agnieszka Maszewska, Iwona Grzejdziak, Silvia Dias de Oliveira, Marieli Chitolina Pradebon, Liviu Steier, Antoni Rozalski, Jose Antonio Poli de Figueiredo
Summary: This study isolated and characterized two phages against E. faecalis and confirmed their lytic activity against the bacteria. The phages showed efficacy against E. faecalis biofilm in an ex vivo model, supporting the potential of phage therapy for prevention and treatment of E. faecalis-associated infections.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Nicole de Mello Fiallos, Ana Luiza Ribeiro Aguiar, Bruno Nascimento da Silva, Mariana Lara Mendes Pergentino, Marcos Fabio Gadelha Rocha, Jose Julio Costa Sidrim, Debora Castelo Branco de Souza Collares Maia, Rossana de Aguiar Cordeiro
Summary: This study aimed to investigate the antimicrobial potential of promethazine (PMZ) and chlorpromazine (CPZ) against dual-species biofilms of Enterococcus faecalis and Candida albicans. Results showed that PMZ was the most efficient phenothiazine, capable of reducing cell counts, biomass, biovolume, carbohydrate and protein contents of the biofilms. PMZ and CPZ did not increase the antimicrobial activity of the irrigants.
Article
Agriculture, Dairy & Animal Science
Dagmara Stepien-Pysniak, Fabrizio Bertelloni, Marta Dec, Giulia Cagnoli, Dorota Pietras-Ozga, Renata Urban-Chmiel, Valentina Virginia Ebani
Summary: The study suggests that pet dogs may act as carriers and spreaders of multidrug-resistant and virulent enterococci, posing a potential risk to other animals and owners.
Article
Nanoscience & Nanotechnology
Ning Li, He-Kuan Luo, Adrielle Xianwen Chen, Jeremy Pang Kern Tan, Chuan Yang, Melgious Jin Yan Ang, Huaqiang Zeng, Yi Yan Yang
Summary: This study introduces a novel class of supramolecules with highly potent antimicrobial activities. These supramolecules exhibit high antimicrobial potency against various bacteria and fungus, with negligible toxicity to mammalian cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Infectious Diseases
Grace Mwikuma, Henson Kainga, Simegnew Adugna Kallu, Chie Nakajima, Yasuhiko Suzuki, Bernard Mudenda Hang'ombe
Summary: The study aimed to determine the prevalence and patterns of antimicrobial resistance and detect drug-resistant genes in Enterococcus species in poultry from four districts in Zambia. The results showed that poultry are a potential source of multidrug-resistant Enterococcus strains, which can be transmitted to humans, posing a significant public health concern.
Review
Microbiology
Parvathy Venkateswaran, Priya M. Lakshmanan, Sudhiksha Muthukrishnan, Hema Bhagavathi, Sahana Vasudevan, Prasanna Neelakantan, Adline P. Solomon
Summary: Enterococcus faecalis, a commensal in the human gastrointestinal tract, is a known cause of nosocomial infections. Its transition from a planktonic to a sessile state, along with the acquisition of multidrug resistance, poses challenges for treatment. Several key genes and molecular pathways, including quorum sensing, aggregation substance, surface adhesions, stress-related response, and sex pheromones, play critical roles in the sessile state. It is crucial to decode the hidden agenda of E. faecalis and understand the factors influencing biofilm formation in order to develop novel strategies to combat infections.
FUTURE MICROBIOLOGY
(2022)
Article
Veterinary Sciences
Yu Jin Lee, Hye-Ri Jung, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee
Summary: Fluoroquinolones are critically important antimicrobials for human medicine, but their extensive use in livestock leads to the rapid spread of antimicrobial resistance, posing a significant health risk to humans. A study found that ciprofloxacin was administered in 40.0%-71.4% of the farms in three out of five integrated broiler operations, with preventive purposes, veterinarian prescriptions, drinking water, and young age having the highest administration rates. High-level ciprofloxacin-resistant Enterococcus faecalis were prevalent in broiler farms in Korea, with multiple drug resistance and specific mutations identified.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Jiakang Li, Lei Yang, Xuelin Huang, Yiping Wen, Qin Zhao, Xiaobo Huang, Jing Xia, Yong Huang, Sanjie Cao, Senyan Du, Rui Wu, Likou Zou, Qigui Yan, Xinfeng Han
Summary: This study revealed a high prevalence of multidrug-resistant Enterococcus faecalis in ducks, with the potential for transmission to humans due to the presence of various resistance and virulence genes. The findings highlight the importance of monitoring antimicrobial resistance in poultry to prevent the spread of potentially harmful pathogens.
Article
Physics, Applied
Yinghui Wen, Yun Luo, Xiaoling Wei, Haibo Tan, Rui Ai, Zhujiang Xiong, Liming Ye
Summary: This study investigates the antibacterial effects of liquid discharge cold plasma (LDCP) on Enterococcus faecalis (E. faecalis) planktonic cultures and root canal biofilms. The results show that LDCP treatment has a significant antibacterial effect on both planktonic E. faecalis and biofilms, surpassing the efficacy of 0.2% chlorhexidine treatment. This work suggests the potential application of liquid discharge plasma devices in root canal treatment.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Infectious Diseases
Md. Liton Rana, Zannatul Firdous, Farhana Binte Ferdous, Md. Ashek Ullah, Mahbubul Pratik Siddique, Md. Tanvir Rahman
Summary: Fish is an important part of Bengali cuisine and economy, but it can also be a potential source of pathogens. This study investigated the distribution of Enterococcus faecalis in wild and cultivated fish in Bangladesh, finding that wild fish had a higher frequency of virulence genes and biofilm-forming genes, while cultivated fish carried more highly multidrug resistant strains.
Article
Food Science & Technology
Marlena Golas-Pradzynska, Magdalena Luszczynska, Jolanta Grazyna Rola
Summary: This study investigates the antimicrobial resistance, virulence, and resistance genes of Enterococcus faecalis and Enterococcus faecium isolated from raw goat's and sheep's milk and cheese. The results show that E. faecalis is the dominant species, with high levels of antimicrobial resistance and presence of virulence genes in some strains.
Article
Microbiology
Renata Kwit, Magdalena Zajac, Aleksandra Smialowska-Weglinska, Magdalena Skarzynska, Arkadiusz Bomba, Anna Lalak, Ewelina Skrzypiec, Dominika Wojdat, Weronika Koza, Emilia Mikos-Wojewoda, Paulina Pasim, Milena Skora, Marcin Polak, Jaroslaw Wiacek, Dariusz Wasyl
Summary: This study aimed to assess the prevalence of Enterococcus spp. in wild birds in Poland, determine their antimicrobial susceptibility, and conduct Whole Genome Sequencing (WGS) analysis. The results showed that out of 138 samples from various species of free-living birds, 66.7% tested positive for Enterococcus. Fourteen species were detected, with Enterococcus faecalis being the most common. Resistance to antimicrobial agents was observed in some E. faecalis and E. faecium strains, along with the presence of multidrug resistance phenotype in one E. faecium strain. WGS analysis also revealed variations in virulence gene diversity between E. faecalis and E. faecium strains, as well as the presence of plasmid replicons in both strains.
Article
Biochemistry & Molecular Biology
Agata Wozniak, Beata Kruszewska, Michal Karol Pieranski, Michal Rychlowski, Mariusz Grinholc
Summary: Enterococcus faecium and Enterococcus faecalis are opportunistic pathogens that can cause a variety of nosocomial infections. E. faecium belongs to the group of ESKAPE microbes, which are difficult to treat due to their resistance to antibiotics. Antimicrobial photodynamic inactivation (aPDI) has shown to significantly impact the survival rate of the bacteria, with different synergy testing results observed between strains and methods. The effectiveness of aPDI in resensitizing bacteria to antibiotics presents great potential for treating infections caused by multidrug-resistant strains.